BR112013025519A2 - composição farmacêutica - Google Patents
composição farmacêuticaInfo
- Publication number
- BR112013025519A2 BR112013025519A2 BR112013025519A BR112013025519A BR112013025519A2 BR 112013025519 A2 BR112013025519 A2 BR 112013025519A2 BR 112013025519 A BR112013025519 A BR 112013025519A BR 112013025519 A BR112013025519 A BR 112013025519A BR 112013025519 A2 BR112013025519 A2 BR 112013025519A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- particles
- coated
- relates
- oral pharmaceutical
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/18—Processes for applying liquids or other fluent materials performed by dipping
- B05D1/22—Processes for applying liquids or other fluent materials performed by dipping using fluidised-bed technique
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
Abstract
abstract the invention relates to an oral pharmaceutical composition comprising coated particles of a complex of at least one active agent with an ion-exchange resin, wherein said particles are coated with a bioadhesive coating layer comprising at least one bioadhesive material. the invention also relates to a process for preparing the oral pharmaceutical composition. tradução do resumo resumo patente de invenção: "composição farmacêutica". a invenção refere-se a uma composição farmacêutica oral que compreende partículas revestidas de um complexo de pelo menos um agente ativo com uma resina de troca de íons, em que as ditas partículas são revestidas com uma camada de revestimento bioadesiva que compreende pelo menos um material bioadesivo. a invenção também se refere a um processo para a preparação da composição farmacêutica oral.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11161398.0 | 2011-04-06 | ||
EP11161398A EP2508174A1 (en) | 2011-04-06 | 2011-04-06 | Pharmaceutical composition |
PCT/EP2012/056366 WO2012136816A2 (en) | 2011-04-06 | 2012-04-05 | Pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013025519A2 true BR112013025519A2 (pt) | 2017-12-12 |
BR112013025519B1 BR112013025519B1 (pt) | 2022-02-01 |
Family
ID=44454073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013025519-6A BR112013025519B1 (pt) | 2011-04-06 | 2012-04-05 | Composição farmacêutica e seu processo de preparação |
Country Status (21)
Country | Link |
---|---|
US (1) | US11103891B2 (pt) |
EP (3) | EP2508174A1 (pt) |
JP (2) | JP6144252B2 (pt) |
KR (1) | KR102078885B1 (pt) |
CN (1) | CN103517708B (pt) |
AP (1) | AP3864A (pt) |
AU (2) | AU2012238629A1 (pt) |
BR (1) | BR112013025519B1 (pt) |
CA (1) | CA2832130C (pt) |
DK (1) | DK2694038T3 (pt) |
EA (1) | EA030074B1 (pt) |
ES (1) | ES2743130T3 (pt) |
HR (1) | HRP20191555T1 (pt) |
HU (1) | HUE045928T2 (pt) |
LT (1) | LT2694038T (pt) |
MX (1) | MX352934B (pt) |
PL (1) | PL2694038T3 (pt) |
PT (1) | PT2694038T (pt) |
RS (1) | RS59061B1 (pt) |
SI (1) | SI2694038T1 (pt) |
WO (1) | WO2012136816A2 (pt) |
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EP2234963B1 (en) | 2007-12-28 | 2020-04-08 | Impax Laboratories, LLC | Controlled release formulations of levodopa and uses thereof |
BR112013003847A8 (pt) | 2010-08-19 | 2017-12-26 | Buck Institute For Age Res | métodos de tratar a deterioração cognitiva moderada (mci) e os distúrbios relacionados |
WO2013123426A1 (en) * | 2012-02-18 | 2013-08-22 | Buck Institute For Research On Aging | Formulations and methods for the treatment or prophylaxis of pre-mci and/or pre-alzheimer's conditions |
EP2725072B1 (en) * | 2012-10-25 | 2015-07-22 | Rohm and Haas Company | Aldehyde abatement with porous amine functional resins |
US9539265B2 (en) | 2013-03-15 | 2017-01-10 | Aihol Corporation | Pharmaceutical formulation containing glycosaminoglycan |
WO2014142938A1 (en) * | 2013-03-15 | 2014-09-18 | Aihol Corporation | Pharmaceutical formulation containing glycosaminoglycan |
WO2014180912A1 (en) * | 2013-05-08 | 2014-11-13 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Modified release formulations of lacosamide |
CN104146978B (zh) * | 2013-05-13 | 2016-12-28 | 沈阳药科大学 | 一种双硫仑肠溶片剂及其制备方法 |
WO2015011119A2 (en) | 2013-07-25 | 2015-01-29 | Basf Se | Salts of dasatinib in amorphous form |
US10987313B2 (en) | 2013-10-07 | 2021-04-27 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
MX369315B (es) * | 2013-10-07 | 2019-11-05 | Impax Laboratories Inc | Formulaciones muco-adhesivas de liberacion controlada de levodopa y/o esteres de levodopa y sus usos. |
CN103622942A (zh) * | 2013-11-04 | 2014-03-12 | 江苏大学 | 左旋多巴/卡比多巴复方缓释混悬剂及其制备方法 |
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KR101601794B1 (ko) * | 2014-05-08 | 2016-03-10 | 주식회사 씨티씨바이오 | 클로미프라민 함유 맛 차폐된 구강 투여용 약학 제제 |
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US20150110871A1 (en) * | 2014-06-02 | 2015-04-23 | David Wong | Gastric retentive tablet compositions |
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US20150133464A1 (en) * | 2015-02-01 | 2015-05-14 | David Wong | Injectable particle |
HUE055000T2 (hu) | 2015-02-27 | 2021-10-28 | Dechra Ltd | Étvágy stimulálása, tömegvesztés kézbentartása és anorexia kezelése kutyák és macskák esetében |
KR20180004756A (ko) * | 2015-05-06 | 2018-01-12 | 신애질 코포레이션 | 약물 입자를 함유하는 제약 현탁액, 그의 투여를 위한 장치, 및 그의 사용 방법 |
CN105223326B (zh) * | 2015-09-23 | 2017-01-18 | 天津中医药大学 | 一种中药口服速释制剂中活性成分的体外分类方法 |
CN105310980A (zh) * | 2015-10-09 | 2016-02-10 | 北京万全德众医药生物技术有限公司 | 帕利哌酮缓释混悬口服液及其制备方法 |
CN105902500B (zh) * | 2016-04-27 | 2019-11-29 | 上海理工大学 | 一种美沙拉嗪肠溶定位控释制剂及其制备方法 |
KR102544141B1 (ko) * | 2016-09-29 | 2023-06-16 | 에스케이케미칼 주식회사 | 라코사미드 서방성 제제 |
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IT1295271B1 (it) | 1997-10-03 | 1999-05-04 | Chiesi Farma Spa | Monolita contenente uno o piu'farmaci costituito da tre strati a meccanismo di rilascio differenziato |
FI109453B (fi) | 1999-06-30 | 2002-08-15 | Orion Yhtymae Oyj | Farmaseuttinen koostumus |
EP1429728A1 (en) * | 2001-08-29 | 2004-06-23 | SRL Technologies, Inc. | Sustained release preparations |
US20030224045A1 (en) | 2002-05-29 | 2003-12-04 | Chien-Hsuan Han | Combination immediate release sustained release levodopa/carbidopa dosage forms |
GEP20074224B (en) * | 2002-12-18 | 2007-10-25 | Ferrer Int | Pharmaceutical compositions of sertaconazole for vaginal use |
AU2004207578B2 (en) * | 2003-01-28 | 2007-06-28 | Collegium Pharmaceutical, Inc. | Multiparticulate compositions of milnacipran for oral administration |
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WO2006081518A2 (en) * | 2005-01-28 | 2006-08-03 | Collegium Pharmaceutical, Inc. | Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents |
US20070003621A1 (en) * | 2005-06-23 | 2007-01-04 | Spherics, Inc. | Dosage forms for movement disorder treatment |
UA95954C2 (ru) | 2006-05-31 | 2011-09-26 | Солвей Фармасьютикалс Гмбх | Продолжительное 24-часовое введение в кишечник леводопа/карбидопа |
US8394415B2 (en) * | 2006-11-21 | 2013-03-12 | Mcneil-Ppc, Inc | Modified release analgesic suspensions |
WO2008151071A1 (en) * | 2007-05-30 | 2008-12-11 | Neos Therapeutics, Lp | Modifying drug release in suspensions of ionic resin systems |
-
2011
- 2011-04-06 EP EP11161398A patent/EP2508174A1/en not_active Withdrawn
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2012
- 2012-04-05 CN CN201280022227.5A patent/CN103517708B/zh active Active
- 2012-04-05 LT LTEP12713721.4T patent/LT2694038T/lt unknown
- 2012-04-05 EA EA201391483A patent/EA030074B1/ru unknown
- 2012-04-05 HU HUE12713721A patent/HUE045928T2/hu unknown
- 2012-04-05 CA CA2832130A patent/CA2832130C/en active Active
- 2012-04-05 ES ES12713721T patent/ES2743130T3/es active Active
- 2012-04-05 JP JP2014503164A patent/JP6144252B2/ja active Active
- 2012-04-05 DK DK12713721.4T patent/DK2694038T3/da active
- 2012-04-05 KR KR1020137029468A patent/KR102078885B1/ko active IP Right Grant
- 2012-04-05 AU AU2012238629A patent/AU2012238629A1/en not_active Abandoned
- 2012-04-05 AP AP2013007227A patent/AP3864A/en active
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- 2012-04-05 PT PT12713721T patent/PT2694038T/pt unknown
- 2012-04-05 BR BR112013025519-6A patent/BR112013025519B1/pt active IP Right Grant
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- 2012-04-05 EP EP12713721.4A patent/EP2694038B1/en active Active
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- 2012-04-05 MX MX2013011572A patent/MX352934B/es active IP Right Grant
- 2012-04-05 EP EP19176943.9A patent/EP3607938A3/en active Pending
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- 2017-06-09 AU AU2017203939A patent/AU2017203939B2/en active Active
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