BG64006B1 - Индазоламидни съединения като серотонинергични средства - Google Patents

Индазоламидни съединения като серотонинергични средства Download PDF

Info

Publication number
BG64006B1
BG64006B1 BG103863A BG10386399A BG64006B1 BG 64006 B1 BG64006 B1 BG 64006B1 BG 103863 A BG103863 A BG 103863A BG 10386399 A BG10386399 A BG 10386399A BG 64006 B1 BG64006 B1 BG 64006B1
Authority
BG
Bulgaria
Prior art keywords
compound
formula
pharmaceutically acceptable
alkyl
group
Prior art date
Application number
BG103863A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103863A (en
Inventor
Allessandra ALISI
Mario Brufani
Nicola Cazzolla
Marilena Giannangeli
Mario Pinza
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Publication of BG103863A publication Critical patent/BG103863A/xx
Publication of BG64006B1 publication Critical patent/BG64006B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
BG103863A 1997-04-15 1999-11-05 Индазоламидни съединения като серотонинергични средства BG64006B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (it) 1997-04-15 1997-04-15 Indazolammidi come agenti serotoninergici
PCT/EP1998/002129 WO1998046589A2 (en) 1997-04-15 1998-04-02 Indazole amide compounds as serotoninergic agents

Publications (2)

Publication Number Publication Date
BG103863A BG103863A (en) 2000-07-31
BG64006B1 true BG64006B1 (bg) 2003-09-30

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103863A BG64006B1 (bg) 1997-04-15 1999-11-05 Индазоламидни съединения като серотонинергични средства

Country Status (27)

Country Link
US (1) US6197769B1 (de)
EP (1) EP0975623B1 (de)
JP (2) JP4578581B2 (de)
KR (1) KR100563867B1 (de)
CN (1) CN1318416C (de)
AR (1) AR012426A1 (de)
AT (1) ATE219490T1 (de)
AU (1) AU740360B2 (de)
BG (1) BG64006B1 (de)
CA (1) CA2286870C (de)
CZ (1) CZ295190B6 (de)
DE (1) DE69806141T2 (de)
DK (1) DK0975623T3 (de)
EA (1) EA002352B1 (de)
ES (1) ES2178205T3 (de)
GE (1) GEP20022654B (de)
HK (1) HK1027811A1 (de)
HU (1) HU227973B1 (de)
IL (1) IL132127A (de)
IT (1) IT1291569B1 (de)
PL (1) PL193308B1 (de)
PT (1) PT975623E (de)
SK (1) SK284731B6 (de)
TR (1) TR199902546T2 (de)
UA (1) UA58550C2 (de)
WO (1) WO1998046589A2 (de)
ZA (1) ZA982926B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
KR100849839B1 (ko) 2001-02-23 2008-08-01 머크 앤드 캄파니 인코포레이티드 Ｎ-치환된 비-아릴-헤테로사이클릭 ｎｍｄａ/ｎｒ2ｂ 길항제 및 이를 포함하는 약제학적 조성물
EP1390034A4 (de) * 2001-04-03 2005-07-13 Merck & Co Inc N-substituierte nonaryl-heterocyclo amidyl-nmda/nr2b-antagonisten
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE441646T1 (de) * 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
JP5042028B2 (ja) * 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
US7419989B2 (en) * 2004-12-22 2008-09-02 Theravance, Inc. Indazole-carboxamide compounds
TW200640921A (en) * 2005-02-17 2006-12-01 Theravance Inc Crystalline form of an indazole-carboxamide compound
EP1871772B1 (de) * 2005-03-02 2014-09-10 Theravance, Inc. Chinolinverbindungen als agonisten des 5-ht4-rezeptors
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
CA2833507A1 (en) * 2011-06-07 2012-12-13 Dainippon Sumitomo Pharma Co., Ltd. Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
RS54539B1 (en) * 2012-02-21 2016-06-30 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. USE OF 1H-INDASOL-3-CARBOXAMIDE COMPOUNDS AS A 3-BETA GLYCOGEN SYNTHETASE KINASE INHIBITOR
ES2564961T3 (es) * 2012-02-21 2016-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta
EP2961403A4 (de) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd Heterocyclische inhibitoren des natriumkanals
BR112022000429A2 (pt) 2019-07-11 2022-03-29 Praxis Prec Medicines Inc Formulações de moduladores do canal de cálcio tipo t e métodos de uso dos mesmos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
NZ243993A (en) * 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5945434A (en) * 1995-05-31 1999-08-31 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici

Also Published As

Publication number Publication date
IL132127A (en) 2005-06-19
EA199900935A1 (ru) 2000-04-24
TR199902546T2 (xx) 2000-05-22
UA58550C2 (uk) 2003-08-15
CZ295190B6 (cs) 2005-06-15
AU740360B2 (en) 2001-11-01
HUP0002057A3 (en) 2002-01-28
SK284731B6 (sk) 2005-10-06
CA2286870A1 (en) 1998-10-22
WO1998046589A2 (en) 1998-10-22
JP5237324B2 (ja) 2013-07-17
ZA982926B (en) 1998-10-09
JP2001518906A (ja) 2001-10-16
JP4578581B2 (ja) 2010-11-10
CN1252798A (zh) 2000-05-10
PL193308B1 (pl) 2007-01-31
AR012426A1 (es) 2000-10-18
PT975623E (pt) 2002-10-31
IL132127A0 (en) 2001-03-19
HUP0002057A2 (hu) 2001-04-28
ES2178205T3 (es) 2002-12-16
ATE219490T1 (de) 2002-07-15
AU7215998A (en) 1998-11-11
KR100563867B1 (ko) 2006-03-24
IT1291569B1 (it) 1999-01-11
EP0975623B1 (de) 2002-06-19
DE69806141T2 (de) 2003-01-30
DK0975623T3 (da) 2002-10-14
CN1318416C (zh) 2007-05-30
PL336348A1 (en) 2000-06-19
HU227973B1 (hu) 2012-07-30
ITMI970867A1 (it) 1998-10-15
CA2286870C (en) 2007-05-22
US6197769B1 (en) 2001-03-06
WO1998046589A3 (en) 1999-01-28
EP0975623A2 (de) 2000-02-02
DE69806141D1 (de) 2002-07-25
HK1027811A1 (en) 2001-01-23
EA002352B1 (ru) 2002-04-25
BG103863A (en) 2000-07-31
KR20010006120A (ko) 2001-01-26
SK142399A3 (en) 2000-08-14
CZ362599A3 (cs) 2000-04-12
JP2010195813A (ja) 2010-09-09
GEP20022654B (en) 2002-03-25

Similar Documents

Publication Publication Date Title
JP5237324B2 (ja) セロトニン様作用薬としてのインダゾールアミド化合物
JP4021477B2 (ja) ５−ｈｔ４拮抗作用を有するジ−置換１，４−ピペリジンエステル類及びアミド類
US5652246A (en) Piperidine compounds
US7288656B2 (en) Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics
EP0144986B1 (de) Indol-3-Carboxamid-Derivate
WO2000009506A1 (fr) Derives de 1h-imidazopyridine
DE60309852T2 (de) Chinolin- und aza-indolderivate und deren verwendung als 5-ht6 liganden
EP0937715B1 (de) Tetrahydrobezindol derivate
DK151017B (da) Analogifremgangsmaade til fremstiiling af substituerede n-(4-indolyl-piperidino-alkyl)-benzimidazoloner eller fysiologisk acceptable syreadditionssalte deraf
SK141998A3 (en) Piperidines and pyrrolidines
MXPA05010288A (es) Derivados de bencenosulfonamida, metodo para su produccion y uso de los mismos para el tratamiento del dolor.
US6645971B1 (en) Quinazolinone derivatives
NZ243337A (en) 1-piperidyl substituted quinoline derivatives and pharmaceutical compositions
SK5122001A3 (en) 3-tetrahydropyridin-4-yl indoles for treatment of psychotic disorders
HUT61301A (en) Process for producing condensed diazepinone derivatives and pharmaceutical compositions comprising same as active ingredient
MXPA99009422A (en) Indazole amide compounds as serotoninergic agents
MXPA97006826A (en) Esteres y amidas of 1,4-piperidina di-sustitu