EE9400255A - Kolmikasendatud pürimido[5,4-d]pürimidiinid multimedikamentse resistentsuse mõjutajana, neid ühendeid sisaldavad ravimid ning nende saamise meetodid - Google Patents
Kolmikasendatud pürimido[5,4-d]pürimidiinid multimedikamentse resistentsuse mõjutajana, neid ühendeid sisaldavad ravimid ning nende saamise meetodidInfo
- Publication number
- EE9400255A EE9400255A EE9400255A EE9400255A EE9400255A EE 9400255 A EE9400255 A EE 9400255A EE 9400255 A EE9400255 A EE 9400255A EE 9400255 A EE9400255 A EE 9400255A EE 9400255 A EE9400255 A EE 9400255A
- Authority
- EE
- Estonia
- Prior art keywords
- pyrimidines
- agents
- compounds
- preparation
- methods
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000036457 multidrug resistance Effects 0.000 title 1
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4325900A DE4325900A1 (de) | 1993-08-02 | 1993-08-02 | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9400255A true EE9400255A (et) | 1996-02-15 |
Family
ID=6494272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400255A EE9400255A (et) | 1993-08-02 | 1994-11-23 | Kolmikasendatud pürimido[5,4-d]pürimidiinid multimedikamentse resistentsuse mõjutajana, neid ühendeid sisaldavad ravimid ning nende saamise meetodid |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5618814A (xx) |
| EP (1) | EP0645390A1 (xx) |
| JP (1) | JPH0789963A (xx) |
| KR (1) | KR950005828A (xx) |
| CN (1) | CN1041091C (xx) |
| AU (1) | AU683888B2 (xx) |
| BG (1) | BG98931A (xx) |
| CA (1) | CA2129179A1 (xx) |
| CZ (1) | CZ184594A3 (xx) |
| DE (1) | DE4325900A1 (xx) |
| EE (1) | EE9400255A (xx) |
| FI (1) | FI943574A (xx) |
| HU (1) | HUT70957A (xx) |
| IL (1) | IL110509A (xx) |
| NO (1) | NO301479B1 (xx) |
| NZ (1) | NZ264133A (xx) |
| PL (1) | PL304512A1 (xx) |
| RO (1) | RO113557B1 (xx) |
| RU (1) | RU94028278A (xx) |
| SK (1) | SK91594A3 (xx) |
| TW (1) | TW251286B (xx) |
| ZA (1) | ZA945689B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| CN115650827B (zh) * | 2022-10-27 | 2024-03-15 | 戊言医药科技（上海）有限公司 | 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3069211D1 (en) * | 1979-07-03 | 1984-10-25 | Thomae Gmbh Dr K | 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them |
| DE2931573A1 (de) * | 1979-08-03 | 1981-02-26 | Thomae Gmbh Dr K | Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung |
| DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
| DE3423092A1 (de) * | 1984-06-22 | 1986-01-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE3833392A1 (de) * | 1988-10-01 | 1990-04-05 | Thomae Gmbh Dr K | Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel |
-
1993
- 1993-08-02 DE DE4325900A patent/DE4325900A1/de not_active Withdrawn
-
1994
- 1994-07-07 TW TW083106205A patent/TW251286B/zh active
- 1994-07-26 EP EP94111739A patent/EP0645390A1/de not_active Withdrawn
- 1994-07-27 RO RO94-01270A patent/RO113557B1/ro unknown
- 1994-07-28 BG BG98931A patent/BG98931A/bg unknown
- 1994-07-29 CA CA002129179A patent/CA2129179A1/en not_active Abandoned
- 1994-07-29 NZ NZ264133A patent/NZ264133A/en unknown
- 1994-07-29 IL IL110509A patent/IL110509A/en not_active IP Right Cessation
- 1994-07-29 SK SK915-94A patent/SK91594A3/sk unknown
- 1994-08-01 KR KR1019940018961A patent/KR950005828A/ko not_active Application Discontinuation
- 1994-08-01 AU AU68813/94A patent/AU683888B2/en not_active Ceased
- 1994-08-01 ZA ZA945689A patent/ZA945689B/xx unknown
- 1994-08-01 RU RU94028278/04A patent/RU94028278A/ru unknown
- 1994-08-01 NO NO942853A patent/NO301479B1/no unknown
- 1994-08-01 PL PL94304512A patent/PL304512A1/xx unknown
- 1994-08-01 FI FI943574A patent/FI943574A/fi unknown
- 1994-08-01 CN CN94114910A patent/CN1041091C/zh not_active Expired - Fee Related
- 1994-08-01 JP JP6179359A patent/JPH0789963A/ja active Pending
- 1994-08-01 HU HU9402253A patent/HUT70957A/hu unknown
- 1994-08-02 CZ CZ941845A patent/CZ184594A3/cs unknown
- 1994-08-02 US US08/284,325 patent/US5618814A/en not_active Expired - Fee Related
- 1994-11-23 EE EE9400255A patent/EE9400255A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU94028278A (ru) | 1996-08-27 |
| AU683888B2 (en) | 1997-11-27 |
| NO942853L (no) | 1995-02-03 |
| IL110509A0 (en) | 1994-10-21 |
| CN1106405A (zh) | 1995-08-09 |
| TW251286B (xx) | 1995-07-11 |
| HU9402253D0 (en) | 1994-09-28 |
| PL304512A1 (en) | 1995-02-06 |
| FI943574A0 (fi) | 1994-08-01 |
| FI943574A (fi) | 1995-02-03 |
| DE4325900A1 (de) | 1995-02-09 |
| CZ184594A3 (en) | 1995-02-15 |
| US5618814A (en) | 1997-04-08 |
| KR950005828A (ko) | 1995-03-20 |
| CA2129179A1 (en) | 1995-02-03 |
| SK91594A3 (en) | 1995-04-12 |
| EP0645390A1 (de) | 1995-03-29 |
| NO942853D0 (xx) | 1994-08-01 |
| JPH0789963A (ja) | 1995-04-04 |
| HUT70957A (en) | 1995-11-28 |
| ZA945689B (en) | 1996-02-01 |
| BG98931A (en) | 1995-09-29 |
| NO301479B1 (no) | 1997-11-03 |
| AU6881394A (en) | 1995-02-09 |
| IL110509A (en) | 1998-01-04 |
| CN1041091C (zh) | 1998-12-09 |
| RO113557B1 (ro) | 1998-08-28 |
| NZ264133A (en) | 1996-05-28 |
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