BR112012016908A2 - linhagens e métodos para a produção de metionina - Google Patents
linhagens e métodos para a produção de metioninaInfo
- Publication number
- BR112012016908A2 BR112012016908A2 BR112012016908A BR112012016908A BR112012016908A2 BR 112012016908 A2 BR112012016908 A2 BR 112012016908A2 BR 112012016908 A BR112012016908 A BR 112012016908A BR 112012016908 A BR112012016908 A BR 112012016908A BR 112012016908 A2 BR112012016908 A2 BR 112012016908A2
- Authority
- BR
- Brazil
- Prior art keywords
- strains
- methods
- methionine production
- methionine
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/02—Hydroxymethyl-, formyl- and related transferases (2.1.2)
- C12Y201/02001—Glycine hydroxymethyltransferase (2.1.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01019—Threonine ammonia-lyase (4.3.1.19)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29097509P | 2009-12-30 | 2009-12-30 | |
| EP09306349.3 | 2009-12-30 | ||
| US61/290,975 | 2009-12-30 | ||
| EP09306349 | 2009-12-30 | ||
| PCT/EP2010/070858 WO2011080301A2 (en) | 2009-12-30 | 2010-12-29 | Strains and method for the production of methionine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012016908A2 true BR112012016908A2 (pt) | 2015-09-15 |
| BR112012016908B1 BR112012016908B1 (pt) | 2020-03-31 |
Family
ID=42562397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012016908-4A BR112012016908B1 (pt) | 2009-12-30 | 2010-12-29 | Linhagens e métodos para a produção de metionina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9382561B2 (pt) |
| EP (1) | EP2519637A2 (pt) |
| JP (1) | JP5922036B2 (pt) |
| KR (1) | KR101915819B1 (pt) |
| CN (1) | CN102782137B (pt) |
| AR (1) | AR079821A1 (pt) |
| BR (1) | BR112012016908B1 (pt) |
| IN (1) | IN2012DN06442A (pt) |
| MX (1) | MX2012007717A (pt) |
| MY (1) | MY172018A (pt) |
| WO (1) | WO2011080301A2 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2519637A2 (en) | 2009-12-30 | 2012-11-07 | Metabolic Explorer | Strains and method for the production of methionine |
| CN103981206B (zh) * | 2014-06-06 | 2016-03-02 | 中国科学院天津工业生物技术研究所 | 一种筛选高产苏氨酸菌株的方法 |
| CA2959563A1 (en) | 2014-09-01 | 2016-03-10 | Metabolic Explorer | Method and microorganism for methionine production by fermentation with improved methionine efflux |
| CN104313071B (zh) * | 2014-10-17 | 2018-04-13 | 湖南宝利士生物技术有限公司 | 高纯L‑α‑氨基酸的生物合成方法 |
| CN104372035B (zh) * | 2014-10-17 | 2017-10-31 | 湖南宝利士生物技术有限公司 | 合成高纯2‑酮酸盐的方法 |
| DK3250701T3 (da) * | 2015-01-27 | 2021-02-08 | Cysbio Aps | Genmodificerede mikroorganismer med forbedret tolerance over for L-serin |
| US20180223319A1 (en) | 2015-08-07 | 2018-08-09 | Evonik Degussa Gmbh | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| CN108291243A (zh) | 2015-11-27 | 2018-07-17 | 赢创德固赛有限公司 | 生产l-甲硫氨酸的方法 |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| WO2018213796A1 (en) * | 2017-05-19 | 2018-11-22 | Zymergen Inc. | Genomic engineering of biosynthetic pathways leading to increased nadph |
| CN109402098B (zh) * | 2018-11-06 | 2021-09-17 | 王喆明 | 苏氨酸醛缩酶、突变体及其在制备取代苯丝氨酸衍生物中的应用 |
| US20200393381A1 (en) * | 2019-06-12 | 2020-12-17 | Henkel IP & Holding GmbH | Method And System For Determining The Presence Of An Odorous Material On A Fabric |
| CN112779200B (zh) * | 2021-01-12 | 2022-07-08 | 浙江工业大学 | 高产l-甲硫氨酸的基因工程菌及其构建与应用 |
| WO2024096123A1 (ja) * | 2022-11-04 | 2024-05-10 | 株式会社バイオパレット | 遺伝子が改変された微生物およびその生産方法 |
| WO2024149616A1 (en) | 2023-01-09 | 2024-07-18 | Evonik Operations Gmbh | Fermentative production guanidinoacetic acid (gaa) from serine using a microorganism having an enhanced l-serine hydroxymethyltransferase activity |
| WO2024149617A1 (en) | 2023-01-09 | 2024-07-18 | Evonik Operations Gmbh | Fermentative production guanidinoacetic acid (gaa) from serine by attenuating l serine ammonia lyase activity in microorganisms |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000157267A (ja) | 1998-11-24 | 2000-06-13 | Ajinomoto Co Inc | 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法 |
| JPWO2002097086A1 (ja) | 2001-05-29 | 2005-04-07 | 協和醗酵工業株式会社 | 工業的生産に有用な微生物 |
| DE10305774A1 (de) * | 2003-02-06 | 2004-08-26 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von L-Methionin |
| MXPA05008857A (es) | 2003-02-18 | 2006-03-09 | Metabolic Explorer Sa | Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas. |
| DE10311399A1 (de) * | 2003-03-13 | 2004-09-23 | Forschungszentrum Jülich GmbH | Nukleotidsequenzen coryneformer Bakterien codierend für am L-Serinstoffwechsel beteiligte Proteine sowie Verfahren zur mikrobiellen Herstellung von L-Serin |
| WO2005111202A1 (en) | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
| NO331033B1 (no) * | 2005-07-07 | 2011-09-19 | I P Huse As | Anordning for transport av kjetting. |
| JP2009504172A (ja) | 2005-08-18 | 2009-02-05 | ビーエーエスエフ ソシエタス・ヨーロピア | 向上したメチオニン合成効率を有する微生物 |
| WO2007077041A1 (en) * | 2006-01-04 | 2007-07-12 | Metabolic Explorer | Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression |
| KR100905381B1 (ko) * | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
| BRPI0807760A2 (pt) | 2007-02-19 | 2014-06-17 | Evonik Degussa Gmbh | Bactérias corineformes com atividade de formato-thf-sintetase e/ou atividade de clivagem de glicina |
| KR100858913B1 (ko) * | 2007-03-09 | 2008-09-17 | 한국과학기술원 | 부위특이적 변이에 의해 제조된 고수율의 ｌ－쓰레오닌생산균주 및 이를 이용한 ｌ－쓰레오닌의 제조방법 |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| WO2010020290A1 (en) * | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Producing methionine without n-acetyl methionine |
| EP2519637A2 (en) * | 2009-12-30 | 2012-11-07 | Metabolic Explorer | Strains and method for the production of methionine |
-
2010
- 2010-12-29 EP EP10798139A patent/EP2519637A2/en not_active Withdrawn
- 2010-12-29 KR KR1020127019853A patent/KR101915819B1/ko active IP Right Grant
- 2010-12-29 US US13/519,526 patent/US9382561B2/en not_active Expired - Fee Related
- 2010-12-29 WO PCT/EP2010/070858 patent/WO2011080301A2/en active Application Filing
- 2010-12-29 BR BR112012016908-4A patent/BR112012016908B1/pt active IP Right Grant
- 2010-12-29 MY MYPI2012002674A patent/MY172018A/en unknown
- 2010-12-29 JP JP2012546444A patent/JP5922036B2/ja not_active Expired - Fee Related
- 2010-12-29 IN IN6442DEN2012 patent/IN2012DN06442A/en unknown
- 2010-12-29 MX MX2012007717A patent/MX2012007717A/es active IP Right Grant
- 2010-12-29 CN CN201080064983.5A patent/CN102782137B/zh active Active
- 2010-12-30 AR ARP100105026A patent/AR079821A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2519637A2 (en) | 2012-11-07 |
| KR20120114325A (ko) | 2012-10-16 |
| US9382561B2 (en) | 2016-07-05 |
| BR112012016908B1 (pt) | 2020-03-31 |
| MY172018A (en) | 2019-11-12 |
| IN2012DN06442A (pt) | 2015-10-09 |
| WO2011080301A2 (en) | 2011-07-07 |
| KR101915819B1 (ko) | 2018-11-06 |
| AR079821A1 (es) | 2012-02-22 |
| US20120288904A1 (en) | 2012-11-15 |
| MX2012007717A (es) | 2012-07-25 |
| JP2013516162A (ja) | 2013-05-13 |
| CN102782137A (zh) | 2012-11-14 |
| CN102782137B (zh) | 2016-01-06 |
| WO2011080301A3 (en) | 2012-04-12 |
| JP5922036B2 (ja) | 2016-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012016908A2 (pt) | linhagens e métodos para a produção de metionina | |
| BR112012002270A2 (pt) | compostos para a redução de produção de beta-amiloide | |
| BR112012002746A2 (pt) | método para produção de copolímero | |
| BR112012012211A2 (pt) | método para a recuperação de butanol e método para a produção de butanol | |
| BR112013005407A2 (pt) | atuador e método para a fabricação do atuador | |
| BR112012001542A2 (pt) | lente de contato, e, método para fabricar uma lente de contato | |
| BR112013002124A2 (pt) | células e processo para a produção de ramnolipídeos | |
| BR112012004289A2 (pt) | Organismos geneticamente modificados para a produção de lipídios | |
| BRPI1014460A2 (pt) | Processo enzimático para a produção de aldéidos | |
| BR112013012801A2 (pt) | método para a produção de um calçado e calçado | |
| BRPI0925048A2 (pt) | Módulo para produção de comprimidos e método para a produção contínua de comprimidos | |
| BR112013013241A2 (pt) | artigo e método para a produção do artigo | |
| BR112013014442A2 (pt) | micro-organismos para a produção de putrescina e método para a produção de putrescina utilizando o mesmo | |
| BRPI1007160A2 (pt) | Método para esterilizar um material | |
| BRPI1014812A2 (pt) | Processo para a produção de alacoóis | |
| BRPI1015147A2 (pt) | métodos para melhorar a farmacocinética | |
| BR112012014490A2 (pt) | processo para a preparação substituída de 1-o-acil-2-desóxi-2-fluoro-4-tio-beta-d-arabinofuranoses | |
| BRPI1014267A2 (pt) | processo para a carbonitrificação | |
| BRPI0922490A2 (pt) | Método para produção de beta-santaleno | |
| BR112012004101A2 (pt) | prensa para produção de um tampão | |
| BR112012031848A2 (pt) | estrutura compósita e processo para fazer a estrutura compósita | |
| BRPI1012025A2 (pt) | componente estrutural e método para produção de um componente estrutural. | |
| BR112012015382A2 (pt) | artigo de estiramento e método para a produção | |
| BR112012004297A2 (pt) | concentrado perolado e método para a fabricação do mesmo. | |
| BRPI1011731A2 (pt) | dispositivo para produzir fechos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: EVONIK DEGUSSA GMBH (DE) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/12/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25D | Requested change of name of applicant approved |
Owner name: EVONIK OPERATIONS GMBH (DE) |