BR0103412A - Processo para fabricação de (all-rac)-alfa-tocoferol - Google Patents

Processo para fabricação de (all-rac)-alfa-tocoferol

Info

Publication number
BR0103412A
BR0103412A BR0103412-0A BR0103412A BR0103412A BR 0103412 A BR0103412 A BR 0103412A BR 0103412 A BR0103412 A BR 0103412A BR 0103412 A BR0103412 A BR 0103412A
Authority
BR
Brazil
Prior art keywords
rac
tocopherol
alpha
acid
manufacturing
Prior art date
Application number
BR0103412-0A
Other languages
English (en)
Inventor
Werner Bonrath
Alois Haas
Eike Hoppmann
Horst Pauling
Original Assignee
Roche Vitamins Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Vitamins Ag filed Critical Roche Vitamins Ag
Publication of BR0103412A publication Critical patent/BR0103412A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: "PROCESSO PARA FABRICAçãO DE (ALL-RAC)-ALFA-TOCOFEROL". Um processo para a fabricação de (ali-rac)-a-tocoferoi pela reação catalisada de trimetilhidroquinona com isofitol ou fitoi caracterizado pela execução da reação na presença de uma bis(perfluorinado hidrocarbil sulfonil)imida ou um seu sal de metal como catalisador em um solvente orgânico. Pode ser utilizado como um co-catalisador, junto com o citado sal de metal, um ácido de Bronsted, por exemplo ácido sulfúrico, ácido fosfórico ou ácido p-toluenossulfónico. O produto do processo é o membro mais ativo do grupo da vitamina E.
BR0103412-0A 2000-08-18 2001-08-16 Processo para fabricação de (all-rac)-alfa-tocoferol BR0103412A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00117761 2000-08-18

Publications (1)

Publication Number Publication Date
BR0103412A true BR0103412A (pt) 2002-03-26

Family

ID=8169565

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0103412-0A BR0103412A (pt) 2000-08-18 2001-08-16 Processo para fabricação de (all-rac)-alfa-tocoferol

Country Status (11)

Country Link
US (1) US6482961B2 (pt)
EP (1) EP1180517B1 (pt)
JP (1) JP2002128775A (pt)
KR (1) KR20020014769A (pt)
CN (1) CN1182131C (pt)
AT (1) ATE246181T1 (pt)
BR (1) BR0103412A (pt)
CA (1) CA2354997A1 (pt)
DE (1) DE60100528T2 (pt)
DK (1) DK1180517T3 (pt)
ES (1) ES2204792T3 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4508642B2 (ja) * 2001-12-14 2010-07-21 ディーエスエム アイピー アセッツ ビー．ブイ． トリメチルヒドロキノンジアシレートの製造
AU2003210291A1 (en) * 2002-02-25 2003-09-09 Dsm Ip Assets B.V. MANUFACTURE OF (ALL-RAC)-Alpha-TOCOPHEROL
DE10393642B4 (de) * 2002-11-21 2017-03-30 Dsm Ip Assets B.V. Herstellung von α-Tocopherol
DE102004038800A1 (de) 2003-08-13 2005-03-31 Dsm Ip Assets B.V. Herstellung von Tocol, Tocolderivaten und Tocopherolen
JP4493393B2 (ja) * 2004-04-23 2010-06-30 東京応化工業株式会社 リソグラフィー用リンス液
US9958363B2 (en) * 2014-06-23 2018-05-01 Agilent Technologies, Inc. Fluorous affinity extraction for ionic liquid-based sample preparation
CN109529902B (zh) * 2018-11-30 2021-08-17 西安凯立新材料股份有限公司 一种高稳定的钯镍炭催化剂催化合成维生素e中间体的方法
CN111646968B (zh) * 2020-05-28 2022-04-22 万华化学集团股份有限公司 一种制备维生素e的方法
CN113083339B (zh) * 2021-04-15 2022-11-08 万华化学(四川)有限公司 一种用于制备维生素e的催化剂及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273840A (en) 1990-08-01 1993-12-28 Covalent Associates Incorporated Methide salts, formulations, electrolytes and batteries formed therefrom
JP3848380B2 (ja) 1993-12-14 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 α−トコフェロール誘導体の製造法
US5554664A (en) 1995-03-06 1996-09-10 Minnesota Mining And Manufacturing Company Energy-activatable salts with fluorocarbon anions
US5908939A (en) * 1996-11-11 1999-06-01 Roche Vitamins Inc. Method of making D,L-A-tocopherol
EP0949255B1 (en) 1998-04-06 2006-05-24 DSM IP Assets B.V. Process for manufacturing d, l-alpha-tocopherol in a carbonate solvent and in the presence of a sulphur-containing acid catalyst
EP1000940A1 (en) * 1998-11-11 2000-05-17 F. Hoffmann-La Roche Ag Process for manufacturing d,l-alpha-tocopherol

Also Published As

Publication number Publication date
ES2204792T3 (es) 2004-05-01
DE60100528T2 (de) 2004-04-15
US20020072619A1 (en) 2002-06-13
CN1339437A (zh) 2002-03-13
CA2354997A1 (en) 2002-02-18
JP2002128775A (ja) 2002-05-09
KR20020014769A (ko) 2002-02-25
EP1180517B1 (en) 2003-07-30
CN1182131C (zh) 2004-12-29
ATE246181T1 (de) 2003-08-15
EP1180517A1 (en) 2002-02-20
DE60100528D1 (de) 2003-09-04
DK1180517T3 (da) 2003-11-17
US6482961B2 (en) 2002-11-19

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]