YU48180B - Derivati aril ili heteroaril piperazinilalkilazona i postupak njihovog dobijanja - Google Patents

Derivati aril ili heteroaril piperazinilalkilazona i postupak njihovog dobijanja

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Publication number
YU48180B
YU48180B YU8292A YU8292A YU48180B YU 48180 B YU48180 B YU 48180B YU 8292 A YU8292 A YU 8292A YU 8292 A YU8292 A YU 8292A YU 48180 B YU48180 B YU 48180B
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YU
Yugoslavia
Prior art keywords
group
substituted
unsubstituted
nitrogen atom
radical
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Application number
YU8292A
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English (en)
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YU8292A (sh
Inventor
R.M. Vidal
J.F. Constansa
S.A. Corominas
Original Assignee
Laboratorios Del Dr. Esteve S.A.
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Application filed by Laboratorios Del Dr. Esteve S.A. filed Critical Laboratorios Del Dr. Esteve S.A.
Publication of YU8292A publication Critical patent/YU8292A/sh
Publication of YU48180B publication Critical patent/YU48180B/sh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

DERIVATI ARIL ILI HETEROARIL PIPERAZINILALKILAZONA I POSTUPAK NJIHOVOG DOBIJANJA naznaceni time, sto imaju opstu formulu I u kojoj Ar predstavlja aromatski radikal, koji moze ili ne mora da sadrzi azot i odabran je od razlicitih supstituisanih arila, 2-pirimidina, 2-N-metilimidazola i 3-(1,2-benzizotriazola), n moze da ima vrednosti od 1 do 6, Z1 predstavlja atom azota ili C-R1 grupu, Z2 predstavlja atom azota ili C-R2 grupu, Z4 predstavlja atom azota ili C-R4 grupu, Z5 predstavlja atom azota ili ugljenikov atom, Z6 predstavlja aza grupu ili metilen grupu koja moze da bude nesupstituisana ili supstituisana, kada Z5 predstavlja atom azota, Z6 je metilen grupa, koja je supstituisana ili nesupstituisana, i kada je Z5 ugljenikov atom, Z6 je aza grupa koja je supstituisana ili nesupstituisana, i R1, R2, R3 i R4, koji mogu da budu isti ili pod uslovom da su razliciti mogu i da grade deo drugog aromatskog ili nearomatskog prstena, predstavljaju atom vodonika, halogen, nizi alkil radikal, hidroksilni radikal, karboksilni radikal, kar-boksamido radikal, alkil karboksilatni radikal ili aril ili supstituisani aril radikal, i kada je Ar 2-pirimidin i Z6 je metilen grupa, supstituisana ili nesupstituisana, celina od Z1 do Z6 obrazuje heterociklicni aromatski radikal, odabran medju grupom koja se sastoji od trisupstituisanog imidazola, ben-zimidazola, koji je supstituisan ili nesupstituisan i im-idazopiridina, koji je supstituisan ili nesupstituisan, i njihove farmaceutski prihvatljive adicione soli kiselina, izuzev za jedinjenja u kojima je Ar fenil, koji je supstituisan ili nesupstituisan, Z5 i Z2 oba predstavljaju atom azota, Z1 predstavlja C-R1 grupu i Z4 predstavlja C-R4 grupu, i R3-R4 obrazuju deo drugog aromatskog prstena. - Prijava sadrzi jos 1 nezavisan i 7 zavisnih zahteva.
YU8292A 1991-01-28 1992-01-27 Derivati aril ili heteroaril piperazinilalkilazona i postupak njihovog dobijanja YU48180B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9100923A FR2672052B1 (fr) 1991-01-28 1991-01-28 Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.

Publications (2)

Publication Number Publication Date
YU8292A YU8292A (sh) 1995-03-27
YU48180B true YU48180B (sh) 1997-07-31

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ID=9409103

Family Applications (1)

Application Number Title Priority Date Filing Date
YU8292A YU48180B (sh) 1991-01-28 1992-01-27 Derivati aril ili heteroaril piperazinilalkilazona i postupak njihovog dobijanja

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Country Link
US (2) US5292739A (sh)
EP (1) EP0497659B1 (sh)
JP (1) JPH0745496B2 (sh)
KR (1) KR0135969B1 (sh)
AT (1) ATE136547T1 (sh)
AU (1) AU658389B2 (sh)
CA (1) CA2060090A1 (sh)
DE (1) DE69209679T2 (sh)
DK (1) DK0497659T3 (sh)
ES (1) ES2042385B1 (sh)
FR (1) FR2672052B1 (sh)
GR (1) GR3020437T3 (sh)
HU (1) HU219909B (sh)
NO (1) NO180539C (sh)
RU (1) RU2088582C1 (sh)
YU (1) YU48180B (sh)
ZA (1) ZA92534B (sh)

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DE69209679T2 (de) 1996-10-10
ZA92534B (en) 1992-10-28
ATE136547T1 (de) 1996-04-15
US5292739A (en) 1994-03-08
CA2060090A1 (fr) 1992-07-29
NO920348L (no) 1992-07-29
NO180539C (no) 1997-05-07
US5382586A (en) 1995-01-17
HU219909B (hu) 2001-09-28
FR2672052B1 (fr) 1995-05-24
FR2672052A1 (fr) 1992-07-31
KR0135969B1 (ko) 1998-04-25
HUT60265A (en) 1992-08-28
GR3020437T3 (en) 1996-10-31
EP0497659A1 (fr) 1992-08-05
JPH0745496B2 (ja) 1995-05-17
DE69209679D1 (de) 1996-05-15
NO920348D0 (no) 1992-01-27
DK0497659T3 (da) 1996-07-15
HU9200262D0 (en) 1992-04-28
JPH04312584A (ja) 1992-11-04
EP0497659B1 (fr) 1996-04-10
ES2042385A1 (es) 1993-12-01
ES2042385B1 (es) 1994-08-01
NO180539B (no) 1997-01-27
YU8292A (sh) 1995-03-27
RU2088582C1 (ru) 1997-08-27
AU1047992A (en) 1992-07-30
KR920014804A (ko) 1992-08-25
AU658389B2 (en) 1995-04-13

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