BR112012029905B1 - Levocarrimicina, composições farmacêutica, métodos de preparação e uso dos mesmos - Google Patents
Levocarrimicina, composições farmacêutica, métodos de preparação e uso dos mesmos Download PDFInfo
- Publication number
- BR112012029905B1 BR112012029905B1 BR112012029905-0A BR112012029905A BR112012029905B1 BR 112012029905 B1 BR112012029905 B1 BR 112012029905B1 BR 112012029905 A BR112012029905 A BR 112012029905A BR 112012029905 B1 BR112012029905 B1 BR 112012029905B1
- Authority
- BR
- Brazil
- Prior art keywords
- levocarrimycin
- iii
- levoisovalerylspiramycin
- crystal compound
- extract
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 59
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 20
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 189
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 142
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 141
- 239000013078 crystal Substances 0.000 claims description 121
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 108
- 238000000855 fermentation Methods 0.000 claims description 77
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 69
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 51
- 239000000284 extract Substances 0.000 claims description 50
- 239000000843 powder Substances 0.000 claims description 50
- 238000003756 stirring Methods 0.000 claims description 50
- 239000012046 mixed solvent Substances 0.000 claims description 47
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 44
- 239000000243 solution Substances 0.000 claims description 37
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 34
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- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 30
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201010182027 | 2010-05-25 | ||
CN201010182027.9 | 2010-05-25 | ||
PCT/CN2011/074658 WO2011147316A1 (fr) | 2010-05-25 | 2011-05-25 | Levocarrimycine, ses compositions pharmaceutiques, ses procédés de préparation et ses utilisations |
Publications (2)
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BR112012029905A2 BR112012029905A2 (pt) | 2019-08-06 |
BR112012029905B1 true BR112012029905B1 (pt) | 2022-01-11 |
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BR112012029905-0A BR112012029905B1 (pt) | 2010-05-25 | 2011-05-25 | Levocarrimicina, composições farmacêutica, métodos de preparação e uso dos mesmos |
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US (1) | US9089586B2 (fr) |
EP (1) | EP2578596B1 (fr) |
JP (1) | JP5866737B2 (fr) |
KR (2) | KR101625262B1 (fr) |
CN (1) | CN102247396B (fr) |
BR (1) | BR112012029905B1 (fr) |
CA (1) | CA2800019C (fr) |
DK (1) | DK2578596T3 (fr) |
ES (1) | ES2633737T3 (fr) |
IN (1) | IN2012MN02623A (fr) |
MX (1) | MX346873B (fr) |
MY (1) | MY164230A (fr) |
PL (1) | PL2578596T3 (fr) |
RU (1) | RU2593499C2 (fr) |
WO (1) | WO2011147316A1 (fr) |
ZA (1) | ZA201209739B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
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DK2578595T3 (en) * | 2010-05-25 | 2017-07-10 | Shenyang Fuyang Pharmaceutical Tech Co Ltd | CRYSTALLINE LEVOISOVALERYL PIRAMYCIN I |
CN103069240B (zh) * | 2010-08-04 | 2015-06-17 | Ima生命北美股份有限公司 | 利用喷洒冷冻和搅拌干燥的散装冷冻干燥系统及方法 |
US9945611B2 (en) | 2010-08-04 | 2018-04-17 | Ima Life North America Inc. | Bulk freeze drying using spray freezing and agitated drying |
CN103694295B (zh) * | 2014-01-08 | 2016-01-20 | 华东理工大学 | 一种优化可利霉素组分的方法 |
CN105497053B (zh) * | 2015-12-31 | 2018-02-13 | 沈阳福洋医药科技有限公司 | 可利霉素在抗结核分枝杆菌感染中的应用 |
CN110545820B (zh) * | 2017-04-06 | 2023-01-10 | 沈阳福洋医药科技有限公司 | 可利霉素及其药学上可接受的盐在制备治疗和/或预防肿瘤药物方面的应用 |
AU2018298187A1 (en) * | 2017-07-04 | 2020-02-06 | Shenyang Fuyang Pharmaceutical Technology Co., Ltd. | Use of isovalerylspiramycin I, II and/or III in preparation of drug for treating and/or preventing tumour, and drug |
CA3088818A1 (fr) * | 2018-01-19 | 2019-07-25 | Shenyang Fuyang Pharmaceutical Technology Co., Ltd. | Inhibiteur de mtor, composition pharmaceutique et son utilisation |
AU2019209740A1 (en) * | 2018-01-19 | 2020-09-10 | Shenyang Fuyang Pharmaceutical Technology Co., Ltd. | Use of carrimycin or active ingredient thereof |
CN110384802B (zh) * | 2018-04-17 | 2021-09-17 | 沈阳福洋医药科技有限公司 | 一种用于预防和/或治疗发热的药物、组合产品及其应用 |
CN110384710B (zh) * | 2018-04-17 | 2023-01-10 | 沈阳福洋医药科技有限公司 | 一种用于预防和/或治疗疼痛的药物、组合产品及其应用 |
AU2019254974A1 (en) * | 2018-04-17 | 2020-11-26 | Shanghai Tonglian Pharmaceutical Co., Ltd. | Drug used for preventing and/or treating pain and/or fever, combination product, and use thereof |
CN108992416A (zh) * | 2018-09-27 | 2018-12-14 | 上海同联制药有限公司 | 一种可利霉素肠溶片及其制备方法 |
JP2022540291A (ja) * | 2019-05-16 | 2022-09-15 | 沈陽福洋医薬科技有限公司 | 線維化を予防、緩和及び/又は治療するための薬物、組成製品及びその応用 |
CN112239483B (zh) * | 2019-07-18 | 2023-10-27 | 沈阳福洋医药科技有限公司 | 一种化合物及药物组合物 |
CN111450066B (zh) * | 2020-04-24 | 2022-06-21 | 沈阳信达泰康医药科技有限公司 | 一种可利霉素冻干粉针制剂及其制备方法 |
CN113577087A (zh) * | 2020-04-30 | 2021-11-02 | 沈阳福洋医药科技有限公司 | 异戊酰螺旋霉素类化合物或其组合物在制备治疗脓毒症疾病药物中的应用 |
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JPS5334788A (en) * | 1976-09-11 | 1978-03-31 | Sanraku Inc | Antibiotics spiramycin derivatives |
CN1169947C (zh) * | 2002-11-19 | 2004-10-06 | 中国医学科学院医药生物技术研究所 | 必特螺旋霉素的基因工程菌株螺旋霉素链霉菌wsj-195 |
CN1237976C (zh) * | 2003-12-23 | 2006-01-25 | 沈阳同联集团有限公司 | 必特螺旋霉素及其在抗感染性疾病中的应用 |
CA2576291A1 (fr) * | 2004-08-12 | 2006-02-23 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Utilisation de conjugues specifiques de cellule pour le traitement de maladies inflammatoires du tractus gastro-intestinal |
KR100662363B1 (ko) * | 2004-10-19 | 2007-01-02 | 엘지전자 주식회사 | 디스플레이 기기의 인스톨 장치 및 방법 |
CN101054553A (zh) * | 2007-04-09 | 2007-10-17 | 中国医学科学院医药生物技术研究所 | 异戊酰螺旋霉素i基因工程菌株的构建 |
CN100554355C (zh) | 2007-04-11 | 2009-10-28 | 华南理工大学 | 一种纳米复合水性隔热外墙涂料及其制备方法 |
CN101649325B (zh) * | 2009-07-03 | 2011-09-07 | 中国医学科学院医药生物技术研究所 | 一种提高基因工程异戊酰螺旋霉素主组分含量的基因串连技术 |
DK2578595T3 (en) * | 2010-05-25 | 2017-07-10 | Shenyang Fuyang Pharmaceutical Tech Co Ltd | CRYSTALLINE LEVOISOVALERYL PIRAMYCIN I |
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2011
- 2011-05-25 RU RU2012156419/04A patent/RU2593499C2/ru active IP Right Revival
- 2011-05-25 MY MYPI2012700968A patent/MY164230A/en unknown
- 2011-05-25 US US13/699,358 patent/US9089586B2/en active Active
- 2011-05-25 MX MX2012013469A patent/MX346873B/es active IP Right Grant
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- 2011-05-25 CA CA2800019A patent/CA2800019C/fr active Active
- 2011-05-25 EP EP11786088.2A patent/EP2578596B1/fr active Active
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- 2011-05-25 WO PCT/CN2011/074658 patent/WO2011147316A1/fr active Application Filing
- 2011-05-25 KR KR1020127033722A patent/KR101625262B1/ko active IP Right Grant
- 2011-05-25 JP JP2013511525A patent/JP5866737B2/ja active Active
- 2011-05-25 BR BR112012029905-0A patent/BR112012029905B1/pt not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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MX2012013469A (es) | 2013-04-03 |
KR101625262B1 (ko) | 2016-05-27 |
EP2578596A4 (fr) | 2013-11-06 |
US9089586B2 (en) | 2015-07-28 |
MY164230A (en) | 2017-11-30 |
PL2578596T3 (pl) | 2017-09-29 |
CN102247396A (zh) | 2011-11-23 |
CA2800019C (fr) | 2015-05-26 |
RU2012156419A (ru) | 2014-06-27 |
JP5866737B2 (ja) | 2016-02-17 |
WO2011147316A1 (fr) | 2011-12-01 |
ES2633737T3 (es) | 2017-09-25 |
EP2578596B1 (fr) | 2017-04-19 |
KR20160019970A (ko) | 2016-02-22 |
IN2012MN02623A (fr) | 2015-06-12 |
CA2800019A1 (fr) | 2011-12-01 |
EP2578596A1 (fr) | 2013-04-10 |
US20130150316A1 (en) | 2013-06-13 |
ZA201209739B (en) | 2014-03-26 |
RU2593499C2 (ru) | 2016-08-10 |
BR112012029905A2 (pt) | 2019-08-06 |
JP2013528167A (ja) | 2013-07-08 |
KR101706519B1 (ko) | 2017-02-14 |
CN102247396B (zh) | 2014-05-28 |
KR20130020906A (ko) | 2013-03-04 |
MX346873B (es) | 2017-03-30 |
DK2578596T3 (en) | 2017-07-17 |
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