BG98931A - Trisubstituted pyrimido [5,4-d]-pyrimidines for the modulation of resistence to medicaments, medicamentous formulations containing them and method for the their preparation - Google Patents
Trisubstituted pyrimido [5,4-d]-pyrimidines for the modulation of resistence to medicaments, medicamentous formulations containing them and method for the their preparation Download PDFInfo
- Publication number
- BG98931A BG98931A BG98931A BG9893194A BG98931A BG 98931 A BG98931 A BG 98931A BG 98931 A BG98931 A BG 98931A BG 9893194 A BG9893194 A BG 9893194A BG 98931 A BG98931 A BG 98931A
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- piperidino
- carbon atoms
- pyrimidine
- pyrimido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4325900A DE4325900A1 (de) | 1993-08-02 | 1993-08-02 | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG98931A true BG98931A (en) | 1995-09-29 |
Family
ID=6494272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG98931A BG98931A (en) | 1993-08-02 | 1994-07-28 | Trisubstituted pyrimido [5,4-d]-pyrimidines for the modulation of resistence to medicaments, medicamentous formulations containing them and method for the their preparation |
Country Status (22)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| DE19608588A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| CN115650827B (zh) * | 2022-10-27 | 2024-03-15 | 戊言医药科技（上海）有限公司 | 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0023559B1 (de) * | 1979-07-03 | 1984-09-19 | Dr. Karl Thomae GmbH | 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel |
| DE2931573A1 (de) * | 1979-08-03 | 1981-02-26 | Thomae Gmbh Dr K | Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung |
| DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
| DE3423092A1 (de) * | 1984-06-22 | 1986-01-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE3833392A1 (de) * | 1988-10-01 | 1990-04-05 | Thomae Gmbh Dr K | Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel |
-
1993
- 1993-08-02 DE DE4325900A patent/DE4325900A1/de not_active Withdrawn
-
1994
- 1994-07-07 TW TW083106205A patent/TW251286B/zh active
- 1994-07-26 EP EP94111739A patent/EP0645390A1/de not_active Withdrawn
- 1994-07-27 RO RO94-01270A patent/RO113557B1/ro unknown
- 1994-07-28 BG BG98931A patent/BG98931A/bg unknown
- 1994-07-29 IL IL110509A patent/IL110509A/en not_active IP Right Cessation
- 1994-07-29 NZ NZ264133A patent/NZ264133A/en unknown
- 1994-07-29 SK SK915-94A patent/SK91594A3/sk unknown
- 1994-07-29 CA CA002129179A patent/CA2129179A1/en not_active Abandoned
- 1994-08-01 CN CN94114910A patent/CN1041091C/zh not_active Expired - Fee Related
- 1994-08-01 RU RU94028278/04A patent/RU94028278A/ru unknown
- 1994-08-01 ZA ZA945689A patent/ZA945689B/xx unknown
- 1994-08-01 HU HU9402253A patent/HUT70957A/hu unknown
- 1994-08-01 KR KR1019940018961A patent/KR950005828A/ko not_active Withdrawn
- 1994-08-01 JP JP6179359A patent/JPH0789963A/ja active Pending
- 1994-08-01 NO NO942853A patent/NO301479B1/no unknown
- 1994-08-01 FI FI943574A patent/FI943574A7/fi unknown
- 1994-08-01 PL PL94304512A patent/PL304512A1/xx unknown
- 1994-08-01 AU AU68813/94A patent/AU683888B2/en not_active Ceased
- 1994-08-02 CZ CZ941845A patent/CZ184594A3/cs unknown
- 1994-08-02 US US08/284,325 patent/US5618814A/en not_active Expired - Fee Related
- 1994-11-23 EE EE9400255A patent/EE9400255A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU94028278A (ru) | 1996-08-27 |
| AU683888B2 (en) | 1997-11-27 |
| HU9402253D0 (en) | 1994-09-28 |
| NO942853L (no) | 1995-02-03 |
| HUT70957A (en) | 1995-11-28 |
| CN1106405A (zh) | 1995-08-09 |
| TW251286B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-07-11 |
| JPH0789963A (ja) | 1995-04-04 |
| IL110509A (en) | 1998-01-04 |
| RO113557B1 (ro) | 1998-08-28 |
| EP0645390A1 (de) | 1995-03-29 |
| CN1041091C (zh) | 1998-12-09 |
| ZA945689B (en) | 1996-02-01 |
| KR950005828A (ko) | 1995-03-20 |
| DE4325900A1 (de) | 1995-02-09 |
| CZ184594A3 (en) | 1995-02-15 |
| IL110509A0 (en) | 1994-10-21 |
| US5618814A (en) | 1997-04-08 |
| SK91594A3 (en) | 1995-04-12 |
| PL304512A1 (en) | 1995-02-06 |
| FI943574A0 (fi) | 1994-08-01 |
| NZ264133A (en) | 1996-05-28 |
| AU6881394A (en) | 1995-02-09 |
| CA2129179A1 (en) | 1995-02-03 |
| EE9400255A (et) | 1996-02-15 |
| NO301479B1 (no) | 1997-11-03 |
| FI943574A7 (fi) | 1995-02-03 |
| NO942853D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU710274B2 (en) | 4-amino-pyrimidine derivates, medicaments containing these compounds, their use and process for their production | |
| KR101221864B1 (ko) | 4-［［(7ｒ)-8-사이클로펜틸-7-에틸-5,6,7,8-테트라하이드로-5-메틸-6-옥소-2-프테리디닐］아미노］-3-메톡시-ｎ-(1-메틸-4-피페리디닐)벤즈아미드의 수화물 및 다형체, 이들의 제조방법, 및 약제로서의 이들의 용도 | |
| MXPA01012899A (es) | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion. | |
| BG98931A (en) | Trisubstituted pyrimido [5,4-d]-pyrimidines for the modulation of resistence to medicaments, medicamentous formulations containing them and method for the their preparation | |
| KR20190099209A (ko) | 8,9-디하이드로이미다졸[1,2-a]피리미도[5,4-e]피리미딘-5(6H)-케톤계 화합물 | |
| CN108349981A (zh) | 新型的吡唑并[3，4－d]嘧啶化合物或其盐 | |
| KR19990087551A (ko) | 피리미도[5,4-d]피리미딘, 이를 함유하는 약물, 이의 용도 및이의 제조방법 | |
| JPH07504681A (ja) | プリノン系の抗アンギナ薬 | |
| EP0319429B1 (en) | 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient | |
| BRPI0710293A2 (pt) | n-(aril- ou heteroaril)-pirazol[1,5-a]pirimidinas 3-substituìdas como inibidores de cinase | |
| Hu et al. | Design, synthesis and biological evaluation of novel 2, 4-diaminopyrimidine derivatives as potent antitumor agents | |
| JPH06184155A (ja) | ４，５−ジヒドロ−４−オキソ−ピロロ［１，２−ａ］キノキサリンおよびそのアザ類似体、それらの製造方法、該化合物を含有する医薬品および該医薬品の製造方法 | |
| EP1163242A2 (en) | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | |
| NO175979B (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive pteridiner | |
| CA1321996C (en) | Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds | |
| AU8545091A (en) | Antiproliferative substituted naphthalene compounds | |
| JPH0441149B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| EP0270692A1 (en) | Antiarrhythmic agent | |
| WO1992005173A1 (en) | Substituted tricyclic compounds | |
| EP3098222B1 (en) | Fused acridine derivative and pharmaceutical composition, preparation method and use thereof | |
| CS254990B2 (en) | Method of 12-aminopyridazino(4,5:3,4)-pyrrolo(2,1-a)isoquinolines production | |
| CN113563330B (zh) | 一类β-卡波林的3位衍生物及其制备方法和用途 | |
| CN114634453B (zh) | 喹唑啉衍生物制备方法及其应用 | |
| JPH05310749A (ja) | アザビシクロ誘導体 | |
| JPH07501812A (ja) | ４−アミノ−３−アシルキノリン誘導体およびその胃酸分泌抑制剤としての使用 |