BR112013000094A2 - composição dental, kit de peças e uso dos mesmos - Google Patents

composição dental, kit de peças e uso dos mesmos

Info

Publication number
BR112013000094A2
BR112013000094A2 BR112013000094A BR112013000094A BR112013000094A2 BR 112013000094 A2 BR112013000094 A2 BR 112013000094A2 BR 112013000094 A BR112013000094 A BR 112013000094A BR 112013000094 A BR112013000094 A BR 112013000094A BR 112013000094 A2 BR112013000094 A2 BR 112013000094A2
Authority
BR
Brazil
Prior art keywords
unit
moiety
carbon atoms
main chain
dental composition
Prior art date
Application number
BR112013000094A
Other languages
English (en)
Other versions
BR112013000094B1 (pt
Inventor
Eckert Adrian
Hailand Bettina
Thalacker Christoph
Raia Gioacchino
Dede Karsten
Kestel Marion
Cub Michael
Bissinger Peter
Hecht Reinhold
Luchterhandt Thomas
Hoheisel Uwe
Steiger Wolf
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of BR112013000094A2 publication Critical patent/BR112013000094A2/pt
Publication of BR112013000094B1 publication Critical patent/BR112013000094B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/30Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/80Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/80Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/891Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A61K6/893Polyurethanes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/60Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
    • C07C2603/64Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings having a tricyclo[2.2.1.0(2,6)]heptstructure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/60Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Dental Preparations (AREA)

Abstract

composição dental, kit de peças e uso dos mesmos. o presente pedido refere-se a uma composição dental que compreende a) um composto (a) com as seguintes características: apenas uma unidade de cadeia principal (u) com 6 a 20 átomos de carbono, ao menos 6 átomos de carbono da mesma formando uma porção cíclica aromática ou alifática, os demais átomos de carbono fazendo parte dos substituintes pendentes da porção cíclica ou fazendo parte dos grupos de ligação às unidades espaçadoras, sendo que um ou mais átomos de carbono pode ser substituído por um átomo de oxigênio, a unidade de cadeia principal não compreendendo uma estrutura de bisfenol e átomos de halogênio, uma ou duas unidade(s) (s) sendo conectada(s) à unidade de cadeia principal (u) através de uma ligação de éter, ao menos uma unidade (s) que compreende uma porção -ch2-ch2-ch2-ch2-o-ch2-ch2-ch(q)-og ou uma porção -ch2-ch(og)-ch2-om ou uma mistura desses dois tipos de porções dentro de uma unidade (s), com g compreendendo ao menos uma porção polimerizável e uma porção de uretano, a porção de uretano atuando como elemento de conexão à(s) unidade(s) (s) e m compreendendo ao menos um grupo selecionado a partir de acroila, metacroila, arila, misturas e combinções dos mesmos, q compreendendo ao menos um grupo selecionado a partir de hidrogênio, metila, felina, fenoximetila, misturas e combinações dos mesmos e com a condição de que, na unidade de cadeia principal (u), ao menos dois substituintes sejam fixados, cada um tendo ao menos um grupo g, sendo que, no caso onde apenas uma unidade (s) está presente, o grupo g que não faz parte da dita unidade (s) está situado no substituinte adicional pendente da unidade (u), b) um enchimento (b) e c) um iniciador (c).
BR112013000094A 2010-07-02 2011-06-24 composição dental, kit de peças e uso dos mesmos BR112013000094B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10168240A EP2401998A1 (en) 2010-07-02 2010-07-02 Dental composition, kit of parts and use thereof
PCT/US2011/041736 WO2012003136A1 (en) 2010-07-02 2011-06-24 Dental composition, kit of parts and use thereof

Publications (2)

Publication Number Publication Date
BR112013000094A2 true BR112013000094A2 (pt) 2018-01-23
BR112013000094B1 BR112013000094B1 (pt) 2018-10-30

Family

ID=43038001

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013000094A BR112013000094B1 (pt) 2010-07-02 2011-06-24 composição dental, kit de peças e uso dos mesmos

Country Status (6)

Country Link
US (1) US8710113B2 (pt)
EP (2) EP2401998A1 (pt)
JP (1) JP5918229B2 (pt)
CN (1) CN102985052B (pt)
BR (1) BR112013000094B1 (pt)
WO (1) WO2012003136A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153948B (zh) * 2010-08-11 2014-12-03 拜耳知识产权有限责任公司 双官能(甲基)丙烯酸酯书写单体
EP2481390A1 (en) * 2011-01-31 2012-08-01 3M Innovative Properties Company Dental composition, method of producing and use thereof
WO2012112321A2 (en) 2011-02-15 2012-08-23 3M Innovative Properties Company Dental compositions comprising mixture of isocyanurate monomer and tricyclodecane monomer
US9056043B2 (en) 2011-02-15 2015-06-16 3M Innovative Properties Company Dental compositions comprising ethylenically unsaturated addition-fragmentation agent
US9433563B2 (en) 2011-06-29 2016-09-06 Bradley D. Craig Dental compositions comprising a fatty mono(meth)acrylate
US9907733B2 (en) 2011-08-23 2018-03-06 3M Innovative Properties Company Dental compositions comprising addition-fragmentation agents
KR102174015B1 (ko) 2012-11-12 2020-11-04 쓰리엠 이노베이티브 프로퍼티즈 컴파니 부가-단편화제를 포함하는 치과용 조성물
US9410030B2 (en) 2012-11-12 2016-08-09 3M Innovative Properties Company Addition-fragmentation agents
JP6306044B2 (ja) 2012-12-17 2018-04-04 スリーエム イノベイティブ プロパティズ カンパニー 付加開裂オリゴマー
CN105209078B (zh) * 2013-03-15 2021-11-09 恩多沙普公司 具有增强的不透射线性的聚合物组合物
EP2976323B1 (en) 2013-03-20 2020-07-15 3M Innovative Properties Company High refractive index addition-fragmentation agents
US9675529B2 (en) 2013-04-15 2017-06-13 3M Innovative Properties Company Dental composition containing high refractive index monomers
EP3046962B1 (en) 2013-09-20 2018-05-23 3M Innovative Properties Company Trithiocarbonate-containing addition-fragmentation agents
KR101712414B1 (ko) 2013-10-16 2017-03-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 알릴 다이설파이드-함유 부가-단편화 올리고머
EP2881103B1 (en) * 2013-12-06 2016-02-24 DENTSPLY DETREY GmbH Dental composition
EP3107975B1 (en) 2014-02-18 2020-01-15 3M Innovative Properties Company Addition-fragmentation oligomers having high refractive index groups
WO2015126666A1 (en) 2014-02-18 2015-08-27 3M Innovative Properties Company Dental composition and use thereof
JP6599346B2 (ja) * 2014-02-18 2019-10-30 スリーエム イノベイティブ プロパティズ カンパニー 歯科用組成物及びその使用
KR102382218B1 (ko) * 2014-04-25 2022-04-05 코베스트로 도이칠란트 아게 홀로그래픽 광중합체 배합물에서의 기록 단량체로서의 방향족 글리콜 에테르
WO2015191436A1 (en) 2014-06-13 2015-12-17 3M Innovative Properties Company Curable compositions and methods for isolating a working area
ES2784676T3 (es) * 2014-07-02 2020-09-29 Dentsply Detrey Gmbh Composición dental
US10350297B2 (en) 2014-10-31 2019-07-16 3M Innovative Properties Company Dental materials and methods
EP3212153A1 (en) 2014-10-31 2017-09-06 3M Innovative Properties Company Dental materials and methods
CN107406723B (zh) 2015-02-20 2021-05-07 3M创新有限公司 加成-断裂低聚物
DE102015104440A1 (de) * 2015-03-24 2016-09-29 Heraeus Kulzer Gmbh Verfahren zur Herstellung dentaler Prothesen sowie gebrauchsfertiges Dentalmaterial und Kit enthaltend das Dentalmaterial
EP3370681A1 (en) 2015-11-06 2018-09-12 3M Innovative Properties Company Redox polymerizable dental composition with photolabile transition metal complexes
EP3370680B1 (en) 2015-11-06 2020-11-25 3M Innovative Properties Company Redox polymerizable composition with photolabile transition metal complexes
EP3383924B1 (en) 2015-12-03 2021-04-14 3M Innovative Properties Company Redox polymerizable composition with photolabile reducing agents
EP3411006A1 (en) 2016-02-05 2018-12-12 3M Innovative Properties Company Dental compositions comprising nanoparticles providing a refractive index differential between polymerizable resin and filler
US10968197B2 (en) 2016-10-20 2021-04-06 3M Innovative Properties Company Photoinitiators with protected carbonyl group
EP3727276A2 (en) 2017-12-21 2020-10-28 3M Innovative Properties Company Inorganic dental fillers including a silane treated surface
EP3864002B1 (en) 2018-10-09 2023-12-27 3M Innovative Properties Company Addition-fragmentation agent with pendent amine groups
CN114901433A (zh) 2019-12-12 2022-08-12 3M创新有限公司 包含连续的聚合物基体的聚合物粘结磨料制品及其制造方法
EP4132452B1 (en) * 2020-04-08 2024-05-29 3M Innovative Properties Company Curable compositions and methods of using the same
US11446116B2 (en) 2020-07-06 2022-09-20 Perfect Fit Crowns, Llc Method and apparatus for dental crown restorations using prefabricated sleeve-crown pairs
EP4251117A1 (en) 2020-11-25 2023-10-04 3M Innovative Properties Company Curable dental compositions and uses thereof

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1495520B2 (de) 1964-05-02 1970-06-25 Deutsche Gold- U. Silber-Scheideanstalt, Vorm. Roessler, 6000 Frankfurt Verfahren zum Polymerisieren
US3541068A (en) 1968-07-12 1970-11-17 Minnesota Mining & Mfg Dental restorative compositions having enhanced stability
GB1408265A (en) 1971-10-18 1975-10-01 Ici Ltd Photopolymerisable composition
US3729313A (en) 1971-12-06 1973-04-24 Minnesota Mining & Mfg Novel photosensitive systems comprising diaryliodonium compounds and their use
US3808006A (en) 1971-12-06 1974-04-30 Minnesota Mining & Mfg Photosensitive material containing a diaryliodium compound, a sensitizer and a color former
US3741769A (en) 1972-10-24 1973-06-26 Minnesota Mining & Mfg Novel photosensitive polymerizable systems and their use
AU497960B2 (en) 1974-04-11 1979-01-25 Minnesota Mining And Manufacturing Company Photopolymerizable compositions
US4250053A (en) 1979-05-21 1981-02-10 Minnesota Mining And Manufacturing Company Sensitized aromatic iodonium or aromatic sulfonium salt photoinitiator systems
DE3107577A1 (de) 1981-02-27 1982-09-16 ESPE Fabrik pharmazeutischer Präparate GmbH, 8031 Seefeld 1,2-6-thiadiazin-3,5-dion-1,1-dioxide und ihre verwendung
DE3443221A1 (de) 1984-11-27 1986-06-05 ESPE Fabrik pharmazeutischer Präparate GmbH, 8031 Seefeld Bisacylphosphinoxide, ihre herstellung und verwendung
US4642126A (en) 1985-02-11 1987-02-10 Norton Company Coated abrasives with rapidly curable adhesives and controllable curvature
DE3522006A1 (de) * 1985-06-20 1987-01-02 Bayer Ag (meth)-acrylsaeure-derivate von tricyclodecanen und ihre verwendung
US4652274A (en) 1985-08-07 1987-03-24 Minnesota Mining And Manufacturing Company Coated abrasive product having radiation curable binder
US4772530A (en) 1986-05-06 1988-09-20 The Mead Corporation Photosensitive materials containing ionic dye compounds as initiators
US4874450A (en) 1987-01-29 1989-10-17 The Mead Corporation Laminating transparent or translucent materials using ionic dye-counter ion complexes
CA1323949C (en) 1987-04-02 1993-11-02 Michael C. Palazzotto Ternary photoinitiator system for addition polymerization
US4954414A (en) 1988-11-08 1990-09-04 The Mead Corporation Photosensitive composition containing a transition metal coordination complex cation and a borate anion and photosensitive materials employing the same
US5057393A (en) 1989-07-10 1991-10-15 The Mead Corporation Dye branched-alkyl borate photoinitiators
US5055372A (en) 1990-04-23 1991-10-08 The Mead Corporation Photohardenable composition containing borate salts and ketone initiators
US5332429A (en) 1991-05-31 1994-07-26 Minnesota Mining And Manufacturing Company Method for treating fluoroaluminosilicate glass
US5624260A (en) 1994-02-28 1997-04-29 Minnesota Mining And Manufacturing Company Delivery system for aqueous paste dental materials
JP2530295B2 (ja) * 1994-12-28 1996-09-04 東亞合成株式会社 光硬化型歯科用樹脂組成物
US5918772A (en) 1995-03-13 1999-07-06 Wilhelm A. Keller Bayonet fastening device for the attachment of an accessory to a multiple component cartridge or dispensing device
DE59508992D1 (de) 1995-06-21 2001-03-01 Sulzer Chemtech Ag Winterthur In einem Rohr angeordneter Mischer
US6184339B1 (en) * 1996-11-14 2001-02-06 The United States Of America As Represented By The Secretary Of The Commerce High strength polymeric networks derived from (meth) acrylate resins with organofluorine content and process for preparing same
DE19651139C2 (de) 1996-12-10 1999-04-15 Heraeus Kulzer Gmbh Kartusche zur Aufnahme von pastösem Material
US5865803A (en) 1997-05-19 1999-02-02 Major; Miklos Syringe device having a vented piston
EP1586294B2 (en) 1999-10-28 2016-02-17 3M Innovative Properties Company Nano-sized silica particles in a dry powder form
US6572693B1 (en) 1999-10-28 2003-06-03 3M Innovative Properties Company Aesthetic dental materials
DE19961342B4 (de) 1999-12-17 2004-02-19 3M Espe Ag Radikalisch härtbare Urethanpräpolymere und deren Verwendung
DE10101537A1 (de) * 2001-01-15 2002-08-08 Dentsply Detrey Gmbh Verfahren zur Herstellung einer polymerisierbaren Dentalzusammensetzung
AU2003200509A1 (en) 2002-02-27 2003-09-11 Centrix, Inc Dental capsule for placement of high viscosity dental composite material with reduced extrusion force
PT1426099E (pt) 2002-12-06 2007-12-04 Systems Ag Misturador estático e método
ES2336919T3 (es) 2003-09-01 2010-04-19 Sulzer Mixpac Ag Dispositivo de descarga con tapon de cierre y anillo de enclavamiento con medios de conexion a bayoneta.
AU2004305357B2 (en) * 2003-12-19 2010-03-04 Kuraray Medical Inc. One-pack type adhesive composition for dental use
JP4514447B2 (ja) * 2003-12-19 2010-07-28 クラレメディカル株式会社 歯科用接着剤組成物
DE102005021332B4 (de) 2005-05-04 2008-02-28 Heraeus Kulzer Gmbh Kompositmaterialien mit geringer Schrumpfkraft
ATE433726T1 (de) 2006-01-24 2009-07-15 3M Espe Ag Kolben für kapsel, verfahren zur herstellung eines solchen kolbens, und zugehörige kapsel
DE102006060983A1 (de) 2006-12-20 2008-06-26 Heraeus Kulzer Gmbh Dentalkomposite mit Tricyclo[5.2.1.02.6]decan-Derivaten
EP2008636A1 (en) 2007-06-29 2008-12-31 3M Innovative Properties Company Dental composition containing a polyfunctional (meth)acrylate comprising urethane, urea or amide groups, method of production and use thereof
DE102007034457A1 (de) 2007-07-20 2009-01-22 Heraeus Kulzer Gmbh Dentalkomposite mit niedriger Schrumpfspannung und hoher Biegefestigkeit
EP2042486A1 (en) * 2007-09-26 2009-04-01 3M Innovative Properties Company Methacrylate Based Monomers containing a Urethane Linkage, Process for Production and Use thereof
EP2133064A1 (en) 2008-06-10 2009-12-16 3M Innovative Properties Company Initiator system containing a diarylalkylamine derivate, hardenable composition and use thereof

Also Published As

Publication number Publication date
US20130109777A1 (en) 2013-05-02
US8710113B2 (en) 2014-04-29
EP2401998A1 (en) 2012-01-04
CN102985052B (zh) 2016-10-19
EP2588061A1 (en) 2013-05-08
JP5918229B2 (ja) 2016-05-18
EP2588061B1 (en) 2018-10-10
WO2012003136A1 (en) 2012-01-05
JP2013530229A (ja) 2013-07-25
BR112013000094B1 (pt) 2018-10-30
CN102985052A (zh) 2013-03-20

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/06/2011, OBSERVADAS AS CONDICOES LEGAIS.