BR112013000946A2 - compostos heterocíclicos agonistas de receptor de ip - Google Patents

compostos heterocíclicos agonistas de receptor de ip

Info

Publication number
BR112013000946A2
BR112013000946A2 BR112013000946A BR112013000946A BR112013000946A2 BR 112013000946 A2 BR112013000946 A2 BR 112013000946A2 BR 112013000946 A BR112013000946 A BR 112013000946A BR 112013000946 A BR112013000946 A BR 112013000946A BR 112013000946 A2 BR112013000946 A2 BR 112013000946A2
Authority
BR
Brazil
Prior art keywords
heterocyclic compounds
receptor agonist
receptor
derivatives
agonist heterocyclic
Prior art date
Application number
BR112013000946A
Other languages
English (en)
Other versions
BR112013000946B1 (pt
Inventor
Catherine Leblanc
Stephen Carl Mckeown
Steven John Charlton
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112013000946A2 publication Critical patent/BR112013000946A2/pt
Publication of BR112013000946B1 publication Critical patent/BR112013000946B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

compostos heterocíclicos agonistas de receptor de ip. a presente invenção refere-se a derivados heterocíclicos que ativam o receptor de ip. a ativação da série de reação de sinalização do receptor de ip é útil para tratar muitas formas de pah, fibrose pulmonar e exerce efeitos benéficos em condições fibróticas de vários órgãos em modelos animais e em pacientes. composições farmacêuticas compreendendo tais derivados são também abrangidos.
BR112013000946-2A 2010-07-14 2011-07-14 Compostos heterocíclicos agonistas de receptor de ip, seus usos, composição e combinação farmacêuticas BR112013000946B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36413510P 2010-07-14 2010-07-14
US61/364,135 2010-07-14
PCT/EP2011/062028 WO2012007539A1 (en) 2010-07-14 2011-07-14 Ip receptor agonist heterocyclic compounds

Publications (2)

Publication Number Publication Date
BR112013000946A2 true BR112013000946A2 (pt) 2016-05-17
BR112013000946B1 BR112013000946B1 (pt) 2020-09-08

Family

ID=44628483

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013000946-2A BR112013000946B1 (pt) 2010-07-14 2011-07-14 Compostos heterocíclicos agonistas de receptor de ip, seus usos, composição e combinação farmacêuticas

Country Status (34)

Country Link
US (2) US8754085B2 (pt)
EP (1) EP2593452B1 (pt)
JP (1) JP5781159B2 (pt)
KR (1) KR101491938B1 (pt)
CN (1) CN103097385B (pt)
AU (1) AU2011278279C1 (pt)
BR (1) BR112013000946B1 (pt)
CA (1) CA2804744C (pt)
CL (1) CL2013000104A1 (pt)
CO (1) CO6660445A2 (pt)
CR (1) CR20130012A (pt)
CU (1) CU24147B1 (pt)
CY (1) CY1118819T1 (pt)
DK (1) DK2593452T3 (pt)
EA (1) EA022046B1 (pt)
EC (1) ECSP13012385A (pt)
ES (1) ES2622519T3 (pt)
GT (1) GT201300018A (pt)
HR (1) HRP20170617T1 (pt)
HU (1) HUE031710T2 (pt)
IL (1) IL224164A (pt)
LT (1) LT2593452T (pt)
MA (1) MA34373B1 (pt)
MX (1) MX2013000537A (pt)
MY (1) MY156795A (pt)
NZ (1) NZ605528A (pt)
PE (1) PE20130404A1 (pt)
PL (1) PL2593452T3 (pt)
PT (1) PT2593452T (pt)
RS (1) RS55856B1 (pt)
SG (1) SG186989A1 (pt)
SI (1) SI2593452T1 (pt)
UA (1) UA109786C2 (pt)
WO (1) WO2012007539A1 (pt)

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Also Published As

Publication number Publication date
CU20130009A7 (es) 2013-04-19
CY1118819T1 (el) 2018-01-10
SI2593452T1 (sl) 2017-06-30
DK2593452T3 (en) 2017-04-24
AU2011278279B2 (en) 2014-08-07
CN103097385B (zh) 2016-08-03
EP2593452A1 (en) 2013-05-22
HRP20170617T1 (hr) 2017-06-30
CA2804744A1 (en) 2012-01-19
HUE031710T2 (en) 2017-07-28
JP5781159B2 (ja) 2015-09-16
KR20130038924A (ko) 2013-04-18
US20130102611A1 (en) 2013-04-25
MA34373B1 (fr) 2013-07-03
EA201300118A1 (ru) 2013-06-28
NZ605528A (en) 2015-02-27
SG186989A1 (en) 2013-02-28
US20140243346A1 (en) 2014-08-28
PT2593452T (pt) 2017-04-24
US9132127B2 (en) 2015-09-15
US8754085B2 (en) 2014-06-17
WO2012007539A9 (en) 2012-11-01
ES2622519T3 (es) 2017-07-06
CO6660445A2 (es) 2013-04-30
MY156795A (en) 2016-03-31
EP2593452B1 (en) 2017-01-18
CR20130012A (es) 2013-02-19
LT2593452T (lt) 2017-04-10
PE20130404A1 (es) 2013-04-17
RS55856B1 (sr) 2017-08-31
JP2013531025A (ja) 2013-08-01
IL224164A (en) 2016-08-31
PL2593452T3 (pl) 2017-07-31
UA109786C2 (xx) 2015-10-12
AU2011278279A1 (en) 2013-02-21
KR101491938B1 (ko) 2015-02-10
CL2013000104A1 (es) 2013-05-17
BR112013000946B1 (pt) 2020-09-08
MX2013000537A (es) 2013-01-29
EA022046B1 (ru) 2015-10-30
CA2804744C (en) 2019-05-28
GT201300018A (es) 2015-11-24
CN103097385A (zh) 2013-05-08
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CU24147B1 (es) 2016-02-29

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