BR0015419A - Complexo contendo ácido nucleico, composição farmacêutica, e , métodos para controlar uma taxa de liberação de ácido nucleico, e para aumentar a função de um ácido nucleico, célula fagocìtica, e, métodos para exibir uma função de um ácido nucleico em um sìtio alvo, e para tratar uma doença ou distúrbio - Google Patents

Complexo contendo ácido nucleico, composição farmacêutica, e , métodos para controlar uma taxa de liberação de ácido nucleico, e para aumentar a função de um ácido nucleico, célula fagocìtica, e, métodos para exibir uma função de um ácido nucleico em um sìtio alvo, e para tratar uma doença ou distúrbio

Info

Publication number
BR0015419A
BR0015419A BR0015419-9A BR0015419A BR0015419A BR 0015419 A BR0015419 A BR 0015419A BR 0015419 A BR0015419 A BR 0015419A BR 0015419 A BR0015419 A BR 0015419A
Authority
BR
Brazil
Prior art keywords
nucleic acid
function
complex
methods
target site
Prior art date
Application number
BR0015419-9A
Other languages
English (en)
Inventor
Hidezo Mori
Yasuhiko Tabata
Kiyoshi Ando
Etsuro Tanaka
Harukazu Iseki
Hiromi Sakamoto
Naoto Fukuyama
Hirofumi Kasahara
Original Assignee
Cmic Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cmic Co Ltd filed Critical Cmic Co Ltd
Publication of BR0015419A publication Critical patent/BR0015419A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

"COMPLEXO CONTENDO áCIDO NUCLEICO, COMPOSIçãO FARMACêUTICA, E, MéTODOS PARA CONTROLAR UMA TAXA DE LIBERAçãO DE áCIDO NUCLEICO, E PARA AUMENTAR A FUNçãO DE UM áCIDO NUCLEICO CéLULA FAGOCìTICA E, MéTODOS PARA EXIBIR UMA FUNçãO DE UM áCIDO NUCLEICO EM UM SìTIO ALVO E PARA TRATAR UMA DOENçA OU DISTúRBIO". é descrito um complexo contendo ácido nucleico, contendo um ácido nucleico e um polímero biodegradável, especialmente um polímero biodegradável insolúvel em água positivamente carregado. O complexo tem as excelentes propriedades de sustentavelmente liberar um ácido nucleico, especialmente DNA, para um sítio em necessidade de tratamento. Uma vez que o complexo pode ser acomodado em fagócitos tais como macrófagos e distribuído especificamente para o sítio alvo, a função do ácido nucleico pode ser exibida em uma maneira específica de sítio alvo e, assim, terapia de gene mais específica pode ser conseguida. O complexo não tem efeitos adversos, tais como ocorrência de recombinantes ou toxicidade, que poderia ser causada pela utilização de um vetor de vírus, tal como adenovírus, ou lipossoma. Assim, o complexo é particularmente preferível para o campo da terapia de gene. Além disso, o complexo aumenta o efeito biológico do ácido nucleico introduzido dentro das células, permitindo uma terapia de gene com uma mais baixa dose de ácidos nucleicos.
BR0015419-9A 1999-11-09 2000-11-09 Complexo contendo ácido nucleico, composição farmacêutica, e , métodos para controlar uma taxa de liberação de ácido nucleico, e para aumentar a função de um ácido nucleico, célula fagocìtica, e, métodos para exibir uma função de um ácido nucleico em um sìtio alvo, e para tratar uma doença ou distúrbio BR0015419A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31818799 1999-11-09
JP2000278878A JP2001199903A (ja) 1999-11-09 2000-09-13 核酸含有複合体
PCT/JP2000/007882 WO2001034206A2 (en) 1999-11-09 2000-11-09 Nucleic acid-containing complex

Publications (1)

Publication Number Publication Date
BR0015419A true BR0015419A (pt) 2002-07-02

Family

ID=26569281

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015419-9A BR0015419A (pt) 1999-11-09 2000-11-09 Complexo contendo ácido nucleico, composição farmacêutica, e , métodos para controlar uma taxa de liberação de ácido nucleico, e para aumentar a função de um ácido nucleico, célula fagocìtica, e, métodos para exibir uma função de um ácido nucleico em um sìtio alvo, e para tratar uma doença ou distúrbio

Country Status (11)

Country Link
US (2) US7276594B1 (pt)
EP (1) EP1229941A2 (pt)
JP (1) JP2001199903A (pt)
KR (1) KR100873593B1 (pt)
CN (1) CN100417418C (pt)
AU (1) AU1303401A (pt)
BR (1) BR0015419A (pt)
CA (1) CA2389506A1 (pt)
IL (2) IL149491A0 (pt)
TW (1) TWI267380B (pt)
WO (1) WO2001034206A2 (pt)

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WO2012129767A1 (zh) * 2011-03-28 2012-10-04 南京大学 阳离子修饰的琼脂糖水凝胶和核酸药物组合物及制法和应用
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BR112014030962A2 (pt) 2012-06-12 2017-06-27 Ferrosan Medical Devices As métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
WO2016058612A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
WO2016102446A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
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Also Published As

Publication number Publication date
WO2001034206A8 (en) 2001-07-26
CN100417418C (zh) 2008-09-10
KR100873593B1 (ko) 2008-12-11
US20090203768A1 (en) 2009-08-13
EP1229941A2 (en) 2002-08-14
CN1390141A (zh) 2003-01-08
US7276594B1 (en) 2007-10-02
WO2001034206A3 (en) 2002-02-07
IL149491A (en) 2008-04-13
CA2389506A1 (en) 2001-05-17
AU1303401A (en) 2001-06-06
JP2001199903A (ja) 2001-07-24
IL149491A0 (en) 2002-11-10
WO2001034206A2 (en) 2001-05-17
KR20020060733A (ko) 2002-07-18
TWI267380B (en) 2006-12-01

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 47/64 (2017.01)