BR0111859A - Compostos para tratamento de relaxamento prejudicado do fundo gástrico - Google Patents

Compostos para tratamento de relaxamento prejudicado do fundo gástrico

Info

Publication number
BR0111859A
BR0111859A BR0111859-5A BR0111859A BR0111859A BR 0111859 A BR0111859 A BR 0111859A BR 0111859 A BR0111859 A BR 0111859A BR 0111859 A BR0111859 A BR 0111859A
Authority
BR
Brazil
Prior art keywords
alkyl
bivalent radical
cycloalkyl
hydrogen
formula
Prior art date
Application number
BR0111859-5A
Other languages
English (en)
Other versions
BR0111859B1 (pt
Inventor
Kristoph Van Emelen
Marcel Frans Leopold De Bruyn
Manuel Jesus Alcazar-Vaca
Jose Ignacio Andres-Gil
Francisco Javi Fernandez-Gadea
Maria Enc Matesanz-Ballesteros
Jose Manuel Bartolome-Nebreda
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0111859A publication Critical patent/BR0111859A/pt
Publication of BR0111859B1 publication Critical patent/BR0111859B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTOS PARA TRATAMENTO DE RELAXAMENTO PREJUDICADO DO FUNDO GáSTRICO". A presente invenção refere-se a compostos de fórmula (I), uma forma estereoquimicamente isomérica dos mesmos, uma forma de N-óxido dos mesmos ou um sal de adição ácido farmaceuticamente aceitável dos mesmos, em que -a^ 1^=a^ 2^-a^ 3^=a^ 4^- é um radical bivalente em que um ou dois de a^ 1^ a a^ 4^ são nitrogênio e o restante de a^ 1^ a a^ 4^ são -CH=; -Z^ 1^-Z^ 2^- é um radical bivalente; -A- é um radical bivalente de fórmula -N(R^ 6^)-Alk^ 2^- e um heterociclo saturado de 5, 6 ou 7 membros contendo um ou dois átomos de nitrogênio; R^ 1^ R^ 2^ e R^ 3^ são cada um independentemente selecionados de hidrogênio, C~ 1-6~alquila, hidróxi, halo e similares; Alk^ 1^ e Alk^ 2^ são C~ 1-6^alcanodiíla opcionalmente substituída; R^ 5^ é um radical de fórmula (d-1), (d-2), (d-3), (d-4), (d-5) em que n é 1 ou 2; p^ 1^ é 0 e p^ 2^ é 1 ou 2;ou p^ 1^ eu 1 ou p^ 2^ é 0; X é oxigênio, enxofre ou =NR^ 9^; Y^ 2^ é oxigênio ou enxofre; R^ 7^ é hidrogênio, C~ 1-6~ alquila, C~ 3-6~cicloalquila, fenila ou fenilmetila; R^ 8^ é C~ 1-6~alquila, C~ 3-6~cicloalquila, fenila ou fenilmetila; R^ 9^ é ciano, C~ 1-6~alquila, C~ 3-6~cicloalquila, C~ 1-6~alquilóxicarbonila ou aminocarbonila; R^ 10^ é hidrogênio ou C~ 1-6~alquila; e Q é um radical bivalente. Processos para preparar os produtos, formulações que compreendem esses produtos e seu uso como medicamento são descritos, em particular para tratar condições que são relacionadas com acomodação perturbada do fundo gástrico.
BRPI0111859-5A 2000-06-22 2001-06-13 Compostos com propriedades de relaxamento do fundo gástrico, seu processo de preparação, bem como composição farmacêutica que os compreende BR0111859B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00202180 2000-06-22
EP00202180.6 2000-06-22
PCT/EP2001/006749 WO2001098306A1 (en) 2000-06-22 2001-06-13 Compounds for treating impaired fundic relaxation

Publications (2)

Publication Number Publication Date
BR0111859A true BR0111859A (pt) 2003-05-13
BR0111859B1 BR0111859B1 (pt) 2015-01-06

Family

ID=8171674

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0111859-5A BR0111859B1 (pt) 2000-06-22 2001-06-13 Compostos com propriedades de relaxamento do fundo gástrico, seu processo de preparação, bem como composição farmacêutica que os compreende

Country Status (34)

Country Link
US (2) US7081453B2 (pt)
EP (1) EP1296987B1 (pt)
JP (1) JP4911860B2 (pt)
KR (1) KR100821107B1 (pt)
CN (2) CN1288157C (pt)
AR (1) AR032158A1 (pt)
AT (1) ATE312104T1 (pt)
AU (1) AU783292B2 (pt)
BG (1) BG65895B1 (pt)
BR (1) BR0111859B1 (pt)
CA (1) CA2410233C (pt)
CZ (1) CZ305005B6 (pt)
DE (1) DE60115647T2 (pt)
EA (1) EA005760B1 (pt)
EE (1) EE04878B1 (pt)
EG (1) EG24462A (pt)
ES (1) ES2254467T3 (pt)
HK (1) HK1057896A1 (pt)
HR (1) HRP20020988B1 (pt)
HU (1) HU227398B1 (pt)
IL (2) IL153559A0 (pt)
IS (1) IS2618B (pt)
JO (1) JO2352B1 (pt)
MX (1) MXPA02012844A (pt)
MY (1) MY155267A (pt)
NO (1) NO328547B1 (pt)
NZ (1) NZ522519A (pt)
PA (1) PA8519601A1 (pt)
PL (1) PL201656B1 (pt)
SA (1) SA01220442B1 (pt)
SK (1) SK287730B6 (pt)
UA (1) UA74576C2 (pt)
WO (1) WO2001098306A1 (pt)
ZA (1) ZA200210303B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60014896T2 (de) 1999-06-02 2006-02-02 Janssen Pharmaceutica N.V. Pyrrolidinyl, piperidinyl oder homopiperidinyl substituierte (benzodioxan, benzofuran oder benzopyran) derivate
HUP0201404A3 (en) 1999-06-02 2005-02-28 Janssen Pharmaceutica Nv Aminoalkyl substituted benzodioxan, benzofuran or benzopyran derivatives, pharmaceutical compositions containing them and their use and process for their preparations
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
ES2563304T3 (es) 2003-04-24 2016-03-14 Incyte Holdings Corporation Derivados azaespiro alcano como inhibidores de metaloproteasas
JP4896476B2 (ja) * 2005-09-16 2012-03-14 広栄化学工業株式会社 メチルオキシメチルアミノピリジン誘導体及びその製造方法
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
KR20100017766A (ko) * 2007-05-10 2010-02-16 에이엠알 테크놀로지, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤조-1,4-디아제핀 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 이의 용도
AP2014007621A0 (en) 2011-11-11 2014-05-31 Pfizer 2-Thiopyrimidinones
TN2017000461A1 (en) 2015-05-05 2019-04-12 Pfizer 2-thiopyrimidinones
CN105481839B (zh) * 2015-11-23 2018-05-11 安徽千和新材料科技发展有限公司 一种光活性环氧啉对映体的制备方法
EP3229193A1 (en) 2016-04-07 2017-10-11 The Boeing Company A computer-implemented method and system for sharing information between passengers and air traffic management stakeholders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910930A (en) 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
DE2400049A1 (de) * 1974-01-02 1975-07-10 Spumalit Anstalt Transportkasten aus kunststoff, insbesondere fuer flaschen
GR71865B (pt) 1978-03-20 1983-07-07 Ciba Geigy
US4329348A (en) * 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
ZA931343B (en) 1992-03-06 1993-09-24 Akzo Nv 1,4-dioxino(2,3-b)pyridine derivatives.
US6403103B1 (en) * 1994-08-12 2002-06-11 Bio Merieux Trypanosoma cruzi antigen, gene encoding therefore, and methods of detecting and treating chagas disease
FR2744451B1 (fr) 1996-02-01 1998-04-24 Pf Medicament Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
DE60014896T2 (de) * 1999-06-02 2006-02-02 Janssen Pharmaceutica N.V. Pyrrolidinyl, piperidinyl oder homopiperidinyl substituierte (benzodioxan, benzofuran oder benzopyran) derivate
HUP0201404A3 (en) * 1999-06-02 2005-02-28 Janssen Pharmaceutica Nv Aminoalkyl substituted benzodioxan, benzofuran or benzopyran derivatives, pharmaceutical compositions containing them and their use and process for their preparations
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus

Also Published As

Publication number Publication date
HRP20020988B1 (en) 2011-06-30
AR032158A1 (es) 2003-10-29
US20060142318A1 (en) 2006-06-29
US20040019051A1 (en) 2004-01-29
NZ522519A (en) 2003-09-26
EE04878B1 (et) 2007-08-15
EP1296987A1 (en) 2003-04-02
CN100516066C (zh) 2009-07-22
AU8386401A (en) 2002-01-02
IL153559A0 (en) 2003-07-06
HRP20020988A2 (en) 2005-02-28
NO20026219D0 (no) 2002-12-23
SA01220442B1 (ar) 2008-05-21
JP2004501157A (ja) 2004-01-15
WO2001098306A1 (en) 2001-12-27
DE60115647T2 (de) 2006-08-24
BG107313A (bg) 2003-06-30
CN1781921A (zh) 2006-06-07
EP1296987B1 (en) 2005-12-07
DE60115647D1 (de) 2006-01-12
JO2352B1 (en) 2006-12-12
PL358886A1 (en) 2004-08-23
CZ305005B6 (cs) 2015-03-25
AU783292B2 (en) 2005-10-13
PA8519601A1 (es) 2002-08-26
ES2254467T3 (es) 2006-06-16
IS6591A (is) 2002-10-25
ZA200210303B (en) 2004-03-19
MY155267A (en) 2015-09-30
KR20030007566A (ko) 2003-01-23
UA74576C2 (en) 2006-01-16
HU227398B1 (hu) 2011-05-30
HK1057896A1 (en) 2004-04-23
CN1437602A (zh) 2003-08-20
NO20026219L (no) 2003-02-17
KR100821107B1 (ko) 2008-04-14
EA005760B1 (ru) 2005-06-30
US7081453B2 (en) 2006-07-25
EA200300049A1 (ru) 2003-04-24
SK492003A3 (en) 2003-07-01
BR0111859B1 (pt) 2015-01-06
NO328547B1 (no) 2010-03-15
BG65895B1 (bg) 2010-04-30
CZ2003115A3 (cs) 2003-06-18
EE200200694A (et) 2004-06-15
JP4911860B2 (ja) 2012-04-04
SK287730B6 (en) 2011-07-06
HUP0301185A3 (en) 2009-03-30
HUP0301185A2 (hu) 2003-08-28
CN1288157C (zh) 2006-12-06
CA2410233C (en) 2011-01-25
EG24462A (en) 2009-07-16
PL201656B1 (pl) 2009-04-30
ATE312104T1 (de) 2005-12-15
IL153559A (en) 2008-03-20
IS2618B (is) 2010-04-15
US7423048B2 (en) 2008-09-09
CA2410233A1 (en) 2001-12-27
MXPA02012844A (es) 2003-05-15

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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