BG61319B2 - Метод за получаване на арилпиперидинкарбиноли - Google Patents

Метод за получаване на арилпиперидинкарбиноли Download PDF

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Publication number
BG61319B2
BG61319B2 BG98349A BG9834993A BG61319B2 BG 61319 B2 BG61319 B2 BG 61319B2 BG 98349 A BG98349 A BG 98349A BG 9834993 A BG9834993 A BG 9834993A BG 61319 B2 BG61319 B2 BG 61319B2
Authority
BG
Bulgaria
Prior art keywords
formula
compound
alkyl
trans
hydrogen
Prior art date
Application number
BG98349A
Other languages
Bulgarian (bg)
English (en)
Inventor
Faruk Ali
Martin Thomas
Original Assignee
Beecham Group P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858520153A external-priority patent/GB8520153D0/en
Priority claimed from GB868612579A external-priority patent/GB8612579D0/en
Application filed by Beecham Group P.L.C. filed Critical Beecham Group P.L.C.
Publication of BG61319B2 publication Critical patent/BG61319B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
BG98349A 1985-08-10 1993-12-29 Метод за получаване на арилпиперидинкарбиноли BG61319B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858520153A GB8520153D0 (en) 1985-08-10 1985-08-10 Chemical process
GB868612579A GB8612579D0 (en) 1986-05-23 1986-05-23 Chemical process

Publications (1)

Publication Number Publication Date
BG61319B2 true BG61319B2 (bg) 1997-05-30

Family

ID=26289644

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98349A BG61319B2 (bg) 1985-08-10 1993-12-29 Метод за получаване на арилпиперидинкарбиноли

Country Status (17)

Country Link
US (1) US4902801A (de)
EP (1) EP0223334B1 (de)
JP (2) JPH0696551B2 (de)
AU (1) AU582456B2 (de)
BG (1) BG61319B2 (de)
CA (1) CA1310649C (de)
CY (1) CY1708A (de)
DE (1) DE3680184D1 (de)
DK (1) DK169730B1 (de)
ES (2) ES2000603A6 (de)
GR (1) GR862102B (de)
HK (1) HK69793A (de)
IE (1) IE58831B1 (de)
MX (1) MX171822B (de)
NZ (1) NZ217141A (de)
PT (1) PT83179B (de)
SG (1) SG27793G (de)

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GB8714707D0 (en) * 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi
JPH04288059A (ja) * 1991-03-14 1992-10-13 Nippon Paint Co Ltd 複素環化合物及びその製造法
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
AU4997096A (en) * 1995-08-03 1997-03-05 Fmc Corporation Reductions using hydrides
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
EP0812827B1 (de) * 1996-06-13 2009-09-02 Sumitomo Chemical Company, Limited Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
WO1998013319A1 (en) * 1996-09-24 1998-04-02 Fmc Corporation Novel reduction compositions and processes for making the same
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
ES2329739T3 (es) * 1997-04-07 2009-11-30 Georgetown University Analogos de cocaina.
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
ATE279393T1 (de) 1997-05-29 2004-10-15 Smithkline Beecham Corp Neues verfahren
WO1998056787A1 (de) 1997-06-10 1998-12-17 Synthon B.V. 4-Phenylpiperidin-Derivate
DE69910691T2 (de) 1998-06-29 2004-07-08 Sumika Fine Chemical Co. Ltd. L-Tartrate von Trans-(-)-4-(4-Fluorphenyl)-3-Hydroxymethyl-Piperidin Verbindungen und Verfahren zu ihrer Herstellung
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
EP1124802A1 (de) * 1998-11-02 2001-08-22 Synthon B.V. Verfahren zur herstellung von 4-arylpiperidin-3-carbinolen und verwandte verbindungen
GB9915303D0 (en) * 1999-06-30 1999-09-01 Smithkline Beecham Plc Novel process
IT1313702B1 (it) 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
GB9920147D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001029002A1 (en) * 1999-10-20 2001-04-26 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
GB9924882D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel process
GB9924855D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel processes
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
AU2000246280A1 (en) * 2000-05-12 2001-11-20 Synthon B.V. Tosylate salts of 4-(p-fluorophenyl)-piperidine-3-carbinols
US6833458B2 (en) 2000-06-05 2004-12-21 Development Center For Biotechnology Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates
AU2001211337A1 (en) * 2000-10-06 2002-04-15 Smithkline Beecham Plc Process for the preparation of aryl-piperidine carbinols and intermediates thereof
ES2232588T3 (es) * 2001-01-04 2005-06-01 Ferrer Internacional, S.A. Procedimiento pra la preparacion de (+-) - trans-4-p-fluorofenil -3- hidroximetil-1-metilpiperidina.
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
WO2002068416A2 (en) * 2001-02-24 2002-09-06 Spurcourt Limited Process of preparing paroxetine and intermediates for use therein
EP1406624A4 (de) 2001-06-13 2005-03-30 Teva Pharma Verfahren zur herstellung von paroxetin, das im wesentlichen frei von alkoxyverunreinigungen ist
KR100477048B1 (ko) * 2002-07-05 2005-03-17 임광민 피페리딘 화합물의 새로운 제조방법
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
CN101205211B (zh) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 一种盐酸帕罗西汀重要中间体的制备方法
IN2013MU03596A (de) * 2013-11-18 2015-07-24 Piramal Entpr Ltd
CN104262255A (zh) * 2014-09-22 2015-01-07 四川大学 一种不对称催化合成γ-硝基吡唑酰胺化合物的方法
CN104402800A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的制备方法
WO2022269643A1 (en) * 2021-06-25 2022-12-29 Vihita Chem Private Limited An improved process for the preparation of intermediate for paroxetine

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
BE625656A (de) * 1961-12-05
NL125654C (de) * 1963-12-17 1900-01-01
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
US3681327A (en) * 1970-07-01 1972-08-01 Exxon Research Engineering Co N-methylenethiophosphate derivatives of 1,3-thiazines and 1,4-thiazanes
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US3947460A (en) * 1974-06-27 1976-03-30 Sandoz, Inc. 5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones
EP0047516B1 (de) * 1980-09-04 1984-01-04 Toray Industries, Inc. Propylaminderivate und Verfahren zu deren Herstellung
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT

Also Published As

Publication number Publication date
AU582456B2 (en) 1989-03-23
CA1310649C (en) 1992-11-24
PT83179B (pt) 1989-03-30
SG27793G (en) 1993-05-21
GR862102B (en) 1986-12-30
NZ217141A (en) 1989-06-28
PT83179A (en) 1986-09-01
JPS6239566A (ja) 1987-02-20
EP0223334A1 (de) 1987-05-27
DK169730B1 (da) 1995-01-30
US4902801A (en) 1990-02-20
IE58831B1 (en) 1993-11-17
EP0223334B1 (de) 1991-07-10
JPH0696551B2 (ja) 1994-11-30
AU6101286A (en) 1987-02-12
DK380986A (da) 1987-02-11
DK380986D0 (da) 1986-08-08
HK69793A (en) 1993-07-30
JPH07138228A (ja) 1995-05-30
JPH08809B2 (ja) 1996-01-10
CY1708A (en) 1994-01-14
ES2005745A6 (es) 1989-03-16
IE862135L (en) 1987-02-10
MX171822B (es) 1993-11-17
DE3680184D1 (de) 1991-08-14
ES2000603A6 (es) 1988-03-01

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