ES8505820A1 - Un procedimiento para producir una vacuna que previene la infeccion de hepatitis b - Google Patents
Un procedimiento para producir una vacuna que previene la infeccion de hepatitis bInfo
- Publication number
- ES8505820A1 ES8505820A1 ES527588A ES527588A ES8505820A1 ES 8505820 A1 ES8505820 A1 ES 8505820A1 ES 527588 A ES527588 A ES 527588A ES 527588 A ES527588 A ES 527588A ES 8505820 A1 ES8505820 A1 ES 8505820A1
- Authority
- ES
- Spain
- Prior art keywords
- hepatitis
- producing
- infection
- causing
- fractionation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000002672 hepatitis B Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000005194 fractionation Methods 0.000 abstract 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO PARA PRODUCIR UNA VACUNA QUE PREVIENE LA INFECCION DE HEPATITIS B.COMPRENDE: A) CALENTAR UNA SOLUCION ACUOSA DE UNA FRACCION DE PROTEINAS DELPLASMA HUMANO QUE CONTIENE ANTIGENO SUPERFICIAL DE HEPATITIS B, A UNA TEMPERATURA ENTRE 50 Y 70JC, DURANTE 8 A 12 HORAS; B) SATURAR A LA SOLUCION CALENTADA DE LA ETAPA (A) CON SULFATO DE AMONIO, PARA SEPARAR UNA FRACCION DE PROTEINAS PRECIPITABLES AL 10-20 Y RECOGER UNA FRACCION DE PROTEINAS PRECIPITABLES AL 40-50; C) PONER EN CONTACTO A LA SOLUCION AL 40-58 CON UN SILICATO COLOIDAL, PARA OBTENER HBSAG ABSORBIDO; D) ELUIR UNA PORCION DE HBSAG ABSORBIDO CON UNA SOLUCION TAMPON A PH ENTRE 8,5 Y 9; E) NEUTRALIZAR AL ELUATO DE LA ETAPA (D); F) AN/ADIR AL ELUATO, POLIETILENGLICOL HASTA UN NIVEL DE 3 A 7 (P/V) PARA SEPARAR VIRUS DE HEPATITIS B Y COMPLEJOS INMUNOLOGICOS; G) CONTINUAR AN/ADIENDO POLIETILENGLICOL HASTA OBTENER UN PRECIPITADO EN LA CAPA SOBRENADANTE DE (15-20) (P/V); H) FILTRAR AL PRECIPITADO PARA RECUPERAR UNA FRACCION DE HBSAG; I) ULTRACENTRIFUGAR A LA FRACCION DE LA ETAPA (H); J) INACTIVAR A LA FRACCION DE LA ETAPA (I) CON FORMALINA, Y K) REPOSAR AL PRODUCTO RESULTANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57210240A JPS59101426A (ja) | 1982-11-29 | 1982-11-29 | B型肝炎感染予防用ワクチンの製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505820A1 true ES8505820A1 (es) | 1985-06-16 |
ES527588A0 ES527588A0 (es) | 1985-06-16 |
Family
ID=16586097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527588A Granted ES527588A0 (es) | 1982-11-29 | 1983-11-28 | Un procedimiento para producir una vacuna que previene la infeccion de hepatitis b |
Country Status (6)
Country | Link |
---|---|
US (1) | US4565697A (es) |
EP (1) | EP0112506B1 (es) |
JP (1) | JPS59101426A (es) |
CA (1) | CA1217138A (es) |
DE (1) | DE3377972D1 (es) |
ES (1) | ES527588A0 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60193925A (ja) * | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
US4695454A (en) * | 1985-04-01 | 1987-09-22 | New York Blood Center, Inc. | Process for preparing hepatitis B surface antigen containing particles in novel forms which are highly immunogenic |
US4683294A (en) * | 1985-04-03 | 1987-07-28 | Smith Kline Rit, S.A. | Process for the extraction and purification of proteins from culture media producing them |
US4649192A (en) * | 1985-05-30 | 1987-03-10 | Smith Kline-Rit | Method for the isolation and purification of hepatitis B surface antigen using polysorbate |
JPH0780785B2 (ja) * | 1985-07-19 | 1995-08-30 | 株式会社ミドリ十字 | B型肝炎ワクチンの製造方法 |
JPH0789951B2 (ja) * | 1986-06-18 | 1995-10-04 | 財団法人阪大微生物病研究会 | 遺伝子発現産物の精製法 |
RU1389060C (ru) * | 1986-08-13 | 1993-06-30 | Институт иммунологии | Способ получени рекомбинатной вакцины к гепатиту В |
US4883865A (en) * | 1987-09-30 | 1989-11-28 | Merck & Co. Inc. | Recovery of pres2+s antigen |
CU22290A1 (es) * | 1990-10-08 | 1995-01-31 | Cigb | Procedimiento para la obtencion de antigeno de superficie del virus de la hepatitis b de superior capacidad inmunoganica y su uso en un preparado vacunal |
US5102989A (en) * | 1991-03-15 | 1992-04-07 | Merck & Co., Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells |
US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
US5543129A (en) * | 1994-11-17 | 1996-08-06 | Mg Industries | Non-cryogenic method and apparatus for producing pure nitrogen |
CN109134620A (zh) * | 2018-09-21 | 2019-01-04 | 中国科学院过程工程研究所 | 一种纯化HBc-VLPs或HBc-VLPs衍生物的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3100737A (en) * | 1958-02-05 | 1963-08-13 | Auerswald Wilhelm | Method of preparing a plasma protein solution free of active hepatitis virus and product produced thereby |
US3636191A (en) * | 1969-10-08 | 1972-01-18 | Cancer Res Inst | Vaccine against viral hepatitis and process |
US3951937A (en) * | 1973-12-20 | 1976-04-20 | The Community Blood Council Of Greater New York, Inc. | Large scale purification of hepatitis type B antigen using polyethylene glycol |
US3994870A (en) * | 1974-01-31 | 1976-11-30 | The Community Blood Council Of Greater New York, Inc. | Purification of hepatitis B surface antigen |
JPS5417002B2 (es) * | 1974-02-18 | 1979-06-27 | ||
DE2611723C3 (de) * | 1976-03-19 | 1978-09-21 | The Green Cross Corp., Osaka (Japan) | Verfahren zur Herstellung von einheitlichen kugelförmigen HBsAg-Teilchen |
US4057628A (en) * | 1976-04-19 | 1977-11-08 | William L. Wilson | Removal of hepatitis associated antigen from plasma |
JPS5840930B2 (ja) * | 1976-09-20 | 1983-09-08 | 株式会社ミドリ十字 | B型肝炎ワクチンの製造方法 |
US4162192A (en) * | 1978-09-28 | 1979-07-24 | Juridical Foundation | Method for purification of HBs antigen |
JPS5610119A (en) * | 1979-07-05 | 1981-02-02 | Alpha Therapeutic Corp | Manufacture of b type hepatitis infection preventive vaccine |
FR2470795A1 (fr) * | 1979-12-07 | 1981-06-12 | Pasteur Institut | Procede de purification de particules d'origine biologique, notamment de l'antigene de surface du virus de l'hepatite b (aghbs) et les produits obtenus |
US4349539A (en) * | 1980-08-15 | 1982-09-14 | Merck & Co., Inc. | Separation of hepatitis B surface antigen |
US4314997A (en) * | 1980-10-06 | 1982-02-09 | Edward Shanbrom | Purification of plasma protein products |
DE3043857A1 (de) * | 1980-11-21 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii |
-
1982
- 1982-11-29 JP JP57210240A patent/JPS59101426A/ja active Granted
-
1983
- 1983-11-15 US US06/552,079 patent/US4565697A/en not_active Expired - Fee Related
- 1983-11-25 DE DE8383111821T patent/DE3377972D1/de not_active Expired
- 1983-11-25 EP EP83111821A patent/EP0112506B1/en not_active Expired
- 1983-11-28 ES ES527588A patent/ES527588A0/es active Granted
- 1983-11-28 CA CA000442088A patent/CA1217138A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0112506A3 (en) | 1985-05-22 |
JPH0585526B2 (es) | 1993-12-07 |
DE3377972D1 (en) | 1988-10-20 |
EP0112506B1 (en) | 1988-09-14 |
ES527588A0 (es) | 1985-06-16 |
CA1217138A (en) | 1987-01-27 |
US4565697A (en) | 1986-01-21 |
JPS59101426A (ja) | 1984-06-12 |
EP0112506A2 (en) | 1984-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |