BR0008760A - Genes pks da schizochytrium - Google Patents

Genes pks da schizochytrium

Info

Publication number
BR0008760A
BR0008760A BR0008760-2A BR0008760A BR0008760A BR 0008760 A BR0008760 A BR 0008760A BR 0008760 A BR0008760 A BR 0008760A BR 0008760 A BR0008760 A BR 0008760A
Authority
BR
Brazil
Prior art keywords
production
genes
pks
long
plants
Prior art date
Application number
BR0008760-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Daniel Facciotti
George James Metz
Michael Lassner
Original Assignee
Omegatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omegatech Inc filed Critical Omegatech Inc
Publication of BR0008760A publication Critical patent/BR0008760A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
BR0008760-2A 1999-01-14 2000-01-14 Genes pks da schizochytrium BR0008760A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/231,899 US6566583B1 (en) 1997-06-04 1999-01-14 Schizochytrium PKS genes
PCT/US2000/000956 WO2000042195A2 (en) 1999-01-14 2000-01-14 Schizochytrium pks genes

Publications (1)

Publication Number Publication Date
BR0008760A true BR0008760A (pt) 2002-10-08

Family

ID=22871074

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008760-2A BR0008760A (pt) 1999-01-14 2000-01-14 Genes pks da schizochytrium

Country Status (10)

Country Link
US (6) US6566583B1 (enExample)
EP (4) EP2333071A1 (enExample)
JP (3) JP2002534123A (enExample)
BR (1) BR0008760A (enExample)
CA (1) CA2359629C (enExample)
ES (1) ES2427017T3 (enExample)
HK (1) HK1041292A1 (enExample)
IL (4) IL144269A0 (enExample)
MX (1) MX252154B (enExample)
WO (1) WO2000042195A2 (enExample)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7271315B2 (en) * 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
RU2336307C2 (ru) 2000-01-19 2008-10-20 Мартек Биосайнсис Корпорейшн Способ получения липидов (варианты) и липиды, полученные этим способом
EP2960325B1 (en) 2000-01-28 2017-09-27 DSM IP Assets B.V. Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors
TWI426126B (zh) * 2001-04-16 2014-02-11 Dsm Ip Assets Bv 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二）
JP2005529728A (ja) 2002-06-18 2005-10-06 マーテック・バイオサイエンシーズ・コーポレーション 水溶液中の油の安定エマルジョンおよびその製造方法
CA2510462A1 (en) 2002-12-19 2004-07-08 University Of Bristol Method for producing polyunsaturated fatty acids in a transgenic plant or microorganism comprising an introduced delta-9-elongase and a delta-8-desaturase
CA2517253C (en) 2003-02-27 2018-07-03 Basf Plant Science Gmbh Method for the production of polyunsaturated fatty acids
US20070082008A1 (en) * 2003-03-07 2007-04-12 Advanced Bionutrition Corporation Feed formulation for terrestrial and aquatic animals
KR101234199B1 (ko) * 2003-03-26 2013-02-20 마텍 바이오싸이언스스 코포레이션 Ｐｕｆａ 폴리케타이드 신타제 시스템 및 이의 용도
EP1613746B1 (de) 2003-03-31 2013-03-06 University Of Bristol Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren
US7646815B2 (en) * 2003-07-15 2010-01-12 Lsi Corporation Intra estimation chroma mode 0 sub-block dependent prediction
US7208590B2 (en) * 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
DE102004017370A1 (de) * 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
DE102004017369A1 (de) * 2004-04-08 2005-11-03 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Screeningverfahren zur Identifizierung von PUFA-PKS in Proben
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
CA3056110C (en) 2004-04-22 2020-07-14 Surinder Pal Singh Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
WO2006092449A2 (en) * 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
ES2626018T3 (es) 2005-06-07 2017-07-21 Dsm Nutritional Products Ag Microorganismos eucariotas para la producción de lípidos y antioxidantes
AU2006265801B2 (en) 2005-07-01 2011-07-14 Martek Biosciences Corporation Polyunsaturated fatty acid-containing oil product and uses and production thereof
JP4943678B2 (ja) * 2005-08-01 2012-05-30 国立大学法人北海道大学 細胞の脂肪酸組成を改変する方法およびその利用
US8795744B2 (en) 2005-11-18 2014-08-05 Commonwealth Scientific And Industrial Research Organisation Feedstuffs for aquaculture comprising stearidonic acid
KR101524398B1 (ko) 2006-03-15 2015-06-04 디에스엠 아이피 어셋츠 비.브이. Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조
TW200806184A (en) * 2006-04-11 2008-02-01 Martek Biosciences Corp Food products comprising long chain polyunsaturated fatty acids and methods for preparing the same
CA2655044C (en) 2006-06-22 2014-05-27 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
CN101981201A (zh) * 2006-08-01 2011-02-23 加拿大海洋营养食品有限公司 产油微生物及改良这些微生物的方法
CN101578363A (zh) 2006-08-29 2009-11-11 联邦科学技术研究组织 脂肪酸的合成
WO2008027991A2 (en) 2006-08-29 2008-03-06 Martek Biosciences Corporation USE OF DPA(n-6) OILS IN INFANT FORMULA
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
JP2010532418A (ja) * 2007-06-29 2010-10-07 マーテック バイオサイエンシーズ コーポレーション 多価不飽和脂肪酸のエステルの製造方法および精製方法
JP2010534474A (ja) 2007-07-26 2010-11-11 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド 分子冗長配列決定
CA2702577A1 (en) 2007-10-15 2009-04-23 Jbs United, Inc. Method for increasing performance of offspring
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US20110076379A1 (en) * 2008-06-13 2011-03-31 Means Michael M High omega saturated fat free meat products
NO2358882T3 (enExample) 2008-11-18 2017-12-23
ES2717102T3 (es) 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
EP2430166A1 (en) 2009-05-13 2012-03-21 BASF Plant Science Company GmbH Acyltransferases and uses thereof in fatty acid production
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
US20110125118A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
EP2529023A4 (en) * 2010-01-27 2015-06-10 Opx Biotechnologies Inc MICRO-ORGANISM MANUFACTURE FROM HIGH-FLOW CHEMICAL PRODUCTS AND CORRESPONDING COMPOSITIONS, METHODS AND SYSTEMS
TW201144442A (en) 2010-05-17 2011-12-16 Dow Agrosciences Llc Production of DHA and other LC-PUFAs in plants
CN103124791B (zh) * 2010-06-01 2016-08-24 帝斯曼知识产权资产管理有限公司 从细胞中提取脂质以及由此获得的产品
NO2585603T3 (enExample) 2010-06-25 2018-05-19
TW201307553A (zh) 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術
PL2861059T3 (pl) 2012-06-15 2017-10-31 Commw Scient Ind Res Org Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych
CA2879154A1 (en) 2012-08-03 2014-02-06 Basf Plant Science Company Gmbh Novel enzymes, enzyme components and uses thereof
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
DK2970926T3 (en) 2013-03-13 2018-04-16 Dsm Nutritional Products Ag GENMANIPULATION OF MICROorganisms
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
TW201525136A (zh) 2013-11-26 2015-07-01 Dow Agrosciences Llc 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸
NZ721036A (en) 2013-12-18 2023-07-28 Grains Res & Dev Corp Lipid comprising long chain polyunsaturated fatty acids
AU2014369042B2 (en) 2013-12-20 2020-04-30 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
SG11201605043TA (en) 2013-12-20 2016-07-28 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
WO2015095693A2 (en) 2013-12-20 2015-06-25 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
PL3082793T3 (pl) 2013-12-20 2020-10-05 Dsm Ip Assets B.V. Sposoby otrzymywania oleju drobnoustrojowego z komórek drobnoustrojowych
NZ721409A (en) 2013-12-20 2022-10-28 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
ES2721269T3 (es) 2014-01-28 2019-07-30 Dsm Ip Assets Bv Factores para la producción y acumulación de ácidos grasos poliinsaturados (PUFA) obtenidos con PUFA sintasas
US10131897B2 (en) 2014-03-03 2018-11-20 Synthetics Genomics, Inc. Molecules associated with fatty acid biosynthetic pathways and uses thereof
PH12016502586B1 (en) 2014-06-27 2023-07-19 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
AU2016228545A1 (en) * 2015-03-12 2017-09-21 Synthetic Genomics. Inc. Microorganisms for fatty acid production using elongase and desaturase enzymes
AR109245A1 (es) 2016-05-12 2018-11-14 Basf Plant Science Co Gmbh Métodos para optimizar la producción de metabolitos en plantas genéticamente modificadas y para procesar estas plantas
CN109477079A (zh) 2016-05-12 2019-03-15 帝斯曼知识产权资产管理有限公司 增加微藻中ω-3多不饱和脂肪酸产量的方法
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
WO2018205165A1 (zh) * 2017-05-10 2018-11-15 南京工业大学 一株裂殖壶菌菌株、其构建方法及应用
US11866788B2 (en) 2018-05-08 2024-01-09 Sanford Burnham Prebys Medical Discovery Institute Role of PVT1 in the diagnosis and treatment of MYC-driven cancer
US11613728B2 (en) 2018-08-10 2023-03-28 Kyowa Hakko Bio Co., Ltd. Microorganism producing eicosapentaenoic acid and method for producing eicosapentaenoic acid
US12241101B2 (en) 2018-08-10 2025-03-04 Kyowa Hakko Bio Co., Ltd. Microorganism producing polyunsaturated fatty acid and method for producing polyunsaturated fatty acid
WO2021055846A1 (en) * 2019-09-19 2021-03-25 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for treating myc-driven cancers

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034322A (en) 1983-01-17 1991-07-23 Monsanto Company Chimeric genes suitable for expression in plant cells
US4792523A (en) 1984-08-31 1988-12-20 Cetus Corporation 3'Expression enhancing fragments and method
US4743548A (en) 1984-09-25 1988-05-10 Calgene, Inc. Plant cell microinjection technique
US5420034A (en) 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
US4943674A (en) 1987-05-26 1990-07-24 Calgene, Inc. Fruit specific transcriptional factors
GB2178752B (en) 1985-07-12 1989-10-11 Unilever Plc Substitute milk fat
US4940835A (en) 1985-10-29 1990-07-10 Monsanto Company Glyphosate-resistant plants
US5068193A (en) 1985-11-06 1991-11-26 Calgene, Inc. Novel method and compositions for introducing alien DNA in vivo
US4795855A (en) 1985-11-14 1989-01-03 Joanne Fillatti Transformation and foreign gene expression with woody species
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
US5565347A (en) 1986-06-10 1996-10-15 Calgene, Inc. Transformation and foreign gene expression with plant species
US5246841A (en) 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
AU612133B2 (en) 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
DE3719097C1 (de) 1987-06-06 1988-06-09 Fratzer Uwe Arzneimittel,enthaltend Eicosapentaensaeure und Docosahexaensaeure als ungesaettigte Fettsaeuren sowie Vitamin E
US5011770A (en) 1987-09-04 1991-04-30 Molecular Devices, Inc. DNA detection method
US4999422A (en) 1988-04-15 1991-03-12 Biogen, N.V. Continuous method of refolding proteins
US5565346A (en) 1988-07-27 1996-10-15 Calgene, Inc. Transformation and regeneration system for legumes
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5162215A (en) 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
AU638438B2 (en) 1989-02-24 1993-07-01 Monsanto Technology Llc Synthetic plant genes and method for preparation
US5106739A (en) 1989-04-18 1992-04-21 Calgene, Inc. CaMv 355 enhanced mannopine synthase promoter and method for using same
US5175095A (en) 1989-07-19 1992-12-29 Calgene, Inc. Ovary-tissue transcriptional factors
US5639790A (en) 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
AU673359B2 (en) 1992-05-15 1996-11-07 Sagami Chemical Research Center Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid
US5798259A (en) 1992-05-15 1998-08-25 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
US5683898A (en) 1992-05-15 1997-11-04 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
US5310242A (en) 1992-09-28 1994-05-10 Golder Kimberly A Portable infant seat
DK0686197T3 (da) 1993-02-26 2000-09-04 Calgene Llc Geminivirusbaseret genekspressionssystem
DE4323727A1 (de) * 1993-07-15 1995-03-09 Boehringer Mannheim Gmbh Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
WO1995024494A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Humanized milk
EP0779359B1 (en) 1994-08-24 2002-02-13 Meiji Milk Products Company Limited Method of culturing avian cells
FR2726003B1 (fr) 1994-10-21 2002-10-18 Agronomique Inst Nat Rech Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires
EP0831149A4 (en) 1995-01-13 2000-12-06 Sagami Chem Res GENES CODING FOR THE GROUP OF ENZYMES FOR BIOSYNTHESIS OF EICOSAPENTIC ACID AND METHOD FOR PRODUCING EICOSAPENTIC ACID
AU5346296A (en) * 1995-04-17 1996-11-07 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms
GB9508023D0 (en) 1995-04-20 1995-06-07 Scotia Holdings Plc Fatty acid derivatives
AU727694B2 (en) * 1996-07-10 2000-12-21 Sagami Chemical Research Center Process for producing icosapentaenoic acid by genetic recombination
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
NZ337459A (en) * 1997-04-11 2000-07-28 Abbott Lab Nucleic acid construct in plants and dietary supplement
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
BR9809946A (pt) 1997-06-04 2000-08-01 Calgene Llc Produção de ácidos graxos poliinsaturados por expressão de genes de sìntese semelhantes a policetìdeo em plantas
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US20070244192A1 (en) 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7271315B2 (en) 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
WO2001094565A2 (en) 2000-06-08 2001-12-13 Miami University FATTY ACID ELONGASE 3-KETOACYL CoA SYNTHASE POLYPEPTIDES
US20040010817A1 (en) 2000-07-21 2004-01-15 Washington State University Research Foundation Plant acyl-CoA synthetases
CN101845446B (zh) 2000-09-28 2016-01-20 生物源食物及科学公司 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用
TWI426126B (zh) 2001-04-16 2014-02-11 Dsm Ip Assets Bv 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二）
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US7045683B2 (en) * 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
AU2002309856B2 (en) * 2001-05-14 2008-10-23 Dsm Ip Assets B.V. Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsaturated fatty acids from microbes, genetically modified plant seeds and marine organisms
US20040005672A1 (en) 2002-02-22 2004-01-08 Santi Daniel V. Heterologous production of polyketides
GB2385852A (en) 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
AU2003224236A1 (en) 2002-03-16 2003-09-29 The University Of York Transgenic plants expressing enzymes involved in fatty acid biosynthesis
US8084074B2 (en) * 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
KR101234199B1 (ko) 2003-03-26 2013-02-20 마텍 바이오싸이언스스 코포레이션 Ｐｕｆａ 폴리케타이드 신타제 시스템 및 이의 용도
EP1613746B1 (de) 2003-03-31 2013-03-06 University Of Bristol Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7208590B2 (en) 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
DE102004060340A1 (de) 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
EP2348117A1 (en) 2004-09-20 2011-07-27 BASF Plant Science GmbH Arabidopsis genes encoding proteins involved in sugar and lipid metabolism and methods of use
US20080260933A1 (en) * 2004-10-08 2008-10-23 Dow Agroscience Llc Certain Plants with "No Saturate" or Reduced Saturate Levels of Fatty Acids in Seeds, and Oil Derived from the Seeds
TWI397582B (zh) * 2004-11-04 2013-06-01 Monsanto Technology Llc 油組合物之製備方法
AR059376A1 (es) * 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
KR101524398B1 (ko) 2006-03-15 2015-06-04 디에스엠 아이피 어셋츠 비.브이. Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조
EA023523B1 (ru) * 2007-08-31 2016-06-30 Мартек Биосайнсиз Корпорейшн Твердые жировые композиции, содержащие полиненасыщенные жирные кислоты, и способы их получения и использования

Also Published As

Publication number Publication date
WO2000042195B1 (en) 2000-11-09
JP2010252811A (ja) 2010-11-11
JP2002534123A (ja) 2002-10-15
EP2333072A1 (en) 2011-06-15
CA2359629A1 (en) 2000-07-20
US20090098622A1 (en) 2009-04-16
WO2000042195A2 (en) 2000-07-20
HK1159166A1 (en) 2012-07-27
HK1041292A1 (zh) 2002-07-05
EP2333072B1 (en) 2013-06-19
JP2008099697A (ja) 2008-05-01
EP2333071A1 (en) 2011-06-15
WO2000042195A3 (en) 2000-09-28
US20080148433A1 (en) 2008-06-19
IL144269A (en) 2010-04-15
US20110250342A1 (en) 2011-10-13
CA2359629C (en) 2015-02-24
EP1147197A2 (en) 2001-10-24
IL144269A0 (en) 2002-05-23
US7214853B2 (en) 2007-05-08
EP2333073A1 (en) 2011-06-15
IL188590A0 (en) 2008-04-13
US8829274B2 (en) 2014-09-09
US20140053299A1 (en) 2014-02-20
ES2427017T3 (es) 2013-10-28
US7897844B2 (en) 2011-03-01
MX252154B (es) 2007-12-04
US20030101486A1 (en) 2003-05-29
US6566583B1 (en) 2003-05-20
IL188590A (en) 2013-06-27
IL224871A (en) 2017-11-30
MXPA01007153A (es) 2003-07-21

Similar Documents

Publication Publication Date Title
BR0008760A (pt) Genes pks da schizochytrium
BR9809946A (pt) Produção de ácidos graxos poliinsaturados por expressão de genes de sìntese semelhantes a policetìdeo em plantas
BR9808506A (pt) Métodos e composições para sìntese de ácidos graxos poliinsaturados de cadeia longa em plantas
FI3472325T3 (fi) Menetelmä kohdennettuun dna:n muuttamiseen kasvisoluissa
DK1086236T3 (da) Polyumættede fedtsyrer i planter
Scarano et al. Plant polyphenols-biofortified foods as a novel tool for the prevention of human gut diseases
CA2692687C (en) Brassica plant comprising mutant fatty acyl-acp thioesterase alleles
BR112019007964A2 (pt) composições e métodos para alterar a floração e arquitetura vegetal para aprimorar o potencial de rendimento
Jain et al. Commiphora wightii (Arnott) Bhandari-a natural source of guggulsterone: facing a high risk of extinction in its natural habitat
AR081303A1 (es) Disminucion del contenido de acidos grasos saturados de semillas vegetales
BRPI0613632A2 (pt) planta de cultivo transgênica transformada com um ácido nucleico isolado, planta transgênica transformada com um ácido nucleico isolado, método para produzir uma planta de cultivo transgênica que contém um ácido nucleico isolado que codifica um polipeptìdeo, semente de planta de cultivo produzida por uma planta de cultivo transgênica, semente de planta produzida pela planta transgênica, ácido nucleico isolado, e, vetor de expressão recombinante que compreende um ácido nucleico isolado
WO2010118338A3 (en) Plant snf1-related protein kinase gene
BR0013596A (pt) Promotores especìficos para semente de linho
AR023290A1 (es) Acidos nucleicos aislados que comprenden las regiones reguladoras 5' que dirigen la expresion en semillas que incluyen los promotores ats1, o ats3 de losgenes de arabidopsis; vectores de transformacion que incluyan dichos aislados de acidos nucleicos en las regiones reguladoras 5' de dichos genes y
AR108834A1 (es) Metodologías y composiciones para crear una recombinación dirigida y romper el enlace entre rasgos
AR069787A1 (es) Proteinas del metabolismo de los lipidos, combinaciones de proteinas del metabolismo de los lipidos y sus usos
BR112012014568A2 (pt) "promotor para regulação de expressão de gene em raízes de planta"
BRPI0520822A2 (pt) seqüência de nucleotìdeos e polipeptìdeos correspondentes que conferem taxa de crescimento vegetal modulada e biomassa em plantas
BR112018001507A2 (pt) cepa de gluconacetobacter diazotrophicus, composição agrícola, método para melhorar a capacidade de fixação de nitrogênio de uma planta, semente que tem um revestimento na mesma, planta ou semente, semente ou progênie de uma planta ou semente, e método para produzir um produto vegetal
Li et al. Progress towards a molecular-level understanding of Curcuma alismatifolia
BR112012033037A2 (pt) acúmulo de ácidos graxos ômega 7 em sementes vegetais.
AR076315A1 (es) Procedimiento para producir maiz hibrido con cubierta aislada y revesti-miento para granos, por medio de una herramienta genetica y un maiz hibrido del mismo
BR0111115A (pt) ácido nucléico que codifica uma enzima biossintética de ácido graxo de cadeia muito longa de planta
Sardar et al. GC-MS analysis of aromatic compounds from leaves of Colebrookea oppositifolia Smith
Shah et al. Targeted Improvement of Medicinal Plant Under Stress Condition Through CRISPR-Cas-Mediated Genome Engineering

Legal Events

Date Code Title Description
B25F Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement

Owner name: OMEGATECH, INC. (US)

Free format text: A FIM DE PROCESSAR A ALTERACAO DE NOME REQUERIDA NA PETICAO NO 066989/RJ DE 03/12/2003, COMO TAMBEM A TRANSFERENCIA DE TITULAR, NA PETICAO NO 02862/RJ DE 16/01/2004, APRESENTE AS LEGALIZACOES CONSULARES.

B25D Requested change of name of applicant approved

Owner name: MARTEK BIOSCIENCES BOULDER CORPORATION (US)

Free format text: ALTERADO DE: OMEGATECH, INC.

B25A Requested transfer of rights approved

Owner name: MARTEK BIOSCIENCES CORPORATION (US)

Free format text: TRANSFERIDO DE: MARTEK BIOSCIENCES BOULDER CORPORATION

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C13, 18, 24 E 25 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: DSM IP ASSETS B.V. (NL)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]