DE69418947T2 - Stilbenderivate und analoga sowie deren anwendung - Google Patents

Stilbenderivate und analoga sowie deren anwendung

Info

Publication number
DE69418947T2
DE69418947T2 DE69418947T DE69418947T DE69418947T2 DE 69418947 T2 DE69418947 T2 DE 69418947T2 DE 69418947 T DE69418947 T DE 69418947T DE 69418947 T DE69418947 T DE 69418947T DE 69418947 T2 DE69418947 T2 DE 69418947T2
Authority
DE
Germany
Prior art keywords
analogs
style
derivatives
style derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69418947T
Other languages
English (en)
Other versions
DE69418947D1 (de
Inventor
Koichi Hashimoto
Akio Yamada
Hirokazu Hamano
Shigehiro Mori
Hisako Moriuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morinaga Milk Industry Co Ltd
Original Assignee
Morinaga Milk Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP18202793A external-priority patent/JP3180127B2/ja
Priority claimed from JP21209793A external-priority patent/JP3144662B2/ja
Priority claimed from JP22503093A external-priority patent/JP3144663B2/ja
Application filed by Morinaga Milk Industry Co Ltd filed Critical Morinaga Milk Industry Co Ltd
Publication of DE69418947D1 publication Critical patent/DE69418947D1/de
Application granted granted Critical
Publication of DE69418947T2 publication Critical patent/DE69418947T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/38—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69418947T 1993-03-10 1994-03-10 Stilbenderivate und analoga sowie deren anwendung Expired - Lifetime DE69418947T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP7499293 1993-03-10
JP18202793A JP3180127B2 (ja) 1993-03-10 1993-06-28 スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
JP21209793A JP3144662B2 (ja) 1993-08-05 1993-08-05 スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
JP22503093A JP3144663B2 (ja) 1993-08-19 1993-08-19 α，β−ジアリールアクリロニトリル誘導体及びその用途
PCT/JP1994/000390 WO1994020456A1 (en) 1993-03-10 1994-03-10 Stilbene derivative and stilbene analog derivative, and use thereof

Publications (2)

Publication Number Publication Date
DE69418947D1 DE69418947D1 (de) 1999-07-15
DE69418947T2 true DE69418947T2 (de) 1999-12-23

Family

ID=27465768

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418947T Expired - Lifetime DE69418947T2 (de) 1993-03-10 1994-03-10 Stilbenderivate und analoga sowie deren anwendung

Country Status (6)

Country Link
US (1) US5589506A (de)
EP (1) EP0640586B1 (de)
AU (1) AU669279B2 (de)
CA (1) CA2135488A1 (de)
DE (1) DE69418947T2 (de)
WO (1) WO1994020456A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10316650A (ja) * 1997-05-13 1998-12-02 Dev Center For Biotechnol 新規な抗アテローム性動脈硬化薬
TW513285B (en) * 1997-02-14 2002-12-11 Ishihara Sangyo Kaisha Acrylonitrile compounds, process and intermediates for their production, method for controlling pests comprising using them and pesticides, fungicides and marine antifouling agents containing them
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
MXPA02007514A (es) * 2000-02-04 2004-02-26 Calyx Therapeutics Inc Compuestos novedosos de difeniletileno.
KR100784958B1 (ko) * 2000-02-04 2007-12-11 테라코스, 인코포레이티드 신규한 디페닐에틸렌 화합물
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
EP1368306B1 (de) 2001-01-18 2013-01-16 Welichem Biotech Inc. Neue 1,2-diphenylethenderivate zur behandlung von immunerkrankungen
AU2003255030A1 (en) * 2002-08-14 2004-03-03 Nissan Chemical Industries, Ltd. Thrombopoetin receptor activator and process for producing the same
EP1591117A4 (de) * 2003-02-04 2006-04-26 Yakult Honsha Kk Bcrp (breast cancer resistance protein) inhibitor
KR101424997B1 (ko) * 2005-03-30 2014-07-31 가부시키가이샤 야쿠르트 혼샤 Ｂｃｒｐ／ａｂｃｇ２ 저해제
NZ589911A (en) * 2008-06-12 2012-08-31 Korea Inst Sci & Tech Styrylbenzofuran derivatives as inhibitors for beta-amyloid fibril formation and preparation method thereof
JP2014527036A (ja) 2011-06-27 2014-10-09 ザ ジャクソン ラボラトリー 癌および自己免疫疾患の処置のための方法および組成物
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
EP3706725A4 (de) 2017-11-10 2021-08-25 Dermavant Sciences GmbH Verfahren zur herstellung von tapinarof
CN111592472B (zh) * 2019-04-28 2022-10-21 纳莹(上海)生物科技有限公司 一种荧光染料及其制备方法和用途
CN112479930B (zh) * 2020-12-23 2023-04-28 洛阳师范学院 α-苯基肉桂腈衍生物及制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2740806A (en) * 1953-01-29 1956-04-03 Searle & Co Nuclearly hydroxylated derivatives of alpha, beta-diphenylalkanonitriles
US2681359A (en) * 1953-07-27 1954-06-15 Searle & Co Alpha (hydroxyphenyl) cyano cinnamonitriles
GB1046380A (en) * 1964-07-06 1966-10-26 American Cyanamid Co New hypocholesteremic compositions
FR2257272B1 (de) * 1974-01-15 1978-08-25 Pharmascience Labo
US4326055A (en) * 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
US4996237A (en) * 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents

Also Published As

Publication number Publication date
WO1994020456A1 (en) 1994-09-15
DE69418947D1 (de) 1999-07-15
EP0640586A1 (de) 1995-03-01
AU6219894A (en) 1994-09-26
US5589506A (en) 1996-12-31
AU669279B2 (en) 1996-05-30
EP0640586B1 (de) 1999-06-09
CA2135488A1 (en) 1994-09-15
EP0640586A4 (de) 1996-03-13

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Legal Events

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8364 No opposition during term of opposition