NO20053956L - Brystkreftresistentsprotein (BCRP)-inhibitor - Google Patents

Brystkreftresistentsprotein (BCRP)-inhibitor

Info

Publication number
NO20053956L
NO20053956L NO20053956A NO20053956A NO20053956L NO 20053956 L NO20053956 L NO 20053956L NO 20053956 A NO20053956 A NO 20053956A NO 20053956 A NO20053956 A NO 20053956A NO 20053956 L NO20053956 L NO 20053956L
Authority
NO
Norway
Prior art keywords
salt
glycopyranosyl
alkyl
alkoxy
hydrogen
Prior art date
Application number
NO20053956A
Other languages
English (en)
Other versions
NO20053956D0 (no
Inventor
Masato Nagaoka
Shusuke Hashimoto
Ryuta Yamazaki
Yukiko Nishiyama
Tomio Furuta
Takeshi Matsuzaki
Hiroshi Hatano
Oh Yoshida
Ritsuo Aiyama
Yoshikazu Sugimoto
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of NO20053956D0 publication Critical patent/NO20053956D0/no
Publication of NO20053956L publication Critical patent/NO20053956L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Et medikament som hemmer BCRP. En brystkreft-resistensprotein-inhibitor inneholdende, som aktiv bestanddel, et difenylakrylnitril-derivat representert ved den følgende formel (1): hvor de 8 R'er er like eller forskjellige, og hver representerer hydrogen, hydroksy, nitro, amino, acetylamino (-NHCOCH3), cyano (-CN), formyl (-CHO), -COOR1 (R1 er hydrogen eller C1-4-alkyl), -O(CH2)nCOOR2 (n er 1-7: R2 er hydrogen eller C1-4-alkyl), -OOCCH2CH2COOR3 (R3 er hydrogen, C1-4-alkyl, (Z)-2-(3,4-dimetoksy-fenyl)-3-(4-hydroksy-fenyl)-akrylnitril eller glykopyranosyl), C1-8 alkoksy, C1-4 alkyl, halogen, C1-4 alkoksy-C1-4 alkoksy- C1-4-alkoksygruppe, C2-8-acyloksy, C2-8-halogenacyloksy, metylendioksy, trifluormetyl, en fosfatgruppe (-OP(O)(OH)2) eller et salt derav, en sulfatgruppe (-OSO3H) eller et salt derav, glykopyranosyl eller et salt derav, glykopyranosylfosfat eller et salt derav, glykopyranosylsulfat eller et salt derav eller piperidinopiperidinokarbonyloksy, eller en ester eller et salt av derivatet.
NO20053956A 2003-02-04 2005-08-25 Brystkreftresistentsprotein (BCRP)-inhibitor NO20053956L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003026856 2003-02-04
PCT/JP2004/001067 WO2004069243A1 (ja) 2003-02-04 2004-02-03 乳癌耐性蛋白（ｂｃｒｐ）阻害剤

Publications (2)

Publication Number Publication Date
NO20053956D0 NO20053956D0 (no) 2005-08-25
NO20053956L true NO20053956L (no) 2005-10-26

Family

ID=32844154

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053956A NO20053956L (no) 2003-02-04 2005-08-25 Brystkreftresistentsprotein (BCRP)-inhibitor

Country Status (16)

Country Link
US (1) US7371773B2 (no)
EP (1) EP1591117A4 (no)
JP (1) JPWO2004069243A1 (no)
KR (1) KR20050096954A (no)
CN (1) CN1744892A (no)
AU (1) AU2004210259B2 (no)
BR (1) BRPI0407264A (no)
CA (1) CA2515174A1 (no)
EA (1) EA009048B1 (no)
IL (1) IL169913A0 (no)
MX (1) MXPA05008298A (no)
NO (1) NO20053956L (no)
PL (1) PL378073A1 (no)
TW (1) TW200505433A (no)
WO (1) WO2004069243A1 (no)
ZA (1) ZA200505988B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2401077T3 (es) * 2001-01-18 2013-04-16 Glaxo Group Limited Nuevos derivados 1,2-difenileteno para el tratamiento de enfermedades inmunológicas
KR20050096954A (ko) 2003-02-04 2005-10-06 가부시키가이샤 야쿠루트 혼샤 유방암 내성 단백 저해제
WO2005050206A2 (en) * 2003-09-17 2005-06-02 Molecular Probes, Inc. Competitive immunoassay
CA2602467C (en) 2005-03-30 2014-09-02 Kabushiki Kaisha Yakult Honsha Bcrp/abcg2 inhibitor
WO2009072267A1 (ja) 2007-12-03 2009-06-11 Kabushiki Kaisha Yakult Honsha Ａｂｃｇ２阻害剤
WO2010083385A2 (en) * 2009-01-15 2010-07-22 The General Hospital Corporation Compounds for reducing drug resistance and uses thereof
FR2941456B1 (fr) * 2009-01-26 2011-03-04 Univ Claude Bernard Lyon Nouveaux composes de type azapeptide ou azapeptidomimetrique inhibiteurs de bcrp et/ou p-gp.
US9168297B2 (en) 2010-06-23 2015-10-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Regulation of skin pigmentation by neuregulin-1 (NRG-1)
CN105503652B (zh) * 2015-12-30 2017-12-05 延边大学 含氰基白藜芦醇类似物及其制备方法和用途
JP7058026B2 (ja) 2020-04-22 2022-04-21 ネオファーマジャパン株式会社 新型コロナウイルス感染症（ｃｏｖｉｄ－１９）の治療及び／又は予防剤

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3151148A (en) * 1964-09-29 Cyano stilbene hypocholesterolemic
JP2799101B2 (ja) * 1992-03-04 1998-09-17 シャープ株式会社 有機非線形光学材料
GB9207437D0 (en) * 1992-04-03 1992-05-20 Orion Yhtymae Oy Topical administration of toremifene and its metabolites
DE69418947T2 (de) * 1993-03-10 1999-12-23 Morinaga Milk Industry Co Ltd Stilbenderivate und analoga sowie deren anwendung
JP3180127B2 (ja) * 1993-03-10 2001-06-25 森永乳業株式会社 スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
JP3144662B2 (ja) * 1993-08-05 2001-03-12 森永乳業株式会社 スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
TW325458B (en) * 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5731353A (en) * 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
JP3163391B2 (ja) * 1995-03-07 2001-05-08 味の素株式会社 スチルベン誘導体及びそれを含有する制癌剤
TW334418B (en) 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
JP4642226B2 (ja) * 1998-02-06 2011-03-02 デ モントフォート ユニヴァーシティ ヒドロキシル化により活性化されたプロドラッグ
ATE328599T1 (de) * 1998-04-03 2006-06-15 Ajinomoto Kk Antitumorale mittel
WO2000040745A1 (en) * 1999-01-08 2000-07-13 Bristol-Myers Squibb Company Prokaryotic system designed to monitor protease activity
KR20050096954A (ko) 2003-02-04 2005-10-06 가부시키가이샤 야쿠루트 혼샤 유방암 내성 단백 저해제

Also Published As

Publication number Publication date
EP1591117A4 (en) 2006-04-26
PL378073A1 (pl) 2006-02-20
US7371773B2 (en) 2008-05-13
BRPI0407264A (pt) 2006-01-31
JPWO2004069243A1 (ja) 2006-05-25
CN1744892A (zh) 2006-03-08
KR20050096954A (ko) 2005-10-06
WO2004069243A1 (ja) 2004-08-19
AU2004210259A1 (en) 2004-08-19
CA2515174A1 (en) 2004-08-19
TW200505433A (en) 2005-02-16
EP1591117A1 (en) 2005-11-02
MXPA05008298A (es) 2005-09-20
AU2004210259B2 (en) 2008-12-11
IL169913A0 (en) 2007-07-04
EA009048B1 (ru) 2007-10-26
US20060128636A1 (en) 2006-06-15
EA200501247A1 (ru) 2006-02-24
NO20053956D0 (no) 2005-08-25
ZA200505988B (en) 2006-12-27

Similar Documents

Publication Publication Date Title
NO20053956L (no) Brystkreftresistentsprotein (BCRP)-inhibitor
EA200300873A1 (ru) Новая соль сукцинат o-десметилвенлафаксина
EA200300776A1 (ru) Производные фенэтаноламина для лечения респираторных заболеваний
ATE297203T1 (de) Antithrombotische mitteln
BR0309427A (pt) Novo uso de um composto (2z)-2-ciano-3-hidroxi-n-[4-(trifluorometil)fenil]-2-hep tano-6-inamida ou 5-(3-butinil)-n-[4-(trifluorometil)fenil]-4-isoxazoleca rbo-amida
ATE475652T1 (de) Chinazolinderivate
ATE302775T1 (de) Carbolinderivate
EA199900620A1 (ru) Фталазиноны
BR9812010A (pt) Determinados ácidos 5-alquil-2-arilaminofenilacéticos e derivados
DE69618231D1 (de) TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER
EA200200208A1 (ru) Синергитическая композиция
CY1106801T1 (el) Νεες ετεροκυκλικες ενωσεις, η παρασκευη τους και η χρηση τους ως φαρμακα, ιδιαιτερα ως αντιβακτηριακα
DE50311898D1 (de) Fredericamycin-derivate als arzneimittel zur tumorbehandlung
BR0315296A (pt) Derivados do ciclohexanol espirocìclicos
EA200300929A1 (ru) Новые лекарственные композиции на основе антихолинергических средств и ингибиторов pde-iv
DE60206911D1 (de) Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren
ATE346067T1 (de) Carbolinderivate
DE60121461D1 (de) Kondensierte pyridoindolderivate
BR0008763A (pt) Derivados de piridopiranoazepinas, a preparação dos mesmos e a respectiva aplicação em terapêutica
BR0108816A (pt) Derivados de quinolina como antagonistas alfa-2
BR0316458A (pt) Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto
ATE300543T1 (de) Kondensierte pyrazindionderivate als pde5 inhibitore
YU59298A (sh) Postupak za dobijanje fenil heterociklusa korisnih kao inhibitora cox-2
SE0302546D0 (sv) New compounds
DE60112960D1 (de) Kondensierte pyridoindolderivate

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application