ATE246181T1 - Verfahren zur herstellung von (alle-rac)-alfa- tocopherol - Google Patents
Verfahren zur herstellung von (alle-rac)-alfa- tocopherolInfo
- Publication number
- ATE246181T1 ATE246181T1 AT01119322T AT01119322T ATE246181T1 AT E246181 T1 ATE246181 T1 AT E246181T1 AT 01119322 T AT01119322 T AT 01119322T AT 01119322 T AT01119322 T AT 01119322T AT E246181 T1 ATE246181 T1 AT E246181T1
- Authority
- AT
- Austria
- Prior art keywords
- rac
- tocopherol
- acid
- alle
- alfa
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229960001295 tocopherol Drugs 0.000 title 1
- 239000011732 tocopherol Substances 0.000 title 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002184 metal Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000001707 (E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol Substances 0.000 abstract 1
- AUFZRCJENRSRLY-UHFFFAOYSA-N 2,3,5-trimethylhydroquinone Chemical compound CC1=CC(O)=C(C)C(C)=C1O AUFZRCJENRSRLY-UHFFFAOYSA-N 0.000 abstract 1
- 239000007848 Bronsted acid Substances 0.000 abstract 1
- KEVYVLWNCKMXJX-ZCNNSNEGSA-N Isophytol Natural products CC(C)CCC[C@H](C)CCC[C@@H](C)CCC[C@@](C)(O)C=C KEVYVLWNCKMXJX-ZCNNSNEGSA-N 0.000 abstract 1
- BLUHKGOSFDHHGX-UHFFFAOYSA-N Phytol Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C=CO BLUHKGOSFDHHGX-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- HNZBNQYXWOLKBA-UHFFFAOYSA-N Tetrahydrofarnesol Natural products CC(C)CCCC(C)CCCC(C)=CCO HNZBNQYXWOLKBA-UHFFFAOYSA-N 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- BOTWFXYSPFMFNR-OALUTQOASA-N all-rac-phytol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)=CCO BOTWFXYSPFMFNR-OALUTQOASA-N 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00117761 | 2000-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246181T1 true ATE246181T1 (de) | 2003-08-15 |
Family
ID=8169565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01119322T ATE246181T1 (de) | 2000-08-18 | 2001-08-10 | Verfahren zur herstellung von (alle-rac)-alfa- tocopherol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6482961B2 (de) |
| EP (1) | EP1180517B1 (de) |
| JP (1) | JP2002128775A (de) |
| KR (1) | KR20020014769A (de) |
| CN (1) | CN1182131C (de) |
| AT (1) | ATE246181T1 (de) |
| BR (1) | BR0103412A (de) |
| CA (1) | CA2354997A1 (de) |
| DE (1) | DE60100528T2 (de) |
| DK (1) | DK1180517T3 (de) |
| ES (1) | ES2204792T3 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100374408C (zh) * | 2001-12-14 | 2008-03-12 | Dsmip资产有限公司 | 三甲基氢醌二酰化物的制备 |
| WO2003070718A1 (en) * | 2002-02-25 | 2003-08-28 | Dsm Ip Assets B.V. | MANUFACTURE OF (ALL-RAC)-α-TOCOPHEROL |
| AU2003270295A1 (en) * | 2002-11-21 | 2004-06-15 | Dsm Ip Assets B.V. | MANUFACTURE OF Alpha-TOCOPHEROL |
| DE102004038800A1 (de) | 2003-08-13 | 2005-03-31 | Dsm Ip Assets B.V. | Herstellung von Tocol, Tocolderivaten und Tocopherolen |
| JP4493393B2 (ja) * | 2004-04-23 | 2010-06-30 | 東京応化工業株式会社 | リソグラフィー用リンス液 |
| US9958363B2 (en) * | 2014-06-23 | 2018-05-01 | Agilent Technologies, Inc. | Fluorous affinity extraction for ionic liquid-based sample preparation |
| JP7082984B2 (ja) * | 2017-02-20 | 2022-06-09 | ノヴァレッド ゲーエムベーハー | 電子半導体デバイスおよびその電子半導体デバイスの製造方法および化合物 |
| CN109529902B (zh) * | 2018-11-30 | 2021-08-17 | 西安凯立新材料股份有限公司 | 一种高稳定的钯镍炭催化剂催化合成维生素e中间体的方法 |
| CN111646968B (zh) * | 2020-05-28 | 2022-04-22 | 万华化学集团股份有限公司 | 一种制备维生素e的方法 |
| CN113083339B (zh) * | 2021-04-15 | 2022-11-08 | 万华化学(四川)有限公司 | 一种用于制备维生素e的催化剂及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273840A (en) | 1990-08-01 | 1993-12-28 | Covalent Associates Incorporated | Methide salts, formulations, electrolytes and batteries formed therefrom |
| JP3848380B2 (ja) | 1993-12-14 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | α−トコフェロール誘導体の製造法 |
| US5554664A (en) | 1995-03-06 | 1996-09-10 | Minnesota Mining And Manufacturing Company | Energy-activatable salts with fluorocarbon anions |
| US5908939A (en) * | 1996-11-11 | 1999-06-01 | Roche Vitamins Inc. | Method of making D,L-A-tocopherol |
| ES2264230T3 (es) | 1998-04-06 | 2006-12-16 | Dsm Ip Assets B.V. | Procedimiento par ala obtencion de d,1-alfa-tocoferol, en un disolvente de carbonato y en presencia de un catalizador de acido conteniendo azufre. |
| EP1000940A1 (de) * | 1998-11-11 | 2000-05-17 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von d,l-alpha-Tocopherol |
-
2001
- 2001-08-10 DE DE60100528T patent/DE60100528T2/de not_active Expired - Lifetime
- 2001-08-10 AT AT01119322T patent/ATE246181T1/de not_active IP Right Cessation
- 2001-08-10 EP EP01119322A patent/EP1180517B1/de not_active Expired - Lifetime
- 2001-08-10 ES ES01119322T patent/ES2204792T3/es not_active Expired - Lifetime
- 2001-08-10 DK DK01119322T patent/DK1180517T3/da active
- 2001-08-13 CA CA002354997A patent/CA2354997A1/en not_active Abandoned
- 2001-08-16 US US09/931,663 patent/US6482961B2/en not_active Expired - Lifetime
- 2001-08-16 BR BR0103412-0A patent/BR0103412A/pt not_active Application Discontinuation
- 2001-08-16 JP JP2001246843A patent/JP2002128775A/ja not_active Withdrawn
- 2001-08-17 CN CNB011255951A patent/CN1182131C/zh not_active Expired - Lifetime
- 2001-08-17 KR KR1020010049669A patent/KR20020014769A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1339437A (zh) | 2002-03-13 |
| DK1180517T3 (da) | 2003-11-17 |
| JP2002128775A (ja) | 2002-05-09 |
| DE60100528D1 (de) | 2003-09-04 |
| US6482961B2 (en) | 2002-11-19 |
| DE60100528T2 (de) | 2004-04-15 |
| CN1182131C (zh) | 2004-12-29 |
| EP1180517B1 (de) | 2003-07-30 |
| KR20020014769A (ko) | 2002-02-25 |
| BR0103412A (pt) | 2002-03-26 |
| EP1180517A1 (de) | 2002-02-20 |
| US20020072619A1 (en) | 2002-06-13 |
| ES2204792T3 (es) | 2004-05-01 |
| CA2354997A1 (en) | 2002-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE246181T1 (de) | Verfahren zur herstellung von (alle-rac)-alfa- tocopherol | |
| ATE353081T1 (de) | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten | |
| DE60127343D1 (de) | Kontinuierliches Verfahren zur Herstellung von Wasserstoffperoxid in organischen Lösungsmitteln, wobei die Konzentration an Wasserstoff kleiner als 4,5>%Vol. und die Konzentration von Sauerstoff kleiner als 21,5 %Vol. beträgt. | |
| DE69911016D1 (de) | Verfahren zur herstellung einer wässrigen monoester percarbonsäurelösung | |
| ATE251148T1 (de) | Verfahren zur herstellung von (all-rac)-alpha- tocopherol | |
| DE60112837D1 (de) | Verfahren zur Herstellung von 1-Menthol | |
| ATE437863T1 (de) | Herstellung von alphahydroxyketonen | |
| ATE312070T1 (de) | Verfahren zur herstellung von polyisocyanaten der diphenylmethanreihe mit vermindertem farbwert | |
| DE60014088D1 (de) | Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten | |
| ATE322499T1 (de) | Verfahren zur herstellung von 2-keto-l-gulonsäure-c-4 c-10 /sb -alkylestern | |
| DE50204071D1 (de) | Verfahren zur Herstellung von Metallformat-Ameisensäure-Mischungen | |
| ATE342247T1 (de) | Verfahren zur alkylierung von salicylsäure | |
| RU2008108096A (ru) | Способ получения 4,4'-дифторбензофенона | |
| ATE250596T1 (de) | Herstellung von (all-rac)-alpha-tocopherol | |
| ATE532764T1 (de) | Herstellung von trimethylhydrochinondiacylaten | |
| ATE219489T1 (de) | Verfahren zur herstellung von 5-carboxyphthalid | |
| DE60104394D1 (de) | Verfahren zur herstellung von quinolylacrylonitrilen and deren zwischenprodukten | |
| ATE519726T1 (de) | Verbessertes verfahren zur herstellung von polyphenolen | |
| ATE411257T1 (de) | Verfahren zur herstellung von wasserstoffperoxid | |
| ATE480511T1 (de) | Verfahren zur herstellung von 2,7-dimethyl-octa-2,4,6-triendial | |
| BR9815616A (pt) | Processo para fabricação de ésteres de 1,3-propanodiol e processo aperfeiçoado para produção éster através da reação de prins | |
| ATE427306T1 (de) | Verfahren zur herstellung von escitalopram | |
| ATE323172T1 (de) | Herstellung von l-ascorbinsäure und d- erythorbinsäure | |
| ATE268321T1 (de) | Kontinuierliches isothermes verfahren zur herstellung von mononitrotoluolen in gegenwart vor phosphorsäure | |
| ATE387433T1 (de) | Verfahren zur herstellung von propylenoxid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |