BR112012010400A2 - composição co-processada, processo para preparar uma composição útil como um excipiente farmacêutico, formulação de granulado ou comprimido, método, e, forma de dosagem sólida - Google Patents

composição co-processada, processo para preparar uma composição útil como um excipiente farmacêutico, formulação de granulado ou comprimido, método, e, forma de dosagem sólida

Info

Publication number
BR112012010400A2
BR112012010400A2 BR112012010400A BR112012010400A BR112012010400A2 BR 112012010400 A2 BR112012010400 A2 BR 112012010400A2 BR 112012010400 A BR112012010400 A BR 112012010400A BR 112012010400 A BR112012010400 A BR 112012010400A BR 112012010400 A2 BR112012010400 A2 BR 112012010400A2
Authority
BR
Brazil
Prior art keywords
composition
solid dosage
processed
preparing
granulate
Prior art date
Application number
BR112012010400A
Other languages
English (en)
Other versions
BR112012010400B1 (pt
Inventor
Bruno Leclercq
Gregory Thoorens
Thomas Ruszkay
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp filed Critical Fmc Corp
Publication of BR112012010400A2 publication Critical patent/BR112012010400A2/pt
Publication of BR112012010400B1 publication Critical patent/BR112012010400B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

composição co-processada, processo para preparar uma composição útil como um excipiente farmacêutico, formulação de granulado ou comprimido, método, e, forma de dosagem sólida. composições co-processadas contendo fosfato de cálcio e celulose microcristalinas são úteis como excipientes na preparação de formas de dosagem sólidas contendo ingredientes farmacêuticos ativos, de um modo particular aqueles preparados através de processos que envolvem múltiplos estágios de compactação. tais composições podem ser obtidas através da preparação de suspensões aquosas de celulose miucrocristalina e de fosfato de cálcio e secagem de tais suspensões, de um modo a produzir particulados. os produtos co-processados exibem uma compactabilidade aperfeiçoada, quando comparados a misturas físicas secas dos mesmos componentes.
BR112012010400-4A 2009-11-05 2010-11-02 composição co-processada, processo para preparar uma composição útil como um excipiente farmacêutico, formulação de granulado ou comprimido, método, e, forma de dosagem sólida BR112012010400B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25839109P 2009-11-05 2009-11-05
PCT/US2010/055068 WO2011056775A2 (en) 2009-11-05 2010-11-02 Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients

Publications (2)

Publication Number Publication Date
BR112012010400A2 true BR112012010400A2 (pt) 2016-07-12
BR112012010400B1 BR112012010400B1 (pt) 2019-11-05

Family

ID=43925704

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012010400-4A BR112012010400B1 (pt) 2009-11-05 2010-11-02 composição co-processada, processo para preparar uma composição útil como um excipiente farmacêutico, formulação de granulado ou comprimido, método, e, forma de dosagem sólida

Country Status (10)

Country Link
US (1) US8329221B2 (pt)
EP (1) EP2496261B1 (pt)
JP (1) JP6092626B2 (pt)
BR (1) BR112012010400B1 (pt)
DK (1) DK2496261T3 (pt)
ES (1) ES2662698T3 (pt)
IL (1) IL219374B (pt)
NO (1) NO2496261T3 (pt)
TW (1) TWI461213B (pt)
WO (1) WO2011056775A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906949B2 (en) * 2010-05-21 2014-12-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Orally disintegrating tablets of zolmitriptan and process for preparing the same
US10793847B2 (en) * 2015-05-11 2020-10-06 Mybiotics Pharma Ltd. Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut
PL3697392T3 (pl) 2017-10-17 2024-03-25 Synthon B.V. Tabletki zawierające tamsulosynę i solifenacynę
CN108815125A (zh) * 2018-07-23 2018-11-16 深圳市优普惠药品股份有限公司 微晶纤维素与无水磷酸氢钙复合物及其制备工艺
CA3107696A1 (en) 2018-10-04 2020-04-09 Chemische Fabrik Budenheim Kg Spherical beads for use in producing pharmaceutically active pellets
EP3892262A1 (en) 2020-04-06 2021-10-13 Chemische Fabrik Budenheim KG Beads comprising a buffer system

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
WO1981002521A1 (en) 1980-03-10 1981-09-17 Mendell Co Inc Edward Pharmaceutical vehicle composition and process of producing same
US4517179A (en) 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
CA1261261A (en) * 1985-03-08 1989-09-26 Dev K. Mehra Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
US4744987A (en) * 1985-03-08 1988-05-17 Fmc Corporation Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US6395303B1 (en) * 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6123964A (en) 1995-10-27 2000-09-26 Merck & Co., Inc. Wet granulation formulation of a growth hormone secretagogue
US5858409A (en) 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
US5747067A (en) 1996-12-06 1998-05-05 Fmc Corporation Co-processed products
US6103260A (en) * 1997-07-17 2000-08-15 Mcneil-Ppc, Inc. Simethicone/anhydrous calcium phosphate compositions
US6716449B2 (en) * 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
AR028253A1 (es) * 2000-03-16 2003-04-30 Pfizer Prod Inc Inhibidores de la glucogeno fosforilasa
AT5874U1 (de) * 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
EP1226818A1 (en) 2001-01-26 2002-07-31 Pfizer Products Inc. Pharmaceutical dosage forms with enhanced cohesive and compressibility properties
DK1476136T3 (da) * 2002-02-14 2006-10-09 Glaxo Group Ltd Farmaceutisk præparat, der omfatter N-[(1-N-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indol-10-carboxamid eller salt, og fremgangsmåde derfor, der omfatter törgranulering
TW200403994A (en) 2002-04-04 2004-03-16 Bristol Myers Squibb Co Oral administration of EPOTHILONES
GB0211620D0 (en) 2002-05-21 2002-07-03 Bioprogress Technology Ltd Powder compaction and enrobing
GB0322358D0 (en) 2003-09-24 2003-10-22 Bioprogress Technology Ltd Improvements in powder compaction and enrobing
JP3841804B2 (ja) 2003-10-15 2006-11-08 富士化学工業株式会社 口腔内速崩壊性錠剤用の組成物
CN101065091A (zh) 2004-09-24 2007-10-31 生物进展技术有限公司 对粉末压实和包覆的额外改进
DE102005046146A1 (de) * 2005-02-25 2006-08-31 Bayerische Motoren Werke Ag Teilintegralbremse für ein Motorrad
CN101360725B (zh) * 2005-11-18 2011-09-21 阿斯利康公司 固体制剂
US7998505B2 (en) 2006-10-27 2011-08-16 Fmc Corporation Dry granulation binders, products, and use thereof
CA2644179C (en) * 2007-11-21 2018-09-25 Pharmascience Inc. Novel pharmaceutical composition comprising a disintegration matrix

Also Published As

Publication number Publication date
EP2496261A2 (en) 2012-09-12
EP2496261B1 (en) 2017-12-20
ES2662698T3 (es) 2018-04-09
WO2011056775A3 (en) 2011-11-03
JP2013510157A (ja) 2013-03-21
DK2496261T3 (en) 2018-03-26
US20110104288A1 (en) 2011-05-05
IL219374B (en) 2019-05-30
BR112012010400B1 (pt) 2019-11-05
WO2011056775A2 (en) 2011-05-12
TW201124157A (en) 2011-07-16
NO2496261T3 (pt) 2018-05-19
IL219374A0 (en) 2012-06-28
EP2496261A4 (en) 2014-03-26
TWI461213B (zh) 2014-11-21
US8329221B2 (en) 2012-12-11
JP6092626B2 (ja) 2017-03-08

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B25G Requested change of headquarter approved

Owner name: FMC CORPORATION (US)

B25A Requested transfer of rights approved

Owner name: DUPONT NUTRITION USA, INC. (US)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/11/2010, OBSERVADAS AS CONDICOES LEGAIS.