YU128291A - Postpak za dobijanje 6-(3-substituisanih aminopropionil) 7-deacetilforskolinskih derivata - Google Patents

Postpak za dobijanje 6-(3-substituisanih aminopropionil) 7-deacetilforskolinskih derivata

Info

Publication number
YU128291A
YU128291A YU128291A YU128291A YU128291A YU 128291 A YU128291 A YU 128291A YU 128291 A YU128291 A YU 128291A YU 128291 A YU128291 A YU 128291A YU 128291 A YU128291 A YU 128291A
Authority
YU
Yugoslavia
Prior art keywords
substituted
preparation
derivatives
formula
deacetylforscolin
Prior art date
Application number
YU128291A
Other languages
English (en)
Inventor
Y. Khandelwal
B. Lal
J. Blumbach
Original Assignee
Joechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joechst Aktiengesellschaft filed Critical Joechst Aktiengesellschaft
Publication of YU128291A publication Critical patent/YU128291A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)

Abstract

POSTPAK ZA DOBIJANJE 6-(3-SUBSTITUISANIH AMINOPROPIONIL) 7-DEACETILFORSKOLINSKIH DERIVATA, opisan je postupak za pripremu 6beta-/(3-supst.amino)-propioniloksi/-7-deacetilforskolinskih derivata opšte formule gde R1 i R2 predstavljaju vodonik, alkil, aril, aralkil ili dialkil-aminoalkil; R1 i R2 zajedno sa azotom, na koga su vezani, čine heterociklični spoj koji može da sadrži dodatni heteroatom, kao N, O, S, i u datom primeru može biti supstituisan na jednom ili više položaja sa alkilom, alkoksi, hidroksilom, halogenom ili arilom, kao i njihovim farmaceutsko prihvatljivim solima, reakcijom 7-deacetil-forskolina formule II sa 3-halopropionilhalidom u prisustvu organske baze i tako dobijeni 6beta (3-halopropioniloksi) derivat, obradimo aminom formule gde R1 i R2 imaju gorenje značenje i konačno po želji, jedinjenja formule I prevedemo u njihove farmaceutsko prihvatljive soli.
YU128291A 1990-07-24 1991-07-22 Postpak za dobijanje 6-(3-substituisanih aminopropionil) 7-deacetilforskolinskih derivata YU128291A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90114125 1990-07-24

Publications (1)

Publication Number Publication Date
YU128291A true YU128291A (sh) 1994-09-09

Family

ID=8204250

Family Applications (1)

Application Number Title Priority Date Filing Date
YU128291A YU128291A (sh) 1990-07-24 1991-07-22 Postpak za dobijanje 6-(3-substituisanih aminopropionil) 7-deacetilforskolinskih derivata

Country Status (17)

Country Link
US (1) US5250682A (sh)
EP (1) EP0468443A1 (sh)
JP (1) JPH04297473A (sh)
KR (1) KR920002574A (sh)
CN (1) CN1059721A (sh)
AU (1) AU643045B2 (sh)
CA (1) CA2047940A1 (sh)
CS (1) CS231491A3 (sh)
FI (1) FI913507A (sh)
HU (1) HU208967B (sh)
IE (1) IE912593A1 (sh)
IL (1) IL98913A0 (sh)
MX (1) MX9100344A (sh)
PL (1) PL291200A1 (sh)
RU (1) RU2034840C1 (sh)
YU (1) YU128291A (sh)
ZA (1) ZA915762B (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY106512A (en) * 1990-07-24 1995-06-30 Hoechst Ag Process for the preparation of 6-(substitutedaminopro- pionyl)-derivatives of fokskolin.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639446A (en) * 1984-12-14 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes, pharmaceutical compositions and use
ATE62683T1 (de) * 1985-03-01 1991-05-15 Hoechst Roussel Pharma Labdanderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel.
IN163242B (sh) * 1985-05-03 1988-08-27 Hoechst India
AU591196B2 (en) * 1985-11-15 1989-11-30 Nippon Kayaku Kabushiki Kaisha Novel forskolin derivatives
DE3730748A1 (de) * 1987-06-06 1988-12-22 Hoechst Ag Neue polyoxygenierte labdanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS649986A (en) * 1987-07-01 1989-01-13 Nippon Kayaku Kk Novel phosphocholin derivative
US5041565A (en) * 1988-05-09 1991-08-20 Hoechst-Roussel Pharmaceuticals Inc. Process for preparing hydrazinocarbonyloxylabdanes
US4883793A (en) * 1988-05-09 1989-11-28 Hoechst-Roussel Pharmaceuticals Inc. Hydrazinocarbonyloxylabdanes for treating cardiac failure
EP0447962A1 (en) * 1990-03-17 1991-09-25 Hoechst Aktiengesellschaft Labdanes and process for their preparation
MY106512A (en) * 1990-07-24 1995-06-30 Hoechst Ag Process for the preparation of 6-(substitutedaminopro- pionyl)-derivatives of fokskolin.

Also Published As

Publication number Publication date
AU8120991A (en) 1992-03-26
IE912593A1 (en) 1992-01-29
US5250682A (en) 1993-10-05
MX9100344A (es) 1992-02-28
CA2047940A1 (en) 1992-01-25
FI913507A (fi) 1992-01-25
AU643045B2 (en) 1993-11-04
PL291200A1 (en) 1992-03-09
CN1059721A (zh) 1992-03-25
CS231491A3 (en) 1992-02-19
RU2034840C1 (ru) 1995-05-10
ZA915762B (en) 1992-04-29
IL98913A0 (en) 1992-07-15
HU912490D0 (en) 1991-12-30
FI913507A0 (fi) 1991-07-22
KR920002574A (ko) 1992-02-28
HU208967B (en) 1994-02-28
JPH04297473A (ja) 1992-10-21
HUT58716A (en) 1992-03-30
EP0468443A1 (en) 1992-01-29

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