BR0114457A - Derivados de flavonas e de isoflavonas, processo para sua preparação, composição famacêutica, e utilização de um derivado de flavona ou de isoflavona - Google Patents

Derivados de flavonas e de isoflavonas, processo para sua preparação, composição famacêutica, e utilização de um derivado de flavona ou de isoflavona

Info

Publication number
BR0114457A
BR0114457A BR0114457-0A BR0114457A BR0114457A BR 0114457 A BR0114457 A BR 0114457A BR 0114457 A BR0114457 A BR 0114457A BR 0114457 A BR0114457 A BR 0114457A
Authority
BR
Brazil
Prior art keywords
sub
group
flavone
derivatives
isoflavones
Prior art date
Application number
BR0114457-0A
Other languages
English (en)
Inventor
Jean-Pierre Gesson
Nadia Fonteneau
Martine Mondon
Suzy Charbit
Herve Ficheux
Francois Schutze
Original Assignee
Negma Lerads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Negma Lerads filed Critical Negma Lerads
Publication of BR0114457A publication Critical patent/BR0114457A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE FLAVONAS E DE ISOFLAVONAS, PROCESSO PARA SUA PREPARAçãO, COMPOSIçãO FARMACêUTICA, E UTILIZAçãO DE UM DERIVADO DE FLAVONA OU DE ISOFLAVONA". A invenção refere-se a novos derivados de flavonas e de isoflavonas (ver fórmulas): em que X representa um grupo de fórmula -COOR, ou -PO(OR)~ 2~, R representa um átomo de hidrogênio ou de metal alcalino ou alcalino-terroso, ou um grupo alquila inferior, R~ 1~ representa um grupo hidróxi, um grupo alcóxi inferior ou um grupo acilóxi, R~ 2~ e R~ 3~, idênticos ou diferentes, representam um átomo de hidrogênio ou de halogênio, ou um grupo trifluorometila, um grupo triclorometila, um grupo hidróxi, um grupo alcóxi ou um grupo acilóxi compreendendo 1 a 5 átomos de carbono, ou R~ 2~ e R~ 3~ podem se associar para formar um grupo alquileno dióxi. Aplicação ao tratamento de doenças reumáticas.
BR0114457-0A 2000-10-06 2001-10-05 Derivados de flavonas e de isoflavonas, processo para sua preparação, composição famacêutica, e utilização de um derivado de flavona ou de isoflavona BR0114457A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0012846A FR2815033B1 (fr) 2000-10-06 2000-10-06 Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique
PCT/FR2001/003075 WO2002028851A1 (fr) 2000-10-06 2001-10-05 Dérivés de 7-carboxy-flavones, procédé de préparation et application en thérapeutique

Publications (1)

Publication Number Publication Date
BR0114457A true BR0114457A (pt) 2003-10-21

Family

ID=8855113

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114457-0A BR0114457A (pt) 2000-10-06 2001-10-05 Derivados de flavonas e de isoflavonas, processo para sua preparação, composição famacêutica, e utilização de um derivado de flavona ou de isoflavona

Country Status (15)

Country Link
US (1) US6965039B2 (pt)
EP (1) EP1212313B1 (pt)
JP (1) JP2004510770A (pt)
CN (1) CN1301987C (pt)
AT (1) ATE241609T1 (pt)
AU (1) AU2001293956A1 (pt)
BR (1) BR0114457A (pt)
CA (1) CA2424993A1 (pt)
DE (1) DE60100314T2 (pt)
DK (1) DK1212313T3 (pt)
ES (1) ES2199213T3 (pt)
FR (1) FR2815033B1 (pt)
MX (1) MXPA03002986A (pt)
PT (1) PT1212313E (pt)
WO (1) WO2002028851A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100841901B1 (ko) * 2002-03-18 2008-06-27 동화약품공업주식회사 플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품
GB0412768D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
EP2182801A4 (en) * 2007-07-31 2011-04-13 Limerick Biopharma Inc COMPOSITIONS OF PYRONE ANALOGS AND METHODS
WO2009018338A2 (en) * 2007-07-31 2009-02-05 Limerick Biopharma, Inc. Phosphorylated pyrone analogs and methods
US20100297020A1 (en) * 2008-10-10 2010-11-25 Limerick Biopharma, Inc. Phosphorylated and phosphonated pyrone analogs for therapeutic treatment
JP2012525331A (ja) * 2009-04-27 2012-10-22 リメリック バイオファーマ， インコーポレイテッド 治療的処置のためのリン酸化ピロン類似体
CN108329287B (zh) * 2018-02-24 2020-06-16 海南师范大学 大果榕中带有环氧基的化合物及其制备方法和应用
CN111388464A (zh) * 2020-04-28 2020-07-10 滨州医学院 芒柄花素磺酸钠在制备治疗类风湿性关节炎药物中的应用
CN111875571A (zh) * 2020-07-23 2020-11-03 长沙理工大学 一种从酱油渣中提取大豆异黄酮的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157334A (en) 1974-12-26 1979-06-05 Carlo Erba S. P. A. 6-Carboxy-flavone derivatives and process for their preparation
FR2543140B1 (fr) 1983-03-24 1985-06-21 Cortial Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique
JPS62215581A (ja) 1986-03-18 1987-09-22 Koichi Shiyudo フラボンカルボン酸誘導体
DE3715779A1 (de) 1987-05-12 1988-11-24 Kali Chemie Pharma Gmbh Flavon-3-carbonsaeure-verbindungen sowie verfahren, zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2689127B1 (fr) 1992-03-31 1994-05-06 Adir Cie Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5399584A (en) 1992-05-05 1995-03-21 The Procter & Gamble Company Use of flavone derivatives for gastroprotection
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
JP3957795B2 (ja) * 1996-10-04 2007-08-15 興和株式会社 フラボン誘導体及びこれを含有する医薬

Also Published As

Publication number Publication date
WO2002028851A1 (fr) 2002-04-11
ES2199213T3 (es) 2004-02-16
PT1212313E (pt) 2003-10-31
DE60100314D1 (de) 2003-07-03
AU2001293956A1 (en) 2002-04-15
ATE241609T1 (de) 2003-06-15
US6965039B2 (en) 2005-11-15
DK1212313T3 (da) 2003-09-22
US20040059136A1 (en) 2004-03-25
EP1212313A1 (fr) 2002-06-12
FR2815033A1 (fr) 2002-04-12
JP2004510770A (ja) 2004-04-08
CN1301987C (zh) 2007-02-28
CN1468228A (zh) 2004-01-14
DE60100314T2 (de) 2004-04-01
FR2815033B1 (fr) 2003-09-05
CA2424993A1 (fr) 2002-04-11
EP1212313B1 (fr) 2003-05-28
MXPA03002986A (es) 2004-05-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A, 9A E 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.