RU94028278A - Производные пиридо-[5,4-d]пиримидина и их соли - Google Patents

Производные пиридо-[5,4-d]пиримидина и их соли

Info

Publication number
RU94028278A
RU94028278A RU94028278/04A RU94028278A RU94028278A RU 94028278 A RU94028278 A RU 94028278A RU 94028278/04 A RU94028278/04 A RU 94028278/04A RU 94028278 A RU94028278 A RU 94028278A RU 94028278 A RU94028278 A RU 94028278A
Authority
RU
Russia
Prior art keywords
group
carbon atoms
alkyl
substituted
phenyl
Prior art date
Application number
RU94028278/04A
Other languages
English (en)
Inventor
Хекель Армин
De]
Бамбергер Уве
Мауц Аннерозе
Original Assignee
Др.Карл Томэ ГмбХ (DE)
Др.Карл Томэ ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Др.Карл Томэ ГмбХ (DE), Др.Карл Томэ ГмбХ filed Critical Др.Карл Томэ ГмбХ (DE)
Publication of RU94028278A publication Critical patent/RU94028278A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Объектом изобретения являются производные пиримидо(5,4-d)пиримидина общей формулы I, приведенной в описании, и их соли.

Claims (1)

  1. Объектом изобретения являются производные пиримидо(5,4-d)пиримидина общей формулы I, приведенной в описании, и их соли.
RU94028278/04A 1993-08-02 1994-08-01 Производные пиридо-[5,4-d]пиримидина и их соли RU94028278A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4325900.6 1993-08-02
DE4325900A DE4325900A1 (de) 1993-08-02 1993-08-02 Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
RU94028278A true RU94028278A (ru) 1996-08-27

Family

ID=6494272

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94028278/04A RU94028278A (ru) 1993-08-02 1994-08-01 Производные пиридо-[5,4-d]пиримидина и их соли

Country Status (22)

Country Link
US (1) US5618814A (ru)
EP (1) EP0645390A1 (ru)
JP (1) JPH0789963A (ru)
KR (1) KR950005828A (ru)
CN (1) CN1041091C (ru)
AU (1) AU683888B2 (ru)
BG (1) BG98931A (ru)
CA (1) CA2129179A1 (ru)
CZ (1) CZ184594A3 (ru)
DE (1) DE4325900A1 (ru)
EE (1) EE9400255A (ru)
FI (1) FI943574A (ru)
HU (1) HUT70957A (ru)
IL (1) IL110509A (ru)
NO (1) NO301479B1 (ru)
NZ (1) NZ264133A (ru)
PL (1) PL304512A1 (ru)
RO (1) RO113557B1 (ru)
RU (1) RU94028278A (ru)
SK (1) SK91594A3 (ru)
TW (1) TW251286B (ru)
ZA (1) ZA945689B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CN1984660B (zh) * 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CN115650827B (zh) * 2022-10-27 2024-03-15 戊言医药科技（上海）有限公司 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069211D1 (en) * 1979-07-03 1984-10-25 Thomae Gmbh Dr K 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them
DE2931573A1 (de) * 1979-08-03 1981-02-26 Thomae Gmbh Dr K Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3833392A1 (de) * 1988-10-01 1990-04-05 Thomae Gmbh Dr K Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
AU683888B2 (en) 1997-11-27
NO942853L (no) 1995-02-03
IL110509A0 (en) 1994-10-21
CN1106405A (zh) 1995-08-09
TW251286B (ru) 1995-07-11
HU9402253D0 (en) 1994-09-28
PL304512A1 (en) 1995-02-06
FI943574A0 (fi) 1994-08-01
FI943574A (fi) 1995-02-03
DE4325900A1 (de) 1995-02-09
CZ184594A3 (en) 1995-02-15
US5618814A (en) 1997-04-08
KR950005828A (ko) 1995-03-20
CA2129179A1 (en) 1995-02-03
SK91594A3 (en) 1995-04-12
EP0645390A1 (de) 1995-03-29
NO942853D0 (ru) 1994-08-01
JPH0789963A (ja) 1995-04-04
HUT70957A (en) 1995-11-28
ZA945689B (en) 1996-02-01
BG98931A (en) 1995-09-29
NO301479B1 (no) 1997-11-03
AU6881394A (en) 1995-02-09
IL110509A (en) 1998-01-04
CN1041091C (zh) 1998-12-09
RO113557B1 (ro) 1998-08-28
EE9400255A (et) 1996-02-15
NZ264133A (en) 1996-05-28

Similar Documents

Publication Publication Date Title
RU94028278A (ru) Производные пиридо-[5,4-d]пиримидина и их соли
EE200200148A (et) Kinasoliini derivaadid, nende valmistamise meetodning kasutamine
BR0010391A (pt) Composto, composição farmacêutica, método de preparação de um composto, e, uso de um composto
AR038481A1 (es) Derivados de dihidrobenzodiazepin-2-ona iii para el tratamiento de desordenes neurologicos
KR900009598A (ko) 혈관평활근 이완작용을 가진 화합물과 그의 제조방법
GR1000684B (el) Μεθοδος παρασκευης παραγωγων ταξολης και τα εξ αυτης προκυπτοντα προιοντα.
EP1094065A3 (en) Cucurbituril derivatives, their preparation methods and uses
GEP20053541B (en) Pyrrolo[2,3-d]Pyrimidine Compounds
CA2209598A1 (en) Aryl and heteroaryl purine compounds
BR9907962A (pt) Composição farmacêntica, composto, e, processo para preparar o mesmo
ATE147386T1 (de) Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel
ES2193746T3 (es) Acelerantes para sistemas reticulables.
ES8203845A1 (es) Procedimiento para preparar derivados de piridoxina
ES2103931T3 (es) Imidazoacridinas y su uso antineoplasico.
GB1135259A (en) New pyrimidines and process for their manufacture
ATE496056T1 (de) Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
CY1105695T1 (el) Παραγωγα της εχινοκανδινης, μεθοδος παρασκευης τους και εφαρμογη τους σαν αντι-μυκητιασικα
IT1254931B (it) Stabilizzanti polisilossanici contenenti gruppi fenolici stericamente impediti e gruppi ossammidici.
DE69910568D1 (de) Furopyridinderivate und ihre therapeutische verwendung
PL329894A1 (en) Novel pyrrolic compounds, method of obtaining such compounds and pharmaceutic compositions containing them
RU94045257A (ru) Производные винилкарбоновой кислоты, способ их получения и применение
MX9706014A (es) Derivados de xanteno y acridina y su empleo.
NO994150D0 (no) Nye derivater av erytromycin, fremgangsmåte for fremstilling av disse og deres anvendelse som medikamenter
ATE132498T1 (de) Salze von n5, n10 - methylen-5,6,7,8- tetrahydrofolsäure
JPS56127370A (en) Novel piperazine compound, its preparation and utilization