BG63697B1 - Нови дипептидни амидини и използването им като инхибитори на тромбин - Google Patents
Нови дипептидни амидини и използването им като инхибитори на тромбин Download PDFInfo
- Publication number
- BG63697B1 BG63697B1 BG101835A BG10183597A BG63697B1 BG 63697 B1 BG63697 B1 BG 63697B1 BG 101835 A BG101835 A BG 101835A BG 10183597 A BG10183597 A BG 10183597A BG 63697 B1 BG63697 B1 BG 63697B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- alkylene
- group
- phenyl
- boc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19505484 | 1995-02-17 | ||
| DE19506611 | 1995-02-24 | ||
| DE19507455 | 1995-03-03 | ||
| PCT/EP1996/000582 WO1996025426A1 (de) | 1995-02-17 | 1996-02-12 | Neue dipeptidische amidine als thrombin-inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG101835A BG101835A (bg) | 1998-05-29 |
| BG63697B1 true BG63697B1 (bg) | 2002-09-30 |
Family
ID=27214848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG101835A BG63697B1 (bg) | 1995-02-17 | 1997-08-15 | Нови дипептидни амидини и използването им като инхибитори на тромбин |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6030972A (cs) |
| EP (1) | EP0873356A1 (cs) |
| JP (1) | JPH11500120A (cs) |
| KR (1) | KR100388185B1 (cs) |
| CN (1) | CN1198839C (cs) |
| AR (1) | AR002277A1 (cs) |
| AU (1) | AU708001B2 (cs) |
| BG (1) | BG63697B1 (cs) |
| BR (1) | BR9607582A (cs) |
| CA (1) | CA2211109A1 (cs) |
| CZ (1) | CZ245797A3 (cs) |
| EA (1) | EA199700186A1 (cs) |
| FI (1) | FI973360A7 (cs) |
| HR (1) | HRP960075B1 (cs) |
| HU (1) | HUP9800263A3 (cs) |
| IL (1) | IL117165A0 (cs) |
| MX (1) | MX9706069A (cs) |
| MY (1) | MY132115A (cs) |
| NO (1) | NO973764L (cs) |
| NZ (1) | NZ302649A (cs) |
| PL (1) | PL321759A1 (cs) |
| SI (1) | SI9620037A (cs) |
| SK (1) | SK104697A3 (cs) |
| TR (1) | TR199700803T1 (cs) |
| TW (1) | TW450968B (cs) |
| WO (1) | WO1996025426A1 (cs) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| CZ245797A3 (cs) * | 1995-02-17 | 1998-06-17 | Basf Aktiengesellschaft | Derivát amidinu dipeptidu jako inhibitor thrombinu |
| US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| AR005245A1 (es) | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
| SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| EP1110968B1 (en) * | 1996-06-25 | 2003-10-01 | Eli Lilly & Company | Intermediate for the preparation of Thrombininhibitors as anticoagulant agents |
| US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
| AU3496297A (en) * | 1996-06-25 | 1998-01-14 | Eli Lilly And Company | Anticoagulant agents |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| DE19632772A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| DE19632773A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| AR013084A1 (es) * | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
| JP2002501044A (ja) * | 1998-01-26 | 2002-01-15 | ビーエーエスエフ アクチェンゲゼルシャフト | カリクレインプロテアーゼ阻害剤としての複素環アミジン |
| WO1999055355A1 (en) | 1998-04-24 | 1999-11-04 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
| SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
| US6486193B2 (en) | 1998-12-31 | 2002-11-26 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases |
| EE200100371A (et) | 1999-01-13 | 2002-02-15 | Astrazeneca Ab | Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena |
| PL352834A1 (en) * | 1999-04-09 | 2003-09-08 | Abbott Gmbh & Co.Kg | Prodrugs of thrombin inhibitors |
| CA2369378A1 (en) | 1999-04-09 | 2000-10-19 | Basf Aktiengesellschaft | Low-molecular inhibitors of complement proteases |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| DE19921346A1 (de) | 1999-05-10 | 2000-11-16 | Basf Ag | Sprühtrocknung von Thrombininhibitoren |
| ATE279435T1 (de) | 1999-05-10 | 2004-10-15 | Abbott Gmbh & Co Kg | Salze von thrombininhibitoren |
| SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| DE10029015A1 (de) | 2000-06-15 | 2001-12-20 | Curacyte Ag | Hemmstoffe für den Gerinnungsfaktor Xa |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| DE10049937A1 (de) * | 2000-10-06 | 2002-04-11 | Knoll Ag | Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten |
| RU2300521C2 (ru) * | 2000-12-01 | 2007-06-10 | Астразенека Аб | Новые производные миндальной кислоты и их применение в качестве ингибиторов тромбина |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| US6774110B2 (en) * | 2001-03-19 | 2004-08-10 | Lg Life Sciences Ltd. | Orally available peptidic thrombin inhibitors |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| DE10210590A1 (de) * | 2002-03-11 | 2003-10-02 | Curacyte Ag | Hemmstoffe des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| EP1485345B1 (de) | 2002-03-11 | 2008-06-25 | Curacyte AG | Hemmstoffe der urokinase, ihre herstellung und verwendung |
| AU2003223510B2 (en) | 2002-04-12 | 2008-05-08 | Merck Sharp & Dohme Corp. | Bicyclic amides |
| SE0201659D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| RU2228930C1 (ru) * | 2003-05-20 | 2004-05-20 | ООО "Исследовательский институт химического разнообразия" | Замещенные 3-пиридилметиламины и фокусированная библиотека |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| EP1682120A4 (en) * | 2003-11-04 | 2009-05-27 | Merck & Co Inc | CAPACITATED PHENYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDAS IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES |
| US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
| CA2565211A1 (en) | 2004-04-29 | 2005-11-24 | Abbott Laboratories | Amino-tetrazoles analogues and methods of use |
| JP4561197B2 (ja) * | 2004-06-28 | 2010-10-13 | 宇部興産株式会社 | ５−（４−テトラヒドロピラニル）ヒダントインの製法及びその中間体 |
| JP4572618B2 (ja) * | 2004-08-04 | 2010-11-04 | 宇部興産株式会社 | ４−テトラヒドロピラニルグリシンの製法 |
| US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| CN102464701B (zh) * | 2010-11-08 | 2015-10-21 | 上海医药工业研究院 | 一类新型化合物、其制备方法及用途 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2113982A1 (de) * | 1970-03-25 | 1971-10-14 | Sumitomo Chemical Co | Verfahren zur Herstellung von Benzodiazepinen |
| DE2059922A1 (de) * | 1970-12-05 | 1972-06-15 | Boehringer Mannheim Gmbh | Neue N(6)-Aralkyl-adenosin-Derivate und Verfahren zur Herstellung derselben |
| HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| GB8305985D0 (en) * | 1983-03-04 | 1983-04-07 | Szelke M | Enzyme inhibition |
| HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| IL77748A (en) * | 1985-02-04 | 1991-11-21 | Merrell Dow Pharma | Amino acid and peptide derivatives as peptidase inhibitors |
| US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) * | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897515B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| CA2021660A1 (en) * | 1989-07-26 | 1991-01-27 | Philippe Bey | Peptidase inhibitors |
| GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
| GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
| EP0503203A1 (en) * | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Novel thrombin inhibitors |
| CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| NZ245039A (en) * | 1991-11-12 | 1994-12-22 | Lilly Co Eli | N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions |
| SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| ATE171709T1 (de) * | 1992-02-14 | 1998-10-15 | Corvas Int Inc | Inhibitoren der thrombose |
| US5760235A (en) * | 1992-03-04 | 1998-06-02 | Gyogyszerkutato Intezet Kft. | Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof |
| FR2695562B1 (fr) * | 1992-09-11 | 1994-10-14 | Synthelabo | Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique. |
| US5371072A (en) * | 1992-10-16 | 1994-12-06 | Corvas International, Inc. | Asp-Pro-Arg α-keto-amide enzyme inhibitors |
| US5346129A (en) * | 1993-05-17 | 1994-09-13 | Honeywell Inc. | Indoor climate controller system adjusting both dry-bulb temperature and wet-bulb or dew point temperature in the enclosure |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
| AU1025795A (en) * | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| SK286094B6 (sk) * | 1994-04-26 | 2008-03-05 | Aventis Pharmaceuticals Inc. | Zlúčenina špecificky inhibujúca aktivitu faktora Xa, farmaceutická kompozícia s jej obsahom a jej použitie |
| US5849510A (en) * | 1994-04-26 | 1998-12-15 | Selectide Corporation | Factor Xa inhibitors |
| US5543396A (en) * | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
| DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| CZ245797A3 (cs) * | 1995-02-17 | 1998-06-17 | Basf Aktiengesellschaft | Derivát amidinu dipeptidu jako inhibitor thrombinu |
| US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
-
1996
- 1996-02-12 CZ CZ972457A patent/CZ245797A3/cs unknown
- 1996-02-12 AU AU48751/96A patent/AU708001B2/en not_active Ceased
- 1996-02-12 EP EP96904759A patent/EP0873356A1/de not_active Withdrawn
- 1996-02-12 PL PL96321759A patent/PL321759A1/xx unknown
- 1996-02-12 SI SI9620037A patent/SI9620037A/sl not_active IP Right Cessation
- 1996-02-12 TR TR97/00803T patent/TR199700803T1/xx unknown
- 1996-02-12 CN CNB961919671A patent/CN1198839C/zh not_active Expired - Fee Related
- 1996-02-12 US US08/894,252 patent/US6030972A/en not_active Expired - Lifetime
- 1996-02-12 EA EA199700186A patent/EA199700186A1/ru unknown
- 1996-02-12 SK SK1046-97A patent/SK104697A3/sk unknown
- 1996-02-12 CA CA002211109A patent/CA2211109A1/en not_active Abandoned
- 1996-02-12 HU HU9800263A patent/HUP9800263A3/hu unknown
- 1996-02-12 BR BR9607582A patent/BR9607582A/pt not_active IP Right Cessation
- 1996-02-12 NZ NZ302649A patent/NZ302649A/xx unknown
- 1996-02-12 JP JP8524648A patent/JPH11500120A/ja not_active Ceased
- 1996-02-12 KR KR1019970705682A patent/KR100388185B1/ko not_active Expired - Fee Related
- 1996-02-12 FI FI973360A patent/FI973360A7/fi not_active IP Right Cessation
- 1996-02-12 WO PCT/EP1996/000582 patent/WO1996025426A1/de not_active Ceased
- 1996-02-12 MX MX9706069A patent/MX9706069A/es unknown
- 1996-02-15 AR ARP960101389A patent/AR002277A1/es not_active Application Discontinuation
- 1996-02-15 HR HR960075A patent/HRP960075B1/xx not_active IP Right Cessation
- 1996-02-16 TW TW085102085A patent/TW450968B/zh not_active IP Right Cessation
- 1996-02-17 MY MYPI96000644A patent/MY132115A/en unknown
- 1996-02-18 IL IL11716596A patent/IL117165A0/xx unknown
-
1997
- 1997-08-15 NO NO973764A patent/NO973764L/no not_active Application Discontinuation
- 1997-08-15 BG BG101835A patent/BG63697B1/bg unknown
-
1999
- 1999-10-08 US US09/414,681 patent/US6444817B1/en not_active Expired - Lifetime
-
2002
- 2002-03-19 US US10/100,099 patent/US6900319B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG63697B1 (bg) | Нови дипептидни амидини и използването им като инхибитори на тромбин | |
| US5932567A (en) | Thrombin inhibitors | |
| KR100223662B1 (ko) | 자동 금전 출납기를 사용하여 송금된 돈을 지급하는 전자 송금 시스템 및 방법 | |
| JP3205558B2 (ja) | 新規ペプチド誘導体 | |
| KR100366328B1 (ko) | 엘라스타제의퍼플루오로알킬케톤억제제및이들의제조방법 | |
| JP4089981B2 (ja) | トロンビン阻害剤 | |
| HRP950338A2 (en) | New thrombin inhibitors, their preparation and use | |
| WO1996025426A9 (de) | Neue dipeptidische amidine als thrombin-inhibitoren | |
| US5852051A (en) | Dipeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals | |
| KR100689923B1 (ko) | 트롬빈 억제제 | |
| AU709088B2 (en) | Thrombin inhibitors | |
| US5798377A (en) | Thrombin inhibitors | |
| EP0832879A1 (en) | Process for preparing intermediates for thrombin inhibitors | |
| CA2368830A1 (en) | Prodrugs of thrombin inhibitors | |
| CZ20002463A3 (cs) | Nové inhibitory trombinu |