JPS649986A - Novel phosphocholin derivative - Google Patents
Novel phosphocholin derivativeInfo
- Publication number
- JPS649986A JPS649986A JP16238387A JP16238387A JPS649986A JP S649986 A JPS649986 A JP S649986A JP 16238387 A JP16238387 A JP 16238387A JP 16238387 A JP16238387 A JP 16238387A JP S649986 A JPS649986 A JP S649986A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- compound expressed
- reacted
- phosphocholin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YHHSONZFOIEMCP-UHFFFAOYSA-N 2-(trimethylazaniumyl)ethyl hydrogen phosphate Chemical class C[N+](C)(C)CCOP(O)([O-])=O YHHSONZFOIEMCP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 102000030621 adenylate cyclase Human genes 0.000 abstract 1
- 108060000200 adenylate cyclase Proteins 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000000297 inotrophic effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I {R<1> is vinyl or ethyl; R<2> is piperiodinoacetyl] or formula II [R<4> is lower alkyl; R<5> is morpholino or formula III (R<6> and R<7> are H or lower alkyl; n is integer of 0-3)]; R<3> is lower alkylcarbonyl and salt thereof. EXAMPLE:6-(2-Morpholinopropionyl)phosphocholin. USE:Heat failure treating agent, antihypertensive agent, cerebral vasodilator, etc., excellent in positive thixotropy inotropic action, adenylyl cyclase activating action, water solubility, etc. PREPARATION:A 7-deacetylphorcholic expressed by formula IV is reacted with a carboxylic acid expressed by the formula R<2>OH to afford a compound expressed by formula V, which is reacted with a base such as triethylamine to provide the compound expressed by formula VI. Then the resultant compound expressed by formula VI is reacted with a carboxylic acid expressed by the formula R<3>OH to give a compound expressed by VII and then acyl at 1-position thereof and R<3> thereof are selectively removed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16238387A JPS649986A (en) | 1987-07-01 | 1987-07-01 | Novel phosphocholin derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16238387A JPS649986A (en) | 1987-07-01 | 1987-07-01 | Novel phosphocholin derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS649986A true JPS649986A (en) | 1989-01-13 |
Family
ID=15753538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16238387A Pending JPS649986A (en) | 1987-07-01 | 1987-07-01 | Novel phosphocholin derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS649986A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5245052A (en) * | 1990-07-23 | 1993-09-14 | Nippon Kayaku Co. Ltd. | Process for producing 6-acyl-7-deacetylforskolin derivatives |
| US5250682A (en) * | 1990-07-24 | 1993-10-05 | Hoechst Aktiengesellschaft | Process for the preparation of 6-[3-substitutedaminopropionyl]-7-deacetylforskolin derivatives |
-
1987
- 1987-07-01 JP JP16238387A patent/JPS649986A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5245052A (en) * | 1990-07-23 | 1993-09-14 | Nippon Kayaku Co. Ltd. | Process for producing 6-acyl-7-deacetylforskolin derivatives |
| US5250682A (en) * | 1990-07-24 | 1993-10-05 | Hoechst Aktiengesellschaft | Process for the preparation of 6-[3-substitutedaminopropionyl]-7-deacetylforskolin derivatives |
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