WO1999064616A3 - Polyunsaturated fatty acids in plants - Google Patents
Polyunsaturated fatty acids in plants Download PDFInfo
- Publication number
- WO1999064616A3 WO1999064616A3 PCT/US1999/013332 US9913332W WO9964616A3 WO 1999064616 A3 WO1999064616 A3 WO 1999064616A3 US 9913332 W US9913332 W US 9913332W WO 9964616 A3 WO9964616 A3 WO 9964616A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- desaturases
- acid
- plants
- plant
- fatty acids
- Prior art date
Links
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 abstract 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 150000004668 long chain fatty acids Chemical class 0.000 abstract 2
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 abstract 1
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 abstract 1
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 abstract 1
- 102000009114 Fatty acid desaturases Human genes 0.000 abstract 1
- 108010087894 Fatty acid desaturases Proteins 0.000 abstract 1
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
- 235000021342 arachidonic acid Nutrition 0.000 abstract 1
- 229940114079 arachidonic acid Drugs 0.000 abstract 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 1
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 abstract 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 abstract 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 abstract 1
- 229960002733 gamolenic acid Drugs 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 229960004488 linolenic acid Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000010773 plant oil Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention relates to compositions and methods for preparing polyunsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding fatty acid desaturases, including Δ5-desaturases, Δ6-desaturases and Δ12-desaturases, are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more desaturases. Expression of the desaturases with different substrate specificities in the plant system permits the large scale production of polyunsaturated long chain fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, α-linolenic acid, gamma-linolenic acid, arachidonic acid and the like for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU45643/99A AU4564399A (en) | 1998-06-12 | 1999-06-11 | Polyunsaturated fatty acids in plants |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8914998P | 1998-06-12 | 1998-06-12 | |
US60/089,149 | 1998-06-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999064616A2 WO1999064616A2 (en) | 1999-12-16 |
WO1999064616A3 true WO1999064616A3 (en) | 2000-03-09 |
Family
ID=22215964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/013332 WO1999064616A2 (en) | 1998-06-12 | 1999-06-11 | Polyunsaturated fatty acids in plants |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4564399A (en) |
WO (1) | WO1999064616A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8853432B2 (en) | 2004-04-22 | 2014-10-07 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2329159A1 (en) * | 1998-05-29 | 1999-12-02 | Bruce Kelder | Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products |
DE10030976A1 (en) | 2000-06-30 | 2002-01-10 | Basf Ag | Production of unsaturated fatty acids, useful e.g. in nutrition, cosmetics or pharmaceuticals, in organisms transformed with Physcomitrella patens delta-6-desaturase nucleic acid |
KR20020073580A (en) | 2000-02-09 | 2002-09-27 | 바스프 악티엔게젤샤프트 | Novel Elongase Gene and Method for Producing Multiple-Unsaturated Fatty Acids |
GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
MXPA04007327A (en) * | 2002-01-30 | 2004-11-26 | Basf Plant Science Gmbh | Novel elongase gene and method for producing polyunsaturated fatty acids. |
GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
US7700833B2 (en) | 2002-03-01 | 2010-04-20 | Cornell University | Process for the production of unsaturated fatty acids |
DE10208812A1 (en) * | 2002-03-01 | 2003-09-11 | Basf Plant Science Gmbh | Process for the production of unsaturated fatty acids |
WO2004057001A2 (en) | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
CA2517253C (en) | 2003-02-27 | 2018-07-03 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
CA2520795C (en) | 2003-03-31 | 2015-06-23 | University Of Bristol | Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
WO2004090123A2 (en) | 2003-04-08 | 2004-10-21 | Basf Plant Science Gmbh | Δ-4 desaturases from euglena gracilis, expressing plants, and oils containing pufa |
EP2169053B1 (en) | 2003-08-01 | 2015-09-09 | BASF Plant Science GmbH | Method for production of polyunsaturated fatty acids in transgenic organisms |
US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
AU2004298565B2 (en) * | 2003-12-17 | 2009-06-04 | Suntory Holdings Limited | Arachidonic acid-containing plant and utilization of the same |
CA2556088A1 (en) * | 2004-02-04 | 2005-08-25 | The General Hospital Corporation | Compositions and methods for modifying the content of polyunsaturated fatty acids in biological cells |
US9458436B2 (en) | 2004-02-27 | 2016-10-04 | Basf Plant Science Gmbh | Method for producing polyunsaturated fatty acids in transgenic plants |
EP1720988B1 (en) | 2004-02-27 | 2011-10-12 | BASF Plant Science GmbH | METHOD FOR PRODUCING UNSATURATED omega-3 FATTY ACIDS IN TRANSGENIC ORGANISMS |
BRPI0510132A (en) | 2004-04-22 | 2007-10-02 | Commw Scient Ind Res Org | long chain polyunsaturated fatty acid synthesis by recombinant cells |
CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
DE102005013779A1 (en) | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Process for the preparation of polyunsaturated C20 and C22 fatty acids having at least four double bonds in transgenic plants |
DE102005038036A1 (en) | 2005-08-09 | 2007-02-15 | Basf Plant Science Gmbh | Process for the preparation of arachidonic acid and / or eicosapentaenoic acid in transgenic crops |
GB2431158A (en) | 2005-10-13 | 2007-04-18 | Rothamsted Res Ltd | Process for the production of arachidonic and/or eicosapentaenoic acid |
DE102005052551A1 (en) | 2005-11-02 | 2007-05-16 | Rothamsted Res Harpenden | Process for the preparation of γ-linolenic acid and / or stearidonic acid in transgenic Brassicaceae and Linaceae |
GB0603160D0 (en) | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
AR059376A1 (en) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | PROCEDURE FOR THE PRODUCTION OF POLYINSATURATED FATTY ACIDS |
EP2500420B1 (en) | 2006-08-24 | 2016-06-22 | BASF Plant Science GmbH | Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
EP2059588A4 (en) | 2006-08-29 | 2010-07-28 | Commw Scient Ind Res Org | Synthesis of fatty acids |
WO2008040787A2 (en) | 2006-10-06 | 2008-04-10 | Basf Plant Science Gmbh | Processes for producing polyunsaturated fatty acids in transgenic organisms |
US8318914B2 (en) | 2007-07-31 | 2012-11-27 | Bioriginal Food & Science Corp. | Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms |
AU2008337600A1 (en) | 2007-12-14 | 2009-06-25 | Basf Plant Science Gmbh | Promoters from brassica napus for seed specific gene expression |
CA2723072C (en) | 2008-04-30 | 2017-01-10 | Rothamsted Research Ltd. | Desaturase and method for the production of polyunsaturated fatty acids in transgenic organisms |
EP3431607A3 (en) | 2008-07-01 | 2019-03-06 | BASF Plant Science GmbH | Promoters from brassica napus for seed specific gene expression |
US9090902B2 (en) | 2008-08-26 | 2015-07-28 | Basf Plant Science Gmbh | Nucleic acids encoding desaturases and modified plant oil |
CN114045301A (en) | 2008-11-18 | 2022-02-15 | 联邦科学技术研究组织 | Enzymes and methods for producing omega-3 fatty acids |
WO2010066703A2 (en) | 2008-12-12 | 2010-06-17 | Basf Plant Science Gmbh | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms |
US9212371B2 (en) | 2009-05-13 | 2015-12-15 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
US9388437B2 (en) | 2010-06-25 | 2016-07-12 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
US8816111B2 (en) | 2012-06-15 | 2014-08-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising polyunsaturated fatty acids |
CN104726473B (en) | 2013-12-18 | 2020-02-14 | 联邦科学技术研究组织 | Extracted plant lipids comprising docosahexaenoic acid |
CN105219789B (en) | 2014-06-27 | 2023-04-07 | 联邦科学技术研究组织 | Extracted plant lipids comprising docosapentaenoic acid |
CN107429256B (en) * | 2014-11-14 | 2022-03-04 | 巴斯夫植物科学有限公司 | Materials and methods for increasing tocopherol content in seed oil |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057419A (en) * | 1988-09-22 | 1991-10-15 | Rutgers University | Genetically engineered plasmid and organisms for the production of specialized oils |
-
1999
- 1999-06-11 WO PCT/US1999/013332 patent/WO1999064616A2/en active Application Filing
- 1999-06-11 AU AU45643/99A patent/AU4564399A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057419A (en) * | 1988-09-22 | 1991-10-15 | Rutgers University | Genetically engineered plasmid and organisms for the production of specialized oils |
Non-Patent Citations (2)
Title |
---|
MICHAELSON L ET AL: "Isolation of a delta5-fatty acid desaturase gene from Mortierella alpina", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 30, no. 273, pages 19055-19059, XP002076636, ISSN: 0021-9258 * |
SPYCHALLA J ET AL: "Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 4, no. 94, pages 1142-1147, XP002076628, ISSN: 0027-8424 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8853432B2 (en) | 2004-04-22 | 2014-10-07 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell |
Also Published As
Publication number | Publication date |
---|---|
AU4564399A (en) | 1999-12-30 |
WO1999064616A2 (en) | 1999-12-16 |
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