BR0211191A - ensaios baseados em ácido nucléico para se diagnosticar precisamente infecção por parvovìrus b19 e inciadores e marcadores para uso nesses ensaios - Google Patents

ensaios baseados em ácido nucléico para se diagnosticar precisamente infecção por parvovìrus b19 e inciadores e marcadores para uso nesses ensaios

Info

Publication number
BR0211191A
BR0211191A BRPI0211191-8A BR0211191A BR0211191A BR 0211191 A BR0211191 A BR 0211191A BR 0211191 A BR0211191 A BR 0211191A BR 0211191 A BR0211191 A BR 0211191A
Authority
BR
Brazil
Prior art keywords
assays
nucleic acid
parvovirus
markers
initiators
Prior art date
Application number
BRPI0211191-8A
Other languages
English (en)
Other versions
BRPI0211191B8 (pt
BRPI0211191B1 (pt
Inventor
Sergio Pichuantes
Venkatakrishna Shyamala
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of BR0211191A publication Critical patent/BR0211191A/pt
Publication of BRPI0211191B1 publication Critical patent/BRPI0211191B1/pt
Publication of BRPI0211191B8 publication Critical patent/BRPI0211191B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

"ENSAIOS BASEADOS EM áCIDO NUCLéICO PARA SE DIAGNOSTICAR PRECISAMENTE INFECçãO POR PARVOVìRUS B19 E INICIADORES E MARCADORES PARA USO NESSES ENSAIOS". São revelados iniciadores e marcadores de parvovírus B19 humano derivados de regiões conservadas do genoma do parvovírus B19. Também são revelados ensaios baseados em ácido nucléico usando os iniciadores e marcadores.
BRPI0211191A 2001-06-28 2002-06-28 ensaios baseados em ácido nucléico para se diagnosticar precisamente infecção por parvovírus b19 e inciadores e marcadores para uso nesses ensaios BRPI0211191B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30207701P 2001-06-28 2001-06-28
US36595602P 2002-03-19 2002-03-19
US36922402P 2002-03-29 2002-03-29
PCT/US2002/020684 WO2003002753A2 (en) 2001-06-28 2002-06-28 Diagnostic assays for parvovirus b19

Publications (3)

Publication Number Publication Date
BR0211191A true BR0211191A (pt) 2006-05-23
BRPI0211191B1 BRPI0211191B1 (pt) 2015-09-15
BRPI0211191B8 BRPI0211191B8 (pt) 2021-07-27

Family

ID=28794978

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0211191A BRPI0211191B8 (pt) 2001-06-28 2002-06-28 ensaios baseados em ácido nucléico para se diagnosticar precisamente infecção por parvovírus b19 e inciadores e marcadores para uso nesses ensaios

Country Status (20)

Country Link
US (2) US6936442B2 (pt)
EP (1) EP1537235B1 (pt)
JP (5) JP2005511004A (pt)
KR (2) KR100944674B1 (pt)
CN (1) CN1324147C (pt)
AU (2) AU2002318450B2 (pt)
BG (1) BG66283B1 (pt)
BR (1) BRPI0211191B8 (pt)
CA (2) CA2451756A1 (pt)
CZ (1) CZ308201B6 (pt)
ES (1) ES2537549T3 (pt)
HK (1) HK1080516B (pt)
HU (1) HU230244B1 (pt)
MX (1) MXPA03011802A (pt)
NO (1) NO337901B1 (pt)
NZ (1) NZ530602A (pt)
PL (1) PL210849B1 (pt)
RU (1) RU2301263C2 (pt)
SK (1) SK15752003A3 (pt)
WO (1) WO2003002753A2 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1421095B1 (en) 2001-08-31 2013-10-09 Gen-Probe Incorporated Assay for detection of human parvovirus b19 nucleic acid
US20120122103A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
WO2005071401A2 (en) * 2004-01-15 2005-08-04 Chiron Corporation Homogeneous multiplex assay for nucleic acid targets
EP1799856A4 (en) * 2004-09-10 2009-03-04 Focus Diagnostics Inc METHOD AND COMPOSITIONS FOR DETECTING ERYTHROVIRUS GENOTYPES
EP1809772B1 (en) * 2004-11-09 2013-06-05 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
US7572584B2 (en) * 2005-06-02 2009-08-11 The United States Of America As Represented By The U.S. Environmental Protection Agency Species-specific primer sets and identification of species-specific DNA sequences using genome fragment enrichment
US8058000B2 (en) * 2005-06-02 2011-11-15 The United States Of America As Represented By The U.S. Environmental Protection Agency Species-specific primer sets and identification of species-specific DNA sequences using genome fragment enrichment
DE102006034844B3 (de) * 2006-07-27 2007-12-06 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Zusammensetzungen und Verfahren zur Amplifikation von Hepatitis A-Viren (HAV) und/oder Parvoviren B19 (PB19) mittels Multiplex-PCR
AU2008206309A1 (en) 2007-01-16 2008-07-24 Talecris Biotherapeutics, Inc. Human erythrovirus
US20110045456A1 (en) * 2007-06-14 2011-02-24 Ibis Biosciences, Inc. Compositions for use in identification of adventitious contaminant viruses
MX2009013628A (es) * 2007-06-14 2010-02-22 Univ Oklahoma State Vacunas que contienen variantes geneticas de parvovirus canino.
US8227583B2 (en) * 2007-06-14 2012-07-24 The Board Of Regents For Oklahoma State University Vaccines containing canine parvovirus genetic variants
US20110130311A1 (en) * 2008-07-23 2011-06-02 Industry-Academic Cooperation Foundation Gyeong National University Method and system for diagnosing virus
EP3257859B1 (en) 2009-02-26 2020-09-23 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
US9598739B1 (en) 2009-03-13 2017-03-21 Grifols Therapeutics Inc. Human erythrovirus
US9744228B2 (en) 2010-04-07 2017-08-29 Norvartis Ag Method for generating a parvovirus B19 virus-like particle
WO2013012708A1 (en) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
CN103451320B (zh) * 2013-08-09 2015-05-06 中国人民解放军军事医学科学院野战输血研究所 人细小病毒B19三种基因型的实时荧光定量PCR检测方法及其通用检测引物、TaqMan探针与试剂盒
US9410172B2 (en) * 2013-09-16 2016-08-09 General Electric Company Isothermal amplification using oligocation-conjugated primer sequences
US10214565B2 (en) 2014-03-10 2019-02-26 University Of Louisville Research Foundation, Inc. Compositions and methods for treating, including preventing, parvovirus infections and related diseases
CN103820581B (zh) * 2014-03-17 2016-01-13 成都蓉生药业有限责任公司 一种检测人细小病毒b19的试剂盒和方法
JP6414409B2 (ja) * 2014-07-29 2018-10-31 株式会社微生物化学研究所 弱毒化パルボウイルスおよび弱毒化パルボウイルスを用いたワクチン
BR112017009321B1 (pt) * 2014-11-05 2024-03-05 King George's Medical University Sonda, mistura reacional, e, kit de teste
TW202336236A (zh) * 2015-03-27 2023-09-16 美商再生元醫藥公司 偵測生物污染物之組成物及方法
CN105158471A (zh) * 2015-08-24 2015-12-16 北京中检安泰诊断科技有限公司 人细小病毒B19型IgM抗体检测试剂盒及其制备方法
CN114410836B (zh) * 2021-12-17 2024-03-01 上海交通大学医学院附属仁济医院 一种集样本处理、核酸提取及多重恒温扩增一体化的检测人细小病毒b19的试剂盒和方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516630A (en) 1983-09-30 1996-05-14 The United States Of America As Represented By The Department Of Health And Human Services Methods of detecting hepatitis A virus
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US6204044B1 (en) * 1989-09-14 2001-03-20 Caroline Sarah Brown Human parvovirus B19 proteins and virus-like particles, their production and their use in diagnostic assays and vaccines
US6379885B1 (en) * 1989-09-14 2002-04-30 Rijksuniversiteit Te Leiden Human parvovirus B19 proteins and virus-like particles, their production and their use in diagnostic assays and vaccines
NL8902301A (nl) 1989-09-14 1991-04-02 Rijksuniversiteit Humaan parvovirus b19 eiwitten, hun produktie en hun gebruik in diagnostische assays en vaccins.
DE4003826C2 (de) 1990-02-08 1995-11-23 Mikrogen Molekularbiol Entw Peptide der Kapsidproteine VP1 oder VP2 des Parvovirus B19
WO1994010294A1 (en) 1992-10-23 1994-05-11 New York University Human monoclonal antibodies to human parvovirus and methods of making and using thereof
US5449608A (en) 1993-03-22 1995-09-12 The United States Of America As Represented By The Department Of Health And Human Services Parvovirus B19 receptor and parvovirus B19 detection
JPH06293798A (ja) 1993-04-06 1994-10-21 Shin Etsu Chem Co Ltd ヒトパルボウイルスｂ１９のエピトープ関連ペプチド
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
WO1996009391A2 (en) 1994-09-22 1996-03-28 Hans Wolf Dna sequence and protein of the non-structural reading frame i of the human parvovirus b19
US6004044A (en) * 1995-05-03 1999-12-21 Itt Cannon, Inc. Optoelectric connector
JPH0910000A (ja) 1995-06-26 1997-01-14 Nippon Sekijiyuujishiya ヒトパルボウイルスの検出方法及びそのための試薬
US6569618B1 (en) * 1995-11-13 2003-05-27 Shionogi & Co., Ltd. Diagnosis of diseases associated with coronary twitching
WO1997021346A1 (en) 1995-12-14 1997-06-19 Cerus Corporation Inactivation of non-enveloped virus
US6094338A (en) * 1997-07-09 2000-07-25 Mitsubishi Chemical Corporation Electric double-layer capacitor
WO1999018227A1 (en) 1997-10-08 1999-04-15 Advanced Research And Technology Institute Chimeric parvovirus-based recombinant vector system that specifically targets the erythroid lineage
DE19752898A1 (de) 1997-11-28 1999-08-05 Centeon Pharma Gmbh Verfahren zum Nachweis hoher Vierenkonzentrationen im Blutplasma und/oder Blutserum mittels der Polymerasekettenreaktion
JP4388694B2 (ja) * 1998-02-04 2009-12-24 アプライド バイオシステムズ， エルエルシー 複数のアレル部位における増幅産物のゲノム型決定
RU2146372C1 (ru) * 1998-04-16 2000-03-10 Гематологический научный центр РАМН Способ определения парвовируса б19
US6238860B1 (en) * 1998-11-05 2001-05-29 Dyax Corp. Binding moieties for human parvovirus B19
US6642033B1 (en) 1999-07-20 2003-11-04 V.I. Technologies, Inc. Nucleic acids for detecting parvovirus and methods of using same
JP4796252B2 (ja) * 1999-07-23 2011-10-19 ジェン−プローブ・インコーポレーテッド ポリヌクレオチド増幅方法

Also Published As

Publication number Publication date
HU230244B1 (hu) 2015-11-30
CZ308201B6 (cs) 2020-02-26
JP2016182149A (ja) 2016-10-20
EP1537235B1 (en) 2015-04-01
AU2007231822A1 (en) 2007-11-29
CN1636071A (zh) 2005-07-06
US6936442B2 (en) 2005-08-30
CZ20033516A3 (cs) 2005-02-16
AU2002318450B2 (en) 2007-11-22
US20050221300A1 (en) 2005-10-06
CA2779653C (en) 2014-08-19
HUP0600779A3 (en) 2010-03-29
WO2003002753A3 (en) 2005-04-14
NO337901B1 (no) 2016-07-04
BRPI0211191B8 (pt) 2021-07-27
KR100944674B1 (ko) 2010-03-04
HUP0600779A2 (en) 2007-01-29
BRPI0211191B1 (pt) 2015-09-15
HK1080516A1 (en) 2006-04-28
KR100888377B1 (ko) 2009-03-13
JP2009011324A (ja) 2009-01-22
KR20090003370A (ko) 2009-01-09
EP1537235A4 (en) 2007-10-03
NO20035732D0 (no) 2003-12-19
JP2005511004A (ja) 2005-04-28
PL210849B1 (pl) 2012-03-30
BG108526A (bg) 2004-09-30
CN1324147C (zh) 2007-07-04
RU2004102205A (ru) 2005-06-10
AU2007231822B2 (en) 2011-01-27
WO2003002753A2 (en) 2003-01-09
US20030170612A1 (en) 2003-09-11
KR20050119220A (ko) 2005-12-21
CA2779653A1 (en) 2003-01-09
HK1080516B (zh) 2008-01-25
BG66283B1 (bg) 2013-01-31
PL368049A1 (en) 2005-03-21
JP2014061007A (ja) 2014-04-10
ES2537549T3 (es) 2015-06-09
JP6026401B2 (ja) 2016-11-16
EP1537235A2 (en) 2005-06-08
NZ530602A (en) 2006-02-24
JP2012075440A (ja) 2012-04-19
RU2301263C2 (ru) 2007-06-20
CA2451756A1 (en) 2003-01-09
NO20035732L (no) 2004-02-27
MXPA03011802A (es) 2004-04-02
SK15752003A3 (sk) 2005-01-03

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