BR9913652A - Gene e proteìna antigênica imunodominante de 120 kda de ehrlichia canis - Google Patents

Gene e proteìna antigênica imunodominante de 120 kda de ehrlichia canis

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Publication number
BR9913652A
BR9913652A BR9913652-0A BR9913652A BR9913652A BR 9913652 A BR9913652 A BR 9913652A BR 9913652 A BR9913652 A BR 9913652A BR 9913652 A BR9913652 A BR 9913652A
Authority
BR
Brazil
Prior art keywords
protein
ehrlichia canis
kda
canis
gene
Prior art date
Application number
BR9913652-0A
Other languages
English (en)
Other versions
BR9913652B1 (pt
Inventor
David H Walker
Xu-Jie Yu
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of BR9913652A publication Critical patent/BR9913652A/pt
Publication of BR9913652B1 publication Critical patent/BR9913652B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/29—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Richettsiales (O)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Patente de Invenção: <B>"GENE E PROTEìNA ANTIGêNICA IMUNODOMINANTE DE 120 KDA DE EHRLICHIA CANIS"<D>. A presente invenção provê um gene de proteína de 120 kDa de Ehrlichia canis, ampliado por PCR usando-se iniciadores derivados das seq³ências de DNA que flanqueiam o gene de proteína de 120 kDa de Ehrlichia chaffeensis. A proteína de 120 kDa de Ehrlichia canis recombinante contém 14 unidades de repetição tandem com 36 aminoácidos cada. As unidades de repetição são hidrofílicas e são preditas ser de superfície exposta. Também revelado é que a proteína de 120 kDa de E. canis recombinante é antigênica e reage com soros oriundos de cachorros convalescentes de erliquiose canina.
BRPI9913652-0A 1998-08-27 1999-08-27 Vetor compreendendo sequência de Ehrlichia canis, bem como microoganismo transgênico BR9913652B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/141,047 US6043085A (en) 1998-08-27 1998-08-27 Ehrlichia canis 120-kDa immunodominant antigenic protein and gene
US09/141,047 1998-08-27
PCT/US1999/019538 WO2000012688A1 (en) 1998-08-27 1999-08-27 Ehrlichia canis 120-kda immunodominant antigenic protein and gene

Publications (2)

Publication Number Publication Date
BR9913652A true BR9913652A (pt) 2001-06-05
BR9913652B1 BR9913652B1 (pt) 2014-02-18

Family

ID=22493934

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9913652-0A BR9913652B1 (pt) 1998-08-27 1999-08-27 Vetor compreendendo sequência de Ehrlichia canis, bem como microoganismo transgênico

Country Status (17)

Country Link
US (1) US6043085A (pt)
EP (1) EP1108014B1 (pt)
JP (1) JP4550998B2 (pt)
KR (1) KR100652469B1 (pt)
CN (1) CN1281747C (pt)
AT (1) ATE328073T1 (pt)
AU (1) AU764853B2 (pt)
BR (1) BR9913652B1 (pt)
CA (1) CA2340462A1 (pt)
DE (1) DE69931639D1 (pt)
IL (2) IL141613A0 (pt)
MX (1) MXPA01002042A (pt)
NZ (1) NZ510103A (pt)
RU (1) RU2232814C2 (pt)
TW (1) TW557326B (pt)
WO (1) WO2000012688A1 (pt)
ZA (1) ZA200101440B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6392023B1 (en) * 1999-03-03 2002-05-21 Research Development Foundation Homologous 28-kilodalton immunodominant protein genes of Ehrlicha canis and uses thereof
US20020115840A1 (en) * 1998-11-30 2002-08-22 Walker David H. Homologous 28-kilodaltion immunodominant protein genes of Ehrlichia canis and uses thereof
US7335754B2 (en) 1999-07-21 2008-02-26 Cornell Research Foundation, Inc. Ehrlichia canis genes and vaccines
US6355777B1 (en) * 2000-04-28 2002-03-12 Research Development Foundation P43 antigen for the immunodiagnosis of canine ehrlichiosis and uses thereof
AU2001259304A1 (en) * 2000-05-01 2001-11-12 Research Development Foundation Ehrlichia chaffeensis 28 kda outer membrane protein multigene family
MXPA05004804A (es) * 2002-11-04 2005-12-05 Res Dev Foundation Antigenos de p153 y p156 para el inmunodiagnostico de erliquiosis canina y humana y usos de los mismos.
US20050202046A1 (en) * 2004-03-11 2005-09-15 Wyeth Canine vaccine for protection against ehrlichiosis
EP1879914B1 (en) 2005-04-04 2015-07-15 Idexx Laboratories, Inc. Ehrlichia canis diva (differentiate infected from vaccinated animals) antigens
US7842474B2 (en) 2005-04-04 2010-11-30 Idexx Laboratories, Inc. Ehrlichia canis DIVA (differentiate infected from vaccinated animals)
WO2009034575A1 (en) 2007-09-11 2009-03-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Attenuated ehrlichiosis vaccine
CA2700474C (en) * 2007-09-21 2016-10-04 Idexx Laboratories, Inc. Methods and compositions for detection of ehrlichia chaffeensis (p120)
CN101970463A (zh) * 2007-09-21 2011-02-09 艾德克斯实验室公司 用于检测恰菲埃里希氏体(vlpt)的方法和组合物
EP2045816A1 (en) * 2007-10-01 2009-04-08 Paul Scherrer Institut Fast readout method and swiched capacitor array circuitry for waveform digitizing
CZ2007716A3 (cs) 2007-10-15 2009-04-29 Elmarco S. R. O. Zpusob výroby nanovláken
KR101621038B1 (ko) * 2007-10-31 2016-05-16 아이덱스 래보러토리즈, 인코포레이티드 에를리히아 카니스 ｄｉｖａ（감염된 동물을 백신접종된 동물과 구별）
KR101010432B1 (ko) * 2008-08-30 2011-01-21 이영수 여과기
EP2424880B1 (en) * 2009-04-28 2016-07-20 Research Development Foundation Immunoreactive ehrlichia p120/p140 epitopes and uses thereof
CN105203755B (zh) * 2009-11-20 2018-01-05 爱贝斯股份有限公司 用于检测埃里希体属抗体的肽、装置和方法
BR112012033751B1 (pt) * 2010-07-02 2021-06-01 Intervet International B.V. Composição de vacina e processo para produzir a composição de vacina
JP6325553B2 (ja) 2012-10-11 2018-05-16 アバクシス， インコーポレイテッド エールリヒア抗体の検出のためのペプチド、デバイス、および方法
US9442112B2 (en) 2014-04-04 2016-09-13 Abaxis, Inc. Compositions and methods for identifying Ehrlichia species
WO2020023950A1 (en) * 2018-07-27 2020-01-30 Research Development Foundation Chimeric immunogenic polypeptides
WO2021011456A1 (en) * 2019-07-12 2021-01-21 Research Development Foundation Ehrlichia vaccines and immunogenic compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015691A (en) * 1996-05-31 2000-01-18 Research Development Foundation Immunodominant 120 kDa surface-exposed adhesion protein genes of Ehrlichia chaffeensis

Also Published As

Publication number Publication date
KR100652469B1 (ko) 2006-12-01
MXPA01002042A (es) 2002-06-21
EP1108014B1 (en) 2006-05-31
US6043085A (en) 2000-03-28
EP1108014A4 (en) 2004-12-15
IL141613A (en) 2010-05-31
CN1321190A (zh) 2001-11-07
NZ510103A (en) 2004-10-29
ATE328073T1 (de) 2006-06-15
AU764853B2 (en) 2003-09-04
WO2000012688A1 (en) 2000-03-09
DE69931639D1 (en) 2006-07-06
TW557326B (en) 2003-10-11
BR9913652B1 (pt) 2014-02-18
EP1108014A1 (en) 2001-06-20
JP2002523087A (ja) 2002-07-30
KR20010072997A (ko) 2001-07-31
AU5586499A (en) 2000-03-21
IL141613A0 (en) 2002-03-10
RU2232814C2 (ru) 2004-07-20
JP4550998B2 (ja) 2010-09-22
CN1281747C (zh) 2006-10-25
CA2340462A1 (en) 2000-03-09
ZA200101440B (en) 2002-01-30

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B09A Decision: intention to grant [chapter 9.1 patent gazette]
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Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2476 DE 19-06-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.