BR0013905A - Uso de um ingrediente ativo, composição farmacêutica, métodos para induzir secreção g-csf dentro do corpo de um indivìduo, para tratamento terapêutico, para induzir a proliferação ou diferenciação de medula óssea ou células brancas do sangue em um indivìduo, para a prevenção ou tratamento de leucopenia, para a prevenção ou tratamento de efeitos colaterais tóxicos de uma droga, para inibir o crescimento anormal de células, para o tratamento de câncer, e, uso de a3rag - Google Patents

Uso de um ingrediente ativo, composição farmacêutica, métodos para induzir secreção g-csf dentro do corpo de um indivìduo, para tratamento terapêutico, para induzir a proliferação ou diferenciação de medula óssea ou células brancas do sangue em um indivìduo, para a prevenção ou tratamento de leucopenia, para a prevenção ou tratamento de efeitos colaterais tóxicos de uma droga, para inibir o crescimento anormal de células, para o tratamento de câncer, e, uso de a3rag

Info

Publication number
BR0013905A
BR0013905A BR0013905-0A BR0013905A BR0013905A BR 0013905 A BR0013905 A BR 0013905A BR 0013905 A BR0013905 A BR 0013905A BR 0013905 A BR0013905 A BR 0013905A
Authority
BR
Brazil
Prior art keywords
treatment
prevention
individual
inducing
drug
Prior art date
Application number
BR0013905-0A
Other languages
English (en)
Inventor
Pnina Fishman
Original Assignee
Can Fite Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13186499A external-priority patent/IL131864A0/xx
Application filed by Can Fite Biopharma Ltd filed Critical Can Fite Biopharma Ltd
Publication of BR0013905A publication Critical patent/BR0013905A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"USO DE UM INGREDIENTE ATIVO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA INDUZIR SECREçãO G-CSF DENTRO DO CORPO DE UM INDIVìDUO, PARA TRATAMENTO TERAPêUTICO, PARA INDUZIR A PROLIFERAçãO OU DIFERENCIAçãO DE MEDULA óSSEA OU CéLULAS BRANCAS DO SANGUE EM UM INDIVìDUO, PARA A PREVENçãO OU TRATAMENTO DE LEUCOPENIA, PARA A PREVENçãO OU TRATAMENTO DE EFEITOS COLATERAIS TóXICOS DE UMA DROGA, PARA INIBIR O CRESCIMENTO ANORMAL DE CéLULAS, PARA O TRATAMENTO DE CâNCER, E, USO DE A3RAG". Agonistas de receptor de adenosina, particularmente um agonista que liga o receptor de adenosina A3, são usados para indução de produção ou secreção de G-CSF dentro do corpo, prevenção ou tratamento de efeitos colaterais tóxicos de uma droga ou prevenção ou tratamento de leucopenia, particularmente leucopenias induzidas por drogas, e inibição de proliferação e crescimento anormal de células.
BR0013905-0A 1999-09-10 2000-09-08 Uso de um ingrediente ativo, composição farmacêutica, métodos para induzir secreção g-csf dentro do corpo de um indivìduo, para tratamento terapêutico, para induzir a proliferação ou diferenciação de medula óssea ou células brancas do sangue em um indivìduo, para a prevenção ou tratamento de leucopenia, para a prevenção ou tratamento de efeitos colaterais tóxicos de uma droga, para inibir o crescimento anormal de células, para o tratamento de câncer, e, uso de a3rag BR0013905A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL13186499A IL131864A0 (en) 1999-09-10 1999-09-10 Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
IL13368099A IL133680A0 (en) 1999-09-10 1999-12-23 Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
PCT/IL2000/000550 WO2001019360A2 (en) 1999-09-10 2000-09-08 Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist

Publications (1)

Publication Number Publication Date
BR0013905A true BR0013905A (pt) 2003-07-15

Family

ID=26323880

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013905-0A BR0013905A (pt) 1999-09-10 2000-09-08 Uso de um ingrediente ativo, composição farmacêutica, métodos para induzir secreção g-csf dentro do corpo de um indivìduo, para tratamento terapêutico, para induzir a proliferação ou diferenciação de medula óssea ou células brancas do sangue em um indivìduo, para a prevenção ou tratamento de leucopenia, para a prevenção ou tratamento de efeitos colaterais tóxicos de uma droga, para inibir o crescimento anormal de células, para o tratamento de câncer, e, uso de a3rag

Country Status (19)

Country Link
US (2) US7064112B1 (pt)
EP (1) EP1261322B1 (pt)
JP (2) JP4980530B2 (pt)
KR (2) KR100584797B1 (pt)
CN (1) CN100358512C (pt)
AU (1) AU782826B2 (pt)
BR (1) BR0013905A (pt)
CA (1) CA2384111C (pt)
DE (1) DE60037277T2 (pt)
DK (1) DK1261322T3 (pt)
ES (1) ES2296637T3 (pt)
HK (1) HK1052653B (pt)
HU (1) HU226913B1 (pt)
IL (1) IL133680A0 (pt)
MX (1) MXPA02002546A (pt)
PL (1) PL199852B1 (pt)
PT (1) PT1261322E (pt)
RU (1) RU2239455C2 (pt)
WO (1) WO2001019360A2 (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121272A (en) * 1997-07-10 2000-06-01 Can Fite Technologies Ltd Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia
CN1234358C (zh) 2000-06-21 2006-01-04 弗·哈夫曼-拉罗切有限公司 苯并噻唑衍生物
CA2434906C (en) * 2001-01-16 2008-08-19 Can-Fite Biopharma Ltd. Use of an adenosine a3 receptor agonist for inhibition of viral replication
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
US20040204481A1 (en) * 2001-04-12 2004-10-14 Pnina Fishman Activation of natural killer cells by adenosine A3 receptor agonists
US7049303B2 (en) 2001-11-07 2006-05-23 Medical Research Council Inhibition of viruses
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
US20040137477A1 (en) * 2002-10-22 2004-07-15 Can-Fite Biopharma, Ltd. A3AR as a marker for a diseased state
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
DK1753760T3 (da) 2004-05-24 2008-04-14 Hoffmann La Roche 4-hydroxy-4-methyl-piperidin-1-carboxylsyre-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amid
ES2343421T3 (es) 2004-05-26 2010-07-30 Inotek Pharmaceuticals Corporation Derivados de purina como agonistas de los receptores a1 de adenosina y metodos de uso de los mismos.
US7825102B2 (en) 2004-07-28 2010-11-02 Can-Fite Biopharma Ltd. Treatment of dry eye conditions
CN101437526A (zh) 2004-09-20 2009-05-20 伊诺泰克制药公司 嘌呤衍生物及其用法
CA2586931C (en) 2004-11-05 2013-08-06 Paul Spurr Process for preparation of isonicotinic acid derivatives
CN101072554A (zh) * 2004-11-08 2007-11-14 坎-菲特生物药物有限公司 对于加速性骨再吸收的治疗
WO2007040565A2 (en) * 2004-11-22 2007-04-12 King Pharmaceuticals Research & Development, Inc. Enhancing treatment of cancer and hif-1 mediated disoders with adenosine a3 receptor antagonists
PT1863818E (pt) 2005-03-23 2010-04-09 Hoffmann La Roche Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2
KR101121292B1 (ko) 2005-09-27 2012-04-13 에프. 호프만-라 로슈 아게 Mglur2 길항제로서 옥사다이아졸일 피라졸로-피리미딘
NZ568392A (en) 2005-11-30 2011-07-29 Inotek Pharmaceuticals Corp Purine derivatives and methods of use thereof
CN101365430B (zh) * 2006-01-27 2011-09-21 坎-菲特生物药物有限公司 用于治疗干眼病的腺苷a3受体激动剂
WO2008023362A2 (en) * 2006-08-21 2008-02-28 Can-Fite Biopharma Ltd. Use of a combination of methotrexate and an a3ar agonist for the treatment of cancer
CA2665616A1 (en) * 2006-10-06 2008-04-17 The Trustees Of The University Of Pennsylvania Effective delivery of cross-species a3 adenosine-receptor antagonists toreduce intraocular pressure
GB0625100D0 (en) * 2006-12-15 2007-01-24 Univ Murcia Epigallocatechin-3-gallate compositions for cancer therapy and chemoprotection
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
EP2178370A4 (en) * 2007-07-17 2011-01-12 Zalicus Inc COMBINATIONS FOR THE TREATMENT OF PROLIFERATIVE B-CELL DISEASES
BRPI0813516A2 (pt) * 2007-07-17 2014-12-30 Combinatorx Inc Tratamento de distúrbios proliferativos de células b
WO2009151569A2 (en) * 2008-06-09 2009-12-17 Combinatorx, Incorporated Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders
WO2010027935A1 (en) * 2008-09-08 2010-03-11 Merck Sharp & Dohme Corp. Ahcy hydrolase inhibitors for treatment of hyper homocysteinemia
AU2010250759B2 (en) 2009-05-17 2013-03-14 Can-Fite Biopharma Ltd. A3 adenosine receptor agonists for the reduction of intraocular pressure
US9199102B2 (en) 2009-07-21 2015-12-01 Oradin Pharmaceutical Ltd. A3 adenosine receptor ligands for modulation of pigmentation
US20120322815A1 (en) * 2009-12-17 2012-12-20 Ewha University-Industry Collaboration Foundation Pharmaceutical composition containing a3 adenosine receptor agonist
ES2613698T3 (es) 2010-01-11 2017-05-25 Inotek Pharmaceuticals Corporation Combinación, kit y método de reducción de la presión intraocular
KR20130072189A (ko) 2010-03-03 2013-07-01 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 레프리젠티드 바이 더 세크러터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비스즈 포도막염의 치료를 위한 a3ar 작동약
EP2569325A4 (en) 2010-03-26 2013-10-09 Inotek Pharmaceuticals Corp METHOD FOR REDUCING INTRAOCULAR PRESSURE IN HUMANS USING N6-CYCLOPENTYLADENOSINE (CPA) DERIVATIVES OR CPA PRODRUGS
US20130109645A1 (en) 2010-03-31 2013-05-02 The united States of America,as represented by Secretary,Dept.,of Health and Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
RS58099B1 (sr) 2011-12-22 2019-02-28 Alios Biopharma Inc Supstituisani nukleozidi, nukleotidi i njihovi analozi
JP2015504088A (ja) * 2012-01-23 2015-02-05 キャン−ファイト バイオファーマ リミテッドCan−Fite BioPharma Ltd. 肝疾患の治療
JP2015508751A (ja) 2012-01-26 2015-03-23 イノテック ファーマシューティカルズ コーポレイション [(2r,3s,4r,5r)−5−(6−(シクロペンチルアミノ)−9h−プリン−9−イル)−3,4−ジヒドロキシテトラヒドロフラン−2−イル]メチルナイトレートの無水多形体及びその製造方法
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US8822460B2 (en) 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
EP2875023B1 (en) 2012-07-19 2017-04-05 Janssen Pharmaceutica NV Octahydro-cyclopentapyrrolyl antagonists of ccr2
JP6140825B2 (ja) 2012-08-09 2017-05-31 キャン−ファイト バイオファーマ リミテッドCan−Fite BioPharma Ltd. 性機能不全の治療に使用するためのa3アデノシン受容体リガンド
AU2014239222A1 (en) 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation Ophthalmic formulations
IL242723B (en) 2015-11-23 2019-12-31 Can Fite Biopharma Ltd A3 adenosine receptor ligand for the treatment of ectopic fat accumulation
JP7109005B2 (ja) 2016-04-21 2022-07-29 アストロサイト ファーマシューティカルズ, インコーポレイテッド 神経学的状態および心血管状態を処置するための化合物および方法
IL254535A0 (en) 2017-09-17 2017-11-30 Can Fite Biopharma Ltd Adenosine a3 receptor ligand for use in the management of cytokine release syndrome
JP7311855B2 (ja) 2018-02-09 2023-07-20 アストロサイト ファーマシューティカルズ, インコーポレイテッド 嗜癖および関連する障害を処置するための化合物および方法
CA3113250A1 (en) 2018-09-26 2020-04-02 Astrocyte Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
IL264112A (en) 2019-01-06 2020-07-30 Fishman Pnina Adenosine a3 receptor ligand for use in lowering adipocyte levels

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
EP0708781B1 (en) * 1993-07-13 2001-10-04 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services A 3 adenosine receptor agonists
US5688774A (en) 1993-07-13 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
GB2289218A (en) * 1994-05-06 1995-11-15 Merck & Co Inc Inhibition of TNFalpha production with agonists of the A2b subtype of the adenosine receptor
RU2071770C1 (ru) 1994-12-14 1997-01-20 Владислав Алексеевич Шматко Способ лечения рака шейки матки и яичников
RU2071771C1 (ru) 1995-01-11 1997-01-20 Владислав Алексеевич Шматко Способ лечения рака молочной железы
AU750322B2 (en) * 1997-05-09 2002-07-18 Trustees Of The University Of Pennsylvania, The Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
IL121272A (en) * 1997-07-10 2000-06-01 Can Fite Technologies Ltd Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia
US6048865A (en) * 1997-07-29 2000-04-11 Medco Research, Inc. N6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator
CA2296485A1 (en) * 1997-07-29 1999-02-11 Medco Research, Inc. N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators
WO1999020284A1 (en) 1997-10-23 1999-04-29 Trustees Of The University Of Pennsylvania Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid a and adenosine receptor agents
AU4675699A (en) 1998-06-08 1999-12-30 Epigenesis Pharmaceuticals, Inc. Composition and method for prevention and treatment of cardiopulmonary and renal failure or damage associated with ischemia, endotoxin release, ards or brought about by administration of certain drugs
US6448253B1 (en) 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
IL127947A0 (en) * 1999-01-07 1999-11-30 Can Fite Technologies Ltd Pharmaceutical use of adenosine agonists
IL144188A0 (en) 1999-02-01 2002-05-23 Univ Virginia Compositions for treating inflammatory response
IL131096A (en) 1999-07-26 2004-09-27 Can Fite Technologies Ltd Method for preparing a composition derived from muscle tissue

Also Published As

Publication number Publication date
CN100358512C (zh) 2008-01-02
PL199852B1 (pl) 2008-11-28
KR100674529B1 (ko) 2007-01-30
KR20020038749A (ko) 2002-05-23
EP1261322B1 (en) 2007-11-28
US20060084626A1 (en) 2006-04-20
CA2384111A1 (en) 2001-03-22
EP1261322A2 (en) 2002-12-04
PT1261322E (pt) 2008-01-09
JP2007204496A (ja) 2007-08-16
ES2296637T3 (es) 2008-05-01
HK1052653B (zh) 2008-08-01
WO2001019360A3 (en) 2002-09-19
WO2001019360A2 (en) 2001-03-22
AU6863400A (en) 2001-04-17
DK1261322T3 (da) 2008-04-07
HU226913B1 (en) 2010-03-01
DE60037277D1 (de) 2008-01-10
RU2239455C2 (ru) 2004-11-10
JP2003514771A (ja) 2003-04-22
CA2384111C (en) 2008-05-27
HK1052653A1 (en) 2003-09-26
KR20060036490A (ko) 2006-04-28
HUP0203870A2 (hu) 2003-03-28
PL356469A1 (en) 2004-06-28
RU2002109228A (ru) 2004-01-10
US7064112B1 (en) 2006-06-20
IL133680A0 (en) 2001-04-30
AU782826B2 (en) 2005-09-01
DE60037277T2 (de) 2008-10-09
CN1391468A (zh) 2003-01-15
KR100584797B1 (ko) 2006-06-02
MXPA02002546A (es) 2003-07-21
HUP0203870A3 (en) 2005-07-28
JP4980530B2 (ja) 2012-07-18

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