BG60762B2 - Заместени имидазолови производни и тяхното получаване и приложение - Google Patents

Заместени имидазолови производни и тяхното получаване и приложение Download PDF

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Publication number
BG60762B2
BG60762B2 BG98378A BG9837894A BG60762B2 BG 60762 B2 BG60762 B2 BG 60762B2 BG 98378 A BG98378 A BG 98378A BG 9837894 A BG9837894 A BG 9837894A BG 60762 B2 BG60762 B2 BG 60762B2
Authority
BG
Bulgaria
Prior art keywords
imidazole
dihydro
inden
compound
methyl
Prior art date
Application number
BG98378A
Other languages
Bulgarian (bg)
English (en)
Inventor
Arto Karjalainen
Raimo Virtanen
Arja Karjalainen
Kauko Kurkela
Original Assignee
Orion- Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion- Yhtymae Oy filed Critical Orion- Yhtymae Oy
Publication of BG60762B2 publication Critical patent/BG60762B2/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
BG98378A 1984-11-23 1994-01-18 Заместени имидазолови производни и тяхното получаване и приложение BG60762B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use

Publications (1)

Publication Number Publication Date
BG60762B2 true BG60762B2 (bg) 1996-02-29

Family

ID=10570140

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98378A BG60762B2 (bg) 1984-11-23 1994-01-18 Заместени имидазолови производни и тяхното получаване и приложение

Country Status (26)

Country Link
US (1) US4689339A (ja)
EP (2) EP0310745B1 (ja)
JP (1) JPH064597B2 (ja)
KR (1) KR930004673B1 (ja)
AT (2) ATE85050T1 (ja)
AU (2) AU586839B2 (ja)
BG (1) BG60762B2 (ja)
CA (1) CA1268770C (ja)
DD (1) DD258230A1 (ja)
DE (2) DE3587045T2 (ja)
DK (2) DK164903C (ja)
ES (2) ES8704462A1 (ja)
FI (1) FI80264C (ja)
GB (1) GB2167408B (ja)
GR (1) GR852817B (ja)
HK (1) HK3592A (ja)
HU (1) HU195189B (ja)
IE (1) IE58165B1 (ja)
IL (1) IL77111A (ja)
NO (1) NO166585C (ja)
NZ (1) NZ214258A (ja)
PH (1) PH22016A (ja)
PT (1) PT81542B (ja)
SG (1) SG106891G (ja)
SU (1) SU1424736A3 (ja)
ZA (1) ZA858942B (ja)

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WO1987004431A1 (en) * 1986-01-28 1987-07-30 Mitsui Petrochemical Industries, Ltd. Process for preparing 2-unsubstituted imidazoles
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
DK0612244T3 (da) * 1991-11-05 2002-01-14 Smithkline Beecham Corp Endothelinreceptorantagonister
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
JP2002510300A (ja) 1997-06-05 2002-04-02 ヴィーナンティアス・リミテッド インダン化合物及びそれらの医薬学的使用
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
WO2000042023A1 (en) * 1999-01-18 2000-07-20 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6388090B2 (en) * 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
DE60112917T2 (de) 2000-05-08 2006-06-08 Orion Corp. Neue polyzyklische indanylimidazole mit alpha2 adrenergik aktivität
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
US7592350B2 (en) 2002-04-03 2009-09-22 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
ATE411799T1 (de) * 2003-11-04 2008-11-15 Intervet Int Bv Ectoparasitische formulierungen von spinosyns und azol-pestiziden
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
WO2007044976A2 (en) 2005-10-12 2007-04-19 Unimed Pharmaceuticals, Llc Improved testosterone gel and method of use
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP2010500315A (ja) * 2006-08-08 2010-01-07 インターベツト・インターナシヨナル・ベー・ベー 増強された抗寄生虫活性組成物
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
JP6446054B2 (ja) 2013-11-05 2018-12-26 スリーエム・イノベイティブ・プロパティーズ・カンパニー ゴマ油ベースの注射製剤
TWI704145B (zh) 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
EP3370718B1 (en) * 2015-11-05 2021-01-27 University Of Louisville Research Foundation, Inc. Local and regional anesthesia and analgesia
EA201990158A1 (ru) 2016-06-29 2019-05-31 Орион Корпорейшн Производные бензодиоксана и их фармацевтическое применение
WO2020126536A1 (en) 2018-12-21 2020-06-25 Societe Des Produits Nestle S.A. Nutritional composition for inducing a feeling of satiety, a better sleep and/or limiting nocturnal awaking in infants or young children
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
US4342775A (en) * 1980-03-04 1982-08-03 Farmitalia Carlo Erba S.P.A. 3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
ZW13782A1 (en) * 1981-07-28 1982-10-06 Reckitt & Colmann Prod Ltd Imidazoline derivatives
ES8503669A1 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
JPS61143366A (ja) 1986-07-01
ZA858942B (en) 1986-08-27
DK540485A (da) 1986-05-24
DK58292D0 (da) 1992-05-04
DK164903C (da) 1993-01-25
NZ214258A (en) 1989-02-24
NO166585B (no) 1991-05-06
HK3592A (en) 1992-01-17
KR860004028A (ko) 1986-06-16
ATE85050T1 (de) 1993-02-15
NO166585C (no) 1991-08-21
DE3587045D1 (de) 1993-03-11
EP0310745A3 (en) 1989-10-11
CA1268770C (en) 1990-05-08
FI854335A0 (fi) 1985-11-05
EP0310745A2 (en) 1989-04-12
CA1266669A1 (en) 1990-03-13
DK58292A (da) 1992-05-04
FI80264B (fi) 1990-01-31
PT81542B (pt) 1988-03-03
GB2167408B (en) 1988-05-25
IE58165B1 (en) 1993-07-28
ATE47997T1 (de) 1989-12-15
DK540485D0 (da) 1985-11-22
AU586839B2 (en) 1989-07-27
DE3587045T2 (de) 1993-06-03
KR930004673B1 (ko) 1993-06-03
EP0310745B1 (en) 1993-01-27
AU3332989A (en) 1989-08-10
DD258230A1 (de) 1988-07-13
EP0183492B1 (en) 1989-11-15
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
ES8801248A1 (es) 1987-12-16
ES549178A0 (es) 1987-04-01
FI854335A (fi) 1986-05-24
IE852929L (en) 1986-05-23
SG106891G (en) 1992-02-14
JPH064597B2 (ja) 1994-01-19
ES557268A0 (es) 1987-12-16
GB2167408A (en) 1986-05-29
IL77111A (en) 1989-09-28
US4689339A (en) 1987-08-25
PT81542A (en) 1985-12-01
DK164903B (da) 1992-09-07
FI80264C (fi) 1990-05-10
AU5008385A (en) 1986-05-29
HUT38913A (en) 1986-07-28
ES8704462A1 (es) 1987-04-01
IL77111A0 (en) 1986-04-29
HU195189B (en) 1988-04-28
DE3574252D1 (en) 1989-12-21
EP0183492A1 (en) 1986-06-04
SU1424736A3 (ru) 1988-09-15
GB8429578D0 (en) 1985-01-03
GR852817B (ja) 1986-03-21

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