BG61267B1 - Growth hormone crystals and method for production thereof - Google Patents
Growth hormone crystals and method for production thereof Download PDFInfo
- Publication number
- BG61267B1 BG61267B1 BG97281A BG9728193A BG61267B1 BG 61267 B1 BG61267 B1 BG 61267B1 BG 97281 A BG97281 A BG 97281A BG 9728193 A BG9728193 A BG 9728193A BG 61267 B1 BG61267 B1 BG 61267B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- crystals
- concentration
- mol
- added
- organic solvent
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title claims abstract description 74
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- 239000000122 growth hormone Substances 0.000 title claims description 17
- 108010051696 Growth Hormone Proteins 0.000 title claims description 13
- 102000018997 Growth Hormone Human genes 0.000 title claims description 13
- 238000000034 method Methods 0.000 claims abstract description 32
- 230000008569 process Effects 0.000 claims abstract description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 150000001768 cations Chemical class 0.000 claims description 19
- 239000003960 organic solvent Substances 0.000 claims description 16
- 238000002425 crystallisation Methods 0.000 claims description 10
- 230000008025 crystallization Effects 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 125000002091 cationic group Chemical group 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- -1 aromatic alcohols Chemical class 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 17
- 230000012010 growth Effects 0.000 abstract description 2
- 239000005556 hormone Substances 0.000 abstract description 2
- 229940088597 hormone Drugs 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 13
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 9
- 239000000725 suspension Substances 0.000 description 9
- 239000011701 zinc Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000007710 freezing Methods 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- 238000004255 ion exchange chromatography Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000019445 benzyl alcohol Nutrition 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108010006025 bovine growth hormone Proteins 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000011548 crystallization buffer Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101000868138 Ovis aries Somatotropin Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 210000004198 anterior pituitary gland Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001767 cationic compounds Chemical class 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- RCFKEIREOSXLET-UHFFFAOYSA-N disulfamide Chemical group CC1=CC(Cl)=C(S(N)(=O)=O)C=C1S(N)(=O)=O RCFKEIREOSXLET-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 229910001411 inorganic cation Inorganic materials 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- 230000004879 molecular function Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- 229940089531 polyethylene glycol 3500 Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 230000009576 somatic growth Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK168790A DK168790D0 (ru) | 1990-07-13 | 1990-07-13 | |
| PCT/DK1991/000203 WO1992000998A1 (en) | 1990-07-13 | 1991-07-12 | Growth hormone crystals and a process for production of these gh-crystals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG97281A BG97281A (bg) | 1994-03-24 |
| BG61267B1 true BG61267B1 (en) | 1997-04-30 |
Family
ID=8107212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG97281A BG61267B1 (en) | 1990-07-13 | 1993-01-12 | Growth hormone crystals and method for production thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6117984A (ru) |
| EP (1) | EP0540582B1 (ru) |
| JP (1) | JP2524446B2 (ru) |
| AT (1) | ATE110745T1 (ru) |
| AU (1) | AU666465B2 (ru) |
| BG (1) | BG61267B1 (ru) |
| CA (1) | CA2086087C (ru) |
| DE (1) | DE69103755T2 (ru) |
| DK (2) | DK168790D0 (ru) |
| ES (1) | ES2060399T3 (ru) |
| HU (2) | HUT64086A (ru) |
| IE (1) | IE67054B1 (ru) |
| NZ (1) | NZ238904A (ru) |
| PT (1) | PT98297B (ru) |
| RU (1) | RU2108341C1 (ru) |
| WO (1) | WO1992000998A1 (ru) |
| ZA (1) | ZA915446B (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6894023B1 (en) * | 1990-07-13 | 2005-05-17 | Novo Nordisk A/S | Growth hormone crystals and a process for production of these GH-crystals |
| DK168790D0 (ru) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
| DE10399015I1 (de) * | 1991-12-20 | 2012-05-03 | Novo Nordisk As | Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält |
| SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
| ZA9711385B (en) | 1996-12-20 | 1999-06-18 | Takeda Chemical Industries Ltd | Method of producing a sustained-release preparation |
| US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| JP3723857B2 (ja) * | 1998-02-04 | 2005-12-07 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモン含有水性医薬組成物 |
| US7101575B2 (en) | 1998-03-19 | 2006-09-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly |
| US6451347B1 (en) | 1999-03-01 | 2002-09-17 | Alkermes Controlled Therapeutics, Inc. | Method for purifying human growth hormone |
| DE60000622T2 (de) * | 1999-06-10 | 2003-02-27 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Einkapselung von kristallen mit mehrschichtigem überzug |
| US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
| EP1309312A2 (en) | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| SE517422C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Farmaceutiskt acceptabel stärkelse |
| SE517421C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav |
| AU2001294459A1 (en) | 2000-10-06 | 2002-04-15 | Jagotec Ag | A controlled-release, parenterally administrable microparticle preparation |
| SE518007C2 (sv) | 2000-11-16 | 2002-08-13 | Bioglan Ab | Förfarande för framställning av mikropartiklar |
| US7105181B2 (en) | 2001-10-05 | 2006-09-12 | Jagotec, Ag | Microparticles |
| SE0201599D0 (sv) | 2002-03-21 | 2002-05-30 | Skyepharma Ab | Microparticles |
| SE0202719D0 (sv) * | 2002-09-13 | 2002-09-13 | Pharmacia Ab | Process for mfg crystals of growth hormone |
| AU2003303646B2 (en) | 2002-12-31 | 2010-03-04 | Altus Pharmaceuticals Inc. | Human growth hormone crystals and methods for preparing them |
| MXPA05007182A (es) * | 2002-12-31 | 2006-04-07 | Altus Pharmaceuticals Inc | Complejos de cristales de proteina y polimeros ionicos. |
| CN101659701B (zh) * | 2002-12-31 | 2019-03-26 | 阿尔特斯制药公司 | 人生长激素晶体和制备它们的方法 |
| WO2005014034A1 (en) * | 2003-07-14 | 2005-02-17 | Nps Allelix Corp. | Stabilized formulation of parathyroid hormone |
| CA2634053A1 (en) * | 2005-12-23 | 2007-07-05 | Altus Pharmaceuticals Inc. | Compositions comprising polycation-complexed protein crystals and methods of treatment using them |
| JP2010513309A (ja) * | 2006-12-18 | 2010-04-30 | アルタス ファーマシューティカルズ インコーポレイテッド | ヒト成長ホルモン製剤 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA653324A (en) * | 1962-12-04 | G. Brink Norman | Growth hormone and methods of preparing the same | |
| US2143590A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Insulin preparation and process of producing crystals of insulin |
| US2174862A (en) * | 1938-12-30 | 1939-10-03 | Frederick Stearns & Company | Process of producing crystalline insulin |
| US2595278A (en) * | 1950-04-28 | 1952-05-06 | Armour & Co | Preparation of insulin from pancreas glands |
| US3102077A (en) * | 1953-08-19 | 1963-08-27 | Christensen Henry Marinus | Preparation of insulin containing 2.75 to 8 percent zinc content |
| US2897117A (en) * | 1955-02-10 | 1959-07-28 | Univ Alberta | Insulin process |
| US3856771A (en) * | 1973-07-16 | 1974-12-24 | Lilly Co Eli | Process for manufacturing alkali metal or ammonium insulin |
| EP0343696B1 (en) * | 1984-10-04 | 1996-01-03 | Monsanto Company | Zinc-associated somatotropins |
| ES8702440A1 (es) * | 1984-10-04 | 1986-12-16 | Monsanto Co | Un procedimiento para la preparacion de una composicion de polipeptido inyectable sustancialmente no acuosa. |
| IL79681A (en) * | 1985-08-12 | 1991-06-10 | Int Minerals & Chem Corp | Transition metal complexes of growth hormones and their prolonged release compositions |
| JPS63216898A (ja) * | 1987-01-30 | 1988-09-09 | インターナシヨナル・ミネラルズ・アンド・ケミカル・コーポレイシヨン | 希薄水溶液からソマトトロビンを回収する方法 |
| US4764592A (en) * | 1987-04-23 | 1988-08-16 | Eli Lilly And Company | Crystalline human proinsulin and process for its production |
| ATE198353T1 (de) * | 1988-08-24 | 2001-01-15 | American Cyanamid Co | Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung |
| US5109117A (en) * | 1990-06-26 | 1992-04-28 | Monsanto Company | Method of somatotropin naturation using urea and a soluble organic alcohol |
| US5780599A (en) * | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
| DK168790D0 (ru) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As |
-
1990
- 1990-07-13 DK DK168790A patent/DK168790D0/da active IP Right Grant
-
1991
- 1991-07-10 NZ NZ238904A patent/NZ238904A/xx unknown
- 1991-07-11 PT PT98297A patent/PT98297B/pt not_active IP Right Cessation
- 1991-07-12 HU HU9300067A patent/HUT64086A/hu unknown
- 1991-07-12 DK DK91913240.7T patent/DK0540582T3/da active
- 1991-07-12 IE IE244491A patent/IE67054B1/en not_active IP Right Cessation
- 1991-07-12 ES ES91913240T patent/ES2060399T3/es not_active Expired - Lifetime
- 1991-07-12 AU AU82846/91A patent/AU666465B2/en not_active Ceased
- 1991-07-12 ZA ZA915446A patent/ZA915446B/xx unknown
- 1991-07-12 CA CA002086087A patent/CA2086087C/en not_active Expired - Fee Related
- 1991-07-12 WO PCT/DK1991/000203 patent/WO1992000998A1/en active IP Right Grant
- 1991-07-12 JP JP3512511A patent/JP2524446B2/ja not_active Expired - Fee Related
- 1991-07-12 HU HU9300067A patent/HU210323B/hu unknown
- 1991-07-12 AT AT91913240T patent/ATE110745T1/de not_active IP Right Cessation
- 1991-07-12 RU RU93005051/13A patent/RU2108341C1/ru not_active IP Right Cessation
- 1991-07-12 DE DE69103755T patent/DE69103755T2/de not_active Expired - Fee Related
- 1991-07-12 EP EP91913240A patent/EP0540582B1/en not_active Expired - Lifetime
-
1993
- 1993-01-12 BG BG97281A patent/BG61267B1/bg unknown
-
1998
- 1998-04-21 US US09/063,749 patent/US6117984A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2524446B2 (ja) | 1996-08-14 |
| CA2086087C (en) | 1999-09-14 |
| ES2060399T3 (es) | 1994-11-16 |
| HU9300067D0 (en) | 1993-04-28 |
| DK0540582T3 (da) | 1995-01-30 |
| HU210323B (en) | 1995-03-28 |
| ATE110745T1 (de) | 1994-09-15 |
| EP0540582A1 (en) | 1993-05-12 |
| US6117984A (en) | 2000-09-12 |
| AU666465B2 (en) | 1996-02-15 |
| DE69103755T2 (de) | 1995-02-23 |
| DK168790D0 (ru) | 1990-07-13 |
| IE67054B1 (en) | 1996-02-21 |
| ZA915446B (en) | 1992-03-25 |
| DE69103755D1 (de) | 1994-10-06 |
| NZ238904A (en) | 1993-04-28 |
| PT98297A (pt) | 1992-05-29 |
| PT98297B (pt) | 1999-01-29 |
| CA2086087A1 (en) | 1992-01-14 |
| AU8284691A (en) | 1992-02-04 |
| IE912444A1 (en) | 1992-01-15 |
| RU2108341C1 (ru) | 1998-04-10 |
| HUT64086A (en) | 1993-11-29 |
| JPH05507497A (ja) | 1993-10-28 |
| BG97281A (bg) | 1994-03-24 |
| WO1992000998A1 (en) | 1992-01-23 |
| EP0540582B1 (en) | 1994-08-31 |
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