BG64456B1 - Фармацевтични продукти за лечение и предпазване от болести, свързани с дисфункцията на васкуларни ендотелиални клетки - Google Patents

Фармацевтични продукти за лечение и предпазване от болести, свързани с дисфункцията на васкуларни ендотелиални клетки Download PDF

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Publication number
BG64456B1
BG64456B1 BG103194A BG10319499A BG64456B1 BG 64456 B1 BG64456 B1 BG 64456B1 BG 103194 A BG103194 A BG 103194A BG 10319499 A BG10319499 A BG 10319499A BG 64456 B1 BG64456 B1 BG 64456B1
Authority
BG
Bulgaria
Prior art keywords
group
compounds
general formula
carbon atoms
propoxy
Prior art date
Application number
BG103194A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103194A (en
Inventor
Andrea Jednakovits
Laszlo Ueroegdi
Ede Marvanyos
Mihaly Barabas
Istvan Kurucz
Ernoe Bacsy
Laszlo Koranyi
Sandor Erdoe
Gyoergy Dorman
Marta Vitai
Gyoergy Schmidt
Marta Sinka
Magdolna Toeroek
Original Assignee
Biorex Kutato Es Fejlesztoe Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9602204A external-priority patent/HUP9602204D0/hu
Priority claimed from HU9701349A external-priority patent/HUP9701349A1/hu
Application filed by Biorex Kutato Es Fejlesztoe Rt. filed Critical Biorex Kutato Es Fejlesztoe Rt.
Publication of BG103194A publication Critical patent/BG103194A/xx
Publication of BG64456B1 publication Critical patent/BG64456B1/bg

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4453Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BG103194A 1996-08-09 1999-02-22 Фармацевтични продукти за лечение и предпазване от болести, свързани с дисфункцията на васкуларни ендотелиални клетки BG64456B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9602204A HUP9602204D0 (en) 1996-08-09 1996-08-09 Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells
HU9701349A HUP9701349A1 (hu) 1997-08-04 1997-08-04 Gyógyászati készítmények a vaszkuláris endoteliális sejtek rendellenes működésével összefüggő betegségek gyógyítására vagy megelőzésére

Publications (2)

Publication Number Publication Date
BG103194A BG103194A (en) 1999-09-30
BG64456B1 true BG64456B1 (bg) 2005-03-31

Family

ID=90014231

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103194A BG64456B1 (bg) 1996-08-09 1999-02-22 Фармацевтични продукти за лечение и предпазване от болести, свързани с дисфункцията на васкуларни ендотелиални клетки

Country Status (20)

Country Link
US (1) US6143741A (fr)
EP (1) EP0966283B1 (fr)
JP (1) JP2001504446A (fr)
AT (1) ATE329592T1 (fr)
AU (1) AU739614B2 (fr)
BG (1) BG64456B1 (fr)
CA (1) CA2262997C (fr)
CZ (1) CZ298542B6 (fr)
DE (1) DE69736130T2 (fr)
DK (1) DK0966283T3 (fr)
EE (1) EE04044B1 (fr)
ES (1) ES2267148T3 (fr)
HK (1) HK1025506A1 (fr)
IL (1) IL128256A (fr)
NO (1) NO325109B1 (fr)
PT (1) PT966283E (fr)
RS (1) RS49719B (fr)
SK (1) SK284301B6 (fr)
UA (1) UA64716C2 (fr)
WO (1) WO1998006400A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9701081D0 (en) 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
HU226617B1 (en) * 1998-12-14 2009-04-28 Cytrx Corp Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
NZ533795A (en) 2002-01-11 2006-03-31 Biorex Kutato Fejlesztoe Kft Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
CA2671049A1 (fr) * 2006-12-01 2008-06-12 Cytrx Corporation Retablissement apres une attaque
TW200901958A (en) * 2007-05-04 2009-01-16 Cytrx Corp Diabetic wound healing
JP5429865B2 (ja) * 2009-09-15 2014-02-26 学校法人日本大学 生体外創傷治癒試験用用具または創傷作製方法
HUP1100535A2 (en) * 2011-09-26 2013-04-29 Bracelia Invest Ltd Pharmaceutical composition for enhancement of stem cell treatment
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
GB9017351D0 (en) * 1990-08-08 1990-09-19 Wellcome Found Medicaments for treatment of atherosclerosis
WO1995030649A1 (fr) * 1994-05-06 1995-11-16 Biorex Kutató És Fejleszto^' Rt. Nouveaux derives d'acide hydroximique, compositions pharmaceutiques les contenant, et leur procede de preparation
HU218480B (hu) * 1995-06-15 2000-09-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására

Also Published As

Publication number Publication date
DE69736130D1 (de) 2006-07-27
IL128256A (en) 2004-05-12
EE04044B1 (et) 2003-06-16
SK15499A3 (en) 2000-02-14
YU5199A (sh) 2000-10-30
EE9900044A (et) 1999-08-16
DE69736130T2 (de) 2007-01-04
UA64716C2 (en) 2004-03-15
ATE329592T1 (de) 2006-07-15
AU3704997A (en) 1998-03-06
SK284301B6 (sk) 2005-01-03
CZ298542B6 (cs) 2007-10-31
DK0966283T3 (da) 2006-10-09
NO990547D0 (no) 1999-02-05
EP0966283A2 (fr) 1999-12-29
BG103194A (en) 1999-09-30
IL128256A0 (en) 2000-02-17
NO325109B1 (no) 2008-02-04
RS49719B (sr) 2007-12-31
EP0966283B1 (fr) 2006-06-14
CZ43599A3 (cs) 1999-07-14
WO1998006400A3 (fr) 1998-03-26
ES2267148T3 (es) 2007-03-01
HK1025506A1 (en) 2000-11-17
WO1998006400A2 (fr) 1998-02-19
CA2262997A1 (fr) 1998-02-19
NO990547L (no) 1999-03-25
AU739614B2 (en) 2001-10-18
CA2262997C (fr) 2008-07-29
PT966283E (pt) 2006-08-31
US6143741A (en) 2000-11-07
JP2001504446A (ja) 2001-04-03

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