RS49719B - Farmaceutski proizvodi za lečenje i sprečavanje bolesti nastalih od oštećenja vaskularnih endotelialnih ćelija - Google Patents
Farmaceutski proizvodi za lečenje i sprečavanje bolesti nastalih od oštećenja vaskularnih endotelialnih ćelijaInfo
- Publication number
- RS49719B RS49719B YUP-51/99A YU5199A RS49719B RS 49719 B RS49719 B RS 49719B YU 5199 A YU5199 A YU 5199A RS 49719 B RS49719 B RS 49719B
- Authority
- RS
- Serbia
- Prior art keywords
- group
- refers
- general formula
- carbon atoms
- normal
- Prior art date
Links
- 210000003556 vascular endothelial cell Anatomy 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000033892 Hyperhomocysteinemia Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000003225 hyperhomocysteinemia Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9602204A HUP9602204D0 (en) | 1996-08-09 | 1996-08-09 | Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells |
| HU9701349A HUP9701349A1 (hu) | 1997-08-04 | 1997-08-04 | Gyógyászati készítmények a vaszkuláris endoteliális sejtek rendellenes működésével összefüggő betegségek gyógyítására vagy megelőzésére |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU5199A YU5199A (sh) | 2000-10-30 |
| RS49719B true RS49719B (sr) | 2007-12-31 |
Family
ID=90014231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-51/99A RS49719B (sr) | 1996-08-09 | 1997-08-06 | Farmaceutski proizvodi za lečenje i sprečavanje bolesti nastalih od oštećenja vaskularnih endotelialnih ćelija |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6143741A (sr) |
| EP (1) | EP0966283B1 (sr) |
| JP (1) | JP2001504446A (sr) |
| AT (1) | ATE329592T1 (sr) |
| AU (1) | AU739614B2 (sr) |
| BG (1) | BG64456B1 (sr) |
| CA (1) | CA2262997C (sr) |
| CZ (1) | CZ298542B6 (sr) |
| DE (1) | DE69736130T2 (sr) |
| DK (1) | DK0966283T3 (sr) |
| EE (1) | EE04044B1 (sr) |
| ES (1) | ES2267148T3 (sr) |
| HK (1) | HK1025506A1 (sr) |
| IL (1) | IL128256A (sr) |
| NO (1) | NO325109B1 (sr) |
| PT (1) | PT966283E (sr) |
| RS (1) | RS49719B (sr) |
| SK (1) | SK284301B6 (sr) |
| UA (1) | UA64716C2 (sr) |
| WO (1) | WO1998006400A2 (sr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU9701081D0 (en) | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
| HU226617B1 (en) * | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| NZ533795A (en) * | 2002-01-11 | 2006-03-31 | Biorex Kutato Fejlesztoe Kft | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| WO2008039514A1 (en) * | 2006-09-26 | 2008-04-03 | Cytrx Corporation | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| EP2089033A2 (en) * | 2006-12-01 | 2009-08-19 | CytRx Corporation | Stroke recovery |
| TW200901958A (en) * | 2007-05-04 | 2009-01-16 | Cytrx Corp | Diabetic wound healing |
| JP5429865B2 (ja) * | 2009-09-15 | 2014-02-26 | 学校法人日本大学 | 生体外創傷治癒試験用用具または創傷作製方法 |
| HUP1100535A2 (en) * | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
| EP4247792A1 (en) | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| GB9017351D0 (en) * | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| ES2123252T3 (es) * | 1994-05-06 | 1999-01-01 | Biorex Kutato Fejlesztoe Kft | Nuevos derivados de acido hidroximico, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. |
| HU218480B (hu) * | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
-
1997
- 1997-06-08 UA UA99020697A patent/UA64716C2/uk unknown
- 1997-08-06 PT PT97933813T patent/PT966283E/pt unknown
- 1997-08-06 SK SK154-99A patent/SK284301B6/sk not_active IP Right Cessation
- 1997-08-06 AT AT97933813T patent/ATE329592T1/de active
- 1997-08-06 RS YUP-51/99A patent/RS49719B/sr unknown
- 1997-08-06 EP EP97933813A patent/EP0966283B1/en not_active Expired - Lifetime
- 1997-08-06 IL IL12825697A patent/IL128256A/en not_active IP Right Cessation
- 1997-08-06 AU AU37049/97A patent/AU739614B2/en not_active Ceased
- 1997-08-06 WO PCT/HU1997/000044 patent/WO1998006400A2/en active IP Right Grant
- 1997-08-06 US US09/230,941 patent/US6143741A/en not_active Expired - Fee Related
- 1997-08-06 CA CA002262997A patent/CA2262997C/en not_active Expired - Fee Related
- 1997-08-06 DK DK97933813T patent/DK0966283T3/da active
- 1997-08-06 DE DE69736130T patent/DE69736130T2/de not_active Expired - Lifetime
- 1997-08-06 CZ CZ0043599A patent/CZ298542B6/cs not_active IP Right Cessation
- 1997-08-06 JP JP50952798A patent/JP2001504446A/ja not_active Ceased
- 1997-08-06 EE EEP199900044A patent/EE04044B1/xx not_active IP Right Cessation
- 1997-08-06 ES ES97933813T patent/ES2267148T3/es not_active Expired - Lifetime
-
1999
- 1999-02-05 NO NO19990547A patent/NO325109B1/no not_active IP Right Cessation
- 1999-02-22 BG BG103194A patent/BG64456B1/bg unknown
-
2000
- 2000-06-28 HK HK00103903A patent/HK1025506A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2262997A1 (en) | 1998-02-19 |
| BG103194A (en) | 1999-09-30 |
| EP0966283B1 (en) | 2006-06-14 |
| BG64456B1 (bg) | 2005-03-31 |
| CA2262997C (en) | 2008-07-29 |
| NO990547D0 (no) | 1999-02-05 |
| EE9900044A (et) | 1999-08-16 |
| CZ298542B6 (cs) | 2007-10-31 |
| NO325109B1 (no) | 2008-02-04 |
| DE69736130T2 (de) | 2007-01-04 |
| DK0966283T3 (da) | 2006-10-09 |
| AU3704997A (en) | 1998-03-06 |
| IL128256A0 (en) | 2000-02-17 |
| US6143741A (en) | 2000-11-07 |
| EP0966283A2 (en) | 1999-12-29 |
| NO990547L (no) | 1999-03-25 |
| EE04044B1 (et) | 2003-06-16 |
| IL128256A (en) | 2004-05-12 |
| SK15499A3 (en) | 2000-02-14 |
| CZ43599A3 (cs) | 1999-07-14 |
| ATE329592T1 (de) | 2006-07-15 |
| SK284301B6 (sk) | 2005-01-03 |
| WO1998006400A3 (en) | 1998-03-26 |
| AU739614B2 (en) | 2001-10-18 |
| WO1998006400A2 (en) | 1998-02-19 |
| YU5199A (sh) | 2000-10-30 |
| DE69736130D1 (de) | 2006-07-27 |
| PT966283E (pt) | 2006-08-31 |
| JP2001504446A (ja) | 2001-04-03 |
| HK1025506A1 (en) | 2000-11-17 |
| UA64716C2 (en) | 2004-03-15 |
| ES2267148T3 (es) | 2007-03-01 |
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