BR0008647A - Derivados peptìdicos de baixo peso molecular como inibidores da interação laminina/nidogênio - Google Patents

Derivados peptìdicos de baixo peso molecular como inibidores da interação laminina/nidogênio

Info

Publication number
BR0008647A
BR0008647A BR0008647-9A BR0008647A BR0008647A BR 0008647 A BR0008647 A BR 0008647A BR 0008647 A BR0008647 A BR 0008647A BR 0008647 A BR0008647 A BR 0008647A
Authority
BR
Brazil
Prior art keywords
laminin
inhibitors
peptide derivatives
nidogen
interaction
Prior art date
Application number
BR0008647-9A
Other languages
English (en)
Inventor
Hans Ulrich Stilz
Martin Gerl
Gary A Flynn
Magda Stankova
Robert A Binnie
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0008647A publication Critical patent/BR0008647A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Patente de Invenção: "DERIVADOS PEPTìDICOS DE BAIXO PESO MOLECULAR COMO INIBIDORES DA INTERAçãO LAMININA/NIDOGêNIO". O objeto da presente invenção são derivados peptídicos de baixos pesos moleculares que são capazes de atuar como inibidores da interação entre laminina e nidogênio (interação laminina/nidogênio), um processo para sua preparação, composições farmacêuticas preparadas a partir desses derivados e seu uso para preparar produtos farmacêuticos e para identificar inibidores da interação laminina/nidogênio.
BR0008647-9A 1999-03-01 2000-02-19 Derivados peptìdicos de baixo peso molecular como inibidores da interação laminina/nidogênio BR0008647A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99103869A EP1070727A1 (en) 1999-03-01 1999-03-01 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
PCT/EP2000/001386 WO2000052051A1 (en) 1999-03-01 2000-02-19 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Publications (1)

Publication Number Publication Date
BR0008647A true BR0008647A (pt) 2002-01-22

Family

ID=8237658

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008647-9A BR0008647A (pt) 1999-03-01 2000-02-19 Derivados peptìdicos de baixo peso molecular como inibidores da interação laminina/nidogênio

Country Status (22)

Country Link
US (1) US6365572B1 (pt)
EP (4) EP1070727A1 (pt)
JP (1) JP4542272B2 (pt)
CN (2) CN1237075C (pt)
AT (2) ATE370969T1 (pt)
AU (1) AU779779B2 (pt)
BR (1) BR0008647A (pt)
CA (1) CA2363958C (pt)
CY (1) CY1106967T1 (pt)
CZ (1) CZ300736B6 (pt)
DE (2) DE60044832D1 (pt)
DK (1) DK1157040T3 (pt)
ES (1) ES2288844T3 (pt)
HK (2) HK1042499A1 (pt)
HU (1) HU228993B1 (pt)
ID (1) ID30183A (pt)
PL (2) PL202887B1 (pt)
PT (1) PT1157040E (pt)
RU (2) RU2380371C2 (pt)
TR (2) TR200800782T2 (pt)
WO (1) WO2000052051A1 (pt)
ZA (1) ZA200106972B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070727A1 (en) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
CA2389751A1 (en) * 1999-11-01 2001-05-10 Curagen Corporation Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
US7407660B2 (en) 2003-04-16 2008-08-05 Genentech, Inc. Methods and compositions for selective modulation of vascularization
FR2947452B1 (fr) * 2009-07-01 2012-04-20 Fabre Pierre Dermo Cosmetique L-serine et/ou l-asparagine et/ou l-valine pour prevenir et/ou au traiter des reactions inflammatoires de la peau.
RU2622018C1 (ru) * 2016-06-16 2017-06-08 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Быстро растворяющаяся трансбуккальная плёнка для лечения депрессивных расстройств, тревоги и расстройств адаптации
WO2018107167A1 (en) * 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493008A (en) * 1994-08-15 1996-02-20 The University Of Virginia Patent Foundation Two non-contiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin γ1 chain
DE19701607A1 (de) 1997-01-17 1998-07-23 Hoechst Ag Anitkörper, die an die Nidogen-Bindungsdomäne des Laminins binden, deren Herstellung und Verwendung
EP1070727A1 (en) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Also Published As

Publication number Publication date
CN1342167A (zh) 2002-03-27
AU779779B2 (en) 2005-02-10
DE60036087D1 (de) 2007-10-04
TR200800782T2 (tr) 2008-08-21
PT1157040E (pt) 2007-09-25
ZA200106972B (en) 2002-08-07
DE60036087T2 (de) 2008-05-15
ATE370969T1 (de) 2007-09-15
EP1157040A1 (en) 2001-11-28
DK1157040T3 (da) 2007-12-03
PL351483A1 (en) 2003-04-22
JP2002539092A (ja) 2002-11-19
PL202887B1 (pl) 2009-08-31
DE60044832D1 (de) 2010-09-23
CA2363958A1 (en) 2000-09-08
RU2262509C2 (ru) 2005-10-20
HUP0200192A2 (en) 2002-06-29
CN1775801A (zh) 2006-05-24
CY1106967T1 (el) 2012-01-25
CN100441594C (zh) 2008-12-10
CN1237075C (zh) 2006-01-18
ID30183A (id) 2001-11-08
EP2239270A3 (en) 2011-01-12
ATE477271T1 (de) 2010-08-15
HK1042499A1 (en) 2002-08-16
TR200102560T2 (tr) 2002-01-21
EP2239270A2 (en) 2010-10-13
HK1087126A1 (en) 2006-10-06
EP1070727A1 (en) 2001-01-24
CA2363958C (en) 2012-04-17
JP4542272B2 (ja) 2010-09-08
RU2005114905A (ru) 2006-11-20
WO2000052051A1 (en) 2000-09-08
ES2288844T3 (es) 2008-02-01
HUP0200192A3 (en) 2002-09-30
EP1845106B1 (en) 2010-08-11
AU3157700A (en) 2000-09-21
EP1845106A1 (en) 2007-10-17
EP1157040B1 (en) 2007-08-22
PL208356B1 (pl) 2011-04-29
RU2380371C2 (ru) 2010-01-27
US6365572B1 (en) 2002-04-02
CZ20013063A3 (cs) 2001-11-14
CZ300736B6 (cs) 2009-07-29
HU228993B1 (en) 2013-07-29

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 17A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]