DE60036087D1 - Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung - Google Patents

Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung

Info

Publication number
DE60036087D1
DE60036087D1 DE60036087T DE60036087T DE60036087D1 DE 60036087 D1 DE60036087 D1 DE 60036087D1 DE 60036087 T DE60036087 T DE 60036087T DE 60036087 T DE60036087 T DE 60036087T DE 60036087 D1 DE60036087 D1 DE 60036087D1
Authority
DE
Germany
Prior art keywords
laminin
inhibitors
peptide derivatives
nidogen
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036087T
Other languages
English (en)
Other versions
DE60036087T2 (de
Inventor
Hans Ulrich Stilz
Martin Gerl
Gary A Flynn
Magda Stankova
Robert A Binnie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Application granted granted Critical
Publication of DE60036087D1 publication Critical patent/DE60036087D1/de
Publication of DE60036087T2 publication Critical patent/DE60036087T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
DE60036087T 1999-03-01 2000-02-19 Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung Expired - Lifetime DE60036087T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99103869 1999-03-01
EP99103869A EP1070727A1 (de) 1999-03-01 1999-03-01 Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung
PCT/EP2000/001386 WO2000052051A1 (en) 1999-03-01 2000-02-19 Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

Publications (2)

Publication Number Publication Date
DE60036087D1 true DE60036087D1 (de) 2007-10-04
DE60036087T2 DE60036087T2 (de) 2008-05-15

Family

ID=8237658

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60036087T Expired - Lifetime DE60036087T2 (de) 1999-03-01 2000-02-19 Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung
DE60044832T Expired - Lifetime DE60044832D1 (de) 1999-03-01 2000-02-19 Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60044832T Expired - Lifetime DE60044832D1 (de) 1999-03-01 2000-02-19 Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung

Country Status (22)

Country Link
US (1) US6365572B1 (de)
EP (4) EP1070727A1 (de)
JP (1) JP4542272B2 (de)
CN (2) CN100441594C (de)
AT (2) ATE477271T1 (de)
AU (1) AU779779B2 (de)
BR (1) BR0008647A (de)
CA (1) CA2363958C (de)
CY (1) CY1106967T1 (de)
CZ (1) CZ300736B6 (de)
DE (2) DE60036087T2 (de)
DK (1) DK1157040T3 (de)
ES (1) ES2288844T3 (de)
HK (2) HK1042499A1 (de)
HU (1) HU228993B1 (de)
ID (1) ID30183A (de)
PL (2) PL208356B1 (de)
PT (1) PT1157040E (de)
RU (2) RU2262509C2 (de)
TR (2) TR200102560T2 (de)
WO (1) WO2000052051A1 (de)
ZA (1) ZA200106972B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070727A1 (de) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung
JP2003525595A (ja) * 1999-11-01 2003-09-02 キュラゲン コーポレイション 脈管形成に含まれる差動発現遺伝子、それにコードされるポリペプチド、及びそれを用いた方法
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
US7407660B2 (en) 2003-04-16 2008-08-05 Genentech, Inc. Methods and compositions for selective modulation of vascularization
FR2947452B1 (fr) * 2009-07-01 2012-04-20 Fabre Pierre Dermo Cosmetique L-serine et/ou l-asparagine et/ou l-valine pour prevenir et/ou au traiter des reactions inflammatoires de la peau.
RU2622018C1 (ru) * 2016-06-16 2017-06-08 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Быстро растворяющаяся трансбуккальная плёнка для лечения депрессивных расстройств, тревоги и расстройств адаптации
EP3551608A1 (de) * 2016-12-09 2019-10-16 Celtaxsys Inc. Anhängende amine und derivate als inhibitoren der leukotrien-a4-hydrolase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493008A (en) * 1994-08-15 1996-02-20 The University Of Virginia Patent Foundation Two non-contiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin γ1 chain
DE19701607A1 (de) 1997-01-17 1998-07-23 Hoechst Ag Anitkörper, die an die Nidogen-Bindungsdomäne des Laminins binden, deren Herstellung und Verwendung
EP1070727A1 (de) * 1999-03-01 2001-01-24 Aventis Pharma Deutschland GmbH Niedermolekulare Peptide als Inhibitoren der Laminin/Nidogen Wechselwirkung

Also Published As

Publication number Publication date
CA2363958C (en) 2012-04-17
HK1042499A1 (en) 2002-08-16
CN1342167A (zh) 2002-03-27
JP2002539092A (ja) 2002-11-19
RU2380371C2 (ru) 2010-01-27
RU2262509C2 (ru) 2005-10-20
US6365572B1 (en) 2002-04-02
DE60044832D1 (de) 2010-09-23
HK1087126A1 (en) 2006-10-06
CN1237075C (zh) 2006-01-18
EP1157040A1 (de) 2001-11-28
ES2288844T3 (es) 2008-02-01
AU3157700A (en) 2000-09-21
CA2363958A1 (en) 2000-09-08
EP1845106B1 (de) 2010-08-11
CZ300736B6 (cs) 2009-07-29
HU228993B1 (en) 2013-07-29
JP4542272B2 (ja) 2010-09-08
PL208356B1 (pl) 2011-04-29
CN100441594C (zh) 2008-12-10
CN1775801A (zh) 2006-05-24
TR200102560T2 (tr) 2002-01-21
DE60036087T2 (de) 2008-05-15
PL202887B1 (pl) 2009-08-31
PL351483A1 (en) 2003-04-22
EP2239270A3 (de) 2011-01-12
HUP0200192A2 (en) 2002-06-29
ATE477271T1 (de) 2010-08-15
WO2000052051A1 (en) 2000-09-08
TR200800782T2 (tr) 2008-08-21
RU2005114905A (ru) 2006-11-20
ATE370969T1 (de) 2007-09-15
PT1157040E (pt) 2007-09-25
EP2239270A2 (de) 2010-10-13
ZA200106972B (en) 2002-08-07
EP1845106A1 (de) 2007-10-17
CY1106967T1 (el) 2012-01-25
EP1070727A1 (de) 2001-01-24
ID30183A (id) 2001-11-08
HUP0200192A3 (en) 2002-09-30
CZ20013063A3 (cs) 2001-11-14
EP1157040B1 (de) 2007-08-22
AU779779B2 (en) 2005-02-10
DK1157040T3 (da) 2007-12-03
BR0008647A (pt) 2002-01-22

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