HK1042499A1 - Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction - Google Patents

Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Info

Publication number
HK1042499A1
HK1042499A1 HK02104064A HK02104064A HK1042499A1 HK 1042499 A1 HK1042499 A1 HK 1042499A1 HK 02104064 A HK02104064 A HK 02104064A HK 02104064 A HK02104064 A HK 02104064A HK 1042499 A1 HK1042499 A1 HK 1042499A1
Authority
HK
Hong Kong
Prior art keywords
laminin
inhibitors
molecular weight
low molecular
peptide derivatives
Prior art date
Application number
HK02104064A
Other languages
English (en)
Inventor
Hans Ulrich Stilz
Martin Gerl
Gary A Flynn
Magda Stankova
Robert A Binnie
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1042499A1 publication Critical patent/HK1042499A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
HK02104064A 1999-03-01 2002-05-31 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction HK1042499A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99103869A EP1070727A1 (en) 1999-03-01 1999-03-01 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
PCT/EP2000/001386 WO2000052051A1 (en) 1999-03-01 2000-02-19 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Publications (1)

Publication Number Publication Date
HK1042499A1 true HK1042499A1 (en) 2002-08-16

Family

ID=8237658

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02104064A HK1042499A1 (en) 1999-03-01 2002-05-31 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
HK06107299.7A HK1087126A1 (en) 1999-03-01 2006-06-28 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK06107299.7A HK1087126A1 (en) 1999-03-01 2006-06-28 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Country Status (22)

Country Link
US (1) US6365572B1 (xx)
EP (4) EP1070727A1 (xx)
JP (1) JP4542272B2 (xx)
CN (2) CN100441594C (xx)
AT (2) ATE477271T1 (xx)
AU (1) AU779779B2 (xx)
BR (1) BR0008647A (xx)
CA (1) CA2363958C (xx)
CY (1) CY1106967T1 (xx)
CZ (1) CZ300736B6 (xx)
DE (2) DE60036087T2 (xx)
DK (1) DK1157040T3 (xx)
ES (1) ES2288844T3 (xx)
HK (2) HK1042499A1 (xx)
HU (1) HU228993B1 (xx)
ID (1) ID30183A (xx)
PL (2) PL208356B1 (xx)
PT (1) PT1157040E (xx)
RU (2) RU2262509C2 (xx)
TR (2) TR200102560T2 (xx)
WO (1) WO2000052051A1 (xx)
ZA (1) ZA200106972B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070727A1 (en) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction
JP2003525595A (ja) * 1999-11-01 2003-09-02 キュラゲン コーポレイション 脈管形成に含まれる差動発現遺伝子、それにコードされるポリペプチド、及びそれを用いた方法
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
US7407660B2 (en) 2003-04-16 2008-08-05 Genentech, Inc. Methods and compositions for selective modulation of vascularization
FR2947452B1 (fr) * 2009-07-01 2012-04-20 Fabre Pierre Dermo Cosmetique L-serine et/ou l-asparagine et/ou l-valine pour prevenir et/ou au traiter des reactions inflammatoires de la peau.
RU2622018C1 (ru) * 2016-06-16 2017-06-08 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Быстро растворяющаяся трансбуккальная плёнка для лечения депрессивных расстройств, тревоги и расстройств адаптации
EP3551608A1 (en) * 2016-12-09 2019-10-16 Celtaxsys Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493008A (en) * 1994-08-15 1996-02-20 The University Of Virginia Patent Foundation Two non-contiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin γ1 chain
DE19701607A1 (de) 1997-01-17 1998-07-23 Hoechst Ag Anitkörper, die an die Nidogen-Bindungsdomäne des Laminins binden, deren Herstellung und Verwendung
EP1070727A1 (en) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Also Published As

Publication number Publication date
CA2363958C (en) 2012-04-17
CN1342167A (zh) 2002-03-27
JP2002539092A (ja) 2002-11-19
RU2380371C2 (ru) 2010-01-27
RU2262509C2 (ru) 2005-10-20
US6365572B1 (en) 2002-04-02
DE60044832D1 (de) 2010-09-23
HK1087126A1 (en) 2006-10-06
CN1237075C (zh) 2006-01-18
EP1157040A1 (en) 2001-11-28
ES2288844T3 (es) 2008-02-01
AU3157700A (en) 2000-09-21
CA2363958A1 (en) 2000-09-08
EP1845106B1 (en) 2010-08-11
CZ300736B6 (cs) 2009-07-29
HU228993B1 (en) 2013-07-29
JP4542272B2 (ja) 2010-09-08
PL208356B1 (pl) 2011-04-29
CN100441594C (zh) 2008-12-10
CN1775801A (zh) 2006-05-24
TR200102560T2 (tr) 2002-01-21
DE60036087T2 (de) 2008-05-15
PL202887B1 (pl) 2009-08-31
PL351483A1 (en) 2003-04-22
EP2239270A3 (en) 2011-01-12
HUP0200192A2 (en) 2002-06-29
ATE477271T1 (de) 2010-08-15
DE60036087D1 (de) 2007-10-04
WO2000052051A1 (en) 2000-09-08
TR200800782T2 (tr) 2008-08-21
RU2005114905A (ru) 2006-11-20
ATE370969T1 (de) 2007-09-15
PT1157040E (pt) 2007-09-25
EP2239270A2 (en) 2010-10-13
ZA200106972B (en) 2002-08-07
EP1845106A1 (en) 2007-10-17
CY1106967T1 (el) 2012-01-25
EP1070727A1 (en) 2001-01-24
ID30183A (id) 2001-11-08
HUP0200192A3 (en) 2002-09-30
CZ20013063A3 (cs) 2001-11-14
EP1157040B1 (en) 2007-08-22
AU779779B2 (en) 2005-02-10
DK1157040T3 (da) 2007-12-03
BR0008647A (pt) 2002-01-22

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20160219