MXPA03002986A - Derivados de 7-carboxiflavona, procedimiento de preparacion y aplicacion terapeutica. - Google Patents
Derivados de 7-carboxiflavona, procedimiento de preparacion y aplicacion terapeutica.Info
- Publication number
- MXPA03002986A MXPA03002986A MXPA03002986A MXPA03002986A MXPA03002986A MX PA03002986 A MXPA03002986 A MX PA03002986A MX PA03002986 A MXPA03002986 A MX PA03002986A MX PA03002986 A MXPA03002986 A MX PA03002986A MX PA03002986 A MXPA03002986 A MX PA03002986A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- carboxy
- preparation
- therapeutic use
- alkaline
- Prior art date
Links
- OHCNSTOLJWDQMJ-UHFFFAOYSA-N 4-oxo-2-phenylchromene-7-carboxylic acid Chemical class C=1C(C(=O)O)=CC=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 OHCNSTOLJWDQMJ-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229930003944 flavone Natural products 0.000 abstract 1
- 150000002213 flavones Chemical class 0.000 abstract 1
- 235000011949 flavones Nutrition 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229930012930 isoflavone derivative Natural products 0.000 abstract 1
- 150000002515 isoflavone derivatives Chemical class 0.000 abstract 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invencion se refiere a nuevos derivados de flavona e isoflavona de la formula (Ia) y (Ib), en donde X representa un grupo de la formula -COOR, o -PO(OR)2; R representa un atomo de hidrogeno o un metal alcalino o alcalino-terreo, o un grupo alquilo inferior; R1 representa un grupo hidroxi, un grupo alcoxi inferior o un grupo aciloxi; R2 y R3, identicos o diferentes representan un atomo de hidrogeno o de halogeno, o un grupo trifluorometil, un grupo triclorometil, un grupo hidroxi, un grupo alcoxi o un grupo aciloxi; el grupo comprende de 1 a 5 atomos de carbono, o R2 y R3 se pueden combinar para formar un grupo dioxi-alquileno. El invento es util para el tratamiento de males reumaticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0012846A FR2815033B1 (fr) | 2000-10-06 | 2000-10-06 | Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique |
| PCT/FR2001/003075 WO2002028851A1 (fr) | 2000-10-06 | 2001-10-05 | Dérivés de 7-carboxy-flavones, procédé de préparation et application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03002986A true MXPA03002986A (es) | 2004-05-24 |
Family
ID=8855113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03002986A MXPA03002986A (es) | 2000-10-06 | 2001-10-05 | Derivados de 7-carboxiflavona, procedimiento de preparacion y aplicacion terapeutica. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6965039B2 (es) |
| EP (1) | EP1212313B1 (es) |
| JP (1) | JP2004510770A (es) |
| CN (1) | CN1301987C (es) |
| AT (1) | ATE241609T1 (es) |
| AU (1) | AU2001293956A1 (es) |
| BR (1) | BR0114457A (es) |
| CA (1) | CA2424993A1 (es) |
| DE (1) | DE60100314T2 (es) |
| DK (1) | DK1212313T3 (es) |
| ES (1) | ES2199213T3 (es) |
| FR (1) | FR2815033B1 (es) |
| MX (1) | MXPA03002986A (es) |
| PT (1) | PT1212313E (es) |
| WO (1) | WO2002028851A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100841901B1 (ko) * | 2002-03-18 | 2008-06-27 | 동화약품공업주식회사 | 플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품 |
| GB0412768D0 (en) * | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| EP2182801A4 (en) * | 2007-07-31 | 2011-04-13 | Limerick Biopharma Inc | COMPOSITIONS OF PYRONE ANALOGS AND METHODS |
| WO2009018338A2 (en) * | 2007-07-31 | 2009-02-05 | Limerick Biopharma, Inc. | Phosphorylated pyrone analogs and methods |
| US20100297020A1 (en) * | 2008-10-10 | 2010-11-25 | Limerick Biopharma, Inc. | Phosphorylated and phosphonated pyrone analogs for therapeutic treatment |
| JP2012525331A (ja) * | 2009-04-27 | 2012-10-22 | リメリック バイオファーマ， インコーポレイテッド | 治療的処置のためのリン酸化ピロン類似体 |
| CN108329287B (zh) * | 2018-02-24 | 2020-06-16 | 海南师范大学 | 大果榕中带有环氧基的化合物及其制备方法和应用 |
| CN111388464A (zh) * | 2020-04-28 | 2020-07-10 | 滨州医学院 | 芒柄花素磺酸钠在制备治疗类风湿性关节炎药物中的应用 |
| CN111875571A (zh) * | 2020-07-23 | 2020-11-03 | 长沙理工大学 | 一种从酱油渣中提取大豆异黄酮的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4157334A (en) | 1974-12-26 | 1979-06-05 | Carlo Erba S. P. A. | 6-Carboxy-flavone derivatives and process for their preparation |
| FR2543140B1 (fr) | 1983-03-24 | 1985-06-21 | Cortial | Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique |
| JPS62215581A (ja) | 1986-03-18 | 1987-09-22 | Koichi Shiyudo | フラボンカルボン酸誘導体 |
| DE3715779A1 (de) | 1987-05-12 | 1988-11-24 | Kali Chemie Pharma Gmbh | Flavon-3-carbonsaeure-verbindungen sowie verfahren, zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2689127B1 (fr) | 1992-03-31 | 1994-05-06 | Adir Cie | Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| US5399584A (en) | 1992-05-05 | 1995-03-21 | The Procter & Gamble Company | Use of flavone derivatives for gastroprotection |
| AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| JP3957795B2 (ja) * | 1996-10-04 | 2007-08-15 | 興和株式会社 | フラボン誘導体及びこれを含有する医薬 |
-
2000
- 2000-10-06 FR FR0012846A patent/FR2815033B1/fr not_active Expired - Fee Related
-
2001
- 2001-10-05 PT PT01974441T patent/PT1212313E/pt unknown
- 2001-10-05 MX MXPA03002986A patent/MXPA03002986A/es active IP Right Grant
- 2001-10-05 AU AU2001293956A patent/AU2001293956A1/en not_active Abandoned
- 2001-10-05 JP JP2002532436A patent/JP2004510770A/ja active Pending
- 2001-10-05 CA CA002424993A patent/CA2424993A1/fr not_active Abandoned
- 2001-10-05 CN CNB018169449A patent/CN1301987C/zh not_active Expired - Fee Related
- 2001-10-05 US US10/398,187 patent/US6965039B2/en not_active Expired - Fee Related
- 2001-10-05 DK DK01974441T patent/DK1212313T3/da active
- 2001-10-05 WO PCT/FR2001/003075 patent/WO2002028851A1/fr active Application Filing
- 2001-10-05 EP EP01974441A patent/EP1212313B1/fr not_active Expired - Lifetime
- 2001-10-05 BR BR0114457-0A patent/BR0114457A/pt not_active IP Right Cessation
- 2001-10-05 AT AT01974441T patent/ATE241609T1/de not_active IP Right Cessation
- 2001-10-05 DE DE60100314T patent/DE60100314T2/de not_active Expired - Fee Related
- 2001-10-05 ES ES01974441T patent/ES2199213T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002028851A1 (fr) | 2002-04-11 |
| ES2199213T3 (es) | 2004-02-16 |
| PT1212313E (pt) | 2003-10-31 |
| DE60100314D1 (de) | 2003-07-03 |
| AU2001293956A1 (en) | 2002-04-15 |
| ATE241609T1 (de) | 2003-06-15 |
| US6965039B2 (en) | 2005-11-15 |
| BR0114457A (pt) | 2003-10-21 |
| DK1212313T3 (da) | 2003-09-22 |
| US20040059136A1 (en) | 2004-03-25 |
| EP1212313A1 (fr) | 2002-06-12 |
| FR2815033A1 (fr) | 2002-04-12 |
| JP2004510770A (ja) | 2004-04-08 |
| CN1301987C (zh) | 2007-02-28 |
| CN1468228A (zh) | 2004-01-14 |
| DE60100314T2 (de) | 2004-04-01 |
| FR2815033B1 (fr) | 2003-09-05 |
| CA2424993A1 (fr) | 2002-04-11 |
| EP1212313B1 (fr) | 2003-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |