BR112013019880A2 - sistemas e métodos para dividir gotículas - Google Patents

sistemas e métodos para dividir gotículas

Info

Publication number
BR112013019880A2
BR112013019880A2 BR112013019880A BR112013019880A BR112013019880A2 BR 112013019880 A2 BR112013019880 A2 BR 112013019880A2 BR 112013019880 A BR112013019880 A BR 112013019880A BR 112013019880 A BR112013019880 A BR 112013019880A BR 112013019880 A2 BR112013019880 A2 BR 112013019880A2
Authority
BR
Brazil
Prior art keywords
droplets
droplet
systems
cases
divided
Prior art date
Application number
BR112013019880A
Other languages
English (en)
Portuguese (pt)
Inventor
Adam R Abate
David A Weitz
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of BR112013019880A2 publication Critical patent/BR112013019880A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85938—Non-valved flow dividers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
BR112013019880A 2011-02-07 2012-02-06 sistemas e métodos para dividir gotículas BR112013019880A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161440198P 2011-02-07 2011-02-07
PCT/US2012/023961 WO2012109138A1 (en) 2011-02-07 2012-02-06 Systems and methods for splitting droplets

Publications (1)

Publication Number Publication Date
BR112013019880A2 true BR112013019880A2 (pt) 2016-10-11

Family

ID=45774321

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013019880A BR112013019880A2 (pt) 2011-02-07 2012-02-06 sistemas e métodos para dividir gotículas

Country Status (7)

Country Link
US (1) US20140026968A1 (enExample)
EP (1) EP2673088A1 (enExample)
JP (2) JP2014505594A (enExample)
KR (1) KR20140063507A (enExample)
CN (2) CN105689030A (enExample)
BR (1) BR112013019880A2 (enExample)
WO (1) WO2012109138A1 (enExample)

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US9475013B2 (en) 2012-02-08 2016-10-25 President And Fellows Of Harvard College Droplet formation using fluid breakup
DE102012217487A1 (de) * 2012-09-26 2014-04-17 Agilent Technologies, Inc. - A Delaware Corporation - Fluidschnittstelle zwischen Fluidleitungen unterschiedlicher Querschnitte
EP2964390B1 (en) * 2013-03-06 2018-12-26 President and Fellows of Harvard College Use of devices for forming relatively monodisperse droplets
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CN103285947A (zh) * 2013-05-27 2013-09-11 苏州扬清芯片科技有限公司 一种液滴微流控芯片及其操控方法
WO2015112985A1 (en) * 2014-01-24 2015-07-30 The Johns Hopkins University System and device for high throughput generation of combinatorial droplets and methods of use
CN105478177A (zh) * 2014-09-18 2016-04-13 苏州贝和医疗科技有限公司 一种用于数字pcr的液滴生成装置及方法
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CN108956558B (zh) * 2018-05-24 2023-09-15 深圳市帝迈生物技术有限公司 一种微流控芯片和免疫荧光分析仪
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CN111821927B (zh) * 2019-04-17 2021-12-07 北京大学 一种制备微/纳结构材料的方法及装置
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CN110449195A (zh) * 2019-09-05 2019-11-15 北京工业大学 一种提高液滴在不对称通道分裂均匀度的装置
CN110643488A (zh) * 2019-09-27 2020-01-03 晶准生物医学（深圳）有限公司 微流控液滴操纵分割装置及其操纵分割方法
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CN111537398B (zh) * 2020-05-29 2021-10-15 河南农业大学 一种控制液滴撞击形态、接触时间及液滴可控分裂的方法
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Also Published As

Publication number Publication date
JP2016224057A (ja) 2016-12-28
KR20140063507A (ko) 2014-05-27
US20140026968A1 (en) 2014-01-30
CN103347612A (zh) 2013-10-09
CN103347612B (zh) 2016-03-16
CN105689030A (zh) 2016-06-22
JP2014505594A (ja) 2014-03-06
WO2012109138A1 (en) 2012-08-16
EP2673088A1 (en) 2013-12-18

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]