DK1157040T3 - Peptidderivater med lav molekylvægt, der virker som inhibitorer af laminin//nidogen-interaktion - Google Patents

Peptidderivater med lav molekylvægt, der virker som inhibitorer af laminin//nidogen-interaktion

Info

Publication number
DK1157040T3
DK1157040T3 DK00909221T DK00909221T DK1157040T3 DK 1157040 T3 DK1157040 T3 DK 1157040T3 DK 00909221 T DK00909221 T DK 00909221T DK 00909221 T DK00909221 T DK 00909221T DK 1157040 T3 DK1157040 T3 DK 1157040T3
Authority
DK
Denmark
Prior art keywords
laminin
inhibitors
act
molecular weight
low molecular
Prior art date
Application number
DK00909221T
Other languages
English (en)
Inventor
Hans Ulrich Stilz
Martin Gerl
Gary A Flynn
Magda Stankova
Robert A Binnie
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK1157040T3 publication Critical patent/DK1157040T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
DK00909221T 1999-03-01 2000-02-19 Peptidderivater med lav molekylvægt, der virker som inhibitorer af laminin//nidogen-interaktion DK1157040T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99103869A EP1070727A1 (en) 1999-03-01 1999-03-01 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
PCT/EP2000/001386 WO2000052051A1 (en) 1999-03-01 2000-02-19 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Publications (1)

Publication Number Publication Date
DK1157040T3 true DK1157040T3 (da) 2007-12-03

Family

ID=8237658

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00909221T DK1157040T3 (da) 1999-03-01 2000-02-19 Peptidderivater med lav molekylvægt, der virker som inhibitorer af laminin//nidogen-interaktion

Country Status (22)

Country Link
US (1) US6365572B1 (da)
EP (4) EP1070727A1 (da)
JP (1) JP4542272B2 (da)
CN (2) CN1237075C (da)
AT (2) ATE370969T1 (da)
AU (1) AU779779B2 (da)
BR (1) BR0008647A (da)
CA (1) CA2363958C (da)
CY (1) CY1106967T1 (da)
CZ (1) CZ300736B6 (da)
DE (2) DE60036087T2 (da)
DK (1) DK1157040T3 (da)
ES (1) ES2288844T3 (da)
HK (2) HK1042499A1 (da)
HU (1) HU228993B1 (da)
ID (1) ID30183A (da)
PL (2) PL202887B1 (da)
PT (1) PT1157040E (da)
RU (2) RU2262509C2 (da)
TR (2) TR200102560T2 (da)
WO (1) WO2000052051A1 (da)
ZA (1) ZA200106972B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070727A1 (en) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
AU784338B2 (en) * 1999-11-01 2006-03-16 Curagen Corporation Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
US7407660B2 (en) 2003-04-16 2008-08-05 Genentech, Inc. Methods and compositions for selective modulation of vascularization
FR2947452B1 (fr) * 2009-07-01 2012-04-20 Fabre Pierre Dermo Cosmetique L-serine et/ou l-asparagine et/ou l-valine pour prevenir et/ou au traiter des reactions inflammatoires de la peau.
RU2622018C1 (ru) * 2016-06-16 2017-06-08 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Быстро растворяющаяся трансбуккальная плёнка для лечения депрессивных расстройств, тревоги и расстройств адаптации
AU2017371362A1 (en) 2016-12-09 2019-07-25 Celltaxis, Llc Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493008A (en) * 1994-08-15 1996-02-20 The University Of Virginia Patent Foundation Two non-contiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin γ1 chain
DE19701607A1 (de) 1997-01-17 1998-07-23 Hoechst Ag Anitkörper, die an die Nidogen-Bindungsdomäne des Laminins binden, deren Herstellung und Verwendung
EP1070727A1 (en) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Also Published As

Publication number Publication date
EP1845106A1 (en) 2007-10-17
AU779779B2 (en) 2005-02-10
RU2380371C2 (ru) 2010-01-27
CN1237075C (zh) 2006-01-18
JP2002539092A (ja) 2002-11-19
EP2239270A3 (en) 2011-01-12
PL202887B1 (pl) 2009-08-31
US6365572B1 (en) 2002-04-02
EP1070727A1 (en) 2001-01-24
ATE370969T1 (de) 2007-09-15
CN1775801A (zh) 2006-05-24
ID30183A (id) 2001-11-08
EP1845106B1 (en) 2010-08-11
WO2000052051A1 (en) 2000-09-08
ZA200106972B (en) 2002-08-07
JP4542272B2 (ja) 2010-09-08
HK1042499A1 (en) 2002-08-16
CN100441594C (zh) 2008-12-10
RU2005114905A (ru) 2006-11-20
PL351483A1 (en) 2003-04-22
DE60044832D1 (de) 2010-09-23
TR200102560T2 (tr) 2002-01-21
CY1106967T1 (el) 2012-01-25
CN1342167A (zh) 2002-03-27
EP1157040A1 (en) 2001-11-28
ES2288844T3 (es) 2008-02-01
CA2363958A1 (en) 2000-09-08
DE60036087T2 (de) 2008-05-15
CA2363958C (en) 2012-04-17
HU228993B1 (en) 2013-07-29
HK1087126A1 (en) 2006-10-06
AU3157700A (en) 2000-09-21
HUP0200192A3 (en) 2002-09-30
EP2239270A2 (en) 2010-10-13
HUP0200192A2 (en) 2002-06-29
BR0008647A (pt) 2002-01-22
TR200800782T2 (tr) 2008-08-21
DE60036087D1 (de) 2007-10-04
CZ20013063A3 (cs) 2001-11-14
EP1157040B1 (en) 2007-08-22
PL208356B1 (pl) 2011-04-29
ATE477271T1 (de) 2010-08-15
RU2262509C2 (ru) 2005-10-20
CZ300736B6 (cs) 2009-07-29
PT1157040E (pt) 2007-09-25

Similar Documents

Publication Publication Date Title
DK0891325T3 (da) Para-substituerede phenylpropansyrederivater som integrinantagonister
BR0016396A (pt) Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares
NO20016038L (no) Benzenderivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme
IS6002A (is) Pýrazólkarboxýlsýruafleiður, framleiðsla þeirra, lyfjasamsetningar sem innihalda þær
DK0889877T3 (da) Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
EE05198B1 (et) Asendatud aminometlrhma sisaldavad N-(arlsulfonl)beetaaminohappe derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsi£onid
SE9904505D0 (sv) Novel compounds
EE05081B1 (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, 3-aminoasetidiini derivaadid ja nende valmistamise meetodid
SE9901875D0 (sv) Novel compounds
DK1115720T3 (da) Derivater af N-(iminomethyl)aminer, fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater, der indeholder dem
EE05091B1 (et) Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
NO20062824L (no) 1,3-Difenylprop-2-en-1-on-avledete forbindelser, fremgangsmater for fremstilling derav, samt anvendelse av samme
ATE300541T1 (de) Pyrazolopyridinderivate
EA200100774A1 (ru) Гетероциклические производные с функциональными группами (варианты), фармацевтическая композиция и комбинация, способ модулирования активности рецептора хемокина (варианты), способ профилактики инфицирования вич и лечения инфекции вич, замедления проявления спид и лечения спид, способ лечения воспалительных процессов
DK1421075T3 (da) Piperidinderivater, der er nyttige som CCR5-antagonister til behandling af HIV
HK1087126A1 (en) Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
HUP0401499A3 (en) Indole derivatives as cox ii inhibitors, process for their preparation and pharmaceutical compositions containing them
TR199900732T2 (xx) PDE IV inhibe eden 2-siyanoiminoimidazol t�revleri.
HUP0203739A3 (en) Bicyclic imidazo-3-yl-amine derivatives which are substituted on the sixth ring, process for their preparation and pharmaceutical compositions containing them
IL157540A (en) Pharmaceutical compositions comprising n-(aryl)-2-arylethenesulfonamides, some such novel compounds and process for their preparation
EE200200252A (et) Antikehade kasutamine vaktsiinidena, antikehi sisaldavad farmatseutilised kompositsioonid, meetod antikehapreparaadi valmistamiseks ja meetod farmatseutilise kompositsiooni valmistamiseks
HUP0202706A3 (en) Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing them
ATE274515T1 (de) Pyrazolopyridinderivate
EE04525B1 (et) Morfoliini derivaadid, nende valmistamismeetod janeid sisaldavad farmatseutilised kompositsioonid
MXPA05005340A (es) Nuevos derivados antagonistas del receptor de la vitronectina, sus procedimientos de preparacion, su aplicacion como medicamentos y los compuestos farmaceuticos que los contienen.