BR0109740A - Método para produção de igg a partir de plasma para aplicações médicas - Google Patents
Método para produção de igg a partir de plasma para aplicações médicasInfo
- Publication number
- BR0109740A BR0109740A BR0109740-7A BR0109740A BR0109740A BR 0109740 A BR0109740 A BR 0109740A BR 0109740 A BR0109740 A BR 0109740A BR 0109740 A BR0109740 A BR 0109740A
- Authority
- BR
- Brazil
- Prior art keywords
- igg
- igg fraction
- plasma
- iii
- medical applications
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 230000002779 inactivation Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 230000003171 anti-complementary effect Effects 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODO PARA PRODUçãO DE IgG A PARTIR DE PLASMA PARA APLICAçõES MéDICAS". Método para produção de IgG a partir de plasma para aplicações médicas, compreendendo pelo menos : (i') remoção de albumina resultando em uma fração de IgG, (ii') purificação de IgG de uma fração de IgG derivada daquela obtida na etapa (i'), por adsorção de IgG em um trocador de cátions e coleta da fração de IgG adsorvida, e (iii') inativação de vírus em uma fração de IgG derivada daquela coletada na etapa (ii'). O método é caracterizado por (I) concentração da fração de IgG obtida na etapa (i'), (II) ajuste de pH a 4<sym>0,1 na fração de IgG liberada do trocador de cátions na etapa (ii'), e preferivelmente mantendo o pH abaixo de 6,0 durante as etapas remanescentes do método; e (III) realização da inativação de vírus (etapa iii'), pelo uso de produtos químicos em uma temperatura de 30<198>C <sym> 2<198>C por pelo menos 4 horas. Atividade anticomplementar fica tipicamente abaixo de 1 CH~ 50~/mg de imunoglobulina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001128A SE0001128D0 (sv) | 2000-03-30 | 2000-03-30 | A method of producing IgG |
| SE0001128-8 | 2000-03-30 | ||
| PCT/EP2001/003624 WO2001072844A2 (en) | 2000-03-30 | 2001-03-29 | A METHOD OF PRODUCING IgG |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0109740A true BR0109740A (pt) | 2003-02-04 |
| BR0109740B1 BR0109740B1 (pt) | 2015-01-06 |
| BRPI0109740B8 BRPI0109740B8 (pt) | 2021-05-25 |
Family
ID=20279068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0109740A BRPI0109740B8 (pt) | 2000-03-30 | 2001-03-29 | método para produção de igg a partir de plasma para aplicações médicas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6835379B2 (pt) |
| EP (1) | EP1268551B1 (pt) |
| JP (1) | JP2003530326A (pt) |
| CN (1) | CN1419566A (pt) |
| AT (1) | ATE260297T1 (pt) |
| AU (2) | AU2001273907B2 (pt) |
| BR (1) | BRPI0109740B8 (pt) |
| CA (1) | CA2402784A1 (pt) |
| DE (1) | DE60102144T2 (pt) |
| IL (1) | IL151667A0 (pt) |
| PT (1) | PT1268551E (pt) |
| RU (1) | RU2266914C2 (pt) |
| SE (1) | SE0001128D0 (pt) |
| TR (1) | TR200400701T4 (pt) |
| WO (1) | WO2001072844A2 (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE540050T1 (de) * | 2003-09-05 | 2012-01-15 | Toray Industries | Verfahren zur herstellung einer proteomanalyse- lösung |
| CN100451031C (zh) * | 2003-09-05 | 2009-01-14 | 东丽株式会社 | 生物体成分组成改变了的溶液的调制方法 |
| EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
| TWI391399B (zh) | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
| US8293242B2 (en) * | 2005-09-01 | 2012-10-23 | Plasma Technologies, Llc | Ultra-high yield of alpha-1-anti-trypsin |
| US7879332B2 (en) * | 2005-09-01 | 2011-02-01 | Plasma Technologies, Llc | Ultra-high yield intravenous immune globulin preparation |
| US20070049732A1 (en) * | 2005-09-01 | 2007-03-01 | Zurlo Eugene J | Ultra-high yield intravenous immune globulin preparation |
| CN100362022C (zh) * | 2005-11-07 | 2008-01-16 | 中国人民解放军第二军医大学 | 海螵蛸多糖cps-1及其制备方法和用途 |
| US20070128693A1 (en) * | 2005-12-06 | 2007-06-07 | Advantek Serum Laboratories Limited3/F | Method for the inactivation and removal of dengue virus from biological samples |
| WO2007136327A1 (en) * | 2006-05-22 | 2007-11-29 | Ge Healthcare Bio-Sciences Ab | A method of producing igg |
| US20100158893A1 (en) * | 2008-12-19 | 2010-06-24 | Baxter International Inc. | Systems and methods for obtaining immunoglobulin from blood |
| SG176256A1 (en) | 2009-05-27 | 2012-01-30 | Baxter Int | A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use |
| EP4328305A3 (en) | 2009-12-18 | 2024-08-14 | CSL Ltd. | Method of purifying polypeptides |
| EP2519537A4 (en) * | 2009-12-29 | 2013-07-10 | Reddys Lab Ltd Dr | CLEANING PROTEINS |
| AU2011212440B2 (en) | 2010-02-04 | 2015-01-22 | Csl Behring Ag | Immunoglobulin preparation |
| EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
| US8796430B2 (en) | 2010-05-26 | 2014-08-05 | Baxter International Inc. | Method to produce an immunoglobulin preparation with improved yield |
| US8772462B2 (en) | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| AR087953A1 (es) * | 2011-08-26 | 2014-04-30 | Baxter Int | Metodo para reducir el potencial tromboembolico de una composicion de inmunoglobulina derivada de plasma |
| TWI629283B (zh) | 2012-02-23 | 2018-07-11 | 巴克斯歐塔公司 | 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱 |
| CN110343171A (zh) | 2012-02-29 | 2019-10-18 | 百深公司 | 周围神经的IgG刺激髓鞘再生 |
| AU2013203043B2 (en) * | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
| FR3018450B1 (fr) * | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
| CN104231065A (zh) * | 2014-09-09 | 2014-12-24 | 青岛康大食品有限公司 | 兔血中球蛋白的纯化制备方法 |
| EP3362464B1 (en) | 2015-10-15 | 2021-04-28 | Plasma Technologies LLC | Methods for extracting proteins from blood plasma |
| MX2018009331A (es) * | 2016-02-03 | 2018-11-09 | Plasma Tech Llc | Metodos para extraer proteinas a partir de un material a base de sangre. |
| US10815270B1 (en) * | 2019-09-20 | 2020-10-27 | Plasma Technologies, Llc | Compositions and methods for high efficiency protein precipitation |
| US10836790B1 (en) * | 2019-09-20 | 2020-11-17 | Plasma Technologies, Llc | Therapeutic protein compositions and methods |
| EP4126930A1 (en) | 2020-03-31 | 2023-02-08 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3927111C3 (de) | 1989-08-17 | 1994-09-01 | Biotest Pharma Gmbh | Verfahren zur Herstellung nicht modifizierter intravenös verabreichbarer IgM- und/oderIgA-haltiger Immunglobulinpräparate |
| ATE122054T1 (de) | 1990-03-22 | 1995-05-15 | Biotest Pharma Gmbh | Verfahren zur herstellung eines intravenös verträglichen immunglobulin-g-präparates. |
| DE4118912C1 (pt) * | 1991-06-08 | 1992-07-02 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
| EP0659767B2 (de) * | 1993-12-27 | 2002-11-06 | ZLB Bioplasma AG | Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält |
| US5429746A (en) * | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| US5886154A (en) * | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| IL121900A (en) | 1997-10-07 | 2001-12-23 | Omrix Biopharmaceuticals Ltd | A method for the purification of immunoglobulins |
| AU753468B2 (en) | 1998-06-09 | 2002-10-17 | Csl Behring Ag | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
| ES2527915T3 (es) * | 1998-06-09 | 2015-02-02 | Csl Behring Ag | Producto de inmunoglobulina G (IgG) líquido |
| DE19923027C2 (de) * | 1999-05-19 | 2002-09-19 | Aventis Behring Gmbh | Verfahren zur Inaktivierung von Viren |
-
2000
- 2000-03-30 SE SE0001128A patent/SE0001128D0/xx unknown
-
2001
- 2001-03-29 WO PCT/EP2001/003624 patent/WO2001072844A2/en active IP Right Grant
- 2001-03-29 CN CN01807338A patent/CN1419566A/zh active Pending
- 2001-03-29 AT AT01940271T patent/ATE260297T1/de not_active IP Right Cessation
- 2001-03-29 DE DE60102144T patent/DE60102144T2/de not_active Expired - Fee Related
- 2001-03-29 TR TR2004/00701T patent/TR200400701T4/xx unknown
- 2001-03-29 BR BRPI0109740A patent/BRPI0109740B8/pt not_active IP Right Cessation
- 2001-03-29 EP EP20010940271 patent/EP1268551B1/en not_active Expired - Lifetime
- 2001-03-29 CA CA002402784A patent/CA2402784A1/en not_active Abandoned
- 2001-03-29 JP JP2001571775A patent/JP2003530326A/ja active Pending
- 2001-03-29 PT PT01940271T patent/PT1268551E/pt unknown
- 2001-03-29 AU AU2001273907A patent/AU2001273907B2/en not_active Ceased
- 2001-03-29 US US10/220,929 patent/US6835379B2/en not_active Expired - Lifetime
- 2001-03-29 RU RU2002124857/04A patent/RU2266914C2/ru not_active IP Right Cessation
- 2001-03-29 IL IL15166701A patent/IL151667A0/xx not_active IP Right Cessation
- 2001-04-02 AU AU7390701A patent/AU7390701A/xx active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1268551A2 (en) | 2003-01-02 |
| AU2001273907B2 (en) | 2006-02-02 |
| DE60102144D1 (de) | 2004-04-01 |
| DE60102144T2 (de) | 2004-10-28 |
| IL151667A0 (en) | 2003-04-10 |
| EP1268551B1 (en) | 2004-02-25 |
| WO2001072844A2 (en) | 2001-10-04 |
| US20030143222A1 (en) | 2003-07-31 |
| TR200400701T4 (tr) | 2004-05-21 |
| AU7390701A (en) | 2001-10-08 |
| PT1268551E (pt) | 2004-07-30 |
| CN1419566A (zh) | 2003-05-21 |
| WO2001072844A3 (en) | 2002-04-11 |
| RU2002124857A (ru) | 2004-02-20 |
| SE0001128D0 (sv) | 2000-03-30 |
| CA2402784A1 (en) | 2001-10-04 |
| BR0109740B1 (pt) | 2015-01-06 |
| ATE260297T1 (de) | 2004-03-15 |
| US6835379B2 (en) | 2004-12-28 |
| JP2003530326A (ja) | 2003-10-14 |
| RU2266914C2 (ru) | 2005-12-27 |
| BRPI0109740B8 (pt) | 2021-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: GE HEALTHCARE BIO-SCIENCES AB (SE) Free format text: ALTERADO DE: AMERSHAM BIOSCIENCES AB |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/01/2015, OBSERVADAS AS CONDICOES LEGAIS. |
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| B25A | Requested transfer of rights approved | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/03/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 29/03/2021 |
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| B25E | Requested change of name of applicant rejected |
Free format text: INDEFERIDO O PEDIDO DE ALTERACAO DE NOME CONTIDO NA PETICAO 870210009765 DE28/01/2021 DEVIDO AO DESPACHO PUBLICADO NA RPI 2630 DE 01/06/2021. |