BR112012015977A2 - composto derivado de poli (ácido lático), método para preparar o composto derivado de poli (ácido lático), complexo do composto de derivado de poli (ácido lático), composição de liberação prolongada de droga, e, método para preparar a composição de liberação prolongada de droga - Google Patents
composto derivado de poli (ácido lático), método para preparar o composto derivado de poli (ácido lático), complexo do composto de derivado de poli (ácido lático), composição de liberação prolongada de droga, e, método para preparar a composição de liberação prolongada de drogaInfo
- Publication number
- BR112012015977A2 BR112012015977A2 BR112012015977A BR112012015977A BR112012015977A2 BR 112012015977 A2 BR112012015977 A2 BR 112012015977A2 BR 112012015977 A BR112012015977 A BR 112012015977A BR 112012015977 A BR112012015977 A BR 112012015977A BR 112012015977 A2 BR112012015977 A2 BR 112012015977A2
- Authority
- BR
- Brazil
- Prior art keywords
- poly
- lactic acid
- preparing
- derivative
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/465—Preparation of carboxylic acid esters by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C07C69/68—Lactic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
- C08J3/21—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the polymer being premixed with a liquid phase
- C08J3/215—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the polymer being premixed with a liquid phase at least one additive being also premixed with a liquid phase
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
composto derivado de poli (ácido lático), método para preparar o composto derivado de poli (ácido lático), complexo do composto de derivado de poli (ácido lático), composição de liberação prolongada de droga, e, método para preparar a composição de liberação prolongada de droga. a presente invenção refere-se a uma macromolécula para dispensar drogas de proteína, de polipeptídeo ou de peptídeo e a um método de produção da mesma, bem como a uma composição de liberação lenta para drogas de proteína, de polipeptídeo ou de peptídeo compreendendo a mesma, e mais especificamente se refere a um composto derivado de poli(ácido lático) de fórmula química 1 cujo peso molecular numérico médio e não maior do que 7,000 daltons e a um método de produção do mesmo, bem como a uma composição de liberação lenta para drogas de proteína, de polipeptídeo ou de peptídeo usando o mesmo e a um método de produção da mesma.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20090132861 | 2009-12-29 | ||
| KR10-2009-0132861 | 2009-12-29 | ||
| PCT/KR2010/009421 WO2011081406A2 (ko) | 2009-12-29 | 2010-12-28 | 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012015977A2 true BR112012015977A2 (pt) | 2018-05-29 |
| BR112012015977B1 BR112012015977B1 (pt) | 2020-10-06 |
Family
ID=44227011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012015977-1A BR112012015977B1 (pt) | 2009-12-29 | 2010-12-28 | Complexo de um polímero iônico, composição de micropartícula de liberação prolongada de droga, e, método para preparar a composição de liberação prolongada de droga |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9603931B2 (pt) |
| EP (1) | EP2520600B1 (pt) |
| JP (1) | JP5597724B2 (pt) |
| KR (1) | KR101224004B1 (pt) |
| CN (1) | CN102741317B (pt) |
| AU (1) | AU2010339080B2 (pt) |
| BR (1) | BR112012015977B1 (pt) |
| CA (1) | CA2784990C (pt) |
| ES (1) | ES2628137T3 (pt) |
| MX (1) | MX342712B (pt) |
| NZ (1) | NZ600775A (pt) |
| WO (1) | WO2011081406A2 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101424163B1 (ko) * | 2010-12-24 | 2014-08-01 | 주식회사 삼양바이오팜 | 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법 |
| KR101467275B1 (ko) * | 2011-12-19 | 2014-12-02 | 주식회사 삼양바이오팜 | 분산성이 향상된 생분해성 고분자 미립자의 조성물 및 그 제조방법 |
| JP6139029B2 (ja) * | 2013-06-21 | 2017-05-31 | ザ カトリック ユニバーシティ オブ コリア インダストリー−アカデミック コーオペレイション ファウンデーション | 薬物送達用還元性または非還元性ポリヌクレオチド高分子及びその製造方法 |
| KR101547633B1 (ko) | 2013-06-21 | 2015-08-26 | 가톨릭대학교 산학협력단 | 약물 전달용 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법 |
| KR101547634B1 (ko) | 2013-06-21 | 2015-08-26 | 가톨릭대학교 산학협력단 | 약물 전달용 환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법 |
| ZA201407536B (en) * | 2013-10-21 | 2017-09-27 | Ems Sa | Parenteral pharmaceutical composition containing cosyntropin |
| US10391491B2 (en) * | 2014-08-07 | 2019-08-27 | The General Hospital Corporation | Platelet-targeted microfluidic isolation of cells |
| WO2016175752A1 (en) | 2015-04-27 | 2016-11-03 | Halliburton Energy Services, Inc. | Delayed-release additives in a degradable matrix |
| KR101547636B1 (ko) | 2015-07-20 | 2015-08-27 | 가톨릭대학교 산학협력단 | 환원성 폴리뉴클레오타이드 고분자를 포함하는 비바이러스성 약물전달용 조성물 |
| KR101547635B1 (ko) | 2015-07-20 | 2015-08-27 | 가톨릭대학교 산학협력단 | 비환원성 폴리뉴클레오타이드 고분자를 포함하는 비바이러스성 약물전달용 조성물 |
| CN108660614B (zh) * | 2018-05-22 | 2020-04-03 | 西南交通大学 | 一种聚乳酸多孔薄膜及其制备方法 |
| WO2023100260A1 (ja) * | 2021-11-30 | 2023-06-08 | 日清紡ホールディングス株式会社 | 海洋生分解性ポリマー化合物、海洋生分解促進剤及び海洋生分解性樹脂組成物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE556559A (pt) * | 1956-04-13 | |||
| JPS62135521A (ja) * | 1985-12-10 | 1987-06-18 | Daicel Chem Ind Ltd | 末端にカルボキシル基を有するポリカプロラクトン |
| JPS6369825A (ja) * | 1986-09-11 | 1988-03-29 | Mitsui Toatsu Chem Inc | ブロツク共重合体及びその製造方法 |
| US5196502A (en) * | 1991-11-05 | 1993-03-23 | Eastman Kodak Company | Method for the preparation of multiply-branched aromatic polyesters |
| US6221958B1 (en) | 1993-01-06 | 2001-04-24 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| WO1994015587A2 (en) * | 1993-01-06 | 1994-07-21 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| JP3287425B2 (ja) * | 1993-02-04 | 2002-06-04 | 東洋紡績株式会社 | 水酸基末端をエステル封鎖したポリ乳酸およびその製造法 |
| KR0141431B1 (ko) * | 1994-05-17 | 1998-07-01 | 김상웅 | 생분해성 하이드로겔 고분자 |
| JPH0859642A (ja) | 1994-08-22 | 1996-03-05 | Mitsubishi Chem Corp | ３，４−アルキレン−１，３，４−チアジアゾリジン−２−オン類の製造方法 |
| US5668288A (en) | 1996-04-16 | 1997-09-16 | Depuy Orthopaedics, Inc. | Polyester ionomers for implant fabrication |
| IE960308A1 (en) | 1996-04-23 | 1997-11-05 | Kinerton Ltd | Sustained release ionic conjugate |
| US6197350B1 (en) * | 1996-12-20 | 2001-03-06 | Takeda Chemical Industries, Ltd. | Method of producing a sustained-release preparation |
| JPH1121343A (ja) * | 1997-07-01 | 1999-01-26 | Mitsui Chem Inc | ポリヒドロキシカルボン酸の製造方法 |
| JPH1160928A (ja) * | 1997-08-27 | 1999-03-05 | Nishikawa Rubber Co Ltd | ポリヒドロキシカルボン酸樹脂組成物およびその製造方法 |
| US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
| CA2463517C (en) | 2001-10-18 | 2010-03-16 | Samyang Corporation | Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery |
| CA2463172C (en) * | 2001-10-18 | 2009-08-18 | Samyang Corporation | Polymeric micelle composition with improved stability |
| AU2005239948B9 (en) | 2004-05-06 | 2009-04-23 | Samyang Biopharmaceuticals Corporation | Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising an amphiphilic block polymer and a polylacticacid derivative |
| EP1773908B1 (en) * | 2004-08-02 | 2012-09-19 | Samyang Biopharmaceuticals Corporation | Biodegradable multi-block polymeric composition capable of sol-gel transition |
| EP1647567A1 (en) * | 2004-10-15 | 2006-04-19 | SOLVAY (Société Anonyme) | Methods of producing amine-terminated caprolactone polymers and uses of the produced polymers |
| CN101104706A (zh) * | 2007-08-06 | 2008-01-16 | 四川大学 | 聚乳酸及其衍生物的电子束辐射改性方法 |
| KR101024742B1 (ko) | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
-
2010
- 2010-12-23 KR KR20100133192A patent/KR101224004B1/ko active IP Right Grant
- 2010-12-28 CA CA2784990A patent/CA2784990C/en not_active Expired - Fee Related
- 2010-12-28 EP EP10841238.8A patent/EP2520600B1/en active Active
- 2010-12-28 ES ES10841238.8T patent/ES2628137T3/es active Active
- 2010-12-28 BR BR112012015977-1A patent/BR112012015977B1/pt not_active IP Right Cessation
- 2010-12-28 AU AU2010339080A patent/AU2010339080B2/en not_active Ceased
- 2010-12-28 WO PCT/KR2010/009421 patent/WO2011081406A2/ko active Application Filing
- 2010-12-28 CN CN201080063259.0A patent/CN102741317B/zh active Active
- 2010-12-28 MX MX2012007603A patent/MX342712B/es active IP Right Grant
- 2010-12-28 US US13/519,729 patent/US9603931B2/en active Active
- 2010-12-28 JP JP2012547015A patent/JP5597724B2/ja active Active
- 2010-12-28 NZ NZ600775A patent/NZ600775A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010339080A1 (en) | 2012-07-19 |
| NZ600775A (en) | 2015-01-30 |
| KR101224004B1 (ko) | 2013-01-22 |
| WO2011081406A2 (ko) | 2011-07-07 |
| JP2013515833A (ja) | 2013-05-09 |
| MX342712B (es) | 2016-10-10 |
| US9603931B2 (en) | 2017-03-28 |
| MX2012007603A (es) | 2012-08-01 |
| JP5597724B2 (ja) | 2014-10-01 |
| CA2784990A1 (en) | 2011-07-07 |
| CN102741317A (zh) | 2012-10-17 |
| AU2010339080B2 (en) | 2015-09-17 |
| EP2520600A2 (en) | 2012-11-07 |
| EP2520600A4 (en) | 2014-01-08 |
| EP2520600B1 (en) | 2017-03-29 |
| KR20110076783A (ko) | 2011-07-06 |
| CA2784990C (en) | 2015-03-31 |
| WO2011081406A3 (ko) | 2011-12-01 |
| ES2628137T3 (es) | 2017-08-01 |
| US20130274188A1 (en) | 2013-10-17 |
| AU2010339080A9 (en) | 2015-09-17 |
| CN102741317B (zh) | 2015-01-07 |
| BR112012015977B1 (pt) | 2020-10-06 |
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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PANO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESETENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2703 DE 25-10-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |