BR0007782A - Processo para purificar ácido hialurÈnico de alto peso molecular - Google Patents
Processo para purificar ácido hialurÈnico de alto peso molecularInfo
- Publication number
- BR0007782A BR0007782A BR0007782-8A BR0007782A BR0007782A BR 0007782 A BR0007782 A BR 0007782A BR 0007782 A BR0007782 A BR 0007782A BR 0007782 A BR0007782 A BR 0007782A
- Authority
- BR
- Brazil
- Prior art keywords
- molecular weight
- hyaluronic acid
- high molecular
- weight hyaluronic
- purifying high
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
Abstract
"PROCESSO PARA PURIFICAR áCIDO HIALURÈNICO DE ALTO PESO MOLECULAR". Um processo para purificar ácido hialurónico de alto peso molecular proveniente de uma fonte biológica, incluindo as etapa de ajustar o pH de uma solução aquosa contendo ácido hialurónico de alto peso molecular proveniente de uma fonte biológica a um pH na faixa de 1,7 a 3,3, e então diafiltrar a dita solução aquosa no mesmo pH usando um filtro tendo um tamanho de poro na faixa de corte de peso molecular nominal de 100.000 Daltons até 0,45 <109>m, e de remover células da solução aquosa contendo ácido hialurónico de alto peso molecular proveniente de fonte biológica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH00154/99A CH692919A5 (fr) | 1999-01-28 | 1999-01-28 | Procédé de purification de l'acide hyaluronique à poids moléculaire élevé. |
| PCT/IB2000/000082 WO2000044925A1 (en) | 1999-01-28 | 2000-01-27 | Process for purifying high molecular weight hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0007782A true BR0007782A (pt) | 2002-09-10 |
| BR0007782B1 BR0007782B1 (pt) | 2013-08-27 |
Family
ID=4180486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0007782-8B1A BR0007782B1 (pt) | 1999-01-28 | 2000-01-27 | processo para purificar Ácido hialurânico de alto peso molecular. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6489467B1 (pt) |
| EP (1) | EP1144668B1 (pt) |
| AT (1) | ATE242816T1 (pt) |
| AU (1) | AU3070400A (pt) |
| BR (1) | BR0007782B1 (pt) |
| CA (1) | CA2360343C (pt) |
| CH (1) | CH692919A5 (pt) |
| CZ (1) | CZ301306B6 (pt) |
| DE (1) | DE60003282T2 (pt) |
| ES (1) | ES2200812T3 (pt) |
| PL (1) | PL200677B1 (pt) |
| SK (1) | SK286327B6 (pt) |
| WO (1) | WO2000044925A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH692919A5 (fr) * | 1999-01-28 | 2002-12-13 | Trb Chemedica S A | Procédé de purification de l'acide hyaluronique à poids moléculaire élevé. |
| ES2192960B1 (es) * | 2001-11-16 | 2005-03-01 | Consejo Sup. Investig. Cientificas | Nuevo procedimiento de obtencion de acido hialuronico. |
| PT1526859E (pt) * | 2002-08-07 | 2013-01-25 | Medidom Lab | Processo para preparação de uma formulaçâo de ácido hialurónico de elevado peso molecular |
| US7002007B2 (en) * | 2004-05-28 | 2006-02-21 | Calcigen Corporation | Production of high molecular weight hyaluronates |
| KR100577075B1 (ko) * | 2004-06-16 | 2006-05-08 | 주식회사 티앤라이프시스템 | 칼슘염 및 인산염, 또는 인산칼슘염을 이용한 히아루론산정제방법 |
| GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| CN102617754B (zh) | 2006-07-06 | 2015-09-16 | 利莱恩斯生命科学有限公司 | 用于纯化高分子量透明质酸的有效方法 |
| CN100478360C (zh) * | 2006-10-31 | 2009-04-15 | 山东福瑞达生物化工有限公司 | 将浓缩用于透明质酸或其盐的生产的方法 |
| ES2622834T3 (es) * | 2007-11-13 | 2017-07-07 | Bio-Technology General (Israel) Ltd. | Procedimiento de esterilización por filtración en estado diluido para biopolímeros viscoelásticos |
| DE102009021372A1 (de) * | 2009-05-14 | 2010-11-18 | Ursapharm Arzneimittel Gmbh | Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung |
| US8283463B2 (en) | 2010-02-09 | 2012-10-09 | Bausch & Lomb Incorporated | Sterile hyaluronic acid solutions |
| JP5713995B2 (ja) * | 2010-03-17 | 2015-05-07 | 電気化学工業株式会社 | ヒアルロン酸及び／又はその塩の精製方法 |
| CN102504047A (zh) * | 2011-11-30 | 2012-06-20 | 上海景峰制药有限公司 | 一种玻璃酸钠发酵液的超滤方法 |
| WO2013116819A1 (en) | 2012-02-03 | 2013-08-08 | University Of Rochester | Compositions and methods for recombinant synthesis of high molecular weight hyaluronic acid |
| CN105237656A (zh) * | 2015-10-30 | 2016-01-13 | 深圳市阳光之路生物材料科技有限公司 | 一种提纯透明质酸钠的方法 |
| GB201703850D0 (en) * | 2017-03-10 | 2017-04-26 | Givaudan Sa | Improvements in or relating to organic compounds |
| IT201900019724A1 (it) | 2019-10-24 | 2021-04-24 | Bmg Pharma S P A | “procedimento in solvente organico per la purificazione dell’acido ialuronico sale sodico” |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4517295A (en) * | 1983-02-18 | 1985-05-14 | Diagnostic, Inc. | Hyaluronic acid from bacterial culture |
| JPH072117B2 (ja) * | 1986-10-09 | 1995-01-18 | 三菱レイヨン株式会社 | ヒアルロン酸の製造法 |
| IT1271001B (it) * | 1994-07-26 | 1997-05-26 | Poli Ind Chimica Spa | Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus |
| CH692919A5 (fr) * | 1999-01-28 | 2002-12-13 | Trb Chemedica S A | Procédé de purification de l'acide hyaluronique à poids moléculaire élevé. |
-
1999
- 1999-01-28 CH CH00154/99A patent/CH692919A5/fr not_active IP Right Cessation
-
2000
- 2000-01-27 WO PCT/IB2000/000082 patent/WO2000044925A1/en active IP Right Grant
- 2000-01-27 EP EP00900777A patent/EP1144668B1/en not_active Expired - Lifetime
- 2000-01-27 ES ES00900777T patent/ES2200812T3/es not_active Expired - Lifetime
- 2000-01-27 CZ CZ20012694A patent/CZ301306B6/cs not_active IP Right Cessation
- 2000-01-27 US US09/868,529 patent/US6489467B1/en not_active Expired - Lifetime
- 2000-01-27 BR BRPI0007782-8B1A patent/BR0007782B1/pt active IP Right Grant
- 2000-01-27 AU AU30704/00A patent/AU3070400A/en not_active Abandoned
- 2000-01-27 AT AT00900777T patent/ATE242816T1/de active
- 2000-01-27 DE DE60003282T patent/DE60003282T2/de not_active Expired - Lifetime
- 2000-01-27 PL PL350135A patent/PL200677B1/pl unknown
- 2000-01-27 SK SK1063-2001A patent/SK286327B6/sk not_active IP Right Cessation
- 2000-01-27 CA CA2360343A patent/CA2360343C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1144668A1 (en) | 2001-10-17 |
| ES2200812T3 (es) | 2004-03-16 |
| WO2000044925A1 (en) | 2000-08-03 |
| CA2360343C (en) | 2010-02-23 |
| EP1144668B1 (en) | 2003-06-11 |
| SK10632001A3 (sk) | 2002-04-04 |
| AU3070400A (en) | 2000-08-18 |
| CZ301306B6 (cs) | 2010-01-06 |
| PL350135A1 (en) | 2002-11-04 |
| CH692919A5 (fr) | 2002-12-13 |
| SK286327B6 (en) | 2008-07-07 |
| BR0007782B1 (pt) | 2013-08-27 |
| ATE242816T1 (de) | 2003-06-15 |
| PL200677B1 (pl) | 2009-01-30 |
| CA2360343A1 (en) | 2000-08-03 |
| DE60003282D1 (de) | 2003-07-17 |
| CZ20012694A3 (cs) | 2002-02-13 |
| US6489467B1 (en) | 2002-12-03 |
| DE60003282T2 (de) | 2004-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2013, OBSERVADAS AS CONDICOES LEGAIS. |