BR0011394A - Molécula, protéina purificada, ácido nucleico isolado, célula recombinante, métodos para produção de uma proteìna, para o tratamento ou prevenção de câncer e de um distúrbio imune e para ativação ou aumento da resposta imune em um indivìduo, animal não humano, planta ou uma célula isolada transgênicos, composição farmacêutica, e, anticporpo - Google Patents
Molécula, protéina purificada, ácido nucleico isolado, célula recombinante, métodos para produção de uma proteìna, para o tratamento ou prevenção de câncer e de um distúrbio imune e para ativação ou aumento da resposta imune em um indivìduo, animal não humano, planta ou uma célula isolada transgênicos, composição farmacêutica, e, anticporpoInfo
- Publication number
- BR0011394A BR0011394A BR0011394-8A BR0011394A BR0011394A BR 0011394 A BR0011394 A BR 0011394A BR 0011394 A BR0011394 A BR 0011394A BR 0011394 A BR0011394 A BR 0011394A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- methods
- cell
- antibody
- molecule
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 208000026278 immune system disease Diseases 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 230000003213 activating effect Effects 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 108010029697 CD40 Ligand Proteins 0.000 abstract 1
- 101150013553 CD40 gene Proteins 0.000 abstract 1
- 102100032937 CD40 ligand Human genes 0.000 abstract 1
- 101000850762 Homo sapiens TNF receptor-associated factor 3 Proteins 0.000 abstract 1
- 102100033082 TNF receptor-associated factor 3 Human genes 0.000 abstract 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/328,296 US6946129B1 (en) | 1999-06-08 | 1999-06-08 | Recombinant anti-CD40 antibody and uses thereof |
| PCT/US2000/015749 WO2000075348A1 (en) | 1999-06-08 | 2000-06-08 | Recombinant anti-cd40 antibody and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011394A true BR0011394A (pt) | 2004-06-08 |
Family
ID=23280379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011394-8A BR0011394A (pt) | 1999-06-08 | 2000-06-08 | Molécula, protéina purificada, ácido nucleico isolado, célula recombinante, métodos para produção de uma proteìna, para o tratamento ou prevenção de câncer e de um distúrbio imune e para ativação ou aumento da resposta imune em um indivìduo, animal não humano, planta ou uma célula isolada transgênicos, composição farmacêutica, e, anticporpo |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US6946129B1 (enExample) |
| EP (1) | EP1190074B1 (enExample) |
| JP (1) | JP2003519470A (enExample) |
| KR (2) | KR20090088929A (enExample) |
| CN (1) | CN1369015A (enExample) |
| AT (1) | ATE519501T1 (enExample) |
| AU (1) | AU784313B2 (enExample) |
| BR (1) | BR0011394A (enExample) |
| CA (1) | CA2376485C (enExample) |
| HK (1) | HK1049500A1 (enExample) |
| HU (1) | HUP0301789A2 (enExample) |
| IL (2) | IL146950A0 (enExample) |
| MX (1) | MXPA01012614A (enExample) |
| NO (1) | NO20016007L (enExample) |
| NZ (1) | NZ516250A (enExample) |
| PL (1) | PL363995A1 (enExample) |
| WO (1) | WO2000075348A1 (enExample) |
| ZA (1) | ZA200110215B (enExample) |
Families Citing this family (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050255106A1 (en) * | 1999-05-22 | 2005-11-17 | Linda Diehl | Induction of anti-tumor ctl immunity through in vivo triggering of 4-1bb and/or cd40 |
| US6946129B1 (en) * | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| WO2001034194A1 (en) * | 1999-11-08 | 2001-05-17 | Idec Pharmaceuticals Corporation | Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy |
| EP1253942A4 (en) * | 2000-02-01 | 2004-06-16 | Tanox Inc | CD40-BINDING AND APC-ACTIVATING MOLECULES |
| EP1257585A2 (en) | 2000-02-10 | 2002-11-20 | Basf Aktiengesellschaft | Antibodies that bind human interleukin-18 and methods of making and using |
| US20030059427A1 (en) * | 2000-04-28 | 2003-03-27 | Force Walker R. | Isolation and characterization of highly active anti-CD40 antibody |
| US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
| DK1296714T3 (da) | 2000-06-22 | 2009-12-07 | Coley Pharm Gmbh | Kombination af CpG og antistoffer, der er rettet mod CD19, CD20, CD22 eller CD40 til behandling eller forebyggelse af kræft |
| JP4202127B2 (ja) | 2000-10-02 | 2008-12-24 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アンタゴニスト抗cd40抗体を用いるb細胞悪性腫瘍の治療方法 |
| ES2364816T3 (es) * | 2001-04-02 | 2011-09-14 | Genentech, Inc. | Terapia de combinación. |
| ATE374214T1 (de) * | 2001-04-27 | 2007-10-15 | Kirin Brewery | Monoklonaler anti-cd-40-antikörper |
| EP2163256B1 (en) | 2001-05-11 | 2015-09-02 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| US20080199471A1 (en) * | 2002-03-01 | 2008-08-21 | Bernett Matthew J | Optimized cd40 antibodies and methods of using the same |
| KR100788093B1 (ko) | 2002-04-26 | 2007-12-21 | 제넨테크, 인크. | 단백질의 비친화성 정제 |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| EP1682178B8 (en) | 2003-11-04 | 2010-09-01 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for cancers expressing the cd40 antigen |
| WO2005044305A2 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Methods of therapy for solid tumors expressing the cd40 cell-surface antigen |
| AU2004287480B2 (en) | 2003-11-04 | 2011-09-15 | Novartis Vaccines And Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of chronic lymphocytic leukemia |
| EP1844815B1 (en) | 2003-11-04 | 2011-09-14 | Novartis Vaccines and Diagnostics, Inc. | Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers |
| KR101128777B1 (ko) | 2003-11-04 | 2012-04-13 | 조마 테크놀로지 리미티드 | 다발성 골수종을 치료하기 위한 길항제 항-cd40단클론성 항체의 용도 |
| PL1707627T3 (pl) | 2003-12-25 | 2013-04-30 | Kyowa Hakko Kirin Co Ltd | Mutant antagonistycznego przeciwciała anty-CD40 |
| US20060281699A1 (en) * | 2004-05-12 | 2006-12-14 | Merchiers Pascal G | Methods, compositions and compound assays for inhibiting amyloid-beta protein production |
| US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| TW200714289A (en) * | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
| AU2006236225C1 (en) | 2005-04-19 | 2013-05-02 | Seagen Inc. | Humanized anti-CD70 binding agents and uses thereof |
| HRP20130852T1 (en) | 2005-05-18 | 2013-10-25 | Novartis Ag | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
| BRPI0610470A2 (pt) * | 2005-05-26 | 2010-06-22 | Seattle Genetics Inc | anticorpo isolado ou fragmento de ligação a antìgeno que especificamente se liga a cd40 humano, kit, composição farmacêutica, e, polinucleotìdeo isolado |
| WO2007063424A2 (en) | 2005-06-09 | 2007-06-07 | Gal Markel | The modulation of immunity and ceacam1 activity |
| CN101325970B (zh) * | 2005-11-01 | 2013-08-14 | 诺华有限公司 | 抗cd40抗体的应用 |
| US20090202531A1 (en) * | 2005-11-01 | 2009-08-13 | Novartis Ag | Uses of anti-cd40 antibodies |
| KR20080079301A (ko) * | 2005-12-09 | 2008-08-29 | 시애틀 지네틱스, 인크. | Cd40 결합제를 이용하는 방법 |
| GB0525214D0 (en) | 2005-12-12 | 2006-01-18 | Bioinvent Int Ab | Biological materials and uses thereof |
| KR101317235B1 (ko) | 2006-04-21 | 2013-10-15 | 조마 테크놀로지 리미티드 | 길항제 항-cd40 항체 제약 조성물 |
| EP2019857B1 (en) | 2006-05-03 | 2016-09-28 | The Regents of the University of Colorado, a body corporate | Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| GB0620894D0 (en) * | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| ES2523915T5 (es) | 2006-12-01 | 2022-05-26 | Seagen Inc | Agentes de unión a la diana variantes y usos de los mismos |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| WO2008079280A1 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
| NZ577933A (en) | 2007-01-22 | 2011-12-22 | Genentech Inc | Polyelectrolyte precipitation and purification of antibodies |
| JP5357778B2 (ja) * | 2007-01-23 | 2013-12-04 | ゼンコー・インコーポレイテッド | 最適化cd40抗体および前記を使用する方法 |
| CN104043123B (zh) | 2007-01-25 | 2019-08-13 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| CN101688229B (zh) | 2007-03-15 | 2013-06-12 | 路德维格癌症研究所 | 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途 |
| FI3597659T3 (fi) | 2007-07-09 | 2023-05-03 | Genentech Inc | Disulfidisidoksen pelkistymisen estäminen polypeptidien rekombinantin valmistuksen aikana |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| CN101910414B (zh) | 2007-11-07 | 2016-01-13 | 健泰科生物技术公司 | 用于评估b细胞淋巴瘤对抗cd40抗体治疗的响应性的方法和组合物 |
| CA2712989C (en) | 2008-01-23 | 2015-10-27 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
| WO2009151514A1 (en) | 2008-06-11 | 2009-12-17 | Millipore Corporation | Stirred tank bioreactor |
| WO2010104749A2 (en) | 2009-03-10 | 2010-09-16 | Baylor Research Institute | Antigen presenting cell targeted cancer vaccines |
| DK3604324T3 (da) | 2008-08-14 | 2024-04-08 | Genentech Inc | Fremgangsmåder til at fjerne en kontaminant under anvendelse af ionbytningskromatografi med forskydning af iboende proteiner |
| NO2344540T3 (enExample) | 2008-10-02 | 2018-04-28 | ||
| US20110286916A1 (en) * | 2008-11-20 | 2011-11-24 | Jose Miguel Aste-Amezaga | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
| DK2370561T3 (da) | 2008-12-16 | 2019-10-21 | Emd Millipore Corp | Omrøringstankreaktor og fremgangsmåde |
| CA2948693C (en) | 2009-02-13 | 2018-09-04 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| US20160095939A1 (en) | 2014-10-07 | 2016-04-07 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| US9028833B2 (en) | 2012-12-13 | 2015-05-12 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity |
| CA2752884A1 (en) | 2009-02-27 | 2010-09-02 | Genentech, Inc. | Methods and compositions for protein labelling |
| CA3032548C (en) | 2009-03-10 | 2023-05-09 | Baylor Research Institute | Anti-cd40 antibodies and uses thereof |
| EP3219732A1 (en) * | 2009-03-10 | 2017-09-20 | Baylor Research Institute | Antigen presenting cell targeted cancer vaccines |
| EP2419531B1 (en) | 2009-04-18 | 2016-09-07 | Genentech, Inc. | Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
| MX2012001742A (es) | 2009-08-11 | 2012-03-21 | Genentech Inc | Produccion de proteinas en medios de cultivo de celulas libres de glutamina. |
| CA2772653C (en) | 2009-09-01 | 2019-06-25 | Genentech, Inc. | Enhanced protein purification through a modified protein a elution |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| WO2011095596A1 (en) | 2010-02-04 | 2011-08-11 | Vivalis | Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells |
| SI2550018T1 (sl) | 2010-03-22 | 2019-05-31 | F. Hoffmann-La Roche Ag | Sestavki in metode, uporabni za stabilizacijo formulacij, ki vsebujejo beljakovine |
| JP2013525484A (ja) | 2010-05-03 | 2013-06-20 | ジェネンテック, インコーポレイテッド | タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法 |
| KR101726707B1 (ko) | 2010-05-17 | 2017-04-13 | 이엠디 밀리포어 코포레이션 | 생체분자 정제용 자극 반응성 중합체 |
| MX343604B (es) | 2010-05-28 | 2016-11-11 | Genentech Inc | Disminuir nivel de lactato e incrementar producción de polipéptidos por regulación a la baja de la expresión de lactato dehidrogenasa y piruvato dehidrogenasa quinasa. |
| WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| JP6170840B2 (ja) | 2011-03-11 | 2017-07-26 | ベス イスラエル デアコネス メディカル センター インコーポレイテッド | 抗cd40抗体及びその使用 |
| KR102037432B1 (ko) | 2011-04-29 | 2019-11-27 | 아펙시젠, 인코포레이티드 | 항-cd40 항체 및 사용 방법 |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| GB201115280D0 (en) * | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
| EA034989B1 (ru) | 2011-10-28 | 2020-04-15 | Тева Фармасьютикал Австралия Пти Лтд | Полипептидная конструкция для применения при лечении рака, включающая аттенуированный альфа-интерферон |
| PL2794635T3 (pl) | 2011-12-22 | 2019-02-28 | F.Hoffmann-La Roche Ag | Membranowa chromatografia jonowymienna |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| SG10201912877SA (en) | 2012-03-27 | 2020-02-27 | Genentech Inc | Improved harvest operations for recombinant proteins |
| NZ701915A (en) | 2012-05-18 | 2016-11-25 | Genentech Inc | High-concentration monoclonal antibody formulations |
| EP4406612A3 (en) | 2012-06-19 | 2024-10-16 | Ambrx, Inc. | Anti-cd70 antibody drug conjugates |
| RS62509B1 (sr) | 2012-07-13 | 2021-11-30 | Roche Glycart Ag | Bispecifična anti-vegf/anti-ang-2 antitela i njihova upotreba u lečenju očnih vaskularnih bolesti |
| US9315567B2 (en) | 2012-08-14 | 2016-04-19 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| CN104918957B (zh) | 2012-10-30 | 2018-11-16 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
| WO2017004144A1 (en) | 2015-07-01 | 2017-01-05 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| EP2934602B1 (en) | 2012-12-19 | 2019-02-27 | Genentech, Inc. | Methods and compositions for radiohalogen protein labeling |
| UA113129C2 (xx) | 2013-04-29 | 2016-12-12 | ЗЛИТА КОНСТРУКЦІЯ АНТИТІЛО ПРОТИ CD38 З ОСЛАБЛЕНИМ ІНТЕРФЕРОНОМ АЛЬФА-2b | |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| US10286058B2 (en) | 2014-01-13 | 2019-05-14 | Baylor Research Institute | Vaccines against HPV and HPV-related diseases |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ,インコーポレイテッド | Trop−2発現細胞に対する免疫応答を誘発することによる疾患治療 |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| EP3160504B1 (en) | 2014-06-24 | 2020-09-16 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| JP6826975B2 (ja) | 2014-07-09 | 2021-02-10 | ジェネンテック, インコーポレイテッド | 細胞バンクの解凍復元を改善するためのpH調整 |
| AU2015339128C1 (en) | 2014-10-29 | 2021-12-16 | Seagen Inc. | Dosage and administration of non-fucosylated anti-CD40 antibodies |
| IL251822B2 (en) | 2014-10-29 | 2023-03-01 | Teva Pharmaceuticals Australia Pty Ltd | Variants of interferon alpha-2-b |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| CA2980460A1 (en) | 2015-04-13 | 2016-10-20 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| AU2016252771B2 (en) | 2015-04-22 | 2021-12-16 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells |
| SI3313443T1 (sl) | 2015-06-25 | 2023-11-30 | Immunomedics, Inc. | Kombiniranje protiteles proti HLA-DR ali proti TROP-2 z zaviralci mikrotubulov, zaviralci PARP, zaviralci brutonove kinaze ali zaviralci fosfoinozitid 3-kinaze pomembno izboljša izid zdravljenja pri raku |
| BR112018000903A2 (pt) | 2015-07-16 | 2018-09-11 | Biokine Therapeutics Ltd. | composições e métodos para o tratamento de câncer |
| US10526408B2 (en) | 2015-08-28 | 2020-01-07 | Research Development Foundation | Engineered antibody FC variants |
| EP3906943A1 (en) | 2015-09-04 | 2021-11-10 | Primatope Therapeutics Inc. | Humanized anti-cd40 antibodies and uses thereof |
| PE20181367A1 (es) | 2015-09-30 | 2018-08-27 | Janssen Biotech Inc | Anticuerpos agonistas que se unen especificamente a cd40 humana y metodos de uso |
| JP7208492B2 (ja) | 2016-03-10 | 2023-01-19 | シージー オンコロジー, インコーポレイテッド | 併用療法によって固形腫瘍又はリンパ系腫瘍を処置する方法 |
| JP2019510517A (ja) | 2016-03-29 | 2019-04-18 | ジェルター, インコーポレイテッド | 細胞質内体積に対するペリプラズム体積の比率が0.5:1および10:1の間にあるグラム陰性細菌におけるタンパク質の発現 |
| US12297266B2 (en) | 2016-04-18 | 2025-05-13 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human CD40 and uses thereof |
| EP3464361B1 (en) * | 2016-05-27 | 2021-11-10 | AbbVie Biotherapeutics Inc. | Anti-cd40 antibodies and their uses |
| TW201803905A (zh) | 2016-06-20 | 2018-02-01 | 克馬伯有限公司 | 用於免疫腫瘤學之多重專一性抗體 |
| EA201990293A1 (ru) | 2016-07-14 | 2019-07-31 | Генмаб А/С | Мультиспецифичные антитела против cd40 и cd137 |
| EP3504239B1 (en) | 2016-08-25 | 2024-05-29 | F. Hoffmann-La Roche AG | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
| EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
| CA3044686A1 (en) | 2016-12-22 | 2018-06-28 | Genentech, Inc. | Methods and formulations for reducing reconstitution time of lyophilized polypeptides |
| UA128814C2 (uk) | 2017-02-10 | 2024-10-30 | Генмаб Б.В. | Поліпептид та його застосування |
| BR112019017753B1 (pt) | 2017-04-04 | 2024-04-30 | F. Hoffmann-La Roche Ag | Molécula biespecífica de ligação ao antígeno, composição farmacêutica e uso da molécula biespecífica de ligação ao antígeno |
| IL322942A (en) | 2017-05-24 | 2025-10-01 | Als Therapy Development Inst | Therapeutic anti-CD40 ligand antibodies |
| BR112019025048A2 (pt) | 2017-06-01 | 2020-06-30 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo anti-cd40, fragmento de ligação ao antígeno do mesmo, e uso médico dos mesmos |
| US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
| US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
| EP3806848A2 (en) | 2018-06-15 | 2021-04-21 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
| WO2020010080A1 (en) | 2018-07-03 | 2020-01-09 | Bristol-Myers Squibb Company | Methods of producing recombinant proteins |
| WO2020070041A1 (en) | 2018-10-01 | 2020-04-09 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules comprising anti-fap clone 212 |
| WO2020070288A1 (en) | 2018-10-05 | 2020-04-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
| MA53859A (fr) | 2018-10-10 | 2022-01-19 | Boehringer Ingelheim Int | Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité |
| WO2020089051A1 (en) | 2018-10-29 | 2020-05-07 | F. Hoffmann-La Roche Ag | Antibody formulation |
| TW202039558A (zh) | 2018-11-30 | 2020-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗cd40抗體、其抗原結合片段及其醫藥用途 |
| JP2022513671A (ja) | 2018-11-30 | 2022-02-09 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | Cd40抗体医薬品組成物およびその使用 |
| CN111454364B (zh) * | 2019-03-04 | 2021-03-02 | 北京天广实生物技术股份有限公司 | 结合cd40的抗体及其用途 |
| JP7640466B2 (ja) * | 2019-03-27 | 2025-03-05 | アンスティチュート、ナシオナル、ドゥ、ラ、サンテ、エ、ドゥ、ラ、ルシェルシュ、メディカル | Cd40活性化特性を有する組換えタンパク質 |
| CN113993885B (zh) | 2019-04-12 | 2025-04-25 | 格尔托公司 | 重组弹性蛋白及其生产 |
| MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
| EP4076434A1 (en) | 2019-12-17 | 2022-10-26 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| TW202206100A (zh) | 2020-04-27 | 2022-02-16 | 美商西健公司 | 癌症之治療 |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| WO2022066595A1 (en) | 2020-09-22 | 2022-03-31 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
| WO2022072523A1 (en) | 2020-09-30 | 2022-04-07 | Seagen Inc. | Uveal melanoma treatment using sea-cd40 |
| EP4240415A1 (en) | 2020-11-08 | 2023-09-13 | Seagen Inc. | Combination-therapy antibody drug conjugate with immune cell inhibitor |
| CN112409486B (zh) * | 2020-11-26 | 2022-05-20 | 杭州百凌生物科技有限公司 | 一种抗cd40抗体及其应用 |
| MX2023008949A (es) | 2021-01-28 | 2023-10-23 | Regeneron Pharma | Composiciones y metodos para tratar el sindrome de liberacion de citocinas. |
| WO2022165260A1 (en) | 2021-01-29 | 2022-08-04 | Iovance Biotherapeutics, Inc. | Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy |
| EP4305066A1 (en) | 2021-03-09 | 2024-01-17 | Genmab A/S | Multispecific binding agents against cd40 and cd137 in therapy |
| WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
| IL309831A (en) | 2021-07-13 | 2024-02-01 | BioNTech SE | Multispecific binding agents against CD40 and CD137 in combined cancer therapy |
| EP4377348A1 (en) | 2021-07-30 | 2024-06-05 | Seagen Inc. | Treatment for cancer |
| WO2023049687A1 (en) | 2021-09-21 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
| US12234294B2 (en) | 2021-11-05 | 2025-02-25 | Kiniksa Pharmaceuticals, Gmbh | Pharmaceutical composition of a humanized anti-CD40 antibody |
| EP4469065A1 (en) | 2022-01-28 | 2024-12-04 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| EP4507779A1 (en) | 2022-04-14 | 2025-02-19 | Institut National de la Santé et de la Recherche Médicale | Methods for controlling the tumor cell killing by light |
| AU2023283773A1 (en) | 2022-06-10 | 2024-12-19 | Research Development Foundation | Engineered fcriib selective igg1 fc variants and uses thereof |
| WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
| JP2025541738A (ja) | 2022-12-01 | 2025-12-23 | ビオンテック・ソシエタス・エウロパエア | 抗pd1abと化学療法での併用療法におけるcd40およびcd137に対する多重特異性抗体 |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2025093035A1 (en) * | 2023-11-03 | 2025-05-08 | Utc Therapeutics (Shanghai) Co., Ltd. | Cd40-targetting antibodies and uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5182368A (en) | 1986-06-13 | 1993-01-26 | Ledbetter Jeffrey A | Ligands and methods for augmenting B-cell proliferation |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL84285A (en) | 1986-10-27 | 1993-03-15 | Int Genetic Engineering | Chimeric antibody with specificity to human tumor antigen |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5872215A (en) * | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| CA2128862C (en) | 1992-02-11 | 2008-05-20 | Jonathan G. Seidman | Homogenotization of gene-targeting events |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
| US5874082A (en) | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
| WO1994004570A1 (en) * | 1992-08-21 | 1994-03-03 | Schering Corporation | Cd40 ligand, anti cd40 antibodies, and soluble cd40 |
| US5540926A (en) | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
| US5985847A (en) * | 1993-08-26 | 1999-11-16 | The Regents Of The University Of California | Devices for administration of naked polynucleotides which encode biologically active peptides |
| FI961285L (fi) * | 1993-10-01 | 1996-03-20 | Immunex Corp | CD40:n vasta-aineita |
| US5597569A (en) * | 1993-10-25 | 1997-01-28 | Bristol-Myers Squibb Company | Bryodin 2 a ribosome-inactivating protein isolated from the plant Bryonia dioica |
| ES2222463T3 (es) | 1993-12-23 | 2005-02-01 | Immunex Corporation | Uso de anticuerpos monoclonales o ligandos oligomericos solubles en la fabricacion de un medicamento para la prevencion o tratamiento de trastornos neoplasicos. |
| GB9425060D0 (en) | 1994-12-13 | 1995-02-08 | Univ Birmingham | Carcinoma treatment |
| US6037454A (en) * | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| WO1998033810A2 (en) * | 1997-01-30 | 1998-08-06 | University Of Virginia Patent Foundation | Cysteine-depleted peptides recognized by a3-restricted cytotoxic lymphocytes, and uses therefor |
| CA2294223C (en) * | 1997-06-20 | 2011-02-15 | Pangenetics B.V. | Anti-cd40l immunotoxins for the treatment of diseases |
| US6051228A (en) * | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| ES2330017T3 (es) * | 1998-05-23 | 2009-12-03 | Leiden University Medical Center | Ligandos de cd40 y peptidos de ctl para tratar tumores. |
| US6946129B1 (en) * | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| WO2001079444A2 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc | Albumin fusion proteins |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| US7596539B2 (en) * | 2003-05-29 | 2009-09-29 | International Business Machines Corporation | Method and apparatus for providing connection information of functional components within a computer system |
| US20050136055A1 (en) | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
| US7213446B2 (en) * | 2004-08-27 | 2007-05-08 | Semmaterials, L.P. | Method of selecting a bituminous emulsion based on its coalescence |
| BRPI0610470A2 (pt) | 2005-05-26 | 2010-06-22 | Seattle Genetics Inc | anticorpo isolado ou fragmento de ligação a antìgeno que especificamente se liga a cd40 humano, kit, composição farmacêutica, e, polinucleotìdeo isolado |
| KR20080079301A (ko) | 2005-12-09 | 2008-08-29 | 시애틀 지네틱스, 인크. | Cd40 결합제를 이용하는 방법 |
-
1999
- 1999-06-08 US US09/328,296 patent/US6946129B1/en not_active Expired - Lifetime
-
2000
- 2000-06-08 AT AT00939679T patent/ATE519501T1/de not_active IP Right Cessation
- 2000-06-08 CA CA2376485A patent/CA2376485C/en not_active Expired - Lifetime
- 2000-06-08 IL IL14695000A patent/IL146950A0/xx unknown
- 2000-06-08 MX MXPA01012614A patent/MXPA01012614A/es active IP Right Grant
- 2000-06-08 CN CN00811357A patent/CN1369015A/zh active Pending
- 2000-06-08 KR KR1020097013741A patent/KR20090088929A/ko not_active Ceased
- 2000-06-08 PL PL00363995A patent/PL363995A1/xx not_active Application Discontinuation
- 2000-06-08 NZ NZ516250A patent/NZ516250A/en unknown
- 2000-06-08 JP JP2001501630A patent/JP2003519470A/ja active Pending
- 2000-06-08 HU HU0301789A patent/HUP0301789A2/hu unknown
- 2000-06-08 HK HK03101596.3A patent/HK1049500A1/zh unknown
- 2000-06-08 BR BR0011394-8A patent/BR0011394A/pt not_active Application Discontinuation
- 2000-06-08 AU AU54731/00A patent/AU784313B2/en not_active Ceased
- 2000-06-08 WO PCT/US2000/015749 patent/WO2000075348A1/en not_active Ceased
- 2000-06-08 EP EP00939679A patent/EP1190074B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/724,530 patent/US6843989B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/724,409 patent/US6838261B1/en not_active Expired - Lifetime
-
2001
- 2001-12-06 IL IL146950A patent/IL146950A/en not_active IP Right Cessation
- 2001-12-07 NO NO20016007A patent/NO20016007L/no not_active Application Discontinuation
- 2001-12-08 KR KR1020017015848A patent/KR100917262B1/ko not_active Expired - Fee Related
- 2001-12-12 ZA ZA200110215A patent/ZA200110215B/en unknown
-
2004
- 2004-05-14 US US10/846,981 patent/US7498032B2/en not_active Expired - Fee Related
- 2004-08-16 US US10/919,923 patent/US20050008637A1/en not_active Abandoned
-
2005
- 2005-04-08 US US11/102,743 patent/US7510711B2/en not_active Expired - Fee Related
-
2009
- 2009-01-20 US US12/356,511 patent/US7666422B2/en not_active Expired - Fee Related
- 2009-12-28 US US12/648,108 patent/US7824683B2/en not_active Expired - Fee Related
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