BR0117138A - Processo para a produção de sal de sódio de pravastatina usando-se streptomyces flavidovirens dsm 14455 - Google Patents
Processo para a produção de sal de sódio de pravastatina usando-se streptomyces flavidovirens dsm 14455Info
- Publication number
- BR0117138A BR0117138A BR0117138-0A BR0117138A BR0117138A BR 0117138 A BR0117138 A BR 0117138A BR 0117138 A BR0117138 A BR 0117138A BR 0117138 A BR0117138 A BR 0117138A
- Authority
- BR
- Brazil
- Prior art keywords
- sodium salt
- production
- pravastatin sodium
- streptomyces flavidovirens
- dsm
- Prior art date
Links
- 241000958209 Streptomyces flavidovirens Species 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- VWBQYTRBTXKKOG-IYNICTALSA-M pravastatin sodium Chemical compound [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 VWBQYTRBTXKKOG-IYNICTALSA-M 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCESSO PARA A PRODUçãO DE SAL DE SóDIO DE PRAVASTATINA USANDO-SE STREPTOMYCES FLAVIDOVIRENS DSM 14455". A presente invenção refere-se a um método aperfeiçoado para a fabricação de sal de sódio de pravastatina descrito através de fermentação sob parâmetros ótimos de fermentação usando-se uma nova cepa de Streptomyces flavidovirens.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2001/000161 WO2003027302A1 (en) | 2001-09-27 | 2001-09-27 | Process for producing pravastatin sodium salt using streptomyces flavidovirens dsm 14455 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0117138A true BR0117138A (pt) | 2004-10-13 |
| BRPI0117138B1 BRPI0117138B1 (pt) | 2015-08-04 |
Family
ID=11076380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0117138-0A BRPI0117138B1 (pt) | 2001-09-27 | 2001-09-27 | Processo para a produção de sal de sódio de pravastatina usando-se um microorganismo streptomyces flavidovirens dsm 14455 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7189558B2 (pt) |
| EP (1) | EP1430138B1 (pt) |
| JP (1) | JP2005503174A (pt) |
| KR (1) | KR100725559B1 (pt) |
| AT (1) | ATE316146T1 (pt) |
| AU (1) | AU2001295867A1 (pt) |
| BR (1) | BRPI0117138B1 (pt) |
| CA (1) | CA2461951C (pt) |
| DE (1) | DE60116787T2 (pt) |
| ES (1) | ES2254499T3 (pt) |
| HU (1) | HU225432B1 (pt) |
| IL (2) | IL161079A0 (pt) |
| MX (1) | MXNL04000022A (pt) |
| SI (1) | SI1430138T1 (pt) |
| WO (1) | WO2003027302A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470078B1 (ko) * | 2003-06-12 | 2005-02-04 | 씨제이 주식회사 | 컴팩틴을 프라바스타틴으로 전환할 수 있는 스트렙토마이세스 종(Ｓｔｒｅｐｔｏｍｙｃｅｓ ｓｐ.)ＣＪＰＶ 975652 및 그를 이용한 프라바스타틴의 제조방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US5179013A (en) * | 1987-02-02 | 1993-01-12 | Sankyo Company, Limited | Cytochrome P-450 enzymes |
| EP0317292B1 (en) * | 1987-11-20 | 1993-04-07 | Sankyo Company Limited | New antibiotics of the mureidomycin group, their preparation, and their therapeutic use |
| JP2642707B2 (ja) * | 1987-11-20 | 1997-08-20 | 三共株式会社 | 抗生物質ムレイドマイシンｅ，ｆおよびその誘導体 |
| US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| KR100210482B1 (ko) * | 1997-04-10 | 1999-07-15 | 김종인 | 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 |
| WO1999010499A1 (en) * | 1997-08-22 | 1999-03-04 | Dsm N.V. | Statin production by fermentation |
| KR100414334B1 (ko) * | 2001-09-29 | 2004-01-07 | 코바이오텍 (주) | 프라바스타틴 나트륨의 생산 방법 |
| US6716615B2 (en) * | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
| KR100470078B1 (ko) * | 2003-06-12 | 2005-02-04 | 씨제이 주식회사 | 컴팩틴을 프라바스타틴으로 전환할 수 있는 스트렙토마이세스 종(Ｓｔｒｅｐｔｏｍｙｃｅｓ ｓｐ.)ＣＪＰＶ 975652 및 그를 이용한 프라바스타틴의 제조방법 |
-
2001
- 2001-09-27 SI SI200130477T patent/SI1430138T1/sl unknown
- 2001-09-27 AT AT01976603T patent/ATE316146T1/de not_active IP Right Cessation
- 2001-09-27 WO PCT/IN2001/000161 patent/WO2003027302A1/en active IP Right Grant
- 2001-09-27 KR KR1020047004495A patent/KR100725559B1/ko not_active IP Right Cessation
- 2001-09-27 CA CA2461951A patent/CA2461951C/en not_active Expired - Lifetime
- 2001-09-27 HU HU0401918A patent/HU225432B1/hu not_active IP Right Cessation
- 2001-09-27 DE DE60116787T patent/DE60116787T2/de not_active Expired - Lifetime
- 2001-09-27 JP JP2003530867A patent/JP2005503174A/ja active Pending
- 2001-09-27 IL IL16107901A patent/IL161079A0/xx unknown
- 2001-09-27 MX MXNL04000022A patent/MXNL04000022A/es active IP Right Grant
- 2001-09-27 EP EP01976603A patent/EP1430138B1/en not_active Expired - Lifetime
- 2001-09-27 AU AU2001295867A patent/AU2001295867A1/en not_active Abandoned
- 2001-09-27 ES ES01976603T patent/ES2254499T3/es not_active Expired - Lifetime
- 2001-09-27 BR BRPI0117138-0A patent/BRPI0117138B1/pt not_active IP Right Cessation
- 2001-09-27 US US10/485,782 patent/US7189558B2/en not_active Expired - Lifetime
-
2004
- 2004-03-25 IL IL161079A patent/IL161079A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1430138B1 (en) | 2006-01-18 |
| US7189558B2 (en) | 2007-03-13 |
| JP2005503174A (ja) | 2005-02-03 |
| SI1430138T1 (sl) | 2006-04-30 |
| HU225432B1 (hu) | 2006-11-28 |
| AU2001295867A1 (en) | 2003-04-07 |
| IL161079A0 (en) | 2004-08-31 |
| DE60116787D1 (de) | 2006-04-06 |
| HUP0401918A3 (en) | 2005-05-30 |
| EP1430138A1 (en) | 2004-06-23 |
| WO2003027302A9 (en) | 2003-05-15 |
| CA2461951A1 (en) | 2003-04-03 |
| KR100725559B1 (ko) | 2007-06-08 |
| DE60116787T2 (de) | 2006-08-24 |
| CA2461951C (en) | 2011-08-09 |
| BRPI0117138B1 (pt) | 2015-08-04 |
| WO2003027302A1 (en) | 2003-04-03 |
| US20040209335A1 (en) | 2004-10-21 |
| MXNL04000022A (es) | 2004-11-26 |
| KR20040062551A (ko) | 2004-07-07 |
| ATE316146T1 (de) | 2006-02-15 |
| HUP0401918A2 (hu) | 2004-12-28 |
| IL161079A (en) | 2009-09-22 |
| ES2254499T3 (es) | 2006-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/08/2015, OBSERVADAS AS CONDICOES LEGAIS. |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |