BR0012129A - Derivados de naftiridina, processos para sua preparação, seu uso e composições farmacêuticas compreendendo-os - Google Patents

Derivados de naftiridina, processos para sua preparação, seu uso e composições farmacêuticas compreendendo-os

Info

Publication number
BR0012129A
BR0012129A BR0012129-0A BR0012129A BR0012129A BR 0012129 A BR0012129 A BR 0012129A BR 0012129 A BR0012129 A BR 0012129A BR 0012129 A BR0012129 A BR 0012129A
Authority
BR
Brazil
Prior art keywords
processes
compounds
cell
preparation
pharmaceutical compositions
Prior art date
Application number
BR0012129-0A
Other languages
English (en)
Inventor
Anuschirvan Peyman
Karlheinz Schueneumann
Thomas R Gadek
Jean-Francois Gourvest
Jean-Marie Ruxer
Original Assignee
Aventis Pharma Gmbh
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh, Genentech Inc filed Critical Aventis Pharma Gmbh
Publication of BR0012129A publication Critical patent/BR0012129A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE NAFTIRIDINA, PROCESSOS PARA SUA PREPARAçãO, SEU USO E COMPOSIçõES FARMACêUTICAS COMPREENDENDO-OS". A presente invenção diz respeito aos compostos da fórmula I, em que B, G, Z, X, Y, r, s e t têm os significados indicados nas reivindicações, seus sais fisiologicamente toleráveis e seus pró medicamentos. Os compostos da fórmula I são compostos farmacologicamente ativos valiosos. Eles são antagonistas de receptor de vitronectina e inibidores de adesão celular e são adequados para a terapia e profilaxia de doenças que são com base na interação entre os receptores de vitronectina e seus ligandos nos processos de interação de célula-célula ou célula-matriz ou que podem ser evitadas, amenizadas ou curadas mediante a influência de tais interações. Por exemplo, eles podem ser aplicados para inibir reabsorção óssea pelos osteoclastos e, dessa forma, para tratar e prevenir osteoporose, ou para inibir angiogênese indesejada ou proliferação de células da musculatura lisa vascular. Além disso, a invenção diz respeito aos processos para a preparação de compostos da fórmula I, seu uso, em particular como ingredientes ativos em farmacêuticos, e composições farmacêuticas compreendendo-os.
BR0012129-0A 1999-07-02 2000-06-26 Derivados de naftiridina, processos para sua preparação, seu uso e composições farmacêuticas compreendendo-os BR0012129A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99112636A EP1065207A1 (en) 1999-07-02 1999-07-02 Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
PCT/EP2000/005920 WO2001002398A1 (en) 1999-07-02 2000-06-26 Naphthyridine derivatives, processes for their preparation, their use and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
BR0012129A true BR0012129A (pt) 2002-05-07

Family

ID=8238482

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012129-0A BR0012129A (pt) 1999-07-02 2000-06-26 Derivados de naftiridina, processos para sua preparação, seu uso e composições farmacêuticas compreendendo-os

Country Status (33)

Country Link
US (2) US6743800B1 (pt)
EP (2) EP1065207A1 (pt)
JP (1) JP2003503496A (pt)
KR (1) KR20020015996A (pt)
CN (1) CN1160356C (pt)
AR (1) AR024622A1 (pt)
AT (1) ATE305471T1 (pt)
AU (1) AU775386B2 (pt)
BG (1) BG106257A (pt)
BR (1) BR0012129A (pt)
CA (1) CA2376668C (pt)
CZ (1) CZ20014605A3 (pt)
DE (2) DE60022890D1 (pt)
DK (1) DK1210348T3 (pt)
EA (1) EA004369B1 (pt)
EE (1) EE200100711A (pt)
ES (1) ES2250157T3 (pt)
HK (1) HK1050003B (pt)
HR (1) HRP20010946A2 (pt)
HU (1) HUP0203539A3 (pt)
IL (1) IL147248A0 (pt)
MX (1) MXPA01013435A (pt)
MY (1) MY133246A (pt)
NO (1) NO20016404L (pt)
NZ (1) NZ516058A (pt)
PL (1) PL352280A1 (pt)
SK (1) SK19132001A3 (pt)
TR (1) TR200103856T2 (pt)
TW (1) TW593319B (pt)
UA (1) UA73133C2 (pt)
WO (1) WO2001002398A1 (pt)
YU (1) YU92201A (pt)
ZA (1) ZA200200016B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1065207A1 (en) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
DE10042655A1 (de) 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
FR2847254B1 (fr) 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
EP1657240A4 (en) * 2003-08-18 2009-04-08 Fujifilm Finechemicals Co Ltd PYRIDYLTETRAHYDROPYRIDINE, PYRIDYLPIPERIDINE AND METHOD FOR THE PRODUCTION THEREOF
FR2870541B1 (fr) 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
US20110237605A1 (en) * 2010-03-26 2011-09-29 Eric Phillips Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
JP6215335B2 (ja) 2013-09-24 2017-10-18 富士フイルム株式会社 新規な含窒素化合物もしくはその塩またはそれらと金属との錯体
AU2021267373A1 (en) 2020-05-06 2022-12-08 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
AU2022388555A1 (en) 2021-11-09 2024-05-02 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032710A1 (en) * 1994-05-27 1995-12-07 Merck & Co., Inc. Compounds for inhibiting osteoclast-mediated bone resorption
AU3938997A (en) 1996-08-26 1998-03-19 Novo Nordisk A/S A novel endoglucanase
EP0934305A4 (en) * 1996-08-29 2001-04-11 Merck & Co Inc INTEGRINE ANTAGONISTS
JP2001504456A (ja) * 1996-10-30 2001-04-03 メルク エンド カンパニー インコーポレーテッド インテグリン拮抗薬
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
EP1007026A4 (en) * 1997-01-17 2002-08-07 Merck & Co Inc INTEGRIN ANTAGONISTS
EP0933367A1 (en) * 1997-12-19 1999-08-04 Hoechst Marion Roussel Deutschland GmbH Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists
CN1177832C (zh) * 1998-01-23 2004-12-01 艾文蒂斯药品德国股份有限公司 作为骨重吸收抑制剂和作为细胞粘附抑制剂的新的磺酰胺衍生物
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6365589B1 (en) * 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
EP1065207A1 (en) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
DE10042655A1 (de) * 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
CA2472470A1 (en) * 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
JP2008047614A (ja) 2006-08-11 2008-02-28 Showa Shell Sekiyu Kk 吸着材を利用した改良型太陽電池モジュール

Also Published As

Publication number Publication date
CA2376668C (en) 2007-01-02
PL352280A1 (en) 2003-08-11
MXPA01013435A (es) 2002-07-22
BG106257A (bg) 2002-10-31
CA2376668A1 (en) 2001-01-11
DK1210348T3 (da) 2006-01-16
KR20020015996A (ko) 2002-03-02
ZA200200016B (en) 2003-01-02
TR200103856T2 (tr) 2002-06-21
IL147248A0 (en) 2002-08-14
HK1050003A1 (en) 2003-06-06
MY133246A (en) 2007-10-31
HK1050003B (zh) 2005-04-29
CN1372559A (zh) 2002-10-02
CZ20014605A3 (cs) 2002-06-12
HRP20010946A2 (en) 2003-02-28
EA004369B1 (ru) 2004-04-29
EP1210348B9 (en) 2006-04-26
TW593319B (en) 2004-06-21
AU5978700A (en) 2001-01-22
US20040198718A1 (en) 2004-10-07
AU775386B2 (en) 2004-07-29
ES2250157T3 (es) 2006-04-16
DE60022890T4 (de) 2007-03-29
UA73133C2 (en) 2005-06-15
CN1160356C (zh) 2004-08-04
YU92201A (sh) 2004-07-15
ATE305471T1 (de) 2005-10-15
NO20016404D0 (no) 2001-12-28
NO20016404L (no) 2002-03-01
WO2001002398A1 (en) 2001-01-11
EP1065207A1 (en) 2001-01-03
SK19132001A3 (sk) 2002-07-02
HUP0203539A3 (en) 2005-01-28
AR024622A1 (es) 2002-10-16
HUP0203539A2 (hu) 2003-02-28
DE60022890T2 (de) 2006-06-29
EA200200122A1 (ru) 2002-06-27
NZ516058A (en) 2003-01-31
US6743800B1 (en) 2004-06-01
EP1210348A1 (en) 2002-06-05
DE60022890D1 (de) 2006-02-09
EP1210348B1 (en) 2005-09-28
EE200100711A (et) 2003-04-15
JP2003503496A (ja) 2003-01-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.