BR0308211A - Cumarinas úteis como biomarcadores - Google Patents
Cumarinas úteis como biomarcadoresInfo
- Publication number
- BR0308211A BR0308211A BR0308211-3A BR0308211A BR0308211A BR 0308211 A BR0308211 A BR 0308211A BR 0308211 A BR0308211 A BR 0308211A BR 0308211 A BR0308211 A BR 0308211A
- Authority
- BR
- Brazil
- Prior art keywords
- biomarkers
- useful
- coumarins
- coumarins useful
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0205281.9A GB0205281D0 (en) | 2002-03-06 | 2002-03-06 | Organic compounds |
| PCT/EP2003/002251 WO2003074519A1 (en) | 2002-03-06 | 2003-03-05 | Coumarines useful as biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308211A true BR0308211A (pt) | 2004-12-21 |
Family
ID=9932424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308211-3A BR0308211A (pt) | 2002-03-06 | 2003-03-05 | Cumarinas úteis como biomarcadores |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7569337B2 (xx) |
| EP (1) | EP1483262B1 (xx) |
| JP (2) | JP4247123B2 (xx) |
| KR (1) | KR20040095257A (xx) |
| CN (1) | CN1628114A (xx) |
| AR (1) | AR038723A1 (xx) |
| AT (1) | ATE378333T1 (xx) |
| AU (1) | AU2003210418A1 (xx) |
| BR (1) | BR0308211A (xx) |
| CA (1) | CA2472298A1 (xx) |
| CO (1) | CO5611123A2 (xx) |
| DE (1) | DE60317476T2 (xx) |
| EC (1) | ECSP045255A (xx) |
| ES (1) | ES2294304T3 (xx) |
| GB (1) | GB0205281D0 (xx) |
| MX (1) | MXPA04008570A (xx) |
| NO (1) | NO20044174L (xx) |
| PE (1) | PE20030890A1 (xx) |
| PL (1) | PL370916A1 (xx) |
| PT (1) | PT1483262E (xx) |
| RU (1) | RU2004129733A (xx) |
| TW (1) | TW200400049A (xx) |
| WO (1) | WO2003074519A1 (xx) |
| ZA (1) | ZA200405175B (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| EP1624900A4 (en) * | 2003-05-20 | 2007-05-02 | Univ California | METHOD OF BINDING AGENTS AT BETA AMYLOID PLAQUE |
| WO2006057323A1 (ja) * | 2004-11-26 | 2006-06-01 | Nagasaki University | アミロイド関連疾患診断用組成物 |
| JP2007084526A (ja) * | 2004-11-26 | 2007-04-05 | Nagasaki Univ | アミロイド関連疾患診断用組成物 |
| TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
| TW200808795A (en) * | 2006-05-19 | 2008-02-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity for amyloid |
| TW200811175A (en) * | 2006-06-21 | 2008-03-01 | Nihon Mediphysics Co Ltd | Novel compound with affinity with amyloid |
| EP2042501B1 (en) | 2006-06-21 | 2017-04-12 | Nihon Medi-Physics Co., Ltd. | Compound having affinity for amyloid |
| TWI406674B (zh) | 2007-02-13 | 2013-09-01 | Nihon Mediphysics Co Ltd | Method for manufacturing diagnostic radiographic diagnostic agents |
| CN101903381A (zh) * | 2007-10-24 | 2010-12-01 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物 |
| EP2218463A1 (en) * | 2007-10-30 | 2010-08-18 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
| CA2704139A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Utilization of novel compounds with amyloid affinity and method of producing the same |
| JP6193881B2 (ja) * | 2011-12-30 | 2017-09-06 | ピーティーシー セラピューティクス， インコーポレイテッド | 脊髄性筋萎縮症を治療するための化合物 |
| US9296728B2 (en) | 2012-01-20 | 2016-03-29 | Regents Of The University Of Minnesota | Therapeutic compounds |
| KR102064624B1 (ko) * | 2012-01-26 | 2020-01-09 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| ES2697174T3 (es) | 2012-02-10 | 2019-01-22 | Ptc Therapeutics Inc | Compuestos para tratar atrofia muscular espinal |
| WO2013130689A1 (en) | 2012-03-01 | 2013-09-06 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| BR112014023483B1 (pt) | 2012-03-23 | 2022-05-10 | Ptc Therapeutics, Inc | Composto e seu uso, composição farmacêutica e seu uso |
| CN103420990B (zh) * | 2012-05-23 | 2016-04-20 | 复旦大学 | 7-氧、硫或氮杂取代香豆素及其衍生物和用途 |
| US10195202B2 (en) | 2013-12-19 | 2019-02-05 | Ptc Therapeutics, Inc. | Methods for modulating the amount of RNA transcripts |
| WO2016196386A1 (en) | 2015-05-30 | 2016-12-08 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
| DK3386511T3 (da) | 2015-12-10 | 2021-07-05 | Ptc Therapeutics Inc | Fremgangsmåder til behandling af huntingtons sygdom |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| WO2018114710A1 (en) | 2016-12-22 | 2018-06-28 | Illumina Cambridge Limited | Coumarin compounds and their uses as fluorescent labels |
| CN108061725B (zh) * | 2017-02-16 | 2020-04-21 | 昆明医科大学 | 1,8-萘啶基荧光分子探针在氯胺酮娱乐性滥用神经机制研究及成瘾程度诊断中的应用 |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| EA202090034A1 (ru) | 2017-06-14 | 2020-04-16 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы модификации сплайсинга рнк |
| EP3645121A4 (en) | 2017-06-28 | 2021-03-17 | PTC Therapeutics, Inc. | HUNTINGTON'S DISEASE TREATMENT METHODS |
| WO2019005980A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| BR112020019373A2 (pt) | 2018-03-27 | 2020-12-29 | Ptc Therapeutics, Inc. | Compostos para o tratamento da doença de hutington |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| AU2019294478B2 (en) | 2018-06-27 | 2023-03-23 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating Huntington's disease |
| EP3931263A1 (en) | 2019-03-01 | 2022-01-05 | Illumina Cambridge Limited | Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels |
| CN112300201B (zh) * | 2020-12-07 | 2021-11-23 | 南京林业大学 | 一种三聚茚基香豆素-咔咯-卟啉四元体系星型化合物的合成及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH390250A (de) * | 1958-06-19 | 1965-07-30 | Geigy Ag J R | Verfahren zur Herstellung von fluoreszierenden Farbstoffen |
| DE2065552A1 (de) * | 1970-06-20 | 1974-03-07 | Bayer Ag | Oxazolyl-essigsaeurederivate |
| JPS5529110B2 (xx) * | 1972-12-25 | 1980-08-01 | ||
| DE2410634A1 (de) * | 1974-03-06 | 1975-09-18 | Basf Ag | 3-benzofurylcumarine |
| DE2411969A1 (de) * | 1974-03-13 | 1975-09-25 | Bayer Ag | Farbstofflaser |
| DE2525986A1 (de) * | 1975-06-11 | 1977-05-05 | Bayer Ag | Cumarinverbindungen |
| LU78311A1 (de) * | 1977-10-13 | 1979-06-01 | Ciba Geigy Ag | Neue cumarinfarbstoffe,deren herstellung und verwendung |
| US4892922A (en) * | 1987-11-30 | 1990-01-09 | Eastman Kodak Company | Polyester polymer containing the residue of a benzopyran colorant compound and shaped articles produced therefrom |
| JPH01169327A (ja) * | 1987-12-25 | 1989-07-04 | Mitsui Toatsu Chem Inc | 紫外線検知用樹脂組成物 |
| JP2999841B2 (ja) * | 1991-04-03 | 2000-01-17 | 三井化学株式会社 | 発光スクリーン用樹脂組成物 |
| DE69216498T2 (de) | 1991-08-13 | 1997-04-30 | Bayer Ag | Fluoreszierendes Etikett |
| JPH073179A (ja) * | 1993-06-15 | 1995-01-06 | Nippon Kayaku Co Ltd | インクジェットプリント用インク組成物及びこれを用いる染色法 |
| JP4028155B2 (ja) * | 2000-04-11 | 2007-12-26 | 日本カーバイド工業株式会社 | 蛍光性再帰反射シート |
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
-
2002
- 2002-03-06 GB GBGB0205281.9A patent/GB0205281D0/en not_active Ceased
-
2003
- 2003-03-04 PE PE2003000207A patent/PE20030890A1/es not_active Application Discontinuation
- 2003-03-04 TW TW092104534A patent/TW200400049A/zh unknown
- 2003-03-04 AR ARP030100711A patent/AR038723A1/es unknown
- 2003-03-05 MX MXPA04008570A patent/MXPA04008570A/es active IP Right Grant
- 2003-03-05 PT PT03743381T patent/PT1483262E/pt unknown
- 2003-03-05 PL PL03370916A patent/PL370916A1/xx not_active Application Discontinuation
- 2003-03-05 KR KR10-2004-7013763A patent/KR20040095257A/ko not_active Application Discontinuation
- 2003-03-05 BR BR0308211-3A patent/BR0308211A/pt not_active IP Right Cessation
- 2003-03-05 AU AU2003210418A patent/AU2003210418A1/en not_active Abandoned
- 2003-03-05 ES ES03743381T patent/ES2294304T3/es not_active Expired - Lifetime
- 2003-03-05 JP JP2003572987A patent/JP4247123B2/ja not_active Expired - Fee Related
- 2003-03-05 DE DE60317476T patent/DE60317476T2/de not_active Expired - Fee Related
- 2003-03-05 AT AT03743381T patent/ATE378333T1/de not_active IP Right Cessation
- 2003-03-05 CN CNA038032163A patent/CN1628114A/zh active Pending
- 2003-03-05 CA CA002472298A patent/CA2472298A1/en not_active Abandoned
- 2003-03-05 RU RU2004129733/04A patent/RU2004129733A/ru not_active Application Discontinuation
- 2003-03-05 WO PCT/EP2003/002251 patent/WO2003074519A1/en active IP Right Grant
- 2003-03-05 US US10/506,381 patent/US7569337B2/en not_active Expired - Fee Related
- 2003-03-05 EP EP03743381A patent/EP1483262B1/en not_active Expired - Lifetime
-
2004
- 2004-06-29 ZA ZA200405175A patent/ZA200405175B/en unknown
- 2004-08-27 EC EC2004005255A patent/ECSP045255A/es unknown
- 2004-09-15 CO CO04091787A patent/CO5611123A2/es not_active Application Discontinuation
- 2004-09-30 NO NO20044174A patent/NO20044174L/no not_active Application Discontinuation
-
2008
- 2008-11-27 JP JP2008302570A patent/JP2009102322A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003210418A1 (en) | 2003-09-16 |
| ATE378333T1 (de) | 2007-11-15 |
| DE60317476D1 (de) | 2007-12-27 |
| EP1483262A1 (en) | 2004-12-08 |
| TW200400049A (en) | 2004-01-01 |
| KR20040095257A (ko) | 2004-11-12 |
| EP1483262B1 (en) | 2007-11-14 |
| JP2009102322A (ja) | 2009-05-14 |
| CA2472298A1 (en) | 2003-09-12 |
| JP2005526749A (ja) | 2005-09-08 |
| PT1483262E (pt) | 2008-02-11 |
| WO2003074519A1 (en) | 2003-09-12 |
| NO20044174L (no) | 2004-09-30 |
| JP4247123B2 (ja) | 2009-04-02 |
| ECSP045255A (es) | 2004-09-28 |
| MXPA04008570A (es) | 2004-12-06 |
| CN1628114A (zh) | 2005-06-15 |
| ES2294304T3 (es) | 2008-04-01 |
| PE20030890A1 (es) | 2003-12-05 |
| GB0205281D0 (en) | 2002-04-17 |
| US20050169837A1 (en) | 2005-08-04 |
| AR038723A1 (es) | 2005-01-26 |
| US7569337B2 (en) | 2009-08-04 |
| RU2004129733A (ru) | 2005-06-27 |
| PL370916A1 (en) | 2005-06-13 |
| CO5611123A2 (es) | 2006-02-28 |
| ZA200405175B (en) | 2005-06-21 |
| DE60317476T2 (de) | 2008-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011. |