BR0107618A - Pró-medicamentos solúveis em água de compostos de azol - Google Patents

Pró-medicamentos solúveis em água de compostos de azol

Info

Publication number
BR0107618A
BR0107618A BR0107618-3A BR0107618A BR0107618A BR 0107618 A BR0107618 A BR 0107618A BR 0107618 A BR0107618 A BR 0107618A BR 0107618 A BR0107618 A BR 0107618A
Authority
BR
Brazil
Prior art keywords
water
soluble
azole compounds
compounds
soluble prodrugs
Prior art date
Application number
BR0107618-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Yasutsugu Ueda
John D Matiskella
Jerzy Golik
Thomas W Hudyma
Chung-Pin Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0107618A publication Critical patent/BR0107618A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503Five-membered rings
    • C07F9/6506Five-membered rings having the nitrogen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polymerization Catalysts (AREA)
BR0107618-3A 2000-01-20 2001-01-16 Pró-medicamentos solúveis em água de compostos de azol BR0107618A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17716900P 2000-01-20 2000-01-20
US24996900P 2000-11-20 2000-11-20
PCT/US2001/001284 WO2001052852A1 (en) 2000-01-20 2001-01-16 Water soluble prodrugs of azole compounds

Publications (1)

Publication Number Publication Date
BR0107618A true BR0107618A (pt) 2002-11-12

Family

ID=26873001

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107618-3A BR0107618A (pt) 2000-01-20 2001-01-16 Pró-medicamentos solúveis em água de compostos de azol

Country Status (22)

Country Link
US (1) US6362172B2 (enExample)
EP (1) EP1284737B1 (enExample)
JP (1) JP3766804B2 (enExample)
KR (1) KR100748299B1 (enExample)
CN (1) CN1178665C (enExample)
AT (1) ATE300946T1 (enExample)
AU (1) AU782177C (enExample)
BR (1) BR0107618A (enExample)
CA (1) CA2397734C (enExample)
CZ (1) CZ20022822A3 (enExample)
DE (1) DE60112433T2 (enExample)
DK (1) DK1284737T5 (enExample)
ES (1) ES2247131T3 (enExample)
HU (1) HU229226B1 (enExample)
IL (2) IL150798A0 (enExample)
MX (1) MXPA02007120A (enExample)
NO (1) NO330352B1 (enExample)
NZ (1) NZ519354A (enExample)
PL (1) PL206024B1 (enExample)
PT (1) PT1284737E (enExample)
RU (1) RU2266909C2 (enExample)
WO (1) WO2001052852A1 (enExample)

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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US8178671B2 (en) 2003-07-30 2012-05-15 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1856135B1 (en) 2005-01-19 2009-12-09 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
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DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
WO2007072851A1 (ja) * 2005-12-20 2007-06-28 Eisai R & D Management Co., Ltd. 水溶性アゾールプロドラッグの製造方法
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UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
KR20110067096A (ko) 2008-09-10 2011-06-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 및 관련 상태를 치료하기 위한 병용 요법
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA022310B1 (ru) 2008-12-23 2015-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Солевые формы органического соединения
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
BR112012012641A2 (pt) 2009-11-27 2020-08-11 Boehringer Ingelheim International Gmbh TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA
KR101927068B1 (ko) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
CA2803504C (en) 2010-06-24 2022-08-30 Boehringer Ingelheim International Gmbh A combination for diabetes therapy comprising linagliptin and a long-acting insulin
EP2636409A1 (en) 2010-11-05 2013-09-11 Eisai R&D Management Co., Ltd. Combined pharmaceutical composition as antifungal agent
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
BR112013015085A8 (pt) * 2010-12-16 2018-04-03 Univ Texas Composição farmacêutica, método para preparar uma composição, e, uso de composição
BR112013033239A2 (pt) 2011-06-22 2016-09-06 Vyome Biosciences pró-farmácos de conjugado baseado em atifungicos e antibacterianos
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
CN104136427B (zh) 2012-01-20 2017-03-01 威尔金制药有限公司 金属酶抑制剂化合物
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
SG11201406097SA (en) * 2012-04-20 2014-11-27 Eisai R&D Man Co Ltd Capsule formulation
EP4151218A1 (en) 2012-05-14 2023-03-22 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
CA2914583C (en) 2013-06-04 2019-06-18 Vyome Biosciences Pvt. Ltd. Coated particles and compositions comprising same
MX394441B (es) 2014-01-29 2025-03-24 Vyome Therapeutics Ltd Una formulación a base de besifloxacina para usarse en el tratamiento del acné resistente a fármacos
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Dpp−4阻害薬の医学的使用
CN104926870B (zh) * 2014-03-21 2017-02-08 合肥久诺医药科技有限公司 一种福司氟康唑的精制方法
KR20180072665A (ko) * 2015-07-28 2018-06-29 베타 캐트 파마슈티칼스, 인코포레이티드 안트라센-9,10-디온 디옥심 화합물 전구약물 및 이의 용도
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Also Published As

Publication number Publication date
IL150798A (en) 2006-08-01
DK1284737T5 (da) 2007-09-24
HUP0204405A2 (en) 2003-05-28
DK1284737T3 (da) 2005-11-28
NO20023468D0 (no) 2002-07-19
ATE300946T1 (de) 2005-08-15
AU782177C (en) 2007-10-18
EP1284737B1 (en) 2005-08-03
CN1178665C (zh) 2004-12-08
ES2247131T3 (es) 2006-03-01
HU229226B1 (en) 2013-09-30
AU2948501A (en) 2001-07-31
JP3766804B2 (ja) 2006-04-19
US20010041691A1 (en) 2001-11-15
HUP0204405A3 (en) 2005-02-28
KR20020070492A (ko) 2002-09-09
NZ519354A (en) 2004-05-28
KR100748299B1 (ko) 2007-08-09
NO330352B1 (no) 2011-04-04
EP1284737A4 (en) 2003-03-19
MXPA02007120A (es) 2003-01-28
CN1395485A (zh) 2003-02-05
IL150798A0 (en) 2003-02-12
PL206024B1 (pl) 2010-06-30
DE60112433T2 (de) 2006-05-18
CA2397734A1 (en) 2001-07-26
JP2003520235A (ja) 2003-07-02
PL356164A1 (en) 2004-06-14
EP1284737A1 (en) 2003-02-26
NO20023468L (no) 2002-07-29
CZ20022822A3 (cs) 2003-02-12
WO2001052852A1 (en) 2001-07-26
DE60112433D1 (de) 2005-09-08
RU2266909C2 (ru) 2005-12-27
AU782177B2 (en) 2005-07-07
US6362172B2 (en) 2002-03-26
PT1284737E (pt) 2005-11-30
CA2397734C (en) 2010-08-17

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B25A Requested transfer of rights approved

Owner name: EISAI CO., LTD. (JP)

Free format text: TRANSFERIDO DE: BRISTOL-MYERS SQUIBB COMPANY

B25A Requested transfer of rights approved

Owner name: EISAI RANDD MANAGEMENT CO., LTD. (JP)

Free format text: TRANSFERIDO DE: EISAI CO., LTD.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]