MX2018009331A - Metodos para extraer proteinas a partir de un material a base de sangre. - Google Patents
Metodos para extraer proteinas a partir de un material a base de sangre.Info
- Publication number
- MX2018009331A MX2018009331A MX2018009331A MX2018009331A MX2018009331A MX 2018009331 A MX2018009331 A MX 2018009331A MX 2018009331 A MX2018009331 A MX 2018009331A MX 2018009331 A MX2018009331 A MX 2018009331A MX 2018009331 A MX2018009331 A MX 2018009331A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- blood
- chromatography
- proteins
- albumin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/303—Extraction; Separation; Purification by precipitation by salting out
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3814—Affinity chromatography of the substrate or co-factor - enzyme type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/027—Nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/16—Diafiltration
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Water Supply & Treatment (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen en la presente métodos para producir productos de proteína múltiples a partir de materiales a base de sangre, que incluyen inhibidor de alfa-1-proteinasa, gamma-globulina, albúmina, y otros proteínas. Los métodos de la invención incluyen etapas de: fraccionamiento con sal, cromatografía, ultrafiltración, diafiltración, tratamiento con solvente-detergente, y filtración estéril. Ventajosamente, los métodos de la invenicón son simples y producen inhibidor de alfa1-proteinasa, gamma-globulina, albúmina y otras proteínas en altos rendimientos. La secuencia de etapas de proceso puede ser seleccionada para obtener productos múltiples a partir de varios materiales en proceso, como sobrenadantes, pastas, flujo de paso de cromatografía y lavados de cromatografía.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662290638P | 2016-02-03 | 2016-02-03 | |
PCT/US2017/016595 WO2017136785A1 (en) | 2016-02-03 | 2017-02-03 | Methods for extracting proteins from a blood-based material |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018009331A true MX2018009331A (es) | 2018-11-09 |
Family
ID=59501069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018009331A MX2018009331A (es) | 2016-02-03 | 2017-02-03 | Metodos para extraer proteinas a partir de un material a base de sangre. |
Country Status (9)
Country | Link |
---|---|
US (2) | US11028125B2 (es) |
EP (1) | EP3411383A4 (es) |
JP (2) | JP6946313B2 (es) |
KR (1) | KR20180101583A (es) |
CN (1) | CN108779144B (es) |
AU (1) | AU2017214678B2 (es) |
CA (1) | CA3012694A1 (es) |
MX (1) | MX2018009331A (es) |
WO (1) | WO2017136785A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108473530B (zh) * | 2015-10-15 | 2022-12-23 | 普莱泽玛科技有限公司 | 从血浆中提取蛋白质的方法 |
AU2017214678B2 (en) | 2016-02-03 | 2024-02-01 | Plasma Technologies, Llc | Methods for extracting proteins from a blood-based material |
CN109678969B (zh) * | 2018-12-29 | 2020-02-07 | 北京东方百泰生物科技有限公司 | 一种CTLA4-Ig融合蛋白的纯化方法 |
US10815270B1 (en) * | 2019-09-20 | 2020-10-27 | Plasma Technologies, Llc | Compositions and methods for high efficiency protein precipitation |
WO2021054999A1 (en) * | 2019-09-20 | 2021-03-25 | Plasma Technologies, Llc | Therapeutic protein compositions and methods |
CN112830953A (zh) * | 2019-11-22 | 2021-05-25 | 中国科学院大连化学物理研究所 | 一种干细胞培养液中提取活性蛋白的方法 |
US11732004B2 (en) * | 2020-04-10 | 2023-08-22 | Plasma Technologies, Llc | Compositions and methods for simplified high efficiency isolation of proteins |
CN112409476B (zh) * | 2020-08-13 | 2022-03-29 | 中元汇吉生物技术股份有限公司 | 四种血液来源蛋白的纯化方法 |
WO2023052627A1 (en) | 2021-10-01 | 2023-04-06 | Csl Behring Ag | Improved purification process |
CN114395031A (zh) * | 2022-01-24 | 2022-04-26 | 华南师范大学 | 罗非鱼血清转铁蛋白的纯化方法及其应用 |
CN114835801B (zh) * | 2022-06-20 | 2023-09-22 | 华润博雅生物制药集团股份有限公司 | 一种c1酯酶抑制剂及其制备方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
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US2390074A (en) | 1942-02-09 | 1945-12-04 | Research Corp | Protein product and process |
US4404132A (en) | 1980-05-27 | 1983-09-13 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
JPS584728A (ja) * | 1981-05-01 | 1983-01-11 | メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン | α−1−抗トリプシンの精製 |
US4639513A (en) * | 1984-02-02 | 1987-01-27 | Cuno Inc. | Intravenously injectable immunoglobulin G (IGG) and method for producing same |
US4486282A (en) | 1983-02-22 | 1984-12-04 | University Patents, Inc. | Precipitation of proteins from salt-containing proteinaceous fluids employing a desalting treatment, and use thereof in selective plasmapheresis |
US4697003A (en) | 1985-11-01 | 1987-09-29 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
US5177194A (en) | 1990-02-01 | 1993-01-05 | Baxter International, Inc. | Process for purifying immune serum globulins |
GB9705810D0 (en) | 1997-03-20 | 1997-05-07 | Common Services Agency | Intravenous immune globulin |
US6955917B2 (en) * | 1997-06-20 | 2005-10-18 | Bayer Healthcare Llc | Chromatographic method for high yield purification and viral inactivation of antibodies |
AUPP971399A0 (en) | 1999-04-12 | 1999-05-06 | Life Therapeutics Limited | Separation of plasma components |
SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
US6881731B1 (en) | 2000-10-23 | 2005-04-19 | Shanbrom Technologies, Llc | Enhancers for microbiological disinfection |
US7297716B2 (en) | 2000-10-23 | 2007-11-20 | Shanbrom Technologies, Llc | Enhanced production of blood components, blood cells and plasma without freezing |
ES2184594B1 (es) | 2001-01-17 | 2004-01-01 | Probitas Pharma Sa | Procedimiento para la produccion de gammaglobulina g humana inactivada de virus. |
MXPA03007069A (es) | 2001-02-07 | 2004-10-15 | Shanbrom Tech Llc | Acido carboxilico tal como acido citrico para desinfectar o mejorar la produccion de productos sanguineos tales como el plasma, crioprecipitado y/o plaqueta. |
DK1654284T3 (da) * | 2003-08-12 | 2009-07-20 | Octapharma Ag | Fremgangsmåde til fremstilling af en alfa-1-antitrypsinoplösning |
US8293242B2 (en) * | 2005-09-01 | 2012-10-23 | Plasma Technologies, Llc | Ultra-high yield of alpha-1-anti-trypsin |
US7879332B2 (en) * | 2005-09-01 | 2011-02-01 | Plasma Technologies, Llc | Ultra-high yield intravenous immune globulin preparation |
US20070049732A1 (en) | 2005-09-01 | 2007-03-01 | Zurlo Eugene J | Ultra-high yield intravenous immune globulin preparation |
GB0524432D0 (en) | 2005-11-30 | 2006-01-11 | Nhs Blood & Transplant | Method |
CN102099369A (zh) | 2008-07-18 | 2011-06-15 | 泰勒克里斯生物治疗学公司 | 制备α-1蛋白酶抑制剂的方法 |
EP2419436A1 (en) * | 2009-04-13 | 2012-02-22 | Bristol-Myers Squibb Company | Protein purification by citrate precipitation |
EP2755992B1 (en) * | 2011-09-16 | 2018-11-14 | GE Healthcare BioProcess R&D AB | Plasma protein fractionation by sequential polyacid precipitation |
CN102599332B (zh) * | 2012-03-09 | 2014-07-30 | 上海杰隆生物制品股份有限公司 | 一种利用禽血生产低灰分禽血浆蛋白粉的方法 |
CN108473530B (zh) * | 2015-10-15 | 2022-12-23 | 普莱泽玛科技有限公司 | 从血浆中提取蛋白质的方法 |
AU2017214678B2 (en) | 2016-02-03 | 2024-02-01 | Plasma Technologies, Llc | Methods for extracting proteins from a blood-based material |
-
2017
- 2017-02-03 AU AU2017214678A patent/AU2017214678B2/en active Active
- 2017-02-03 JP JP2018541324A patent/JP6946313B2/ja active Active
- 2017-02-03 CA CA3012694A patent/CA3012694A1/en active Pending
- 2017-02-03 KR KR1020187024161A patent/KR20180101583A/ko not_active Application Discontinuation
- 2017-02-03 CN CN201780009926.9A patent/CN108779144B/zh active Active
- 2017-02-03 EP EP17748315.3A patent/EP3411383A4/en active Pending
- 2017-02-03 MX MX2018009331A patent/MX2018009331A/es unknown
- 2017-02-03 WO PCT/US2017/016595 patent/WO2017136785A1/en active Application Filing
- 2017-08-10 US US16/072,175 patent/US11028125B2/en active Active
-
2021
- 2021-05-13 US US17/320,086 patent/US20210261608A1/en active Pending
- 2021-09-15 JP JP2021150229A patent/JP2022000442A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2017214678A2 (en) | 2018-09-06 |
CN108779144B (zh) | 2022-06-14 |
EP3411383A1 (en) | 2018-12-12 |
KR20180101583A (ko) | 2018-09-12 |
US11028125B2 (en) | 2021-06-08 |
JP2019513119A (ja) | 2019-05-23 |
JP6946313B2 (ja) | 2021-10-06 |
EP3411383A4 (en) | 2019-08-14 |
CN108779144A (zh) | 2018-11-09 |
US20210261608A1 (en) | 2021-08-26 |
WO2017136785A1 (en) | 2017-08-10 |
AU2017214678A1 (en) | 2018-08-16 |
JP2022000442A (ja) | 2022-01-04 |
CA3012694A1 (en) | 2017-08-10 |
US20190055282A1 (en) | 2019-02-21 |
AU2017214678B2 (en) | 2024-02-01 |
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