EE04044B1 - Farmatseutilised tooted veresoonte endoteelirakkude kahjustuste tagajärjel tekkinud haiguste raviksja vältimiseks - Google Patents

Farmatseutilised tooted veresoonte endoteelirakkude kahjustuste tagajärjel tekkinud haiguste raviksja vältimiseks

Info

Publication number
EE04044B1
EE04044B1 EEP199900044A EE9900044A EE04044B1 EE 04044 B1 EE04044 B1 EE 04044B1 EE P199900044 A EEP199900044 A EE P199900044A EE 9900044 A EE9900044 A EE 9900044A EE 04044 B1 EE04044 B1 EE 04044B1
Authority
EE
Estonia
Prior art keywords
pct
prevention
treatment
vascular endothelial
endothelial cell
Prior art date
Application number
EEP199900044A
Other languages
English (en)
Estonian (et)
Other versions
EE9900044A (et
Inventor
Jedn�kovits Andrea
�r�gdi L�szl�
M�rv�nyos Ede
Barab�s Mih�ly
Kurucz Istv�n
B�csy Ern�
Kor�nyi L�szl�
Erd� S�ndor
Dorm�n Gy�rgy
Vitai M�rta
Schmidt Gy�rgy
Sinka M�rta
Original Assignee
Biorex Kutat� �S Fejleszt� Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9602204A external-priority patent/HUP9602204D0/hu
Priority claimed from HU9701349A external-priority patent/HUP9701349A1/hu
Application filed by Biorex Kutat� �S Fejleszt� Rt. filed Critical Biorex Kutat� �S Fejleszt� Rt.
Publication of EE9900044A publication Critical patent/EE9900044A/xx
Publication of EE04044B1 publication Critical patent/EE04044B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EEP199900044A 1996-08-09 1997-08-06 Farmatseutilised tooted veresoonte endoteelirakkude kahjustuste tagajärjel tekkinud haiguste raviksja vältimiseks EE04044B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU9602204A HUP9602204D0 (en) 1996-08-09 1996-08-09 Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells
HU9701349A HUP9701349A1 (hu) 1997-08-04 1997-08-04 Gyógyászati készítmények a vaszkuláris endoteliális sejtek rendellenes működésével összefüggő betegségek gyógyítására vagy megelőzésére
PCT/HU1997/000044 WO1998006400A2 (fr) 1996-08-09 1997-08-06 Produits pharmaceutiques preventifs et curatifs de maladies liees a des defaillances de cellules de l'endothelium vasculaire

Publications (2)

Publication Number Publication Date
EE9900044A EE9900044A (et) 1999-08-16
EE04044B1 true EE04044B1 (et) 2003-06-16

Family

ID=90014231

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900044A EE04044B1 (et) 1996-08-09 1997-08-06 Farmatseutilised tooted veresoonte endoteelirakkude kahjustuste tagajärjel tekkinud haiguste raviksja vältimiseks

Country Status (20)

Country Link
US (1) US6143741A (fr)
EP (1) EP0966283B1 (fr)
JP (1) JP2001504446A (fr)
AT (1) ATE329592T1 (fr)
AU (1) AU739614B2 (fr)
BG (1) BG64456B1 (fr)
CA (1) CA2262997C (fr)
CZ (1) CZ298542B6 (fr)
DE (1) DE69736130T2 (fr)
DK (1) DK0966283T3 (fr)
EE (1) EE04044B1 (fr)
ES (1) ES2267148T3 (fr)
HK (1) HK1025506A1 (fr)
IL (1) IL128256A (fr)
NO (1) NO325109B1 (fr)
PT (1) PT966283E (fr)
RS (1) RS49719B (fr)
SK (1) SK284301B6 (fr)
UA (1) UA64716C2 (fr)
WO (1) WO1998006400A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9701081D0 (en) 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
HU226617B1 (en) * 1998-12-14 2009-04-28 Cytrx Corp Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
NZ533795A (en) 2002-01-11 2006-03-31 Biorex Kutato Fejlesztoe Kft Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
CA2671049A1 (fr) * 2006-12-01 2008-06-12 Cytrx Corporation Retablissement apres une attaque
TW200901958A (en) * 2007-05-04 2009-01-16 Cytrx Corp Diabetic wound healing
JP5429865B2 (ja) * 2009-09-15 2014-02-26 学校法人日本大学 生体外創傷治癒試験用用具または創傷作製方法
HUP1100535A2 (en) * 2011-09-26 2013-04-29 Bracelia Invest Ltd Pharmaceutical composition for enhancement of stem cell treatment
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
GB9017351D0 (en) * 1990-08-08 1990-09-19 Wellcome Found Medicaments for treatment of atherosclerosis
WO1995030649A1 (fr) * 1994-05-06 1995-11-16 Biorex Kutató És Fejleszto^' Rt. Nouveaux derives d'acide hydroximique, compositions pharmaceutiques les contenant, et leur procede de preparation
HU218480B (hu) * 1995-06-15 2000-09-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására

Also Published As

Publication number Publication date
DE69736130D1 (de) 2006-07-27
IL128256A (en) 2004-05-12
SK15499A3 (en) 2000-02-14
YU5199A (sh) 2000-10-30
EE9900044A (et) 1999-08-16
DE69736130T2 (de) 2007-01-04
UA64716C2 (en) 2004-03-15
ATE329592T1 (de) 2006-07-15
AU3704997A (en) 1998-03-06
SK284301B6 (sk) 2005-01-03
CZ298542B6 (cs) 2007-10-31
DK0966283T3 (da) 2006-10-09
NO990547D0 (no) 1999-02-05
EP0966283A2 (fr) 1999-12-29
BG64456B1 (bg) 2005-03-31
BG103194A (en) 1999-09-30
IL128256A0 (en) 2000-02-17
NO325109B1 (no) 2008-02-04
RS49719B (sr) 2007-12-31
EP0966283B1 (fr) 2006-06-14
CZ43599A3 (cs) 1999-07-14
WO1998006400A3 (fr) 1998-03-26
ES2267148T3 (es) 2007-03-01
HK1025506A1 (en) 2000-11-17
WO1998006400A2 (fr) 1998-02-19
CA2262997A1 (fr) 1998-02-19
NO990547L (no) 1999-03-25
AU739614B2 (en) 2001-10-18
CA2262997C (fr) 2008-07-29
PT966283E (pt) 2006-08-31
US6143741A (en) 2000-11-07
JP2001504446A (ja) 2001-04-03

Similar Documents

Publication Publication Date Title
NO20052739L (no) CCR5-antagonister som medikamenter
DE69706566T2 (de) Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit
IT1312377B1 (it) Composizioni a base di acido tiottico, cisteina e/o n-acetil cisteinada utilizzarsi in preparazioni farmaceutiche, dietetiche e cosmetiche
MD1507F2 (en) Inhibitors, pharmaceutical composition on base thereof and process for HIV protease inhibition
EE04044B1 (et) Farmatseutilised tooted veresoonte endoteelirakkude kahjustuste tagajärjel tekkinud haiguste raviksja vältimiseks
PT828728E (pt) Di-hidrobenzofuranos de fenilo
DE69019533D1 (de) Behandlung von hiv-infizierungen und nützliche verbindungen dafür.
ATE230404T1 (de) Cyclohexyldihydrobenzofurane
GEP20053617B (en) Bridged Piperazine Derivatives
LV11728A (lv) Farmaceitiska kompozicija
DE60026491D1 (de) Melagatran zur behandlung von entzündungen
HUP0401018A2 (hu) 2H-1-benzopirán-származékok, eljárás ezek előállítására és ezeket tartalmazó gyógyászati készítmények
DK0609336T3 (da) Anvendelse af prostacyclin-derivater til forebyggelse eller behandling af lidelser i mikrocirkulationssystemet ved administ
FR2701260B1 (fr) Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
IT1284873B1 (it) Derivati stabili di ubichinolo procedimenti per la loro produzione e loro impiego farmaceutico
ATE169922T1 (de) Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase
ATE190845T1 (de) Rektale flunisolid-zubereitung zur behandlung entzündlicher darmerkrankungen
DE69429447T2 (de) Verwendung von 2-aminopurinderivaten zur behandlung und prophylaxe der menschlichen herpesvirus 7 infektionen
DE60011711D1 (de) Pyrroloazepinderivate enthaltende arzneimittel zur behandlung von claudicatio intermittens
ATE300304T1 (de) Verwendung von xanthinederivaten zur herstellung eines arzneimittels zur behandlung oder verhütung von osteoporose
FI970452A0 (fi) Leukotrieenin biosynteesin estäminen ureajohdannaisten avulla
NO931338L (no) Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus
PT1165596E (pt) Derivados de 14,15-alfa-metileno equilenina processos para producao dos mesmos e medicamentos que os contem
UA31078A (uk) Інгібітор вірусу імунодефіциту людини ( даримід )

Legal Events

Date Code Title Description
HD1A Correction of address
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110806