BR112013019880A2 - sistemas e métodos para dividir gotículas - Google Patents
sistemas e métodos para dividir gotículasInfo
- Publication number
- BR112013019880A2 BR112013019880A2 BR112013019880A BR112013019880A BR112013019880A2 BR 112013019880 A2 BR112013019880 A2 BR 112013019880A2 BR 112013019880 A BR112013019880 A BR 112013019880A BR 112013019880 A BR112013019880 A BR 112013019880A BR 112013019880 A2 BR112013019880 A2 BR 112013019880A2
- Authority
- BR
- Brazil
- Prior art keywords
- droplets
- droplet
- systems
- cases
- divided
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/85938—Non-valved flow dividers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
sistemas e métodos para dividir gotículas a presente invenção refere-se em geral a sistemas fluídicos e microfluídicos e, em particular, à criação de gotículas em sistema fluídico. em alguns aspectos, a presente invenção é geralmente direcionada a sistemas e métodos para a divisão de uma gotícula mãe em duas ou mas gotículas, por exemplo, incitando a gotícula mãe para um obstáculo para dividir a gotícula mãe. em alguns casos, a gotícula mãe é dividida em, pelo menos, primeira e segunda gotículas que cada uma se dirige para canais separados. em alguns casos, os canais podem ser construídos e dispostos de tal modo que as velocidades das gotículas da primeira e da segunda gotículas são substancialmente as mesmas que a velocidade da gotícula mãe. em alguns casos, tais gotículas podem ser divididas repetidamente, por exemplo, uma gotícula mãe é dividida em duas gotículas filha, então cada gotícula novamente se divide, e etc., por exemplo, de tal forma que uma gotícula mãe pode, eventualmente, ser dividida em 2^ 2^, 2^ 3^, 2^ 4^, 2^ 5^, 2^ 6^, etc. gotículas filha. em alguns casos, as gotículas filha podem ser substancialmente monodispersas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161440198P | 2011-02-07 | 2011-02-07 | |
PCT/US2012/023961 WO2012109138A1 (en) | 2011-02-07 | 2012-02-06 | Systems and methods for splitting droplets |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013019880A2 true BR112013019880A2 (pt) | 2016-10-11 |
Family
ID=45774321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013019880A BR112013019880A2 (pt) | 2011-02-07 | 2012-02-06 | sistemas e métodos para dividir gotículas |
Country Status (7)
Country | Link |
---|---|
US (1) | US20140026968A1 (pt) |
EP (1) | EP2673088A1 (pt) |
JP (2) | JP2014505594A (pt) |
KR (1) | KR20140063507A (pt) |
CN (2) | CN103347612B (pt) |
BR (1) | BR112013019880A2 (pt) |
WO (1) | WO2012109138A1 (pt) |
Families Citing this family (30)
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PL229042B1 (pl) * | 2011-09-30 | 2018-06-29 | Inst Chemii Fizycznej Polskiej Akademii Nauk | Sposób dzielenia kropel w złączu mikroprzepływowym i układ do dzielenia kropel w złączu mikroprzepływowym |
KR20140122751A (ko) | 2012-02-08 | 2014-10-20 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 유체 파열을 사용한 액적 형성 |
DE102012217487A1 (de) * | 2012-09-26 | 2014-04-17 | Agilent Technologies, Inc. - A Delaware Corporation - | Fluidschnittstelle zwischen Fluidleitungen unterschiedlicher Querschnitte |
US20160008778A1 (en) * | 2013-03-06 | 2016-01-14 | President And Fellows Of Harvard College | Devices and methods for forming relatively monodisperse droplets |
CN103285946A (zh) * | 2013-05-27 | 2013-09-11 | 苏州扬清芯片科技有限公司 | 一种生物芯片及其操控方法 |
CN103285947A (zh) * | 2013-05-27 | 2013-09-11 | 苏州扬清芯片科技有限公司 | 一种液滴微流控芯片及其操控方法 |
EP3096882B1 (en) * | 2014-01-24 | 2021-05-05 | The Johns Hopkins University | System and device for high throughput generation of combinatorial droplets |
CN105478177A (zh) * | 2014-09-18 | 2016-04-13 | 苏州贝和医疗科技有限公司 | 一种用于数字pcr的液滴生成装置及方法 |
US10178027B2 (en) * | 2016-01-27 | 2019-01-08 | Oracle International Corporation | System and method for supporting inter subnet partitions in a high performance computing environment |
US10171353B2 (en) * | 2016-03-04 | 2019-01-01 | Oracle International Corporation | System and method for supporting dual-port virtual router in a high performance computing environment |
US11925933B2 (en) * | 2016-04-15 | 2024-03-12 | President And Fellows Of Harvard College | Systems and methods for the collection of droplets and/or other entities |
US10143129B2 (en) * | 2017-02-27 | 2018-12-04 | Cnh Industrial Canada, Ltd. | Flow splitter for distributing agricultural products and related system |
US10408852B2 (en) | 2017-04-26 | 2019-09-10 | Lawrence Livermore National Security, Llc | Automated control of microfluidic devices based on machine learning |
CN107323090B (zh) * | 2017-07-27 | 2019-01-18 | 京东方科技集团股份有限公司 | 一种打印喷头、打印设备及打印方法 |
CN107754960B (zh) * | 2017-10-26 | 2019-09-03 | 北京工业大学 | 基于附加流量实现双乳液滴非对称分裂的微流控芯片 |
DE102018203047A1 (de) * | 2018-03-01 | 2019-09-05 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung |
CN108956558B (zh) * | 2018-05-24 | 2023-09-15 | 深圳市帝迈生物技术有限公司 | 一种微流控芯片和免疫荧光分析仪 |
US11703427B2 (en) * | 2018-06-25 | 2023-07-18 | 10X Genomics, Inc. | Methods and systems for cell and bead processing |
US10486155B1 (en) | 2018-10-22 | 2019-11-26 | Klaris Corporation | Vacuum-loaded, droplet-generating microfluidic chips and related methods |
CN109289951B (zh) * | 2018-10-29 | 2021-01-05 | 深圳先进技术研究院 | 液滴分裂微流控芯片及应用 |
CN111821927B (zh) * | 2019-04-17 | 2021-12-07 | 北京大学 | 一种制备微/纳结构材料的方法及装置 |
CN112108192B (zh) * | 2019-06-19 | 2022-03-22 | 中国科学院大连化学物理研究所 | 一种微流控芯片及其应用 |
EP3763438A1 (en) * | 2019-07-12 | 2021-01-13 | Curiosity Diagnostics sp. z o.o | Microfluidic chip, production process and uses |
CN110449195A (zh) * | 2019-09-05 | 2019-11-15 | 北京工业大学 | 一种提高液滴在不对称通道分裂均匀度的装置 |
CN110643488A (zh) * | 2019-09-27 | 2020-01-03 | 晶准生物医学(深圳)有限公司 | 微流控液滴操纵分割装置及其操纵分割方法 |
WO2021168768A1 (zh) * | 2020-02-28 | 2021-09-02 | 京东方科技集团股份有限公司 | 一种微流控芯片和微流控系统 |
CN111537398B (zh) * | 2020-05-29 | 2021-10-15 | 河南农业大学 | 一种控制液滴撞击形态、接触时间及液滴可控分裂的方法 |
EP4180123A1 (en) * | 2021-11-12 | 2023-05-17 | Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO | Microfluidic device for sample encapsulation and method for operation thereof |
CN114534811A (zh) * | 2022-02-28 | 2022-05-27 | 上海天马微电子有限公司 | 微流控装置及其制作方法 |
CN115254217B (zh) * | 2022-07-27 | 2023-12-01 | 领航基因科技(杭州)有限公司 | 液滴制备装置及方法 |
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WO2004103565A2 (de) * | 2003-05-19 | 2004-12-02 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung und verfahren zur strukturierung von flüssigkeiten und zum zudosieren von reaktionsflüssigkeiten zu in separationsmedium eingebetteten flüssigkeitskompartimenten |
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US7655470B2 (en) * | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
US7968287B2 (en) * | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
CA2599683A1 (en) | 2005-03-04 | 2006-09-14 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
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US7811603B2 (en) * | 2006-05-09 | 2010-10-12 | The Regents Of The University Of California | Microfluidic device for forming monodisperse lipoplexes |
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WO2008063135A1 (en) * | 2006-11-24 | 2008-05-29 | Agency For Science, Technology And Research | Apparatus for processing a sample in a liquid droplet and method of using the same |
WO2008121342A2 (en) | 2007-03-28 | 2008-10-09 | President And Fellows Of Harvard College | Emulsions and techniques for formation |
US8883291B2 (en) | 2007-08-07 | 2014-11-11 | President And Fellows Of Harvard College | Metal oxide coating on surfaces |
US8802027B2 (en) | 2008-03-28 | 2014-08-12 | President And Fellows Of Harvard College | Surfaces, including microfluidic channels, with controlled wetting properties |
EP3002489B1 (en) | 2008-05-16 | 2017-09-20 | President and Fellows of Harvard College | Valves and other flow control in fluidic systems including microfluidic systems |
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WO2010042744A1 (en) * | 2008-10-08 | 2010-04-15 | Universite De Strasbourg | Microfluidic devices for reliable on-chip incubation of droplets in delay lines |
WO2010104604A1 (en) | 2009-03-13 | 2010-09-16 | President And Fellows Of Harvard College | Method for the controlled creation of emulsions, including multiple emulsions |
US9625454B2 (en) * | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
JP4973721B2 (ja) * | 2009-12-07 | 2012-07-11 | 東ソー株式会社 | 微小粒子構造体およびそれを用いた微小粒子の製造方法 |
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US20140161686A1 (en) * | 2012-12-10 | 2014-06-12 | Advanced Liquid Logic, Inc. | System and method of dispensing liquids in a microfluidic device |
US11141730B2 (en) * | 2013-06-14 | 2021-10-12 | President And Fellows Of Harvard College | Coalescence of droplets |
EP3039119A4 (en) * | 2013-08-27 | 2017-04-05 | GnuBIO, Inc. | Microfluidic devices and methods of their use |
-
2012
- 2012-02-06 US US13/979,984 patent/US20140026968A1/en not_active Abandoned
- 2012-02-06 KR KR1020137023593A patent/KR20140063507A/ko not_active Application Discontinuation
- 2012-02-06 JP JP2013552712A patent/JP2014505594A/ja active Pending
- 2012-02-06 CN CN201280007426.9A patent/CN103347612B/zh not_active Expired - Fee Related
- 2012-02-06 EP EP12706734.6A patent/EP2673088A1/en not_active Withdrawn
- 2012-02-06 WO PCT/US2012/023961 patent/WO2012109138A1/en active Application Filing
- 2012-02-06 CN CN201610085021.7A patent/CN105689030A/zh active Pending
- 2012-02-06 BR BR112013019880A patent/BR112013019880A2/pt not_active IP Right Cessation
-
2016
- 2016-07-28 JP JP2016148580A patent/JP2016224057A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN103347612B (zh) | 2016-03-16 |
EP2673088A1 (en) | 2013-12-18 |
CN103347612A (zh) | 2013-10-09 |
JP2016224057A (ja) | 2016-12-28 |
US20140026968A1 (en) | 2014-01-30 |
CN105689030A (zh) | 2016-06-22 |
KR20140063507A (ko) | 2014-05-27 |
WO2012109138A1 (en) | 2012-08-16 |
JP2014505594A (ja) | 2014-03-06 |
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