BR0111806A - Método de administração de bisfosfonatos - Google Patents
Método de administração de bisfosfonatosInfo
- Publication number
- BR0111806A BR0111806A BR0111806-4A BR0111806A BR0111806A BR 0111806 A BR0111806 A BR 0111806A BR 0111806 A BR0111806 A BR 0111806A BR 0111806 A BR0111806 A BR 0111806A
- Authority
- BR
- Brazil
- Prior art keywords
- bisphosphonates
- administration method
- administration
- bisphosphonate
- bisphosphonate administration
- Prior art date
Links
- 229940122361 Bisphosphonate Drugs 0.000 title abstract 5
- 150000004663 bisphosphonates Chemical class 0.000 title abstract 4
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000030991 negative regulation of bone resorption Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 abstract 1
- 229960004276 zoledronic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"MéTODO DE ADMINISTRAçãO DE BISFOSFONATOS". A presente invenção refere-se a bisfosfonatos, em particular N-bisfosfonatos mais potentes tais como ácido zoledrónico e seus derivados, podem ser usados com resultados satisfatórios para inibição prolongada de ressorção óssea em condições de alteração óssea anormalmente aumentada, por exemplo osteoporose, através de administração intermitente, onde os períodos entre administrações de bisfosfonato são maiores dos que foram anteriormente considerados apropriados, por exemplo um intervalo de dosagem pelo menos de cerca de 6 meses ou menos freq³entemente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59713500A | 2000-06-20 | 2000-06-20 | |
US26768901P | 2001-02-09 | 2001-02-09 | |
PCT/EP2001/006850 WO2001097788A2 (en) | 2000-06-20 | 2001-06-18 | Method of administering bisphosphonates |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0111806A true BR0111806A (pt) | 2003-05-20 |
Family
ID=26952565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0111806-4A BR0111806A (pt) | 2000-06-20 | 2001-06-18 | Método de administração de bisfosfonatos |
Country Status (25)
Country | Link |
---|---|
US (1) | US8052987B2 (pt) |
EP (1) | EP1296689B3 (pt) |
JP (2) | JP4722375B2 (pt) |
KR (1) | KR100864743B1 (pt) |
CN (1) | CN1272013C (pt) |
AT (1) | ATE304856T1 (pt) |
AU (2) | AU2001274109B2 (pt) |
BR (1) | BR0111806A (pt) |
CA (1) | CA2410201C (pt) |
CY (2) | CY1113740T1 (pt) |
CZ (1) | CZ301972B6 (pt) |
DE (1) | DE60113537T3 (pt) |
DK (1) | DK1296689T3 (pt) |
ES (2) | ES2247123T7 (pt) |
HK (1) | HK1072539A1 (pt) |
HU (1) | HU228400B1 (pt) |
IL (2) | IL153229A0 (pt) |
MX (1) | MXPA02012682A (pt) |
NO (1) | NO330459B1 (pt) |
NZ (1) | NZ523086A (pt) |
PL (1) | PL203087B1 (pt) |
PT (1) | PT1591122E (pt) |
SK (1) | SK287278B6 (pt) |
TW (1) | TWI289451B (pt) |
WO (1) | WO2001097788A2 (pt) |
Families Citing this family (40)
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US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
SK287278B6 (sk) | 2000-06-20 | 2010-05-07 | Novartis Ag | Použitie kyseliny 1-hydroxy-2-(imidazol-1-yl)etán-1,1- difosfónovej na prípravu liečiva na liečenie stavov abnormálne zvýšeného kostného obratu |
EP1192945A3 (en) * | 2000-09-21 | 2004-03-03 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating osteoarthritis |
WO2002080933A1 (en) * | 2001-04-03 | 2002-10-17 | The Royal Alexandra Hospital For Children | A drug for use in bone grafting |
US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
GB0204756D0 (en) * | 2002-02-28 | 2002-04-17 | Novartis Ag | Organic compounds |
KR20120065435A (ko) | 2002-05-10 | 2012-06-20 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
PT1542700E (pt) * | 2002-09-16 | 2012-02-01 | Novartis Ag | Método para prevenir ou reduzir fracturas secundárias após a fractura da anca |
TW200410701A (en) * | 2002-10-15 | 2004-07-01 | Novartis Ag | Method of administering bisphosphonates |
SG174628A1 (en) | 2002-12-20 | 2011-10-28 | Hoffmann La Roche | High dose ibandronate formulation |
US20070191311A1 (en) * | 2004-01-30 | 2007-08-16 | Shuichiro Kakimoto | P2x receptor inhibitor |
ATE495747T1 (de) * | 2004-08-23 | 2011-02-15 | Teva Pharma | Kristalline form des ibandronat-natriums und herstellungsverfahren dafür |
US7709508B2 (en) | 2004-12-09 | 2010-05-04 | Merck Sharp & Dohme | Estrogen receptor modulators |
RU2394820C2 (ru) | 2004-12-09 | 2010-07-20 | Мерк Шарп Энд Домэ Корп. | Модуляторы рецептора эстрогена |
US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
US7473684B2 (en) * | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
ES2426445T3 (es) * | 2006-04-07 | 2013-10-23 | Merrion Research Iii Limited | Forma de dosificación oral sólida que contiene un potenciador |
US20090075941A1 (en) * | 2006-04-21 | 2009-03-19 | The Uab Research Foundation | Treating neoplasms |
US20080139514A1 (en) * | 2006-11-29 | 2008-06-12 | Subhash Pandurang Gore | Diphosphonic acid pharmaceutical compositions |
US20100068211A1 (en) * | 2008-02-08 | 2010-03-18 | Bateman Ted A | Use of antiresorptive compounds to prevent ionizing radiation-induced activation of osteoclasts and resulting bone loss |
TW200950801A (en) * | 2008-05-07 | 2009-12-16 | Merrion Res Iii Ltd | Compositions of peptides and processes of preparation thereof |
JP2012518686A (ja) * | 2009-02-25 | 2012-08-16 | メリオン・リサーチ・Iii・リミテッド | ビスホスホネート類の組成物および薬物送達 |
PT2459176T (pt) | 2009-07-31 | 2017-12-11 | Gruenenthal Gmbh | Método de cristalização e biodisponibilidade |
US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
HUE025737T2 (en) | 2009-09-01 | 2016-05-30 | Univ Duke | Bisphosphonate compositions and methods for treating heart failure |
US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
US9089484B2 (en) * | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
KR20140026354A (ko) | 2011-01-07 | 2014-03-05 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여용 철의 제약 조성물 |
CA2856030A1 (en) | 2011-11-16 | 2013-05-23 | Duke University | Bisphosphonate compositions and methods for treating and/or reducing cardiac dysfunction |
CN103623465B (zh) * | 2013-11-21 | 2015-12-30 | 彭江 | 一种可局部调节成破骨活性的组织工程骨支架及制备方法 |
EP3250191B1 (en) | 2015-01-29 | 2024-01-17 | Novo Nordisk A/S | Tablets comprising glp-1 agonist and enteric coating |
US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
KR20180115979A (ko) * | 2017-04-14 | 2018-10-24 | 연세대학교 산학협력단 | 비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물 |
GB201716716D0 (en) | 2017-10-12 | 2017-11-29 | Univ Of Hertfordshire Higher Education Corporation | Method for coating particles |
US20210369769A1 (en) * | 2018-11-02 | 2021-12-02 | Dyve Biosciences, Inc. | Management of risk of cation overload and electrolyte imbalance with topically applied buffers |
KR102049233B1 (ko) * | 2019-01-14 | 2019-11-28 | 연세대학교 산학협력단 | 비스포스포네이트를 포함하는 만성 이식신 기능부전 예방 또는 치료용 조성물 |
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DE3583887D1 (de) | 1984-04-30 | 1991-10-02 | Procter & Gamble | Ausruestung fuer die behandlung der osteoporose. |
US4822609A (en) | 1984-12-21 | 1989-04-18 | The Procter & Gamble Company | Treatment of osteoporosis |
US4812304A (en) | 1984-12-21 | 1989-03-14 | The Procter & Gamble Company | Treatment of osteoporosis |
US4812311A (en) | 1984-12-21 | 1989-03-14 | The Procter & Gamble Company | Kit for use in the treatment of osteoporosis |
US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
ES2038692T4 (es) | 1986-11-21 | 2012-02-10 | Novartis Ag | Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos. |
JPH07502507A (ja) | 1991-12-17 | 1995-03-16 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | ビスホスホネート類及び副甲状腺ホルモンを用いた骨粗鬆症の治療方法 |
EP0648120B1 (en) | 1992-06-30 | 1997-12-29 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Use of phosphonates for the treatment of osteoporosis |
AU670337B2 (en) | 1992-11-30 | 1996-07-11 | Novartis Ag | Use of certain methanebisphosphonic acid derivatives in fracture healing |
EP0600834A1 (en) | 1992-11-30 | 1994-06-08 | Ciba-Geigy Ag | Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing |
US5366965A (en) | 1993-01-29 | 1994-11-22 | Boehringer Mannheim Gmbh | Regimen for treatment or prophylaxis of osteoporosis |
GB9408775D0 (en) | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
AU686458B2 (en) | 1994-09-09 | 1998-02-05 | Procter & Gamble Company, The | Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone |
EP0779813A4 (en) | 1994-09-09 | 1998-05-06 | Procter & Gamble | PHOSPHONATES AND PARATHORMONE AGAINST OSTEOPOROSIS |
ATE290871T1 (de) | 1995-09-29 | 2005-04-15 | Novartis Pharma Gmbh | Verfahren zur behandlung navikularer krankheiten bei pferden |
US5735810A (en) | 1996-06-14 | 1998-04-07 | Becton Dickinson And Company | Device for the iontophoretic administration of bisphosphonates |
US5730715A (en) | 1996-06-14 | 1998-03-24 | Becton Dickinson And Company | Method for the iontophoretic administration of bisphosphonates |
SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
US5994329A (en) | 1997-07-22 | 1999-11-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
KR20030097610A (ko) | 1997-07-22 | 2003-12-31 | 머크 앤드 캄파니 인코포레이티드 | 골 흡수 억제를 위한 조성물 |
US6432932B1 (en) | 1997-07-22 | 2002-08-13 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6015801A (en) | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
FI109088B (fi) | 1997-09-19 | 2002-05-31 | Leiras Oy | Tabletti ja menetelmä sen valmistamiseksi |
SE9703691D0 (sv) | 1997-10-10 | 1997-10-10 | Astra Ab | Pharmaceutical compositions |
IT1296495B1 (it) | 1997-11-21 | 1999-06-25 | Prodotti Antibiotici Spa | Impiego di bisfosfonati nella preparazione di forme farmaceutiche per somministrazione intramuscolare |
GB2336311A (en) | 1998-04-15 | 1999-10-20 | Merck & Co Inc | Bisphosphonate Dosing Regimen |
CA2308532C (en) | 1999-05-12 | 2005-11-29 | Gador S.A. | Use of bisphosphonates for the treatment of osteogenesis imperfecta |
BR0010808A (pt) | 1999-05-21 | 2002-08-27 | Novartis Ag | Composições farmacêuticas e usos |
WO2001045636A1 (en) | 1999-12-20 | 2001-06-28 | Merck & Co., Inc. | Pharmaceutical kit |
GB0012209D0 (en) | 2000-05-19 | 2000-07-12 | Novartis Ag | Organic compounds |
SK287278B6 (sk) | 2000-06-20 | 2010-05-07 | Novartis Ag | Použitie kyseliny 1-hydroxy-2-(imidazol-1-yl)etán-1,1- difosfónovej na prípravu liečiva na liečenie stavov abnormálne zvýšeného kostného obratu |
-
2001
- 2001-06-18 SK SK1808-2002A patent/SK287278B6/sk not_active IP Right Cessation
- 2001-06-18 IL IL15322901A patent/IL153229A0/xx active IP Right Review Request
- 2001-06-18 CA CA2410201A patent/CA2410201C/en not_active Expired - Lifetime
- 2001-06-18 US US10/311,942 patent/US8052987B2/en not_active Expired - Lifetime
- 2001-06-18 ES ES01940580T patent/ES2247123T7/es active Active
- 2001-06-18 NZ NZ523086A patent/NZ523086A/en not_active IP Right Cessation
- 2001-06-18 ES ES05012711T patent/ES2394211T3/es not_active Expired - Lifetime
- 2001-06-18 BR BR0111806-4A patent/BR0111806A/pt not_active Application Discontinuation
- 2001-06-18 JP JP2002503265A patent/JP4722375B2/ja not_active Expired - Lifetime
- 2001-06-18 KR KR1020027017283A patent/KR100864743B1/ko active IP Right Grant
- 2001-06-18 AU AU2001274109A patent/AU2001274109B2/en not_active Expired
- 2001-06-18 MX MXPA02012682A patent/MXPA02012682A/es active IP Right Grant
- 2001-06-18 CZ CZ20024134A patent/CZ301972B6/cs not_active IP Right Cessation
- 2001-06-18 EP EP01940580A patent/EP1296689B3/en not_active Expired - Lifetime
- 2001-06-18 HU HU0301164A patent/HU228400B1/hu active Protection Beyond IP Right Term
- 2001-06-18 AU AU7410901A patent/AU7410901A/xx active Pending
- 2001-06-18 PT PT50127117T patent/PT1591122E/pt unknown
- 2001-06-18 AT AT01940580T patent/ATE304856T1/de active
- 2001-06-18 DE DE60113537T patent/DE60113537T3/de not_active Expired - Lifetime
- 2001-06-18 DK DK01940580T patent/DK1296689T3/da active
- 2001-06-18 CN CNB018113680A patent/CN1272013C/zh not_active Ceased
- 2001-06-18 WO PCT/EP2001/006850 patent/WO2001097788A2/en active IP Right Grant
- 2001-06-18 PL PL358224A patent/PL203087B1/pl unknown
- 2001-06-20 TW TW090114964A patent/TWI289451B/zh not_active IP Right Cessation
-
2002
- 2002-12-02 IL IL153229A patent/IL153229A/en active IP Right Grant
- 2002-12-19 NO NO20026117A patent/NO330459B1/no not_active IP Right Cessation
-
2005
- 2005-05-31 JP JP2005159852A patent/JP5005188B2/ja not_active Expired - Lifetime
- 2005-06-22 HK HK05105175A patent/HK1072539A1/xx not_active IP Right Cessation
-
2012
- 2012-12-14 CY CY20121101222T patent/CY1113740T1/el unknown
-
2013
- 2013-03-22 CY CY2013011C patent/CY2013011I1/el unknown
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